R. Rooswinkel

发表

Inhibition and Stimulation of Intestinal and Hepatic CYP3A Activity: Studies in Humanized CYP3A4 Transgenic Mice Using Triazolam

J. Beijnen, A. V. van Herwaarden, A. Schinkel, 2009, Drug Metabolism and Disposition.

Inhibition and stimulation of intestinal and hepatic CYP3A activity: studies in humanized CYP3A4 transgenic mice using triazolam

J. Beijnen, A. Schinkel, R. Sparidans, 2009 .

Absence of both cytochrome P450 3A and P-glycoprotein dramatically increases docetaxel oral bioavailability and risk of intestinal toxicity.

H. Rosing, J. Beijnen, A. V. van Herwaarden, 2009, Cancer research.

Intestinal cytochrome P450 3A plays an important role in the regulation of detoxifying systems in the liver

A. Schinkel, E. Wagenaar, A. E. Herwaarden, 2009, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Limited Mitochondrial Permeabilization Causes DNA Damage and Genomic Instability in the Absence of Cell Death

Karen Blyth, Martina Haller, Markus Rehm, 2015, Molecular cell.

Polyubiquitination and proteasomal turnover controls the anti-apoptotic activity of Bcl-B

J. Borst, E. de Vries, P. V. van Veelen, 2013, Oncogene.

Antiapoptotic potency of Bcl-2 proteins primarily relies on their stability, not binding selectivity.

M. Verheij, J. Borst, E. de Vries, 2014, Blood.

AT-101, a small molecule inhibitor of anti-apoptotic Bcl-2 family members, activates the SAPK/JNK pathway and enhances radiation-induced apoptosis.

H. Bartelink, Dajun Yang, S. Zerp, 2009, Radiation oncology.

Targeting anti-apoptotic BCL-2 proteins in cancer: the importance of intermolecular interactions and protein turnover

R. Rooswinkel, 2013 .

Bcl-2 is a better ABT-737 target than Bcl-xL or Bcl-w and only Noxa overcomes resistance mediated by Mcl-1, Bfl-1, or Bcl-B

M. Verheij, J. Borst, R W Rooswinkel, 2012, Cell Death and Disease.

Combining Radiotherapy with APO010 in Cancer Treatment

M. Verheij, J. Borst, N. Beltraminelli, 2009, Clinical Cancer Research.

Combining Radiotherapy with APO 010 in Cancer Treatment

J. Borst, N. Beltraminelli, M. Dupuis, 2009 .

Limited Mitochondrial Permeabilization Causes DNA Damage and Genomic Instability in the Absence of Cell Death

A. Oberst, K. Blyth, L. Bouchier-Hayes, 2015, Molecular Cell.

Limited Mitochondrial Per meabilization Causes DNA Damage and Genomic Instability in the Absence of Cell Death Graphical

K. Blyth, L. Bouchier-Hayes, G. Ichim, 2022 .

N-terminal acetylation can stabilize proteins independent of their ubiquitination

J. Borst, E. de Vries, P. V. van Veelen, 2023, Scientific Reports.

Tumor-derived GDF-15 blocks LFA-1 dependent T cell recruitment and suppresses responses to anti-PD-1 treatment

S. H. van der Burg, S. von Felten, R. Dummer, 2023, Nature communications.

Ubiquitination in apoptosis signaling

E. D. Vries, J. Borst, G. Janssen, 2014 .

AT-101, a small molecule inhibitor of anti-apoptotic Bcl-2 family members, activates the SAPK/JNK pathway and enhances radiation-induced apoptosis

H. Bartelink, Dajun Yang, S. Zerp, 2009, Radiation oncology.