Sabine Willems

发表

Scaffold Hopping from Amodiaquine to Novel Nurr1 Agonist Chemotypes via Microscale Analogue Libraries

E. Proschak, D. Merk, J. Heering, 2022, ChemMedChem.

Design and Structural Optimization of Dual FXR/PPARδ Activators.

D. Merk, Pascal Heitel, A. Kaiser, 2020, Journal of medicinal chemistry.

Structure-Based Design of Dual Partial Peroxisome Proliferator-Activated Receptor γ Agonists/Soluble Epoxide Hydrolase Inhibitors.

S. Knapp, D. Steinhilber, E. Proschak, 2021, Journal of medicinal chemistry.

Chemical Starting Matter for HNF4α Ligand Discovery and Chemogenomics

A. Chaikuad, D. Merk, J. Heering, 2020, International journal of molecular sciences.

Medicinal Chemistry and Chemical Biology of Nurr1 Modulators: An Emerging Strategy in Neurodegeneration.

D. Merk, Sabine Willems, 2022, Journal of medicinal chemistry.

A New FXR Ligand Chemotype with Agonist/Antagonist Switch.

D. Merk, A. Kaiser, Jurema Schmidt, 2021, ACS medicinal chemistry letters.

Optical control of the nuclear bile acid receptor FXR with a photohormone† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c9sc02911g

D. Trauner, M. Trauner, D. Merk, 2019, Chemical science.

Targeting Nuclear Receptors in Neurodegeneration and Neuroinflammation.

Sabine Willems, D. Merk, Daniel Zaienne, 2021, Journal of medicinal chemistry.

Boosting Anti-Inflammatory Potency of Zafirlukast by Designed Polypharmacology.

D. Steinhilber, M. Wurglics, E. Proschak, 2018, Journal of medicinal chemistry.

Endogenous vitamin E metabolites mediate allosteric PPARγ activation with unprecedented co-regulatory interactions.

S. Knapp, S. Lorkowski, O. Werz, 2021, Cell chemical biology.

Nurr1 Modulation Mediates Neuroprotective Effects of Statins

J. Heering, Giuseppe Faudone, Whitney Kilu, 2021, bioRxiv.

Development and Profiling of Inverse Agonist Tools for the Neuroprotective Transcription Factor Nurr1.

D. Merk, J. Heering, S. Schierle, 2021, Journal of medicinal chemistry.

The orphan nuclear receptor Nurr1 is responsive to non-steroidal anti-inflammatory drugs

S. Knapp, A. Chaikuad, D. Merk, 2020, Communications Chemistry.

A Photohormone for Light-Dependent Control of PPARα in Live Cells.

D. Trauner, D. Merk, Johannes Morstein, 2021, Journal of medicinal chemistry.

Photohormones Enable Optical Control of the Peroxisome Proliferator-Activated Receptor Gamma (PPAR).

D. Trauner, D. Merk, Johannes Morstein, 2020, Journal of medicinal chemistry.

De Novo Design of Nurr1 Agonists via Fragment-Augmented Generative Deep Learning in Low-Data Regime

F. Grisoni, D. Merk, J. Marschner, 2023, Journal of medicinal chemistry.

Fragment-like Chloroquinolineamines Activate the Orphan Nuclear Receptor Nurr1 and Elucidate Activation Mechanisms.

D. Merk, J. Heering, Whitney Kilu, 2021, Journal of Medicinal Chemistry.

Development of Light‐Activated LXR Agonists

D. Trauner, D. Merk, Johannes Morstein, 2023, ChemMedChem.