H. Yamazaki

发表

Pharmacokinetics of loxoprofen in a self-administered overdose in a Japanese patient admitted to hospital

M. Shimizu, S. Beppu, Koichi Adachi, 2021, Journal of pharmaceutical health care and sciences.

Oxidative metabolism and pharmacokinetics of the EGFR inhibitor BIBX1382 in chimeric NOG-TKm30 mice transplanted with human hepatocytes.

H. Suemizu, Nao Yoneda, H. Yamazaki, 2021, Drug metabolism and pharmacokinetics.

Genetic variants of CYP 3 A 4 and CYP 3 A 5 in cynomolgus and rhesus macaques

N. Osada, K. Fukuzaki, S. Kohara, 2009 .

A Comprehensive Investigation of Dog Cytochrome P450 3A (CYP3A) Reveals a Functional Role of Newly Identified CYP3A98 in Small Intestine

Y. Uno, N. Murayama, H. Yamazaki, 2022, Drug Metabolism and Disposition.

Oxidation of 3’-methoxyflavone, 4’-methoxyflavone, and 3’,4’-dimethoxyflavone and their derivatives having 5,7-dihydroxyl moieties by human cytochromes P450 1B1 and 2A13

T. Shimada, F. Guengerich, Donghak Kim, 2022, Xenobiotica; the fate of foreign compounds in biological systems.

Species Specificity and Selection of Models for Drug Oxidations Mediated by Polymorphic Human Enzymes

M. Shimizu, H. Yamazaki, 2022, Drug Metabolism and Disposition.

Comparison of mouse and human cytochrome P450 mediated-drug metabolising activities in hepatic and extrahepatic microsomes

H. Suemizu, N. Murayama, Nao Yoneda, 2022, Xenobiotica; the fate of foreign compounds in biological systems.

Population pharmacokinetics of fluconazole after administration of fosfluconazole and fluconazole in critically ill patients

K. Hirata, Y. Yamamoto, H. Yamazaki, 2012, Journal of clinical pharmacy and therapeutics.

Humanized liver TK-NOG mice with functional deletion of hepatic murine cytochrome P450s as a model for studying human drug metabolism

M. Oshimura, H. Suemizu, Mamoru Ito, 2022, Scientific Reports.

Cytochrome P450-dependent drug oxidation activities and their expression levels in liver microsomes of chimeric TK-NOG mice with humanized livers.

H. Suemizu, Nao Yoneda, H. Yamazaki, 2022, Drug metabolism and pharmacokinetics.

Combined Risk Assessment of Food-derived Coumarin with in Silico Approaches

W. Tong, A. Hirose, N. Murayama, 2022, Food safety.

A series of simple detection systems for genetic variants of flavin-containing monooxygenase 3 (FMO3) with impaired function in Japanese subjects.

M. Shimizu, H. Yamazaki, Ami Mizugaki, 2021, Drug metabolism and pharmacokinetics.

Effects of multi-kinase inhibitors on the activity of cytochrome P450 2J2

M. Nadai, N. Murayama, M. Katoh, 2022, Xenobiotica; the fate of foreign compounds in biological systems.

Cytochrome P450 2J Genes Are Expressed in Dogs, Cats, and Pigs, and Encode Functional Drug-Metabolizing Enzymes

M. Ishizuka, S. Nakayama, Y. Ikenaka, 2022, Drug Metabolism and Disposition.

A comprehensive analysis of six forms of cytochrome P450 2C (CYP2C) in pigs

Y. Uno, N. Murayama, H. Yamazaki, 2022, Xenobiotica; the fate of foreign compounds in biological systems.

vivo Probe for Studying Induction of CYP 3 A in Cynomolgus Monkeys

Y. Uno, T. Kume, H. Yamazaki, 2010 .

Relationship between interindividual differences in nicotine metabolism and CYP2A6 genetic polymorphism in humans

Hiroshi Yamamoto, H. Yamamoto, Toshinori Yamamoto, 2001, Clinical pharmacology and therapeutics.

Pharmacokinetics of antifungal agent micafungin in critically ill patients receiving continuous hemodialysis filtration.

Yasuhiro Yamamoto, Y. Matsumoto, K. Hirata, 2007, Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan.

Plasma and synovial fluid concentrations of linezolid in patients with knee osteoarthritis infected with Staphylococcus aureus

M. Shimizu, H. Yamazaki, Daisuke Negishi, 2022, Journal of Pharmaceutical Health Care and Sciences.

Pharmacokinetic modeling of over-the-counter drug diphenhydramine self-administered in overdoses in Japanese patients admitted to hospital

M. Shimizu, S. Beppu, M. Terashima, 2021, Journal of pharmaceutical health care and sciences.

Editorial.

G. B. Gori, M. Aschner, D. Schrenk, 2019, Regulatory toxicology and pharmacology : RTP.

A family study of compound variants of flavin-containing monooxygenase 3 (FMO3) in Japanese subjects found by urinary phenotyping for trimethylaminuria.

M. Shimizu, H. Yamazaki, Akane Yamamoto, 2023, Drug metabolism and pharmacokinetics.

Molecular and functional characterization of flavin-containing monooxygenases in pigs, dogs, and cats.

M. Shimizu, M. Ishizuka, H. Kawaguchi, 2022, Biochemical pharmacology.

An improved TK-NOG mouse as a novel platform for humanized liver that overcomes limitations in both male and female animals.

M. Oshimura, H. Suemizu, H. Hikita, 2021, Drug metabolism and pharmacokinetics.

Drug-oxidizing and conjugating non-cytochrome P450 (non-P450) enzymes in cynomolgus monkeys and common marmosets as preclinical models for humans.

Y. Uno, H. Yamazaki, Shotaro Uehara, 2021, Biochemical pharmacology.

CYP2D44 polymorphisms in cynomolgus and rhesus macaques

H. Yamazaki, N. Osada, S. Kohara, 2015, Molecular Biology Reports.

Newly identified tree shrew cytochrome P450 2B6 (CYP2B6) and pig CYP2B6b are functional drug-metabolising enzymes

K. Tsukiyama-Kohara, Y. Uno, N. Murayama, 2022, Xenobiotica; the fate of foreign compounds in biological systems.

Molecular and Functional Characterization of N-Acetyltransferases in Common Marmosets and Pigs

Y. Uno, N. Murayama, H. Yamazaki, 2022, Drug Metabolism and Disposition.

Differences in pharmacokinetics and haematotoxicities of aniline and its dimethyl derivatives orally administered in rats.

M. Shimizu, Tomonori Miura, Yusuke Kamiya, 2021, Biological & pharmaceutical bulletin.

Forward and reverse dosimetry for aniline and 2,6-dimethylaniline in humans extrapolated from humanized-liver mouse data using simplified physiologically based pharmacokinetic models.

M. Shimizu, H. Suemizu, Tomonori Miura, 2022, The Journal of toxicological sciences.

Machine Learning Prediction of the Three Main Input Parameters of a Simplified Physiologically Based Pharmacokinetic Model Subsequently Used to Generate Time-Dependent Plasma Concentration Data in Humans after Oral Doses of 212 Disparate Chemicals.

M. Shimizu, Tomonori Miura, Yusuke Kamiya, 2021, Biological & pharmaceutical bulletin.

Effects of polymorphic cytochrome P450 2A6 genotypes on chemoprevention against colorectal tumors in single Japanese cohort using daily low-dose aspirin: insights into future personalized treatments

M. Shimizu, Sadao Suzuki, H. Ishikawa, 2021, Journal of pharmaceutical health care and sciences.

Trivariate Linear Regression and Machine Learning Prediction of Possible Roles of Efflux Transporters in Estimated Intestinal Permeability Values of 301 Disparate Chemicals.

M. Shimizu, Yusuke Kamiya, H. Yamazaki, 2022, Biological & pharmaceutical bulletin.

An Updated In Silico Prediction Method for Volumes of Systemic Circulation of 323 Disparate Chemicals for Use in Physiologically Based Pharmacokinetic Models to Estimate Plasma and Tissue Concentrations after Oral Doses in Rats.

M. Shimizu, K. Funatsu, Tomonori Miura, 2021, Chemical research in toxicology.

Prediction of permeability across intestinal cell monolayers for 219 disparate chemicals using in vitro experimental coefficients in a pH gradient system and in silico analyses by trivariate linear regressions and machine learning.

K. Funatsu, Yusuke Kamiya, H. Yamazaki, 2021, Biochemical pharmacology.

In vivo Analysis of the Anti-atrial Fibrillatory, Proarrhythmic and Cardiodepressive Profiles of Dronedarone as a Guide for Safety Pharmacological Evaluation of Antiarrhythmic Drugs

A. Naito, Kentaro Ando, Yuji Nakamura, 2017, Cardiovascular Toxicology.

Studies on active substances in the herbs used for oketsu ("stagnant blood") in Chinese medicine. III. On the anticoagulative principles in curcumae rhizoma.

H. Ishida, T. Kosuge, H. Yamazaki, 1985, Chemical & pharmaceutical bulletin.

Low cerebrospinal fluid-to-plasma ratios of orally administered lenalidomide mediated by its low cell membrane permeability in patients with hematologic malignancies

Yusuke Kamiya, N. Murayama, H. Yamazaki, 2022, Annals of Hematology.

Imaging Mass Spectrometry (IMS) for drug discovery and development survey: Results on methods, applications and regulatory compliance.

Kosuke Saito, T. Ishida, Yoshiro Saito, 2021, Drug metabolism and pharmacokinetics.

Probe drug T-1032 N-oxygenation mediated by cytochrome P450 3A5 in human hepatocytes in vitro and in humanized-liver mice in vivo.

M. Shimizu, H. Suemizu, S. Routier, 2022, Drug metabolism and pharmacokinetics.

Liver and Plasma Concentrations of Food Chemicals after Virtual Oral Doses Extrapolated Using in silico Estimated Input Pharmacokinetic Parameters to Confirm Reported Liver Toxicity in Rats.

M. Shimizu, K. Adachi, H. Yamazaki, 2023, Biological & pharmaceutical bulletin.

Systematic identification and characterization of cynomolgus macaque solute carrier transporters.

Y. Uno, H. Yamazaki, 2021, Drug metabolism and pharmacokinetics.

Prediction of in vivo drug clearance from in vitro data. II: Potential inter-ethnic differences

K Rowland-Yeo, H. Yamazaki, G. Tucker, 2006, Xenobiotica; the fate of foreign compounds in biological systems.

Inhibitory effects of amiodarone and its N-deethylated metabolite on human cytochrome P450 activities: prediction of in vivo drug interactions.

H. Yamazaki, M. Nakajima, T. Yokoi, 2000, British journal of clinical pharmacology.

Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians.

H. Yamazaki, T. Shimada, F. Guengerich, 1994, The Journal of pharmacology and experimental therapeutics.

A new Salmonella typhimurium NM5004 strain expressing rat glutathione S-transferase 5-5: use in detection of genotoxicity of dihaloalkanes using an SOS/umu test system.

R Thier, T. Shimada, F. Guengerich, 1996, Carcinogenesis.

HepaSH cells: Experimental human hepatocytes with lesser inter-individual variation and more sustainable availability than primary human hepatocytes.

H. Suemizu, Kazuhiro Murai, H. Hikita, 2023, Biochemical and Biophysical Research Communications - BBRC.

Cytochrome P450 2E1 and 2A6 enzymes as major catalysts for metabolic activation of N-nitrosodialkylamines and tobacco-related nitrosamines in human liver microsomes.

H. Yamazaki, T. Shimada, F. Guengerich, 1992, Carcinogenesis.

Relationship between CYP2C9 and 2C19 genotypes and tolbutamide methyl hydroxylation and S-mephenytoin 4'-hydroxylation activities in livers of Japanese and Caucasian populations.

H. Yamazaki, T. Shimada, F. Guengerich, 1997, Pharmacogenetics.

Interactions of ingested food, beverage, and tobacco components involving human cytochrome P4501A2, 2A6, 2E1, and 3A4 enzymes.

H. Yamazaki, T. Shimada, F. Guengerich, 1994, Environmental health perspectives.

H. Yamazaki, T. Shimada, F. Guengerich, 1996, Xenobiotica; the fate of foreign compounds in biological systems.

Deactivation of anti-cancer drug letrozole to a carbinol metabolite by polymorphic cytochrome P450 2A6 in human liver microsomes

T. Kamataki, K. Nakagawa, R. Kawai, 2009, Xenobiotica; the fate of foreign compounds in biological systems.

Progesterone and testosterone hydroxylation by cytochromes P450 2C19, 2C9, and 3A4 in human liver microsomes.

H. Yamazaki, T. Shimada, H Yamazaki, 1997, Archives of biochemistry and biophysics.

Prediction of human liver microsomal oxidations of 7-ethoxycoumarin and chlorzoxazone with kinetic parameters of recombinant cytochrome P-450 enzymes.

H. Yamazaki, T. Shimada, H Yamazaki, 1999, Drug metabolism and disposition: the biological fate of chemicals.

Activation and detoxication of aflatoxin B1.

H. Yamazaki, T. Shimada, F. Guengerich, 1998, Mutation research.

Cloning and tissue expression of ATP-binding cassette transporters in cynomolgus macaques.

Y. Uno, H. Yamazaki, 2021, Drug metabolism and pharmacokinetics.

Aflatoxin B1 8,9-epoxide hydrolysis in the presence of rat and human epoxide hydrolase.

H. Yamazaki, T. Shimada, F. Guengerich, 1997, Chemical research in toxicology.

Involvement of cytochrome P450, glutathione S-transferase, and epoxide hydrolase in the metabolism of aflatoxin B1 and relevance to risk of human liver cancer.

H. Yamazaki, T. Shimada, F. Guengerich, 1996, Environmental health perspectives.

A decreasing plasma concentration of a toxicologically active metabolite 9-carboxymethoxymethylguanine after dialysis - A potential new clinical biomarker for improving encephalopathy in patients treated with acyclovir.

M. Shimizu, K. Adachi, S. Beppu, 2023, Journal of Infection and Chemotherapy.

Characterization of human lung microsomal cytochrome P-450 1A1 and its role in the oxidation of chemical carcinogens.

P. Beaune, H. Yamazaki, T. Shimada, 1992, Molecular pharmacology.

Modeled Rat Hepatic and Plasma Concentrations of Chemicals after Virtual Administrations Using Two Sets of in silico Liver-to-Plasma Partition Coefficients.

M. Shimizu, K. Adachi, H. Yamazaki, 2023, Biological & pharmaceutical bulletin.

In vivo and in vitro characterization of CYP2E1 activity in Japanese and Caucasians.

H. Yamazaki, R. Kim, T. Shimada, 1996, The Journal of pharmacology and experimental therapeutics.

Characterization of cytochrome P450 enzymes involved in drug oxidations in mouse intestinal microsomes

H. Yamazaki, M. Nakajima, T. Yokoi, 2000, Xenobiotica; the fate of foreign compounds in biological systems.

Effects of arachidonic acid, prostaglandins, retinol, retinoic acid and cholecalciferol on xenobiotic oxidations catalysed by human cytochrome P450 enzymes.

H. Yamazaki, T. Shimada, H. Yamazaki, 1999, Xenobiotica; the fate of foreign compounds in biological systems.

Bufuralol hydroxylation by cytochrome P450 2D6 and 1A2 enzymes in human liver microsomes.

H. Yamazaki, T. Shimada, F. Guengerich, 1994, Molecular pharmacology.

Use of everted sacs of mouse small intestine as enzyme sources for the study of drug oxidation activities in vitro

H. Yamazaki, M. Nakajima, T. Yokoi, 2000, Xenobiotica; the fate of foreign compounds in biological systems.

Characterization of microsomal cytochrome P450 enzymes involved in the oxidation of xenobiotic chemicals in human fetal liver and adult lungs.

H. Yamazaki, T. Shimada, F. Guengerich, 1996, Drug metabolism and disposition: the biological fate of chemicals.

Drug interactions of thalidomide with midazolam and cyclosporine A: heterotropic cooperativity of human cytochrome P450 3A5 1 Fast

M. Shimizu, H. Yamazaki, F. Guengerich, 2008 .

Metabolism of FK506, a potent immunosuppressive agent, by cytochrome P450 3A enzymes in rat, dog and human liver microsomes.

H. Yamazaki, T. Shimada, Y. Funae, 1994, Biochemical pharmacology.

Ethnic differences between Japanese and Caucasians in the expression levels of mRNAs for CYP3A4, CYP3A5 and CYP3A7: lack of co-regulation of the expression of CYP3A in Japanese livers

S. Yamaori, K. Kiyotani, T. Kamataki, 2005, Xenobiotica; the fate of foreign compounds in biological systems.

A significant role of human cytochrome P450 2C8 in amiodarone N-deethylation: an approach to predict the contribution with relative activity factor.

H. Yamazaki, M. Nakajima, T. Yokoi, 2000, Drug metabolism and disposition: the biological fate of chemicals.

High hepatic and plasma exposures of atorvastatin in subjects harboring impaired cytochrome P450 3A4∗16 modeled after virtual administrations and possibly associated with statin intolerance found in the Japanese adverse drug event report database.

M. Shimizu, Yoshiro Saito, Yoichi Tanaka, 2022, Drug metabolism and pharmacokinetics.

Identification of cytochrome P450 2C18 and 2C76 in tree shrews: P450 2C18 effectively oxidizes typical human P450 2C9/2C19 chiral substrates warfarin and omeprazole with less stereoselectivity.

Y. Uno, N. Murayama, H. Yamazaki, 2023, Biochemical pharmacology.

Inhibition and inactivation of human cytochrome P450 isoforms by phenethyl isothiocyanate.

H. Yamazaki, M. Nakajima, T. Yokoi, 2001, Drug metabolism and disposition: the biological fate of chemicals.

Roles of human cytochrome P450 3A4/5 in dexamethasone 6β-hydroxylation mediated by liver microsomes and humanized liver in chimeric mice metabolically suppressed with azamulin.

M. Shimizu, H. Suemizu, H. Yamazaki, 2023, Drug metabolism and pharmacokinetics.

Induction of cytochrome P450 1B1 in lung, liver and kidney of rats exposed to diesel exhaust.

H. Yamazaki, K. Hayakawa, M. Nakajima, 2001, Carcinogenesis.

Pharmacokinetics of caffeine self-administered in overdose in a Japanese patient admitted to hospital

M. Shimizu, J. Tomizawa, K. Adachi, 2021, Journal of Pharmaceutical Health Care and Sciences.

Novel Cytochrome P450 2C119 Enzymes in Cynomolgus and Rhesus Macaques Metabolize Progesterone, Diclofenac, and Omeprazole

Y. Uno, N. Murayama, H. Yamazaki, 2023, Drug Metabolism and Disposition.

Development of genotyping method for functionally relevant variants of cytochromes P450 in cynomolgus macaques.

H. Yamazaki, K. Ikeo, N. Osada, 2018, Journal of veterinary pharmacology and therapeutics.

Liver microsomal cytochrome P450 3A-dependent drug oxidation activities in individual dogs

Y. Uno, N. Murayama, H. Yamazaki, 2023, Xenobiotica; the fate of foreign compounds in biological systems.

Tree shrew cytochrome P450 2E1 is a functional enzyme that metabolises chlorzoxazone and p-nitrophenol

Y. Uno, N. Murayama, H. Yamazaki, 2023, Xenobiotica; the fate of foreign compounds in biological systems.

The influence of temperature on the metabolic activity of CYP2C9, CYP2C19, and CYP3A4 genetic variants in vitro

Koujirou Yamamoto, F. Guengerich, Takeshi Akiyoshi, 2023, Xenobiotica; the fate of foreign compounds in biological systems.

2-Oxidation, 3-methyl hydroxylation, and 6-hydroxylation of skatole, a contributor to the odour of boar-tainted pork meat, mediated by porcine liver microsomal cytochromes P450 1A2, 2A19, 2E1, and 3A22

Y. Uno, N. Murayama, H. Yamazaki, 2023, Xenobiotica; the fate of foreign compounds in biological systems.