Jonathan G. Schlegel

Cell‐permeable high‐affinity tracers for Gq proteins provide structural insights, reveal distinct binding kinetics and identify small molecule inhibitors

C. Müller, B. Fleischmann, M. Gütschow, 2019, British journal of pharmacology.

Design, synthesis and biological evaluation of suramin-derived dual antagonists of the proinflammatory G protein-coupled receptors P2Y2 and GPR17.

C. Müller, Thanigaimalai Pillaiyar, Aliaa Abdelrahman, 2019, European journal of medicinal chemistry.

Irreversible Antagonists for the Adenosine A2B Receptor

C. Müller, Jonathan G. Schlegel, J. Voss, 2022, Molecules.

Macrocyclic Gq Protein Inhibitors FR900359 and/or YM-254890-Fit for Translation?

C. Müller, B. Fleischmann, D. Wenzel, 2021, ACS pharmacology & translational science.

Single Stabilizing Point Mutation Enables High‐Resolution Co‐Crystal Structures of the Adenosine A2A Receptor with Preladenant Conjugates

J. Labahn, Tim A. Klapschinski, Jonathan G. Schlegel, 2022, Angewandte Chemie.

Crystal structure of adenosine A2A receptor in complex with clinical candidate Etrumadenant reveals unprecedented antagonist interaction

R. Cheng, Denis Bucher, N. Sträter, 2023, Communications chemistry.

Sensitive LC-MS/MS Method for the Quantification of Macrocyclic Gαq Protein Inhibitors in Biological Samples

C. Müller, B. Fleischmann, D. Wenzel, 2020, Frontiers in Chemistry.

Structural Insights into Partial Activation of the Prototypic G Protein-Coupled Adenosine A2A Receptor

Jonathan G. Schlegel, R.H.-J. Weisse, T. Claff, 2024, ACS Pharmacology & Translational Science.