K. Sparrer

发表

Spike residue 403 affects binding of coronavirus spikes to human ACE2

K. Conzelmann, F. Kirchhoff, A. Ensser, 2021, Nature Communications.

Determinants of Spike infectivity, processing, and neutralization in SARS-CoV-2 Omicron subvariants BA.1 and BA.2

F. Kirchhoff, Fabian Zech, C. Jung, 2022, bioRxiv.

IFITM proteins promote SARS-CoV-2 infection of human lung cells

F. Kirchhoff, J. Münch, R. Gross, 2020, bioRxiv.

Actin cytoskeleton remodeling primes RIG-I-like receptor activation

F. Kirchhoff, J. Münch, M. Gack, 2022, Cell.

SARS-CoV-2 infects cells of the human exocrine and endocrine pancreas and interferes with beta-cell function

A. Stenzinger, J. Gehrmann, P. MacDonald, 2020 .

Modulation of type I interferon responses potently inhibits SARS-CoV-2 replication and inflammation in rhesus macaques

Leanne S. Whitmore, Jennifer S. Wood, R. Johnson, 2022, bioRxiv.

SARS-CoV-2 causes senescence in human cells and exacerbates the senescence-associated secretory phenotype through TLR-3

F. Kirchhoff, D. B. Allison, L. Niedernhofer, 2021, Aging.

Implications of Innate Immunity in Post-Acute Sequelae of Non-Persistent Viral Infections

K. Sparrer, Maximilian Hirschenberger, Victoria Hunszinger, 2021, Cells.

Cell-penetrating and neurotargeting dendritic siRNA nanostructures.

K. Conzelmann, T. Carell, C. Bräuchle, 2015, Angewandte Chemie.

Omicron: What Makes the Latest SARS-CoV-2 Variant of Concern So Concerning?

F. Kirchhoff, Fabian Zech, Dorota Kmiec, 2022, Journal of virology.

Drug Inhibition of SARS-CoV-2 Replication in Human Pluripotent Stem Cell–Derived Intestinal Organoids

T. Seufferlein, J. Münch, T. Barth, 2020, Cellular and Molecular Gastroenterology and Hepatology.

Click-modified anandamide siRNA enables delivery and gene silencing in neuronal and immune cells.

K. Conzelmann, T. Carell, K. Sparrer, 2012, Journal of the American Chemical Society.

SARS-CoV-2 variants of concern remain dependent on IFITM2 for efficient replication in human lung cells

H. Blum, F. Kirchhoff, M. Frick, 2021, bioRxiv.

IFITM dependency of SARS-CoV-2 variants of concern

F. Kirchhoff, M. Frick, Fabian Zech, 2021, bioRxiv.

Systematic analysis of innate immune antagonism reveals vulnerabilities of SARS-CoV-2

K. Conzelmann, F. Kirchhoff, A. Imhof, 2020 .

Spike mutation T403R allows bat coronavirus RaTG13 to use human ACE2

K. Conzelmann, F. Kirchhoff, A. Ensser, 2021, bioRxiv.

Endogenous IFITMs boost SARS-coronavirus 1 and 2 replication whereas overexpression inhibits infection by relocalizing ACE2

F. Kirchhoff, C. Drosten, D. Niemeyer, 2023, iScience.

Systematic functional analysis of SARS-CoV-2 proteins uncovers viral innate immune antagonists and remaining vulnerabilities

K. Conzelmann, F. Kirchhoff, J. Münch, 2021, Cell Reports.

Near-Native Visualization of SARS-CoV-2 Induced Membrane Remodeling and Virion Morphogenesis

F. Kirchhoff, C. Read, S. Stenger, 2022, Viruses.

Strong attenuation of SARS-CoV-2 Omicron BA.1 and increased replication of the BA.5 subvariant in human cardiomyocytes

F. Kirchhoff, J. Münch, S. Just, 2022, Signal transduction and targeted therapy.

Determinants of species-specific utilization of ACE2 by human and animal coronaviruses

F. Kirchhoff, Qingxing Wang, Fabian Zech, 2023, bioRxiv.

SARS-CoV-2 inhibition and specific targeting of infected cells by VSV particles carrying the ACE2 receptor

F. Kirchhoff, C. Read, M. Volcic, 2023, Signal transduction and targeted therapy.

Head-to-head comparison of different classes of FAP radioligands designed to increase tumor residence time: monomer, dimer, albumin binders, and small molecules vs peptides

R. Mansi, M. Fani, J. Millul, 2023, European Journal of Nuclear Medicine and Molecular Imaging.

SARS-CoV-2 infects and replicates in cells of the human endocrine and exocrine pancreas

A. Stenzinger, J. Gehrmann, P. MacDonald, 2021, Nature Metabolism.

Cap snatch prevention: a novel approach to tackle influenza viruses

F. Kirchhoff, K. Sparrer, 2023, Signal Transduction and Targeted Therapy.

Acetylation of the NS3 helicase by KAT5γ is essential for flavivirus replication.

C. Goins, Santoshi Muppala, C. Chiang, 2023, Cell host & microbe.

Cell-penetrating and neurotargeting dendritic siRNA nanostructures.

K. Conzelmann, T. Carell, C. Bräuchle, 2015, Angewandte Chemie.

ARF1 prevents aberrant type I interferon induction by regulating STING activation and recycling

M. Rodero, A. Lepelley, R. Papa, 2023, Nature communications.

CSNK2 suppresses autophagy by activating FLN-NHL-containing TRIM proteins

Michaela U. Gack, K. Sparrer, L. Koepke, 2023, Autophagy.

Regulation of STING activity in DNA sensing by ISG15 modification.

B. Görg, C. Gertzen, N. V. Fuchs, 2023, Cell reports.

IFITM proteins promote SARS-CoV-2 infection and are targets for virus inhibition in vitro

C. Goffinet, Tatjana Weil, Fabian Zech, 2021, Nature Communications.

Vpr attenuates antiviral immune responses and is critical for full pathogenicity of SIVmac239 in rhesus macaques

G. Silvestri, G. Tharp, S. Bosinger, 2023, iScience.

Friends and Foes: The Ambivalent Role of Autophagy in HIV-1 Infection

K. Sparrer, S. Klute, 2024, Viruses.

Phosphatidylserine-exposing extracellular vesicles in body fluids are an innate defence against apoptotic mimicry viral pathogens

E. Herker, M. Cortese, U. Bunz, 2024, Nature microbiology.

Replication competent HIV-guided CRISPR screen identifies antiviral factors including targets of the accessory protein Nef

Caterina Prelli Bozzo, M. Volcic, K. Sparrer, 2024, Nature communications.

A naturally occurring 22-amino acid fragment of human hemoglobin A inhibits autophagy and HIV-1

L. Ständker, M. Harms, K. Sparrer, 2024, Cellular and molecular life sciences : CMLS.

Orally Bioavailable RORγ/DHODH Dual Host-Targeting Small Molecules with Broad-Spectrum Antiviral Activity.

T. Dobner, Leila Issmail, Tatjana Weil, 2024, Antiviral research.