P. Whittamore

发表

Matched molecular pair analysis of activity and properties of glycogen phosphorylase inhibitors.

P. Kenny, A. Birch, I. Simpson, 2009, Bioorganic & medicinal chemistry letters.

Discovery of a series of indan carboxylic acid glycogen phosphorylase inhibitors.

A. Plowright, N. Selmi, P. Kenny, 2010, Bioorganic & medicinal chemistry letters.

Identification and optimisation of 3,3-dimethyl-azetidin-2-ones as potent and selective inhibitors of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1)

S. Steinbacher, M. Augustin, D. Ogg, 2014 .

A combined spectroscopic and crystallographic approach to probing drug-human serum albumin interactions.

David Buttar, S. Steinbacher, A. Plowright, 2010, Bioorganic & medicinal chemistry.

Novel acidic 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitor with reduced acyl glucuronide liability: the discovery of 4-[4-(2-adamantylcarbamoyl)-5-tert-butyl-pyrazol-1-yl]benzoic acid (AZD8329).

Martin J Packer, Nidhal Selmi, Andrew Stocker, 2012, Journal of medicinal chemistry.

Development of potent, orally active 1-substituted-3,4-dihydro-2-quinolone glycogen phosphorylase inhibitors.

L. Otterbein, N. Oikonomakos, P. Kenny, 2007, Bioorganic & medicinal chemistry letters.

Making medicinal chemistry more effective--application of Lean Sigma to improve processes, speed and quality.

Nidhal Selmi, Jan Kihlberg, Magnus J. Johansson, 2009, Drug discovery today.

Discovery of a potent, selective, and orally bioavailable acidic 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitor: discovery of 2-[(3S)-1-[5-(cyclohexylcarbamoyl)-6-propylsulfanylpyridin-2-yl]-3-piperidyl]acetic acid (AZD4017).

Martin J Packer, Nidhal Selmi, David Hargreaves, 2012, Journal of medicinal chemistry.

Reduction of acyl glucuronidation in a series of acidic 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitors: the discovery of AZD6925

James S. Scott, N. Selmi, M. Packer, 2012 .

Optimisation of pharmacokinetic properties in a neutral series of 11β-HSD1 inhibitors.

A. Gill, James S. Scott, J. Swales, 2012, Bioorganic & medicinal chemistry letters.

Novel acidic 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitor with reduced acyl glucuronide liability: the discovery of 4-[4-(2-adamantylcarbamoyl)-5-tert-butyl-pyrazol-1-yl]benzoic acid (AZD8329).

D. Hargreaves, D. Ogg, James S. Scott, 2012, Journal of medicinal chemistry.