H. Genth

发表

Protection from Clostridium difficile toxin B-catalysed Rac1/Cdc42 glucosylation by tauroursodeoxycholic acid-induced Rac1/Cdc42 phosphorylation

F. Schulz, Vanessa Brandes, I. Schelle, 2012, Biological chemistry.

Difference in protein substrate specificity between hemorrhagic toxin and lethal toxin from Clostridium sordellii.

K. Aktories, I. Just, F. Hofmann, 1996, Biochemical and biophysical research communications.

Yersinia enterocolitica exploits different pathways to accomplish adhesion and toxin injection into host cells

M. Schaller, M. Schütz, I. Autenrieth, 2015, Cellular microbiology.

Adenylate Cyclase Toxin Subverts Phagocyte Function by RhoA Inhibition and Unproductive Ruffling1

O. Benada, I. Linhartova, J. Mašín, 2008, The Journal of Immunology.

Inhibition of macrophage migration by C. botulinum exoenzyme C3

I. Just, I. Schelle, H. Genth, 2012, Naunyn-Schmiedeberg's Archives of Pharmacology.

Large clostridial glycosylating toxins modifying small GTPases: cellular aspects

I. Just, H. Genth, 2015 .

Epithelial cell-cell contacts regulate SRF-mediated transcription via Rac-actin-MAL signalling

Stephan Busche, Arnaud Descot, G. Posern, 2008, Journal of Cell Science.

New Method To Generate Enzymatically DeficientClostridium difficile Toxin B as an Antigen for Immunization

K. Aktories, I. Just, C. Busch, 2000, Infection and Immunity.

Actin-dependent activation of serum response factor in T cells by the viral oncoprotein tip

S. J. de Jong, B. Biesinger, K. Katsch, 2012, Cell Communication and Signaling.

Impaired glyoxalase activity is associated with reduced expression of neurotrophic factors and pro‐inflammatory processes in diabetic skin cells

M. Schmelz, T. Fleming, V. Kaever, 2017, Experimental dermatology.

Difference in Mono-O-Glucosylation of Ras Subtype GTPases Between Toxin A and Toxin B From Clostridioides difficile Strain 10463 and Lethal Toxin From Clostridium sordellii Strain 6018

I. Just, A. Pich, A. Lücke, 2018, Front. Microbiol..

Haemorrhagic toxin and lethal toxin from Clostridium sordellii strain vpi9048: molecular characterization and comparative analysis of substrate specificity of the large clostridial glucosylating toxins

I. Just, Carolina Varela-Chavez, C. Bouchier, 2014, Cellular microbiology.

Clostridiumnovyi’s Alpha-Toxin Changes Proteome and Phosphoproteome of HEp-2 Cells

A. Pich, H. Genth, Theresa Schweitzer, 2022, International journal of molecular sciences.

Increased Cell-Matrix Adhesion upon Constitutive Activation of Rho Proteins by Cytotoxic Necrotizing Factors from E. Coli and Y. Pseudotuberculosis

H. Genth, G. Schmidt, Martin May, 2012, Journal of signal transduction.

Clostridium difficile toxins: more than mere inhibitors of Rho proteins.

I. Just, H. Genth, J. Huelsenbeck, 2008, The international journal of biochemistry & cell biology.

Cellular stability of Rho‐GTPases glucosylated by Clostridium difficile toxin B

I. Just, F. Hofmann, R. Gerhard, 2006, FEBS letters.

Comparison of wild type with recombinant Clostridium difficile toxin A.

I. Just, F. Hofmann, R. Gerhard, 2005, Microbial pathogenesis.

Expression of recombinant Clostridium difficile toxin A using the Bacillus megaterium system.

I. Just, F. Hofmann, R. Gerhard, 2003, Biochemical and biophysical research communications.

Sphingosine-1-Phosphate Mediates Migration of Mature Dendritic Cells1

R. Förster, F. Hofmann, N. Czeloth, 2005, The Journal of Immunology.

Upregulation of the immediate early gene product RhoB by exoenzyme C3 from Clostridium limosum and toxin B from Clostridium difficile.

I. Just, G. Fritz, R. Gerhard, 2007, Biochemistry.

Pyknotic cell death induced by Clostridium difficile TcdB: chromatin condensation and nuclear blister are induced independently of the glucosyltransferase activity

R. Gerhard, H. Genth, H. Tatge, 2014, Cellular microbiology.

Difference in F-Actin Depolymerization Induced by Toxin B from the Clostridium difficile Strain VPI 10463 and Toxin B from the Variant Clostridium difficile Serotype F Strain 1470

H. Genth, Martin May, Tianbang Wang, 2013, Toxins.

Distinct kinetics of (H/K/N)Ras glucosylation and Rac1 glucosylation catalysed by Clostridium sordellii lethal toxin

H. Genth, J. Huelsenbeck, Stefanie C. Huelsenbeck, 2009, FEBS letters.

Prevention of Clostridium sordellii lethal toxin-induced apoptotic cell death by tauroursodeoxycholic acid.

I. Just, F. Schulz, H. Genth, 2009, Biochemistry.

Glucosylation and ADP ribosylation of rho proteins: effects on nucleotide binding, GTPase activity, and effector coupling.

K. Aktories, I. Just, P. Sehr, 1998, Biochemistry.

Role of p38alpha/beta MAP Kinase in Cell Susceptibility to Clostridium sordellii Lethal Toxin and Clostridium difficile Toxin B

I. Schelle, H. Genth, Janina Bruening, 2016, Toxins.

Metal Ion Activation of Clostridium sordellii Lethal Toxin and Clostridium difficile Toxin B

I. Just, I. Schelle, H. Genth, 2016, Toxins.

Clostridium Botulinum C3 Exoenzyme: Rho-Inactivating Tool in Cell Biology and a Neurotrophic Agent~!2009-08-26~!2009-09-08~!2010-03-09~!

I. Just, H. Genth, Stefanie C. Huelsenbeck, 2010 .

Expression and cytoprotective activity of the small GTPase RhoB induced by the Escherichia coli cytotoxic necrotizing factor 1.

K. Rottner, I. Just, C. Brakebusch, 2013, The international journal of biochemistry & cell biology.

Activation of Focal Adhesion Kinase Restores Simulated Microgravity-Induced Inhibition of Osteoblast Differentiation via Wnt/Β-Catenin Pathway

J. Xiang, R. Chibbar, D. Cooper, 2022, International journal of molecular sciences.

Inhibition of macrophage migration by C. botulinum exoenzyme C3

I. Just, I. Schelle, H. Genth, 2012, Naunyn-Schmiedeberg's Archives of Pharmacology.

Bacterial protein toxins inhibiting low-molecular-mass GTP-binding proteins.

I. Just, F. Hofmann, R. Gerhard, 2001, International journal of medical microbiology : IJMM.

Inhibition of cytokinesis by Clostridium difficile toxin B and cytotoxic necrotizing factors--reinforcing the critical role of RhoA in cytokinesis.

Gudula Schmidt, Harald Genth, Stefanie C Huelsenbeck, 2009, Cell motility and the cytoskeleton.

Differences in the skin microbiome and in suction blister fluids between individuals with diabetes mellitus type II and healthy individuals

Von der Naturwissenschaftlichen, H. Genth, 2021 .

The Cytotoxic Necrotizing Factor of Yersinia pseudotuberculosis (CNFY) Enhances Inflammation and Yop Delivery during Infection by Activation of Rho GTPases

J. Huehn, M. Pils, P. Dersch, 2013, PLoS pathogens.

Actin Re-Organization Induced by Chlamydia trachomatis Serovar D - Evidence for a Critical Role of the Effector Protein CT166 Targeting Rac

A. Klos, Katrin Janik, F. Hofmann, 2010, PloS one.

Rac1 and Rho contribute to the migratory and invasive phenotype associated with somatic E-cadherin mutation.

S. Rauser, E. Lengyel, B. Luber, 2009, Human molecular genetics.

Invasion of Endothelial Cells by Tissue-invasive M3 Type Group A Streptococci Requires Src Kinase and Activation of Rac1 by a Phosphatidylinositol 3-Kinase-independent Mechanism

A. Nerlich, M. Rohde, G. S. Chhatwal, 2009, The Journal of Biological Chemistry.

Role of the small Rho GTPases Rac1 and Cdc42 in host cell invasion of Campylobacter jejuni

M. Rohde, R. Hartig, W. König, 2007, Cellular microbiology.

Cytoprotective effect of the small GTPase RhoB expressed upon treatment of fibroblasts with the Ras‐glucosylating Clostridium sordellii lethal toxin

M. Hohenegger, I. Just, G. Fritz, 2012, FEBS letters.

The Essential Role of Rac1 Glucosylation in Clostridioides difficile Toxin B-Induced Arrest of G1-S Transition

K. Rottner, C. Brakebusch, G. Grassl, 2022, Frontiers in Microbiology.

Quantification of small GTPase glucosylation by clostridial glucosylating toxins using multiplexed MRM analysis

I. Just, A. Pich, R. Gerhard, 2017, Proteomics.

Prevention of the cytopathic effect induced by Clostridium difficile Toxin B by active Rac1

K. Rottner, I. Just, Markus Ladwein, 2008, FEBS letters.

Neogenin-RGMa signaling at the growth cone is bone morphogenetic protein-independent and involves RhoA, ROCK, and PKC.

I. Just, F. Hofmann, T. Skutella, 2007, The Journal of Biological Chemistry.

Neogenin-RGMa Signaling at the Growth Cone Is Bone Morphogenetic Protein-independent and Involves RhoA, ROCK, and PKC*

I. Just, F. Hofmann, T. Skutella, 2007, Journal of Biological Chemistry.

Difference in the Cytotoxic Effects of Toxin B from Clostridium difficile Strain VPI 10463 and Toxin B from Variant Clostridium difficile Strain 1470

Ingo Just, H. Barth, I. Just, 2006, Infection and Immunity.

Clostridium difficile toxin A-induced apoptosis is p53-independent but depends on glucosylation of Rho GTPases

Ingo Just, I. Just, Harald Genth, 2007, Apoptosis.

Simulated Microgravity Reduces Focal Adhesions and Alters Cytoskeleton and Nuclear Positioning Leading to Enhanced Apoptosis via Suppressing FAK/RhoA-Mediated mTORC1/NF-κB and ERK1/2 Pathways

J. Xiang, K. Lukong, Yulin Deng, 2018, International journal of molecular sciences.

Clostridium difficile Toxin A Induces Expression of the Stress-induced Early Gene Product RhoB*

I. Just, T. Thum, G. Fritz, 2005, Journal of Biological Chemistry.

Rapid Translocation and Insertion of the Epithelial Na+ Channel in Response to RhoA Signaling*

O. Pochynyuk, A. Staruschenko, N. Gamper, 2006, Journal of Biological Chemistry.

Recognition of RhoA by Clostridium botulinum C3 Exoenzyme*

K. Aktories, I. Just, C. Wilde, 2000, The Journal of Biological Chemistry.

DXD Motif-Dependent and -Independent Effects of the Chlamydia trachomatis Cytotoxin CT166

A. Klos, A. Pich, H. Genth, 2015, Toxins.

Simulated microgravity inhibits cell focal adhesions leading to reduced melanoma cell proliferation and metastasis via FAK/RhoA-regulated mTORC1 and AMPK pathways

J. Xiang, A. Freywald, Yulin Deng, 2018, Scientific Reports.

Monoglucosylation of RhoA at Threonine 37 Blocks Cytosol-Membrane Cycling*

K. Aktories, I. Just, H. Genth, 1999, The Journal of Biological Chemistry.

Activation of phospholipase D1 by ADP-ribosylated RhoA.

K. Aktories, I. Just, Martina Schmidt, 2003, Biochemical and biophysical research communications.

Rac1-dependent recruitment of PAK2 to G2 phase centrosomes and their roles in the regulation of mitotic entry

K. Rottner, C. Brakebusch, I. Schelle, 2014, Cell cycle.

Clostridium Botulinum C3 Exoenzyme: Rho-Inactivating Tool in Cell Biology and a Neurotrophic Agent

I. Just, H. Genth, Stefanie C. Huelsenbeck, 2013 .

Distinct biological activities of C3 and ADP‐ribosyltransferase‐deficient C3‐E174Q

I. Just, H. Genth, A. Rohrbeck, 2012, The FEBS journal.

Killing of rat basophilic leukemia cells by lethal toxin from Clostridium sordellii: critical role of phosphatidylinositide 3'-OH kinase/Akt signaling.

I. Just, F. Schulz, F. Hofmann, 2009, Biochemistry.

Low Density Lipoprotein Receptor-Related Protein-1 (LRP1) Is Involved in the Uptake of Clostridioides difficile Toxin A and Serves as an Internalizing Receptor

R. Lindner, H. Genth, Dennis Schöttelndreier, 2020, Frontiers in Cellular and Infection Microbiology.

Glucosylation of Rho/Ras Proteins by Lethal Toxin – Implications of Actin Re-Organization and Apoptosis in C. Sordellii-Associated Disease

I. Just, F. Schulz, H. Genth, 2013 .

Functional implications of lethal toxin-catalysed glucosylation of (H/K/N)Ras and Rac1 in Clostridium sordellii-associated disease.

I. Just, H. Genth, 2011, European journal of cell biology.

Difference in the biological effects of Clostridium difficile toxin B in proliferating and non-proliferating cells

I. Just, F. Schulz, I. Schelle, 2011, Naunyn-Schmiedeberg's Archives of Pharmacology.

Entrapment of Rho ADP-ribosylated by Clostridium botulinum C3 Exoenzyme in the Rho-Guanine Nucleotide Dissociation Inhibitor-1 Complex*

K. Kaibuchi, A. Maeda, M. Amano, 2003, Journal of Biological Chemistry.

Evaluation of Immunomodulatory Responses and Changed Wound Healing in Type 2 Diabetes—A Study Exploiting Dermal Fibroblasts from Diabetic and Non-Diabetic Human Donors

H. Wenck, H. Genth, U. Wensorra, 2021, Cells.

Expression and (Lacking) Internalization of the Cell Surface Receptors of Clostridioides difficile Toxin B

M. Winny, R. Lindner, G. Grassl, 2018, Front. Microbiol..

Simulated microgravity inhibits cell focal adhesions leading to reduced melanoma cell proliferation and metastasis via FAK/RhoA-regulated mTORC1 and AMPK pathways

Qin Zhao, Jun Zhang, Yulin Deng, 2018, Scientific Reports.

UV radiation induces CXCL5 expression in human skin

M. Schmelz, V. Kaever, L. Terstegen, 2015, Experimental dermatology.