Jae H. Chang

发表

Absorption of Drugs via Passive Diffusion and Carrier‐Mediated Pathways

M. Park, Jae H. Chang, 2011 .

Discovery of a C-8 hydroxychromene as a potent degrader of estrogen receptor alpha with improved rat oral exposure over GDC-0927.

Siew K. Yeap, N. C. Ray, Jun Liang, 2019, Bioorganic & medicinal chemistry letters.

Investigating the Impact of Albumin on the Liver Uptake of Pitavastatin and Warfarin in Nagase Analbuminemic Rats

J. Cheong, Jodie Pang, Yi-Chen Chen, 2019, Drug Metabolism and Disposition.

Differential Effects of Rifampin and Ketoconazole on the Blood and Liver Concentration of Atorvastatin in Wild-Type and Cyp3a and Oatp1a/b Knockout Mice

E. Plise, J. Cheong, J. Ly, 2014, Drug Metabolism and Disposition.

Comprehensive Evaluation of Bile Acid Homeostasis in Human Hepatocyte Co-Culture in the Presence of Troglitazone, Pioglitazone and Acetylsalicylic Acid.

E. Plise, Dewakar Sangaraju, Jae H. Chang, 2019, Molecular pharmaceutics.

Benzo[a]pyrene increases the Nrf2 content by downregulating the Keap1 message.

W. Chan, M. Park, P. M. Nguyen, 2010, Toxicological sciences : an official journal of the Society of Toxicology.

Optimization of Pan-Pim Kinase Activity and Oral Bioavailability Leading to Diaminopyrazole (GDC-0339) for the Treatment of Multiple Myeloma.

A. Ebens, C. Noland, J. Lyssikatos, 2019, Journal of Medicinal Chemistry.

Interleukin-34 produced by human fibroblast-like synovial cells in rheumatoid arthritis supports osteoclastogenesis

W. Robinson, Chang-Keun Lee, Yong‐Gil Kim, 2012, Arthritis Research & Therapy.

Discovery of GNE-149 as a Full Antagonist and Efficient Degrader of Estrogen Receptor alpha for ER+ Breast Cancer.

Jun Liang, Y. Ran, L. Friedman, 2020, ACS medicinal chemistry letters.

Dependence on p38 MAPK signalling in the up‐regulation of TLR2, TLR4 and TLR9 gene expression in Trichomonas vaginalis‐treated HeLa cells

Soo-Ki Kim, Jae H. Chang, Ju-Youn Park, 2006, Immunology.

Trichomonas vaginalis inhibits proinflammatory cytokine production in macrophages by suppressing NF-kappaB activation.

T. Morio, Sang-Kyou Lee, E. Chang, 2004, Molecules and cells.

Validity of SW982 synovial cell line for studying the drugs against rheumatoid arthritis in fluvastatin-induced apoptosis signaling model

Soo-Ki Kim, Kyu-Jae Lee, D. Yoo, 2014, The Indian journal of medical research.

NF‐κB‐dependency and consequent regulation of IL‐8 in echinomycin‐induced apoptosis of HT‐29 colon cancer cells

Soo-Ki Kim, K. Bae, Jae H. Chang, 2008, Cell biology international.

Apoptosis of macrophages induced by Trichomonas vaginalis through the phosphorylation of p38 mitogen-activated protein kinase that locates at downstream of mitochondria-dependent caspase activation.

T. Morio, Soo-Ki Kim, Sang-Kyou Lee, 2006, The international journal of biochemistry & cell biology.

Enhanced inhibitory effects of a novel CpG motif on osteoclast differentiation via TREM-2 down-regulation.

Hong-Hee Kim, Soo-Ki Kim, E. Chang, 2009, Biochemical and biophysical research communications.

Unequal Absorption of Radiolabeled and Nonradiolabeled Drug from the Oral Dose Leads to Incorrect Estimates of Drug Absorption and Circulating Metabolites in a Mass Balance Study.

Xiaorong Liang, Shuguang Ma, Jodie Pang, 2019, Drug metabolism letters.

Discovery of 5-Azaindazole (GNE-955) as a Potent Pan-Pim Inhibitor with Optimized Bioavailability.

M. Volgraf, A. Ebens, John G. Moffat, 2017, Journal of medicinal chemistry.

Evaluating the in vitro inhibition of UGT1A1, OATP1B1, OATP1B3, MRP2, and BSEP in predicting drug-induced hyperbilirubinemia.

E. Plise, J. Cheong, Q. Ho, 2013, Molecular pharmaceutics.

Insensitivity to Pain upon Adult-Onset Deletion of Nav1.7 or Its Blockade with Selective Inhibitors

D. Hackos, S. Shields, O. Foreman, 2018, The Journal of Neuroscience.

Selective NaV1.7 Antagonists with Long Residence Time Show Improved Efficacy against Inflammatory and Neuropathic Pain.

D. Sutherlin, D. Hackos, S. Decker, 2018, Cell reports.

Design of Conformationally Constrained Acyl Sulfonamide Isosteres: Identification of N-([1,2,4]Triazolo[4,3- a]pyridin-3-yl)methane-sulfonamides as Potent and Selective hNaV1.7 Inhibitors for the Treatment of Pain.

D. Sutherlin, D. Hackos, A. D. White, 2018, Journal of medicinal chemistry.

Structure- and Ligand-Based Discovery of Chromane Arylsulfonamide Nav1.7 Inhibitors for the Treatment of Chronic Pain.

D. Sutherlin, Jun Chen, D. Hackos, 2019, Journal of medicinal chemistry.

Identification of Selective Acyl Sulfonamide-Cycloalkylether Inhibitors of the Voltage-Gated Sodium Channel (NaV) 1.7 with Potent Analgesic Activity.

Benjamin D. Sellers, D. Sutherlin, D. Hackos, 2018, Journal of medicinal chemistry.

GDC-9545 (Giredestrant): A Potent and Orally Bioavailable Selective Estrogen Receptor Antagonist and Degrader with an Exceptional Preclinical Profile for ER+ Breast Cancer.

Siew K. Yeap, N. C. Ray, Jun Liang, 2021, Journal of medicinal chemistry.

Efflux of Drugs via Transporters—The Antiabsorption Pathway

M. Park, Jae H. Chang, J. Uchizono, 2011 .

Cancer immunotherapeutic effects of novel CpG ODN in murine tumor model.

Soo-Ki Kim, Jae H. Chang, Ju Youn Park, 2008, International immunopharmacology.

Orally Bioavailable Small Molecule CD73 Inhibitor (OP-5244) Reverses Immunosuppression Through Blockade of Adenosine Production.

L. Friedman, M. Junttila, V. Fantin, 2020, Journal of medicinal chemistry.

Rifampin-Mediated Induction of Tamoxifen Metabolism in a Humanized PXR-CAR-CYP3A4/3A7-CYP2D6 Mouse Model

Liling Liu, J. Ly, Kirsten Messick, 2016, Drug Metabolism and Disposition.

Rosuvastatin Pharmacokinetics in Asian and White Subjects Wild Type for Both OATP1B1 and BCRP Under Control and Inhibited Conditions.

L. Benet, Xiaorong Liang, L. Frassetto, 2017, Journal of pharmaceutical sciences.

Characterizing the in vitro species differences in N-glucuronidation of a potent pan-PIM inhibitor GNE-924 containing a 3,5-substituted 6-azaindazole

Sarah J. Robinson, J. Ly, Susan D. Wong, 2018, Xenobiotica; the fate of foreign compounds in biological systems.

Discovery of Aryl Sulfonamides as Isoform-Selective Inhibitors of NaV1.7 with Efficacy in Rodent Pain Models.

Shifeng Liu, R. Oballa, D. Sutherlin, 2016, ACS medicinal chemistry letters.

Evaluation of a competitive equilibrium dialysis approach for assessing the impact of protein binding on clearance predictions.

Jae H. Chang, Robert S Jones, Mauricio Flores, 2020, Journal of pharmaceutical sciences.

Discovery of GNE-502 as an Orally Bioavailable and Potent Degrader for Estrogen Receptor Positive Breast Cancer.

Jun Liang, Y. Ran, L. Friedman, 2021, Bioorganic & medicinal chemistry letters.

Discovery of Acyl-sulfonamide Nav1.7 Inhibitors GDC-0276 and GDC-0310.

D. Sutherlin, Jun Chen, D. Hackos, 2021, Journal of medicinal chemistry.

Probing Mechanisms of CYP3A Time-Dependent Inhibition Using a Truncated Model System.

J. Lyssikatos, Suzanne Tay, P. Fan, 2015, ACS medicinal chemistry letters.

Unremarkable impact of Oatp inhibition on the liver concentration of fluvastatin, lovastatin and pitavastatin in wild-type and Oatp1a/1b knockout mouse

J. Cheong, J. Ly, E. Chen, 2018, Xenobiotica; the fate of foreign compounds in biological systems.

Unexpected equivalent potency of a constrained chromene enantiomeric pair rationalized by co-crystal structures in complex with estrogen receptor alpha.

Jun Liang, J. Nwachukwu, K. Nettles, 2019, Bioorganic & medicinal chemistry letters.

The role of pH in the glucuronidation of raloxifene, mycophenolic acid and ezetimibe.

Jae H. Chang, Phillip Yoo, Theresa W. Lee, 2009, Molecular pharmaceutics.

Abstract 1648: Discovery and evolution of orally bioavailable selective estrogen receptor degraders for ER+ breast cancer: From GDC-0810 to GDC-0927

Jun Liang, A. Daemen, Andiliy G. Lai, 2018, Cancer Chemistry.