R. Newton

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Regulation and Immunolocalization of Acyl-Coenzyme A:Cholesterol Acyltransferase in Mammalian Cells as Studied with Specific Antibodies (*)

Matthew A. Thomas, M. Pape, Jun Chen, 1995, The Journal of Biological Chemistry.

Antiatherosclerotic effects of antioxidants are lesion-specific when evaluated in hypercholesterolemic New Zealand white rabbits.

T. Bocan, M. J. Mazur, R. Newton, 1992, Experimental and molecular pathology.

Chapter 19. Approaches to Drug Intervention in Atherosclerotic Disease

B. R. Krause, R. Newton, B. Krause, 1986 .

Paraoxonase active site required for protection against LDL oxidation involves its free sulfhydryl group and is different from that required for its arylesterase/paraoxonase activities: selective action of human paraoxonase allozymes Q and R.

B. La Du, C. Bisgaier, M. Aviram, 1998, Arteriosclerosis, thrombosis, and vascular biology.

Apol i pop rote i n changes associated with the p I asm a I i p id- reg u I at i ng activity of gem f i b rozi I in cholesterol-fed rats

B. R. Krause, R. Newton, B. Krause, 1985 .

Selective inhibition of tumor necrosis factor-induced vascular cell adhesion molecule-1 gene expression by a novel flavonoid. Lack of effect on transcription factor NF-kappa B.

J. Wölle, U. Saxena, B. K. Trivedi, 1996, Arteriosclerosis, thrombosis, and vascular biology.

C. Sirtori, G. Chiesa, V. Lorusso, 2008, Journal of the American College of Cardiology.

Modulation of hepatic and extrahepatic LDL receptors: Involvement in the progression of atherosclerosis

R. Newton, 1985 .

Ex Vivo Gene Therapy of Familial Hypercholesterolemia. Howard Hughes Medical Institute, University of Michigan

James M. Wilson, J. Baker, S. Raper, 1992 .

Dietary and mechanically induced rabbit iliac-femoral atherosclerotic lesions: a chemical and morphologic evaluation.

T. Bocan, R. Newton, S. Mueller, 1991, Experimental and molecular pathology.

HDL therapy for the acute treatment of atherosclerosis.

R. Newton, B. Krause, 2002, Atherosclerosis. Supplements.

Efficacy and Safety of a Novel Dual Modulator of Adenosine Triphosphate-Citrate Lyase and Adenosine Monophosphate-Activated Protein Kinase in Patients With Hypercholesterolemia

C. Ballantyne, L. DiCarlo, H. Bays, 2013 .

Prevention of Diet-Induced Metabolic Dysregulation, Inflammation, and Atherosclerosis in Ldlr−/− Mice by Treatment With the ATP-Citrate Lyase Inhibitor Bempedoic Acid

Stephen L. Pinkosky, M. Huff, D. E. Telford, 2017, Arteriosclerosis, thrombosis, and vascular biology.

A novel compound that elevates high density lipoprotein and activates the peroxisome proliferator activated receptor.

T. Rea, T. Leff, M. Pape, 1998, Journal of lipid research.

Effects of insulin and glucose on very low density lipoprotein triglyceride secretion by cultured rat hepatocytes.

D. Steinberg, P. Durrington, D. B. Weinstein, 1982, The Journal of clinical investigation.

Hep-G2 cells and primary rat hepatocytes differ in their response to inhibitors of HMG-CoA reductase.

B. Roth, D. Sliskovic, R. Newton, 1990, Biochemical and biophysical research communications.

Comparison of methods for incorporating a radioiodinated residualizing cholesteryl ester analog into low density lipoprotein.

R. Counsell, L. Deforge, R. Newton, 1992, International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology.

Hypocholesterolemic effects of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors in the guinea pig: atorvastatin versus simvastatin.

M. Fernandez, M. Fernández, R. Newton, 1999, Biochemical pharmacology.

Effect Associated With Enhanced Intracellular Degradation of ApoB ApoB 100 Secretion From HepG 2 Cells is Decreased by the ACAT Inhibitor CI-1011 : An

P. Barrett, M. Huff, R. Newton, 1999 .

ApoB100 secretion from HepG2 cells is decreased by the ACAT inhibitor CI-1011: an effect associated with enhanced intracellular degradation of ApoB.

P. Barrett, L. Wilcox, M. Huff, 1999, Arteriosclerosis, thrombosis, and vascular biology.

Effects of atorvastatin on the intracellular stability and secretion of apolipoprotein B in HepG2 cells.

K. Adeli, A. Mohammadi, J. Macri, 1998, Arteriosclerosis, thrombosis, and vascular biology.

Lipoprotein lipase greatly enhances the retention of lipoprotein(a) to endothelial cell-matrix.

B. Auerbach, C. Bisgaier, U. Saxena, 1999, Atherosclerosis.

Comparative effects of HMG-CoA reductase inhibitors on apo B production in the casein-fed rabbit: atorvastatin versus lovastatin.

B. Auerbach, C. Bisgaier, R. Newton, 1995, Atherosclerosis.

Comparison of CI-976, an ACAT inhibitor, and selected lipid-lowering agents for antiatherosclerotic activity in iliac-femoral and thoracic aortic lesions. A biochemical, morphological, and morphometric evaluation.

T. Bocan, R. Newton, S. Mueller, 1991, Arteriosclerosis and thrombosis : a journal of vascular biology.

Lack of correlation between ACAT mRNA expression and cholesterol esterification in primary liver cells.

T. Rea, R. Demattos, M. Pape, 1996, Biochimica et biophysica acta.

Lipid-lowering activity of atorvastatin and lovastatin in rodent species: triglyceride-lowering in rats correlates with efficacy in LDL animal models.

R. Newton, B. Krause, Roger S. Newton, 1995, Atherosclerosis.

Tissue specific changes in acyl-CoA: cholesterol acyltransferase (ACAT) mRNA levels in rabbits.

P. A. Schultz, T. Rea, R. Demattos, 1995, Journal of lipid research.

Comparison of lifibrol to other lipid-regulating agents in experimental animals.

R. Stanfield, D. Robertson, R. Newton, 1994, Pharmacological research.

ACAT inhibition decreases LDL cholesterol in rabbits fed a cholesterol-free diet. Marked changes in LDL cholesterol without changes in LDL receptor mRNA abundance.

M. Pape, B. Auerbach, R. Homan, 1994, Arteriosclerosis and thrombosis : a journal of vascular biology.

Gemfibrozil treatment and the relationship between HDL cholesterol and apoE distribution in cholesterol-fed rats.

R. Newton, B. Krause, 1986, Atherosclerosis.

Inhibition of tumor necrosis factor induced human aortic endothelial cell adhesion molecule gene expression by an alkoxybenzo[b]thiophene-2-carboxamide.

D. Boschelli, J. Wölle, C. Keshava, 1995, Biochemical and biophysical research communications.

Inhibitors of cholesterol biosynthesis. 1. trans-6-(2-pyrrol-1-ylethyl)-4-hydroxypyran-2-ones, a novel series of HMG-CoA reductase inhibitors. 1. Effects of structural modifications at the 2- and 5-positions of the pyrrole nucleus.

M. Wilson, D. Ortwine, B. Roth, 1990, Journal of medicinal chemistry.

Hypolipidemic activity of select fibrates correlates to changes in hepatic apolipoprotein C-III expression: a potential physiologic basis for their mode of action.

T. Leff, R. Demattos, M. Pape, 1995, Journal of lipid research.

Gemfibrozil increases both apo A-I and apo E concentrations. Comparison to other lipid regulators in cholesterol-fed rats.

R. Newton, B. Krause, 1986, Atherosclerosis.

Attenuation of plasma low density lipoprotein cholesterol by select 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors in mice devoid of low density lipoprotein receptors.

M. Pape, B. Auerbach, C. Bisgaier, 1997, Journal of lipid research.

Hypocholesterolemic actions of atorvastatin are associated with alterations on hepatic cholesterol metabolism and lipoprotein composition in the guinea pig.

M. Fernandez, R. Newton, M. Vergara-Jiménez, 1996, Journal of lipid research.

Differential regulation of human apolipoprotein AI and high-density lipoprotein by fenofibrate in hapoAI and hapoAI-CIII-AIV transgenic mice.

R. Newton, R. Srivastava, Shi-da He, 2011, Biochimica et biophysica acta.

Plasma apolipoproteins and drug discovery

R. Newton, B. Krause, 1984 .

The Magnitude of Decrease in Hepatic Very Low Density Lipoprotein Apolipoprotein B Secretion Is Determined by the Extent of 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase Inhibition in Miniature Pigs1.

J. Burnett, P. Barrett, L. Wilcox, 1999, Endocrinology.

The magnitude of decrease in hepatic very low density lipoprotein apolipoprotein B secretion is determined by the extent of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibition in miniature pigs.

J. Burnett, P. Barrett, L. Wilcox, 1999, Endocrinology.

Inhibition of HMG-CoA reductase by atorvastatin decreases both VLDL and LDL apolipoprotein B production in miniature pigs.

J. Burnett, P. Barrett, L. Wilcox, 1997, Arteriosclerosis, thrombosis, and vascular biology.

Hepatic and nonhepatic sterol synthesis and tissue distribution following administration of a liver selective HMG-CoA reductase inhibitor, CI-981: comparison with selected HMG-CoA reductase inhibitors.

B. Roth, T. Bocan, D. Sliskovic, 1992, Biochimica et biophysica acta.

Synthesis and evaluation of radioiodinated cholesteryl ethers as lipoprotein probes.

R. Counsell, S. Schwendner, L. Deforge, 1991, Bioconjugate chemistry.

Atorvastatin and simvastatin have distinct effects on hydroxy methylglutaryl-CoA reductase activity and mRNA abundance in the guinea pig

H. Freake, M. Fernandez, M. Fernández, 1999, Lipids.

Acyl-coenzyme A:cholesterol-acyltransferase (ACAT) inhibitors modulate monocyte adhesion to aortic endothelial cells.

U. Saxena, R. Newton, E. Ferguson, 1995, Atherosclerosis.

Activities : Selective Action of Human Paraoxonase Allozymes Q and R Sulfhydryl Group and Is Different from That Required for Its Arylesterase/paraoxonase Paraoxonase Active Site Required for Protection against Ldl Oxidation Involves Its Free

C. Bisgaier, Cary Hsu, M. Aviram, 2022 .

Paraoxonase inhibits high-density lipoprotein oxidation and preserves its functions. A possible peroxidative role for paraoxonase.

B. La Du, C. Bisgaier, M. Aviram, 1998, The Journal of clinical investigation.

Lipoprotein lipase-mediated lipolysis of very low density lipoproteins increases monocyte adhesion to aortic endothelial cells.

U. Saxena, R. Newton, N. Kulkarni, 1992, Biochemical and biophysical research communications.

Gemfibrozil significantly lowers cynomolgus monkey plasma lipoprotein[a]-protein and liver apolipoprotein[a] mRNA levels.

R. Ramharack, R. Newton, G. Hicks, 1995, Journal of lipid research.

Human serum paraoxonase (PON 1) is inactivated by oxidized low density lipoprotein and preserved by antioxidants.

B. La Du, S Billecke, M Aviram, 1999, Free radical biology & medicine.

The effects of specific lipogenic substrates and metabolic inhibitors on de novo fatty acid synthesis in isolated hepatocytes from chow-fed female rats.

R. Freedland, R. Newton, 1980, Archives of biochemistry and biophysics.

Bayesian network analysis of panomic biological big data identifies the importance of triglyceride-rich LDL in atherosclerosis development

Alex Greenfield, B. Hayete, M. Barnes, 2023, Frontiers in Cardiovascular Medicine.

Cardiotonic agents. 9. Synthesis and biological evaluation of a series of (E)-4,5-dihydro-6-[2-[4-(1H-imidazol-1-yl)phenyl]ethenyl]-3 (2H)-pyridazinones: a novel class of compounds with positive inotropic, antithrombotic, and vasodilatory activities for the treatment of congestive heart failure.

D. B. Evans, I. Sircar, S. Burke, 1989, Journal of medicinal chemistry.

Inhibitors of cholesterol biosynthesis. 2. 1,3,5-trisubstituted [2-(tetrahydro-4-hydroxy-2-oxopyran-6-yl)ethyl]pyrazoles.

M. Wilson, B. Roth, D. Sliskovic, 1990, Journal of medicinal chemistry.

Inhibitors of cholesterol biosynthesis. 4. trans-6-[2-(substituted-quinolinyl)ethenyl/ethyl]tetrahydro-4-hydroxy-2 H-pyran-2-ones, a novel series of HMG-CoA reductase inhibitors.

B. Roth, D. Sliskovic, R. Newton, 1991, Journal of medicinal chemistry.

Inhibitors of cholesterol biosynthesis. 3. Tetrahydro-4-hydroxy-6-[2-(1H-pyrrol-1-yl)ethyl]-2H-pyran-2-one inhibitors of HMG-CoA reductase. 2. Effects of introducing substituents at positions three and four of the pyrrole nucleus.

C J Blankley, C. J. Blankley, D. Ortwine, 1991, Journal of medicinal chemistry.

Liver-specific ATP-citrate lyase inhibition by bempedoic acid decreases LDL-C and attenuates atherosclerosis

Stephen L. Pinkosky, P. Groot, N. Lalwani, 2016, Nature Communications.

[37] Agaric Acid

R. Freedland, R. Newton, 1981 .

Relationship between tissue selectivity and lipophilicity for inhibitors of HMG-CoA reductase.

C. J. Blankley, B. Roth, T. Bocan, 1991, Journal of medicinal chemistry.

Induction of PPARgamma1 expression in human THP-1 monocytic leukemia cells by 9-cis-retinoic acid is associated with cellular growth suppression.

L. Zhu, C. Bisgaier, R. Newton, 1998, Biochemical and biophysical research communications.

Inhibition of ACAT by avasimibe decreases both VLDL and LDL apolipoprotein B production in miniature pigs.

J. Burnett, P. Barrett, L. Wilcox, 1999, Journal of lipid research.

Select 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors vary in their ability to reduce egg yolk cholesterol levels in laying hens through alteration of hepatic cholesterol biosynthesis and plasma VLDL composition.

S. Donkin, J. Turek, R. Porter, 1999, The Journal of nutrition.

Evaluation of two novel biochemicals on plasma and egg yolk lipid composition and laying hen performance.

B. Watkins, M. Srebnik, R. G. Elkin, 1993, Poultry science.

2.P.31 Reduction of egg yolk cholesterol content through inhibition of hepatic cholesterol biosynthesis and alteration of plasma VLDL composition in laying hens: Comparative effects of atorvastatin, lovastatin, and simvastatin

J. Turek, K. Buhman, R. Homan, 1997 .

Discovery of analogues of non-β oxidizable long-chain dicarboxylic fatty acids as dual inhibitors of fatty acids and cholesterol synthesis: Efficacy of lead compound in hyperlipidemic hamsters reveals novel mechanism.

K. Adeli, D. Oniciu, R. Newton, 2021, Nutrition, metabolism, and cardiovascular diseases : NMCD.

9-cis retinoic acid induces monocyte chemoattractant protein-1 secretion in human monocytic THP-1 cells.

L. Zhu, C. Bisgaier, R. Newton, 1999, Arteriosclerosis, thrombosis, and vascular biology.

Effect of unsaturated fatty acids on human lymphocytes: disparate influences of oleic and linolenic acids on natural cytotoxicity.

D. Hudig, R. Newton, C. Rice, 1981, Clinical immunology and immunopathology.

Opposite effects of bezafibrate and gemfibrozil in both normal and hypertriglyceridemic rats.

R. Stanfield, B. Auerbach, C. Bisgaier, 1996, Atherosclerosis.

Atorvastatin and gemfibrozil metabolites, but not the parent drugs, are potent antioxidants against lipoprotein oxidation.

C. Bisgaier, M. Aviram, R. Newton, 1998, Atherosclerosis.

Recombinant Apolipoprotein A-IMilano Infusion Into Rabbit Carotid Artery Rapidly Removes Lipid From Fatty Streaks

C. Di Mario, G. Franceschini, C. Sirtori, 2002, Circulation research.

Receptor-mediated catabolism of homologous low density lipoproteins in cultured pig hepatocytes.

D. Steinberg, D. B. Weinstein, S. Pangburn, 1981, The Journal of biological chemistry.

Efficacy and Safety of ETC-1002, a Novel Investigational Low-Density Lipoprotein-Cholesterol–Lowering Therapy for the Treatment of Patients With Hypercholesterolemia and Type 2 Diabetes Mellitus

M. Milad, D. Macdougall, P. Strange, 2014, Arteriosclerosis, thrombosis, and vascular biology.

The American Nutrition Association®: Championing the Science and Practice of Personalized Nutrition

J. Blumberg, R. Newton, Dana G. Reed, 2019, Journal of the American College of Nutrition.

Efficacy and safety of a novel dual modulator of adenosine triphosphate-citrate lyase and adenosine monophosphate-activated protein kinase in patients with hypercholesterolemia: results of a multicenter, randomized, double-blind, placebo-controlled, parallel-group trial.

C. Ballantyne, L. DiCarlo, H. Bays, 2013, Journal of the American College of Cardiology.

AMP-activated protein kinase: an emerging drug target to regulate imbalances in lipid and carbohydrate metabolism to treat cardio-metabolic diseases

Stephen L. Pinkosky, R. Newton, J. Hanselman, 2012, Journal of Lipid Research.

Bempedoic Acid Lowers Low-Density Lipoprotein Cholesterol and Attenuates Atherosclerosis in Low-Density Lipoprotein Receptor–Deficient (LDLR+/− and LDLR−/−) Yucatan Miniature Pigs

J. Pickering, P. Barrett, M. Huff, 2018, Arteriosclerosis, thrombosis, and vascular biology.

Use of ETC-1002 to treat hypercholesterolemia in patients with statin intolerance.

P. Thompson, M. Janik, D. Macdougall, 2015, Journal of clinical lipidology.

ETC-1002 regulates immune response, leukocyte homing, and adipose tissue inflammation via LKB1-dependent activation of macrophage AMPK

R. Lister, Stephen L. Pinkosky, R. Newton, 2013, Journal of Lipid Research.

AMP-activated protein kinase and ATP-citrate lyase are two distinct molecular targets for ETC-1002, a novel small molecule regulator of lipid and carbohydrate metabolism[S]

Khosrow Adeli, Sergey Filippov, K. Adeli, 2013, Journal of Lipid Research.

Identification of a novel 85-kDa lipoprotein lipase binding protein on human aortic endothelial cell surface.

J. Wölle, U. Saxena, R. Newton, 1995, Biochemical and Biophysical Research Communications - BBRC.

Development of a lipid-rich, soft plaque in rabbits, monitored by histology and intravascular ultrasound.

C. Di Mario, G. Franceschini, C. Sirtori, 2000, Atherosclerosis.

Effect of diet on fatty acids in the lipoprotein cholesteryl esters of type IIa and normal individuals

R. E. Pitas, R. G. Jensen, R. Newton, 1975, Lipids.

Treatment with ETC-1002 alone and in combination with ezetimibe lowers LDL cholesterol in hypercholesterolemic patients with or without statin intolerance.

J. Mckenney, P. Thompson, C. Ballantyne, 2016, Journal of clinical lipidology.

Inhibitors of cholesterol biosynthesis. 6. trans-6-[2-(2-N-heteroaryl-3,5-disubstituted- pyrazol-4-yl)ethyl/ethenyl]tetrahydro-4-hydroxy-2H-pyran-2-ones.

C. J. Blankley, R. Stanfield, B. Roth, 1992, Journal of medicinal chemistry.

LDL-cholesterol reduction in patients with hypercholesterolemia by modulation of adenosine triphosphate-citrate lyase and adenosine monophosphate-activated protein kinase

Stephen L. Pinkosky, R. Newton, S. Filippov, 2014, Current opinion in lipidology.

Apolipoprotein changes associated with the plasma lipid-regulating activity of gemfibrozil in cholesterol-fed rats.

R. Newton, B. Krause, 1985, Journal of lipid research.

Antiatherosclerotic activity of inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A reductase in cholesterol-fed rabbits: a biochemical and morphological evaluation.

B. Roth, T. Bocan, M. Creswell, 1994, Atherosclerosis.

ETC-1002, A MODULATOR OF ADENOSINE MONOPHOSPHATE-ACTIVATED PROTEIN KINASE AND ADENOSINE TRIPHOSPHATE-CITRATE LYASE, WAS SAFE AND REDUCED LOW-DENSITY LIPOPROTEIN-CHOLESTEROL IN HEALTHY VOLUNTEERS

L. DiCarlo, M. Milad, D. Macdougall, 2013 .

Morphogenetic and cytogenetic effects of 7,12-dimethylbenz(a)anthracene onHaworthia callus in vitro

R. Newton, S. Majumdar, 1972, Experientia.