D. Morrison

发表

Development and Validation of a Higher-Throughput Equilibrium Dialysis Assay for Plasma Protein Binding

Russell Mortishire-Smith, R. Mortishire-Smith, S. van Liempd, 2011, Journal of laboratory automation.

Quantitative determination of L-775,606, a selective 5-hydroxytryptamine 1D agonist, in rat plasma using automated sample preparation and detection by liquid chromatography-tandem mass spectrometry.

A. Watt, D. Morrison, K. Locker, 2001, Journal of chromatography. B, Biomedical sciences and applications.

An evaluation of a four-channel multiplexed electrospray tandem mass spectrometry for higher throughput quantitative analysis.

A. Watt, D. Morrison, A. Davies, 2002, Analytical chemistry.

Fluorination of 3-(3-(piperidin-1-yl)propyl)indoles and 3-(3-(piperazin-1-yl)propyl)indoles gives selective human 5-HT1D receptor ligands with improved pharmacokinetic profiles.

A. Pike, H. Broughton, I. Collins, 1999, Journal of medicinal chemistry.

2-Aryl indole NK1 receptor antagonists: optimisation of indole substitution.

K. Tsao, C. Swain, G. Hollingworth, 2001, Bioorganic & medicinal chemistry letters.

The search for novel TRPV1-antagonists: from carboxamides to benzimidazoles and indazolones.

S. Boyce, G. Mason, S. Fletcher, 2006, Bioorganic & medicinal chemistry letters.

Higher throughput bioanalysis by automation of a protein precipitation assay using a 96-well format with detection by LC-MS/MS.

A P Watt, D Morrison, K L Locker, 2000, Analytical chemistry.

Ultra-performance liquid chromatography coupled to time-of-flight mass spectrometry for robust, high-throughput quantitative analysis of an automated metabolic stability assay, with simultaneous determination of metabolic data.

Desmond O'Connor, Russell Mortishire-Smith, Amy Davies, 2006, Rapid communications in mass spectrometry : RCM.

2-Aryl indole NK(1) antagonists: optimisation of the amide substituent.

C. Swain, G. Chicchi, M. Kurtz, 2001, Bioorganic & medicinal chemistry letters.

The search for novel TRPV1-antagonists: from carboxamides to benzimidazoles and indazolones.

S. Boyce, G. Mason, S. Fletcher, 2006, Bioorganic & medicinal chemistry letters.

Determination of the in vitro metabolism of (+)- and (-)-epibatidine.

A. Watt, D. Morrison, L. Hitzel, 2000, Journal of chromatography. A.

Development and implementation of an enterprise-wide predictive model for early absorption, distribution, metabolism and excretion properties.

R. DesJarlais, H. Ceulemans, V. Chupakhin, 2021, Future medicinal chemistry.

Identification of metabolites of a substance P (neurokinin 1 receptor) antagonist in rat hepatocytes and rat plasma.

R. Mortishire-Smith, U. Gerhard, Sanjeev Kumar, 2002, Drug Metabolism And Disposition.

Approaches to higher-throughput pharmacokinetics (HTPK) in drug discovery.

Evans, Morrison, Watt, 2000, Drug discovery today.