Lin-Kun An

发表

ZTW-41, a Potent Indolizinoquinoline-5,12-Dione Derivative Against Drug-Resistant Staphylococci and Enterococci Bacteria.

Lei Shi, Jian-wen Chen, Chongfa Lai, 2020, Microbial drug resistance.

Spiroconyone A, a new phytosterol with a spiro [5,6] ring system from Conyza japonica.

Ding Li, Qiong Gu, G. Tang, 2020, Organic & biomolecular chemistry.

Syntheses and Evaluation of New Bisacridine Derivatives for Dual Binding of G-Quadruplex and i-Motif in Regulating Oncogene c-myc Expression.

Ding Li, Zhishu Huang, B. Shu, 2020, Journal of medicinal chemistry.

Discovery, enantioselective synthesis of myrtucommulone E analogues as tyrosyl-DNA phosphodiesterase 2 inhibitors and their biological activities.

Fang Wang, Haiyang Liu, Lin-Kun An, 2022, European journal of medicinal chemistry.

Robustadial A and B from Eucalyptus globulus Labill. and their anticancer activity as selective tyrosyl‐DNA phosphodiesterase 2 inhibitors

Haiyang Liu, Xiaocui He, Lin-Kun An, 2021, Phytotherapy research : PTR.

Topoisomerase 1 Regulates Gene Expression in Neurons through Cleavage Complex-Dependent and -Independent Mechanisms

J. Simon, B. Philpot, M. Zylka, 2016, PloS one.

Novel cajaninstilbene acid derivatives as antibacterial agents.

W. Ye, Wei-Min Chen, Hong-Bin Zhang, 2015, European journal of medicinal chemistry.

Synthesis, antimicrobial activity and possible mechanism of action of 9-bromo-substituted indolizinoquinoline-5,12-dione derivatives.

Wei Zhang, Zhishu Huang, Zu-Ping Wu, 2011, European journal of medicinal chemistry.

The activity against methicillin-resistant Staphylococcus aureus and quantitative structure-activity relationship (QSAR) study ofaza-naphthindolizinedione derivatives

Zhanchao Li, Xiaoyong Zou, L. Gu, 2013 .

Oxygen insertion of o-quinone under catalytic hydrogenation conditions.

Zhishu Huang, Wei Zhang, L. Gu, 2013, Organic letters.

New quinazoline derivatives for telomeric G-quadruplex DNA: effects of an added phenyl group on quadruplex binding ability.

Ding Li, Zhishu Huang, Tian-Miao Ou, 2013, European journal of medicinal chemistry.

2-(2-indolyl-)-4(3H)-quinazolines derivates as new inhibitors of AChE: design, synthesis, biological evaluation and molecular modelling

Bin Wang, Ding Li, Jin-Qiang Hou, 2013, Journal of enzyme inhibition and medicinal chemistry.

The first small fluorescent probe as Tyrosyl-DNA phosphodiesterase 1 (TDP1) substrate

Lin-Kun An, Yu Zhang, Qian Yu, 2019, Dyes and Pigments.

Secondary metabolites from Isodon ternifolius (D. Don) Kudo and their anticancer activity as DNA topoisomerase IB and Tyrosyl-DNA phosphodiesterase 1 inhibitors.

Xue-Long Yan, Hong-Li Zhang, Lin-Kun An, 2020, Bioorganic & medicinal chemistry.

Diterpenoids with diverse scaffolds from Vitex trifolia as potential topoisomerase I inhibitor.

Qiong Gu, Jun Xu, Lin-Kun An, 2017, Fitoterapia.

Meroterpenoids with Antitumor Activities from Guava (Psidium guajava).

Haiyang Liu, Afsar Khan, X. Hao, 2017, Journal of agricultural and food chemistry.

A novel DNA topoisomerase I inhibitor with different mechanism from camptothecin induces G2/M phase cell cycle arrest to K562 cells.

Y. Pommier, Jun Du, Ding Li, 2010, Biochemistry.

Synthesis of aza-naphthindolizinedione derivatives

Zhishu Huang, L. Gu, Xianzhang Bu, 2008 .

Synthesis and evaluation of graveoline and graveolinine derivatives with potent anti-angiogenesis activities.

Zhishu Huang, Tian-Miao Ou, Jia-Heng Tan, 2010, European journal of medicinal chemistry.

Discovery, Synthesis, and Evaluation of Oxynitidine Derivatives as Dual Inhibitors of DNA Topoisomerase IB (TOP1) and Tyrosyl-DNA Phosphodiesterase 1 (TDP1), and Potential Antitumor Agents.

Y. Pommier, C. Marchand, K. Agama, 2018, Journal of medicinal chemistry.

Synthesis and biological evaluation of 6-substituted indolizinoquinolinediones as catalytic DNA topoisomerase I inhibitors.

Y. Pommier, Zhishu Huang, Xixin He, 2015, European journal of medicinal chemistry.

Synthesis, cytotoxic activities and structure-activity relationships of topoisomerase I inhibitors: indolizinoquinoline-5,12-dione derivatives.

Yu Cheng, Lian-Quan Gu, Zhi-Shu Huang, 2008, Bioorganic & medicinal chemistry.

Design, Synthesis, and Cytotoxicity of Indolizinoquinoxaline-5,12-dione Derivatives, Novel DNA Topoisomerase IB Inhibitors

N. Wu, Zhishu Huang, Zu-Ping Wu, 2010 .

The synthesis of furoquinolinedione and isoxazoloquinolinedione derivatives as selective Tyrosyl-DNA phosphodiesterase 2 (TDP2) inhibitors.

Y. Pommier, K. Agama, Lin-Kun An, 2021, Bioorganic chemistry.

Synthesis, cytotoxicity and structure-activity relationship of indolizinoquinolinedione derivatives as DNA topoisomerase IB catalytic inhibitors.

Zhishu Huang, L. Gu, Jian-wen Chen, 2018, European journal of medicinal chemistry.

Oxoisoaporphine alkaloid derivatives: synthesis, DNA binding affinity and cytotoxicity.

A. Chan, Zhishu Huang, Xiao-dong Wang, 2008, European journal of medicinal chemistry.

Novel Synthesis of o-Naphthothiophenequinone Derivatives via Regioselective Diels—Alder Reaction.

A. Chan, Zhishu Huang, Peiqing Liu, 2005 .

Synthesis and biological evaluation of benzo[a]phenazine derivatives as a dual inhibitor of topoisomerase I and II.

Ding Li, Shuo-Bin Chen, Zhishu Huang, 2013, Organic & biomolecular chemistry.

Synthesis of 11-aminoalkoxy substituted benzophenanthridine derivatives as tyrosyl-DNA phosphodiesterase 1 inhibitors and their anticancer activity.

Y. Pommier, Fang Wang, K. Agama, 2022, Bioorganic chemistry.

Synthesis of Multi-Functionalized Chromeno[2,3-c]pyrrol-9(2H)-ones: Investigation and Application of Baker―Venkataraman Rearrangement Involved Reactions Catalyzed by 4-(Dimethylamino)pyridine

Jun Du, Jianing Huang, Xianzhang Bu, 2011 .

Pharmacophore-based discovery of triaryl-substituted imidazole as new telomeric G-quadruplex ligand.

Ding Li, Shuo-Bin Chen, Jia-Heng Tan, 2011, Bioorganic & medicinal chemistry letters.

Eucalypglobulusals A-J, Formyl-Phloroglucinol-Terpene Meroterpenoids from Eucalyptus globulus Fruits.

Haiyang Liu, Afsar Khan, X. Hao, 2018, Journal of natural products.

Synthesis and biological evaluation of 5-aminoethyl benzophenanthridone derivatives as DNA topoisomerase IB inhibitors.

Y. Pommier, K. Agama, Jian-wen Chen, 2019, European journal of medicinal chemistry.

Spirostanol and sesquiterpenoid glycosides from the rhizomes of Trillium tschonoskii

Haiyang Liu, Xu-Jie Qin, Lin-Kun An, 2019, Steroids.

Sesquiterpenoids from the aerial parts of Conyza japonica and their inhibitory activity against nitric oxide production.

Hong-Li Zhang, Lin-Kun An, Long-Gao Xiao, 2020, Fitoterapia.

Syntheses and antibacterial activity of soluble 9-bromo substituted indolizinoquinoline-5,12-dione derivatives.

Ding Li, Zhishu Huang, L. Gu, 2017, European journal of medicinal chemistry.

Acylphloroglucinol derivatives from the twigs and leaves of Callistemon salignus

Haiyang Liu, Afsar Khan, X. Hao, 2017 .

Synthesis and evaluation of curcumin analogues as potential thioredoxin reductase inhibitors.

Zhishu Huang, L. Gu, Xianzhang Bu, 2008, Bioorganic & medicinal chemistry.

Pyranodipyran Derivatives with Tyrosyl DNA Phosphodiesterase 1 Inhibitory Activities and Fluorescent Properties from Aspergillus sp. EGF 15-0-3

Cui‐Xian Zhang, Lin-Kun An, Hao Fan, 2022, Marine drugs.

Turning off transcription of the bcl-2 gene by stabilizing the bcl-2 promoter quadruplex with quindoline derivatives.

Ding Li, Zhishu Huang, Tian-Miao Ou, 2010, Journal of medicinal chemistry.

Synthesis of zwitterionic 4-hydroxycoumarin derivatives through a unique reaction of 4-hydroxycoumarins with p- benzoquinone and pyridine.

A. Chan, Zhishu Huang, Lin Ma, 2004, Organic letters.

Syntheses, spectroscopic characterization and application to DNA determination of novel fluorescent pyridophenazine derivatives

Wei Zhang, Ding Li, N. Wu, 2013 .

Imaging of the nuclei of living tumor cells by novel ruthenium(II) complexes coordinated with 6-chloro-5-hydroxylpyrido[3,2-a]phenazine

Wenjie Mei, Yang Ding, Lin-Kun An, 2015 .

Biological Function and Medicinal Research Significance of G-Quadruplex Interactive Proteins.

Ding Li, Zhishu Huang, Tian-Miao Ou, 2015, Current topics in medicinal chemistry.

Syntheses and evaluation of new Quinoline derivatives for inhibition of hnRNP K in regulating oncogene c-myc transcription.

Ding Li, Zhishu Huang, Jiaojiao Cao, 2019, Bioorganic chemistry.

Synthesis and Biological Evaluation of Oleanolic Acid Derivatives as Selective Vascular Endothelial Growth Factor Promoter i-Motif Ligands

Ding Li, Lin-Kun An, Yu Zhang, 2021, International journal of molecular sciences.

Cytotoxic Acylphloroglucinol Derivatives from Callistemon salignus

Haiyang Liu, Afsar Khan, Xu-Jie Qin, 2017, Natural Products and Bioprospecting.

The antitumor activity of CYB-L10, a human topoisomerase IB catalytic inhibitor

Y. Pommier, K. Agama, Hong-Li Zhang, 2019, Journal of enzyme inhibition and medicinal chemistry.

Synthesis and antiproliferative activity of indolizinophthalazine-5,12-dione derivatives, DNA topoisomerase IB inhibitors.

Zhishu Huang, Zu-Ping Wu, L. Gu, 2010, European journal of medicinal chemistry.

Facile preparation of new unsymmetrical curcumin derivatives by solid-phase synthesis strategy

A. Chan, Zhishu Huang, L. Gu, 2006 .

Synthesis and structure-activity relationship of furoquinolinediones as inhibitors of Tyrosyl-DNA phosphodiesterase 2 (TDP2).

Y. Pommier, C. Marchand, K. Agama, 2018, European journal of medicinal chemistry.

Syntheses of diacyltanshinol derivatives and their suppressive effects on macrophage foam cell formation by reducing oxidized LDL uptake.

Zhishu Huang, L. Gu, Jiantao Ye, 2014, Bioorganic chemistry.

The Reaction of Tanshinones with Diamines.

Peiqing Liu, Xiao-hong Song, L. Gu, 2006 .

Reaction of tanshinones with biogenic amine metabolites in vitro

Lin Ma, L. Gu, Hai-qiang Wu, 2002 .

Polyphyllosides A-F, six new spirostanol saponins from the stems and leaves of Paris polyphylla var. chinensis.

Haiyang Liu, Xingkuan Yang, Xu-Jie Qin, 2020, Bioorganic chemistry.

6,6,7,7-Tetrachloro-5,6,7,8-tetrahydroquinoline-5,8-dione

Seik Weng Ng, Yu Cheng, Lian-Quan Gu, 2007 .

Synthesis of Methoxy-, Methylenedioxy-, Hydroxy-, and Halo-Substituted Benzophenanthridinone Derivatives as DNA Topoisomerase IB (TOP1) and Tyrosyl-DNA Phosphodiesterase 1 (TDP1) Inhibitors and Their Biological Activity for Drug-Resistant Cancer.

Y. Pommier, K. Agama, Lin-Kun An, 2021, Journal of medicinal chemistry.

Synthesis and Biological Activities of 11‐ and 12‐Substituted Benzophenanthridinone Derivatives as DNA Topoisomerase IB and Tyrosyl‐DNA Phosphodiesterase 1 Inhibitors

Y. Pommier, Fang Wang, K. Agama, 2023, ChemMedChem.

Synthesis and evaluation of novel rutaecarpine derivatives and related alkaloids derivatives as selective acetylcholinesterase inhibitors.

Bin Wang, Ding Li, Jin-Qiang Hou, 2010, European journal of medicinal chemistry.

The metabolites of mangrove endophytic fungus Zh6-B1 from the South China Sea.

Yongjun Lu, C. Ye, Z. She, 2010, Bioorganic & medicinal chemistry letters.

Synthesis and Acetylcholinesterase and Butyrylcholinesterase Inhibitory Activities of 7‐Alkoxyl Substituted Indolizinoquinoline‐5,12‐dione Derivatives

Zhishu Huang, Zu-Ping Wu, L. Gu, 2012, Archiv der Pharmazie.

Syntheses of tanshinone anhydrides and their suppression on oxidized LDL uptake in macrophages and foam cell formation.

Jun Du, Zhishu Huang, L. Gu, 2014, Die Pharmazie.

The metabolites of mangrove endophytic fungus Zh6-B1 from the South China Sea.

Yongjun Lu, C. Ye, Z. She, 2010, Bioorganic & medicinal chemistry letters.