C. Lomelino

发表

Carbonic anhydrase II microcrystals suitable for XFEL studies.

Chae Un Kim, M. Chung, B. Mahon, 2018, Acta crystallographica. Section F, Structural biology communications.

Carbonic anhydrase inhibitors: a review on the progress of patent literature (2011–2016)

R. McKenna, C. Lomelino, 2016, Expert opinion on therapeutic patents.

Active-site solvent replenishment observed during human carbonic anhydrase II catalysis

Chae Un Kim, SangYoun Park, B. Mahon, 2018, IUCrJ.

Mapping Selective Inhibition of the Cancer-Related Carbonic Anhydrase IX Using Structure-Activity Relationships of Glucosyl-Based Sulfamates.

C. Supuran, D. Vullo, R. McKenna, 2015, Journal of medicinal chemistry.

Sweet Binders: Carbonic Anhydrase IX in Complex with Sucralose.

C. Supuran, R. McKenna, A. Murray, 2018, ACS medicinal chemistry letters.

Carbonic anhydrase II in complex with carboxylic acid-based inhibitors.

R. McKenna, C. Lomelino, 2019, Acta crystallographica. Section F, Structural biology communications.

Kinetic and X-ray crystallographic investigations on carbonic anhydrase isoforms I, II, IX and XII of a thioureido analog of SLC-0111.

C. Supuran, F. Carta, B. Mahon, 2016, Bioorganic & medicinal chemistry.

Carbonic anhydrase II does not exhibit Nitrite reductase or Nitrous Anhydrase Activity

D. Silverman, R. McKenna, E. Swenson, 2018, Free radical biology & medicine.

Sulfonamide Inhibitors of Human Carbonic Anhydrases Designed through a Three-Tails Approach: Improving Ligand/Isoform Matching and Selectivity of Action

C. Supuran, E. Masini, Silvia Bua, 2020, Journal of medicinal chemistry.

Next Generation Sequencing of the Pig αβ TCR Repertoire Identifies the Porcine Invariant NKT Cell Receptor

R. Sachidanandam, A. Jayaprakash, B. Artiaga, 2019, The Journal of Immunology.

4-Hydroxy-3-nitro-5-ureido-benzenesulfonamides Selectively Target the Tumor-Associated Carbonic Anhydrase Isoforms IX and XII Showing Hypoxia-Enhanced Antiproliferative Profiles.

C. Supuran, R. McKenna, C. Ghelardini, 2018, Journal of medicinal chemistry.

Non-Classical Inhibition of Carbonic Anhydrase

C. Supuran, R. McKenna, C. Lomelino, 2016, International journal of molecular sciences.

Cancer Drug Development of Carbonic Anhydrase Inhibitors beyond the Active Site

R. McKenna, S. Frost, M. Mboge, 2018, Molecules.

Discovery of β-Adrenergic Receptors Blocker-Carbonic Anhydrase Inhibitor Hybrids for Multitargeted Antiglaucoma Therapy.

R. Pecori, C. Supuran, E. Masini, 2018, Journal of medicinal chemistry.

One-Pot Procedure for the Synthesis of Asymmetric Substituted Ureido Benzene Sulfonamides as Effective Inhibitors of Carbonic Anhydrase Enzymes.

C. Supuran, E. Masini, M. Ferraroni, 2021, Journal of medicinal chemistry.

"Seriously Sweet": Acesulfame K Exhibits Selective Inhibition Using Alternative Binding Modes in Carbonic Anhydrase Isoforms.

C. Supuran, R. McKenna, A. Murray, 2018, Journal of Medicinal Chemistry.

The three-tails approach as a new strategy to improve selectivity of action of sulphonamide inhibitors against tumour-associated carbonic anhydrase IX and XII

C. Supuran, C. Ghelardini, L. di Cesare Mannelli, 2022, Journal of enzyme inhibition and medicinal chemistry.

Discovery of New Sulfonamide Carbonic Anhydrase IX Inhibitors Incorporating Nitrogenous Bases.

C. Supuran, R. McKenna, C. Ghelardini, 2017, ACS medicinal chemistry letters.

"A Sweet Combination": Developing saccharin and acesulfame K structures for selectively targeting the tumor-associated carbonic anhydrases IX and XII.

C. Supuran, Z. Alothman, H. Abdel‐Aziz, 2019, Journal of medicinal chemistry.

Crystallography and Its Impact on Carbonic Anhydrase Research

R. McKenna, C. Lomelino, J. Andring, 2018, International journal of medicinal chemistry.

Exploring Heteroaryl-pyrazole Carboxylic Acids as Human Carbonic Anhydrase XII Inhibitors.

C. Supuran, D. Vullo, A. Dessì, 2017, ACS medicinal chemistry letters.

Inclusion of a 5-fluorouracil moiety in nitrogenous bases derivatives as human carbonic anhydrase IX and XII inhibitors produced a targeted action against MDA-MB-231 and T47D breast cancer cells.

C. Supuran, Z. Alothman, Wagdy M. Eldehna, 2020, European journal of medicinal chemistry.

The splicing component ISY1 regulates APE1 in base excision repair.

P. Sung, R. Hromas, A. Jaiswal, 2019, DNA repair.

Characterization of a novel variant in siblings with Asparagine Synthetase Deficiency.

S. Sacharow, E. Dudenhausen, M. Kilberg, 2017, Molecular genetics and metabolism.

Asparagine synthetase: Function, structure, and role in disease

M. Kilberg, R. McKenna, C. Lomelino, 2017, The Journal of Biological Chemistry.

The Structure of Carbonic Anhydrase IX Is Adapted for Low-pH Catalysis.

M. Agbandje-McKenna, C. Tu, B. Mahon, 2016, Biochemistry.

Microbatch Mixing: “Shaken not Stirred”, a Method for Macromolecular Microcrystal Production for Serial Crystallography

Ian R. Smith, R. McKenna, M. Agbandje-McKenna, 2016 .

Observed surface lysine acetylation of human carbonic anhydrase II expressed in Escherichia coli

R. McKenna, B. Mahon, M. Pinard, 2015, Protein science : a publication of the Protein Society.

Carbonic anhydrase II microcrystals suitable for XFEL studies.

Chae Un Kim, M. Chung, B. Mahon, 2018, Acta crystallographica. Section F, Structural biology communications.

Crystal Structure of Cleaved Serp-1, a Myxomavirus-Derived Immune Modulating Serpin: Structural Design of Serpin Reactive Center Loop Peptides with Improved Therapeutic Function.

G. McFadden, I. Kurnikov, W. Reeves, 2017, Biochemistry.

Mapping Selective Inhibition of the Cancer-Related Carbonic Anhydrase IX Using Structure-Activity Relationships of Glucosyl-Based Sulfamates.

C. Supuran, D. Vullo, R. McKenna, 2015, Journal of medicinal chemistry.

Characterization of a novel variant in siblings with Asparagine Synthetase Deficiency.

E. Dudenhausen, M. Kilberg, P. Agrawal, 2017, Molecular genetics and metabolism.