Milan Dejmek

发表

Synthesis of Novel Purine‐Based Coxsackievirus Inhibitors Bearing Polycylic Substituents at the N‐9 Position

J. Neyts, P. Jansa, P. Leyssen, 2014, Archiv der Pharmazie.

Synthesis and anti-human immunodeficiency virus activity of substituted (o,o-difluorophenyl)-linked-pyrimidines as potent non‐nucleoside reverse transcriptase inhibitors

G. Stepan, P. Jansa, Li-Ping Gao, 2019, Antiviral chemistry & chemotherapy.

Synthesis of Novel Carbocyclic Nucleoside Analogues Derived from 2-(Hydroxymethyl)bicyclo[2.2.1]heptane

M. Dračínský, A. Holý, Milan Dejmek, 2007 .

Synthesis of novel thienonorbornylpurine derivatives

J. Neyts, P. Leyssen, M. Dračínský, 2012 .

Escape of Tick-Borne Flavivirus from 2′-C-Methylated Nucleoside Antivirals Is Mediated by a Single Conservative Mutation in NS5 That Has a Dramatic Effect on Viral Fitness

E. De Clercq, R. Kizek, J. Černý, 2017, Journal of Virology.

Rational Design of Novel Highly Potent and Selective Phosphatidylinositol 4-Kinase IIIβ (PI4KB) Inhibitors as Broad-Spectrum Antiviral Agents and Tools for Chemical Biology.

Christin Müller, J. Ziebuhr, E. Bouřa, 2017, Journal of medicinal chemistry.

Adenosine triphosphate analogs can efficiently inhibit the Zika virus RNA-dependent RNA polymerase.

E. Bouřa, D. Růžek, Michal Šála, 2017, Antiviral research.

Non-Nucleotide RNA-Dependent RNA Polymerase Inhibitor That Blocks SARS-CoV-2 Replication

E. Bouřa, D. Růžek, L. Eyer, 2021, Viruses.

Remdesivir triphosphate can efficiently inhibit the RNA-dependent RNA polymerase from various flaviviruses

E. Bouřa, Michal Šála, Radim Nencka, 2020, Antiviral Research.

Could 5'-N and S ProTide analogues work as prodrugs of antiviral agents?

D. Růžek, L. Eyer, Michal Šála, 2019, Bioorganic & medicinal chemistry letters.

The high-resolution crystal structure of phosphatidylinositol 4-kinase IIβ and the crystal structure of phosphatidylinositol 4-kinase IIα containing a nucleoside analogue provide a structural basis for isoform-specific inhibitor design.

E. Bouřa, Radim Nencka, Milan Dejmek, 2015, Acta crystallographica. Section D, Biological crystallography.

Design, Synthesis, and Biochemical and Biological Evaluation of Novel 7-Deazapurine Cyclic Dinucleotide Analogues as STING Receptor Agonists

Vojtěch Havlíček, Michal Hocek, J. Brynda, 2022, Journal of medicinal chemistry.

Discovery of isonucleotidic CDNs as potent STING agonists with immunomodulatory potential.

E. Bouřa, M. Dračínský, M. Buděšínský, 2022, Structure.

Structure-based design and modular synthesis of novel PI4K class II inhibitors bearing a 4-aminoquinazoline scaffold.

E. Bouřa, Michal Šála, Radim Nencka, 2022, Bioorganic & medicinal chemistry letters.

Highly Selective Phosphatidylinositol 4-Kinase IIIβ Inhibitors and Structural Insight into Their Mode of Action.

E. Bouřa, Gary Lee, G. Birkuš, 2015, Journal of medicinal chemistry.

Synthesis of locked cyclohexene and cyclohexane nucleic acids (LCeNA and LCNA) with modified adenosine units.

Jiří Rybáček, M. Dračínský, I. Rosenberg, 2015, Organic & biomolecular chemistry.

Norbornane-based nucleoside and nucleotide analogues locked in North conformation.

L. Naesens, E. Bouřa, J. Neyts, 2015, Bioorganic & medicinal chemistry.

Synthesis of novel azanorbornylpurine derivatives

J. Neyts, P. Leyssen, M. Dračínský, 2012 .

SAR studies of 9-norbornylpurines as Coxsackievirus B3 inhibitors.

J. Neyts, A. D. De Palma, P. Leyssen, 2011, Bioorganic & medicinal chemistry letters.

From norbornane-based nucleotide analogs locked in South conformation to novel inhibitors of feline herpes virus.

J. Neyts, J. Balzarini, P. Leyssen, 2014, Bioorganic & medicinal chemistry.

Conformationally locked nucleoside analogues based on the bridgehead substituted 7-oxonorbornane and their antiviral properties

J. Neyts, P. Leyssen, M. Dračínský, 2011 .

Optimization of norbornyl‐based carbocyclic nucleoside analogs as cyclin‐dependent kinase 2 inhibitors

V. Kryštof, P. Hobza, M. Lepšík, 2020, Journal of molecular recognition : JMR.

One-pot build-up procedure for the synthesis of variously substituted purine derivatives

M. Dračínský, Radim Nencka, Eva Zborníková, 2012 .

Enzymatic Preparation of 2'-5', 3'-5'Cyclic Dinucleotides, Their Binding Properties to STING Adaptor Protein, and Structure/Activity Correlations.

I. Štěpánek, J. Brynda, E. Bouřa, 2019, Journal of medicinal chemistry.

Synthesis and Biological Evaluation of Phosphoester and Phosphorothioate Prodrugs of STING Agonist 3',3'-c-Di(2'F,2'dAMP).

E. Bouřa, L. Rulíšek, M. Dračínský, 2021, Journal of medicinal chemistry.

9-Norbornyl-6-chloropurine (NCP) induces cell death through GSH depletion-associated ER stress and mitochondrial dysfunction.

J. Neyts, Radim Nencka, H. Thibaut, 2016, Free radical biology & medicine.

Wet-dry cycles enable the parallel origin of canonical and non-canonical nucleosides by continuous synthesis

T. Carell, Christina Schneider, Tynchtyk Amatov, 2018, Nature Communications.

A large scale high-throughput screen identifies chemical inhibitors of phosphatidylinositol 4-kinase type II alpha[S]

M. Ferrer, Noel Southall, Xin Hu, 2019, Journal of Lipid Research.

Synthetic Stimulator of Interferon Genes (STING) Agonists Induce a Cytokine-Mediated Anti-Hepatitis B Virus Response in Nonparenchymal Liver Cells.

G. Birkuš, Petra Břehová, A. Brazdova, 2022, ACS infectious diseases.

Ligand Strain and Its Conformational Complexity Is a Major Factor in the Binding of Cyclic Dinucleotides to STING Protein

E. Bouřa, L. Rulíšek, M. Kožíšek, 2021, Angewandte Chemie.

Novel substituted 9-norbornylpurines and their activities against RNA viruses.

J. Neyts, A. D. De Palma, P. Leyssen, 2012, Bioorganic & medicinal chemistry letters.

Exploring positions 6 and 7 of a quinazoline-based scaffold leads to changes in selectivity and potency towards RIPK2/3 kinases.

E. Bouřa, Radim Nencka, Helena Mertlíková-Kaiserová, 2023, European journal of medicinal chemistry.

Rational Design of Highly Potent SARS-CoV-2 nsp14 Methyltransferase Inhibitors

M. Vedadi, J. Weber, Radim Nencka, 2023, ACS omega.

Vinylphosphonate-based cyclic dinucleotides enhance STING-mediated cancer immunotherapy.

E. Bouřa, M. Dračínský, M. Buděšínský, 2023, European journal of medicinal chemistry.

Fluorinated cGAMP analogs, which act as STING agonists and are not cleavable by poxins: structural basis of their function

E. Bouřa, G. Birkuš, Radim Nencka, 2023, bioRxiv.

STING Agonist-Mediated Cytokine Secretion Is Accompanied by Monocyte Apoptosis.

G. Birkuš, Petra Břehová, A. Brazdova, 2022, ACS infectious diseases.

SWI/SNF Blockade Disrupts PU.1-Directed Enhancer Programs in Normal Hematopoietic Cells and Acute Myeloid Leukemia

K. Cermakova, H. C. Hodges, Radim Nencka, 2023, Cancer research.

Acidity constants and protonation sites of cyclic dinucleotides determined by capillary electrophoresis, quantum chemical calculations, and NMR spectroscopy

L. Rulíšek, Erik Andris, S. Štěpánová, 2023, Electrophoresis.

Reactivation of the G1 enhancer landscape underlies core circuitry addiction to SWI/SNF

H. C. Hodges, Radim Nencka, Matthew D. Montierth, 2023, Nucleic acids research.

Wet-dry cycles enable the parallel origin of canonical and non-canonical nucleosides by continuous synthesis

T. Carell, Christina Schneider, Tynchtyk Amatov, 2018, Nature Communications.