Gong Chen

发表

Nitroheterocyclic drugs cure experimental Trypanosoma cruzi infections more effectively in the chronic stage than in the acute stage

David M. Shackleford, K. Read, E. Chatelain, 2016, Scientific Reports.

An in vitro toolbox to accelerate anti-malarial drug discovery and development

David M. Shackleford, Dennis A. Smith, S. Charman, 2020, Malaria Journal.

Tetrahydro-2-naphthyl and 2-Indanyl Triazolopyrimidines Targeting Plasmodium falciparum Dihydroorotate Dehydrogenase Display Potent and Selective Antimalarial Activity

P. Rathod, John White, M. Phillips, 2016, Journal of medicinal chemistry.

Discovery and Structure-Activity Relationships of Quinazolinone-2-carboxamide Derivatives as Novel Orally Efficacious Antimalarials.

David M. Shackleford, Laura M Sanz, K. Dechering, 2021, Journal of medicinal chemistry.

Synthesis and profiling of benzylmorpholine 1,2,4,5-tetraoxane analogue N205: Towards tetraoxane scaffolds with potential for single dose cure of malaria.

David M. Shackleford, Brice Campo, M. Belén, 2018, Bioorganic & medicinal chemistry.

Progress in antischistosomal N,N'-diaryl urea SAR.

David M. Shackleford, J. Keiser, S. Charman, 2017, Bioorganic & medicinal chemistry letters.

Metabolic, Pharmacokinetic, and Activity Profile of the Liver Stage Antimalarial (RC-12)

D. Kyle, S. Charman, C. Kocken, 2022, ACS omega.

ELQ-300 Prodrugs for Enhanced Delivery and Single-Dose Cure of Malaria

David M. Shackleford, Galen P. Miley, M. Mather, 2015, Antimicrobial Agents and Chemotherapy.

Novel inhibitors of Plasmodium falciparum based on 2,5-disubstituted furans.

S. Charman, E. Ryan, L. Dias, 2017, European journal of medicinal chemistry.

Inhibition of Cytomegalovirus Replication with Extended-Half-Life Synthetic Ozonides

S. Charman, Xiaofang Wang, J. Vennerstrom, 2018, Antimicrobial Agents and Chemotherapy.

In Vitro and In Vivo Antischistosomal Activity Profiling and Pharmacokinetics of Ozonide Carboxylic Acids.

J. Keiser, S. Charman, Xiaofang Wang, 2023, ACS infectious diseases.

Revisiting the SAR of the Antischistosomal Aryl Hydantoin (Ro 13-3978)

David M. Shackleford, J. Keiser, Jeremy O. Jones, 2016, Journal of medicinal chemistry.

Selection and optimization of hits from a high-throughput phenotypic screen against Trypanosoma cruzi.

M. J. Abbott, Paul W. Alexander, S. Cornwall, 2013, Future medicinal chemistry.

Using Human Plasma as an Assay Medium in Caco-2 Studies Improves Mass Balance for Lipophilic Compounds

David M. Shackleford, S. Charman, Nada Abla, 2018, Pharmaceutical Research.

Lead optimization of a pyrrole-based dihydroorotate dehydrogenase inhibitor series for the treatment of Malaria.

David M. Shackleford, P. Rathod, John White, 2020, Journal of medicinal chemistry.

Potent Antimalarials with Development Potential Identified by Structure-Guided Computational Optimization of a Pyrrole-Based Dihydroorotate Dehydrogenase Inhibitor Series.

David M. Shackleford, E. Winzeler, P. Rathod, 2021, Journal of medicinal chemistry.

SAR of a new antischistosomal urea carboxylic acid.

David M. Shackleford, J. Keiser, S. Charman, 2018, Bioorganic & medicinal chemistry letters.

Selection and optimization of hits from a high-throughput phenotypic screen against Trypanosoma cruzi.

Paul W. Alexander, E. Chatelain, S. Charman, 2013, Future medicinal chemistry.

Using Human Plasma as an Assay Medium in Caco-2 Studies Improves Mass Balance for Lipophilic Compounds

David M. Shackleford, S. Charman, Nada Abla, 2018, Pharmaceutical Research.

Preclinical data do not support the use of amiodarone or dronedarone as antiparasitic drugs for Chagas disease at the approved human dosing regimen

David M. Shackleford, E. Chatelain, S. Charman, 2023, Frontiers in Tropical Diseases.