Maria Osuna-Cabello

发表

Nitroheterocyclic drugs cure experimental Trypanosoma cruzi infections more effectively in the chronic stage than in the acute stage

David M. Shackleford, K. Read, E. Chatelain, 2016, Scientific Reports.

A novel multiple-stage antimalarial agent that inhibits protein synthesis

David W. Gray, E. Winzeler, S. Meister, 2015, Nature.

Lysyl-tRNA synthetase, a target for urgently needed M. tuberculosis drugs

Robert H Bates, L. Stojanovski, K. Read, 2022, Nature Communications.

Identification and Optimization of a Series of 8-Hydroxy Naphthyridines with Potent In Vitro Antileishmanial Activity: Initial SAR and Assessment of In Vivo Activity

S. Norval, Frederick R. C. Simeons, L. Stojanovski, 2020, Journal of medicinal chemistry.

University of Dundee Identification and Optimization of a Series of 8-Hydroxy Naphthyridines with Potent In Vitro Antileishmanial Activity

S. Norval, Frederick R. C. Simeons, L. Stojanovski, 2020 .

Discovery and Optimization of 5-Amino-1,2,3-triazole-4-carboxamide Series against Trypanosoma

A. Hill, Frederick R. C. Simeons, L. Stojanovski, 2017 .

Discovery of pro-soft drug modulators of sphingosine-1-phosphate receptor 1 (S1PR1)

K. Read, P. Wyatt, W. McLean, 2020 .

Identification and development of a series of disubstituted piperazines for the treatment of Chagas disease.

Peter G. Dodd, Frederick R. C. Simeons, L. Stojanovski, 2022, European journal of medicinal chemistry.

University of Dundee Chemical Validation of Methionyl tRNA Synthetase ( MetRS ) as a Druggable Target in Leishmania donovani

Frederick R. C. Simeons, L. Stojanovski, K. Read, 2017 .

Lysyl-tRNA synthetase as a drug target in malaria and cryptosporidiosis

Juan A. Bueren-Calabuig, Andrei V. Pisliakov, David W. Gray, 2019, Proceedings of the National Academy of Sciences.

Discovery of a Quinoline-4-carboxamide Derivative with a Novel Mechanism of Action, Multistage Antimalarial Activity, and Potent in Vivo Efficacy

David W. Gray, E. Winzeler, S. Meister, 2016, Journal of medicinal chemistry.

Trisubstituted Pyrimidines as Efficacious and Fast-Acting Antimalarials

E. Winzeler, S. Meister, S. Norval, 2016, Journal of medicinal chemistry.

The anti-tubercular drug delamanid as a potential oral treatment for visceral leishmaniasis

S. Norval, Frederick R. C. Simeons, L. Stojanovski, 2016, eLife.

The R Enantiomer of the Antitubercular Drug PA-824 as a Potential Oral Treatment for Visceral Leishmaniasis

S. Norval, Frederick R. C. Simeons, L. Stojanovski, 2013, Antimicrobial Agents and Chemotherapy.

Scaffold-Hopping Strategy on a Series of Proteasome Inhibitors Led to a Preclinical Candidate for the Treatment of Visceral Leishmaniasis

Peter G. Dodd, Frederick R. C. Simeons, L. Stojanovski, 2021, Journal of medicinal chemistry.

Preclinical candidate for the treatment of visceral leishmaniasis that acts through proteasome inhibition

Juan A. Bueren-Calabuig, David W. Gray, Frederick R. C. Simeons, 2019, Proceedings of the National Academy of Sciences.

Identification of GSK3186899/DDD853651 as a Preclinical Development Candidate for the Treatment of Visceral Leishmaniasis

David W. Gray, A. Hill, G. Drewes, 2018, Journal of medicinal chemistry.

Discovery and Optimization of 5-Amino-1,2,3-triazole-4-carboxamide Series against Trypanosoma cruzi

A. Hill, Frederick R. C. Simeons, L. Stojanovski, 2017, Journal of medicinal chemistry.

Essential but Not Vulnerable: Indazole Sulfonamides Targeting Inosine Monophosphate Dehydrogenase as Potential Leads against Mycobacterium tuberculosis.

Thomas R. Ioerger, Travis Hartman, Tom L. Blundell, 2017, ACS infectious diseases.

Application of a novel regulatable Cre recombinase system to define the role of liver and gut metabolism in drug oral bioavailability

I. Gilbert, C. Wolf, C. Henderson, 2015, The Biochemical journal.

Chemical Validation of Methionyl-tRNA Synthetase as a Druggable Target in Leishmania donovani

Ian H Gilbert, Manu De Rycker, Sujatha Manthri, 2017, ACS infectious diseases.

2-Mercapto-Quinazolinones as Inhibitors of Type II NADH Dehydrogenase and Mycobacterium tuberculosis: Structure–Activity Relationships, Mechanism of Action and Absorption, Distribution, Metabolism, and Excretion Characterization

K. Read, K. Chibale, T. Ioerger, 2018, ACS infectious diseases.

Corrigendum: A novel multiple-stage antimalarial agent that inhibits protein synthesis

E. Winzeler, S. Meister, J. Rayner, 2016, Nature.

Discovery of Soft-Drug Topical Tool Modulators of Sphingosine-1-phosphate Receptor 1 (S1PR1)

K. Read, P. Wyatt, W. McLean, 2019, ACS medicinal chemistry letters.

Structure-Guided Design and Synthesis of a Pyridazinone Series of Trypanosoma cruzi Proteasome Inhibitors.

Peter G. Dodd, Frederick R. C. Simeons, L. Stojanovski, 2023, Journal of medicinal chemistry.

Identification of 6-amino-1H-pyrazolo[3,4-d]pyrimidines with in vivo efficacy against visceral leishmaniasis† †Electronic supplementary information (ESI) available. See DOI: 10.1039/d0md00203h

S. Norval, Frederick R. C. Simeons, L. Stojanovski, 2020, RSC medicinal chemistry.