S. Brand

发表

Development of a Fluorescence-based Trypanosoma cruzi CYP51 Inhibition Assay for Effective Compound Triaging in Drug Discovery Programmes for Chagas Disease

K. Read, Jennifer Riley, S. Brand, 2015, PLoS neglected tropical diseases.

The proteasome as a target for protozoan parasites

L. Tilley, L. Dick, A. Gould, 2019, Expert opinion on therapeutic targets.

Pharmacological Validation of N-Myristoyltransferase as a Drug Target in Leishmania donovani

L. Stojanovski, K. Read, I. Gilbert, 2018, ACS infectious diseases.

Bis(enediyne) Macrocycles: Synthesis, Reactivity, and Structural Analysis

M. Haley, T. Weakley, S. Brand, 2000 .

Macrocyclic Oligo(phenylacetylenes) and Oligo(phenyldiacetylenes)

M. Haley, J. Pak, S. Brand, 1999 .

Reaction hijacking of tyrosine tRNA synthetase as a whole-of-life-cycle antimalarial strategy

E. Winzeler, M. Parker, C. Morton, 2022, Science.

Discovery and Optimization of 5-Amino-1,2,3-triazole-4-carboxamide Series against Trypanosoma

A. Hill, Frederick R. C. Simeons, L. Stojanovski, 2017 .

University of Dundee Chemical Validation of Methionyl tRNA Synthetase ( MetRS ) as a Druggable Target in Leishmania donovani

Frederick R. C. Simeons, L. Stojanovski, K. Read, 2017 .

ENANTIOSELECTIVE ENZYMATIC SYNTHESIS OF THE ANTI-VIRAL AGENT LAMIVUDINE (3TC)

C. Rayner, S. Brand, M. Jones, 1995 .

Enzymatic Resolution of α-acetoxysulfides: A new approach to the synthesis of homochiral S,O-Acetals

C. Rayner, S. Brand, M. Jones, 1995 .

Discovery of Potent and Fast-Acting Antimalarial Bis-1,2,4-triazines.

David M. Shackleford, J. Baell, V. Avery, 2021, Journal of medicinal chemistry.

One-Pot Desilylation/Dimerization of Ethynyl- and Butadiynyltrimethylsilanes. Synthesis of Tetrayne-Linked Dehydrobenzoannulenes.

M. L. Bell, M. Haley, J. Pak, 1997 .

Enzymatic resolution of α,β-diacetoxysulfides: Synthesis of optically active O,S-acetals by regiospecific enantioselective primary acetate hydrolysis

C. Rayner, S. Brand, M. Jones, 1997 .

Enzymatic Resolution of α,β-Diacetoxysulfides: Synthesis of Optically Active O,S-Acetals by Regiospecific Enantioselective Primary Acetate Hydrolysis.

C. Rayner, S. Brand, M. Jones, 1997 .

The first examples of dynamic kinetic resolution by enantioselective acetylation of hemithioacetals: An efficient synthesis of homochiral α-Acetoxysulfides

C. Rayner, S. Brand, M. Jones, 1995 .

New Enantioselective Routes to Cyclic and Acyclic S,O-acetals; Enzymatic Resolution of α-Acetoxy Sulfides and Enantioselective Synthesis of the Antiviral Agent Lamivudine

C. Rayner, S. Brand, M. Jones, 1997 .

The First Examples of Dynamic Kinetic Resolution by Enantioselective Acetylation of Hemithioacetals: An Efficient Synthesis of Homochiral . alpha.‐Acetoxysulfides.

C. Rayner, S. Brand, M. Jones, 1996 .

Scaffold-Hopping Strategy on a Series of Proteasome Inhibitors Led to a Preclinical Candidate for the Treatment of Visceral Leishmaniasis

Peter G. Dodd, Frederick R. C. Simeons, L. Stojanovski, 2021, Journal of medicinal chemistry.

Preclinical candidate for the treatment of visceral leishmaniasis that acts through proteasome inhibition

Juan A. Bueren-Calabuig, David W. Gray, Frederick R. C. Simeons, 2019, Proceedings of the National Academy of Sciences.

Identification of GSK3186899/DDD853651 as a Preclinical Development Candidate for the Treatment of Visceral Leishmaniasis

David W. Gray, A. Hill, G. Drewes, 2018, Journal of medicinal chemistry.

N-Myristoyltransferase inhibitors as new leads to treat sleeping sickness

Ian H. Gilbert, Chidochangu P. Mpamhanga, Michael Hodgkinson, 2010, Nature.

Optimisation of 2-(N-phenyl carboxamide) triazolopyrimidine antimalarials with moderate to slow acting erythrocytic stage activity.

Danny W. Wilson, G. McFadden, A. Cowman, 2021, Bioorganic chemistry.

Discovery and Optimization of 5-Amino-1,2,3-triazole-4-carboxamide Series against Trypanosoma cruzi

A. Hill, Frederick R. C. Simeons, L. Stojanovski, 2017, Journal of medicinal chemistry.

Lead Optimization of a Pyrazole Sulfonamide Series of Trypanosoma bruceiN-Myristoyltransferase Inhibitors: Identification and Evaluation of CNS Penetrant Compounds as Potential Treatments for Stage 2 Human African Trypanosomiasis

Stuart P. McElroy, S. Norval, Frederick R. C. Simeons, 2014, Journal of medicinal chemistry.

Optimization of 2,3-Dihydroquinazolinone-3-carboxamides as Antimalarials Targeting PfATP4

A. Cowman, Adele M. Lehane, D. Fidock, 2023, Journal of medicinal chemistry.

7-N-Substituted-3-oxadiazole Quinolones with Potent Antimalarial Activity Target the Cytochrome bc1 Complex

E. Winzeler, A. Cowman, G. V. van Dooren, 2023, ACS infectious diseases.

Validation of N-myristoyltransferase as Potential Chemotherapeutic Target in Mammal-Dwelling Stages of Trypanosoma cruzi

I. Gilbert, I. C. Almeida, Armando Varela-Ramírez, 2016, PLoS neglected tropical diseases.

A Molecular Hybridization Approach for the Design of Potent, Highly Selective, and Brain-Penetrant N-Myristoyltransferase Inhibitors

S. Norval, Frederick R. C. Simeons, L. Stojanovski, 2018, Journal of medicinal chemistry.

Development of Small-Molecule Trypanosoma brucei N-Myristoyltransferase Inhibitors: Discovery and Optimisation of a Novel Binding Mode

Stuart P. McElroy, S. Norval, L. Stojanovski, 2015, ChemMedChem.

Chemical Validation of Methionyl-tRNA Synthetase as a Druggable Target in Leishmania donovani

Ian H Gilbert, Manu De Rycker, Sujatha Manthri, 2017, ACS infectious diseases.

Design and Synthesis of Brain Penetrant Trypanocidal N-Myristoyltransferase Inhibitors

Stuart P. McElroy, S. Norval, L. Stojanovski, 2017, Journal of medicinal chemistry.

Discovery of a Novel Class of Orally Active Trypanocidal N-Myristoyltransferase Inhibitors

Ian H. Gilbert, Irene Hallyburton, Alan H. Fairlamb, 2011, Journal of medicinal chemistry.

Design of proteasome inhibitors with oral efficacy in vivo against Plasmodium falciparum and selectivity over the human proteasome

E. Winzeler, L. Tilley, D. Fidock, 2021, Proceedings of the National Academy of Sciences.

Efficient synthesis of 3-aminocyclobut-2-en-1-ones: squaramide surrogates as potent VLA-4 antagonists.

S. Brand, J. Brown, Ben de Candole, 2003, Organic letters.

Enzymatic Resolution of α-Acetoxysulfides: A New Approach to the Synthesis of Homochiral S,O-Acetals.

C. Rayner, S. Brand, M. Jones, 2010 .

Synthesis of expanded graphdiyne substructures

M. Haley, J. Pak, Haley, 2000, Chemistry.

Proteasome inhibition attenuates nitric oxide synthase expression, VCAM-1 transcription and the development of chronic colitis.

J. Davis, J. Davis, E. Conner, 1997, The Journal of pharmacology and experimental therapeutics.