M. Santucci

发表

Computational and biological profile of boronic acids for the detection of bacterial serine- and metallo-β-lactamases

Maria Paola Costi, F. Spyrakis, S. Cross, 2017, Scientific Reports.

Structural Bases for the Synergistic Inhibition of Human Thymidylate Synthase and Ovarian Cancer Cell Growth by Drug Combinations

Maria Paola Costi, S. Mangani, G. Ponterini, 2021, Cancers.

Multitarget, Selective Compound Design Yields Picomolar Inhibitors of a Kinetoplastid Pteridine Reductase 1

Maria Paola Costi, R. Wade, S. Gul, 2020 .

Accelerating Drug Discovery Efforts for Trypanosomatidic Infections Using an Integrated Transnational Academic Drug Discovery Platform

Maria Paola Costi, R. Wade, M. Bolognesi, 2019, SLAS discovery : advancing life sciences R & D.

Chroman-4-One Derivatives Targeting Pteridine Reductase 1 and Showing Anti-Parasitic Activity

Maria Paola Costi, R. Wade, S. Gul, 2017, Molecules.

Identification of a 2,4-diaminopyrimidine scaffold targeting Trypanosoma brucei pteridine reductase 1 from the LIBRA compound library screening campaign.

Maria Paola Costi, A. Cavalli, M. Bolognesi, 2020, European journal of medicinal chemistry.

Cyclic Peptides Acting as Allosteric Inhibitors of Human Thymidylate Synthase and Cancer Cell Growth

Maria Paola Costi, G. Ponterini, P. Linciano, 2019, Molecules.

Conformational Propensity and Biological Studies of Proline Mutated LR Peptides Inhibiting Human Thymidylate Synthase and Ovarian Cancer Cell Growth.

Maria Paola Costi, M. Mor, G. Ponterini, 2018, Journal of medicinal chemistry.

The Hippo Pathway and YAP/TAZ-TEAD Protein-Protein Interaction as Targets for Regenerative Medicine and Cancer Treatment.

Maria Paola Costi, M. Bolognesi, M. Mor, 2015, Journal of medicinal chemistry.

Identification of a Quinone Derivative as a YAP/TEAD Activity Modulator from a Repurposing Library

Maria Paola Costi, M. Bolognesi, M. Mor, 2022, Pharmaceutics.

Virtual screening identifies broad-spectrum β-lactamase inhibitors with activity on clinically relevant serine- and metallo-carbapenemases

F. Spyrakis, S. Cross, G. Cruciani, 2020, Scientific Reports.

Repurposing of Drugs Targeting YAP-TEAD Functions

Maria Paola Costi, M. Bolognesi, M. Mor, 2018, Cancers.

Label-free fiber optic optrode for the detection of class C β-lactamases expressed by drug resistant bacteria.

Antonello Cutolo, Andrea Cusano, Marco Consales, 2017, Biomedical optics express.

Long period fiber grating working in reflection mode as valuable biosensing platform for the detection of drug resistant bacteria

Antonello Cutolo, Andrea Cusano, Marco Consales, 2016 .

Host dihydrofolate reductase (DHFR)-directed cycloguanil analogues endowed with activity against influenza virus and respiratory syncytial virus

Maria Paola Costi, L. Naesens, E. Cichero, 2017, European Journal of Medicinal Chemistry.

Multitarget, Selective Compound Design Yields Potent Inhibitors of a Kinetoplastid Pteridine Reductase 1

Maria Paola Costi, R. Wade, S. Gul, 2022, Journal of medicinal chemistry.

Alanine mutants of the interface residues of human thymidylate synthase decode key features of the binding mode of allosteric anticancer peptides.

Maria Paola Costi, R. Stroud, J. Finer-Moore, 2015, Journal of medicinal chemistry.

Evidence of Destabilization of the Human Thymidylate Synthase (hTS) Dimeric Structure Induced by the Interface Mutation Q62R

Maria Paola Costi, S. Mangani, C. Pozzi, 2019, Biomolecules.

Virtual Screening and X-ray Crystallography Identify Non-Substrate Analog Inhibitors of Flavin-Dependent Thymidylate Synthase.

Maria Paola Costi, T. Blundell, G. Ponterini, 2016, Journal of medicinal chemistry.

Synthesis, biological evaluation and molecular modeling of novel azaspiro dihydrotriazines as influenza virus inhibitors targeting the host factor dihydrofolate reductase (DHFR)

Maria Paola Costi, L. Naesens, E. Cichero, 2018, European Journal of Medicinal Chemistry.

Optimization of peptides that target human thymidylate synthase to inhibit ovarian cancer cell growth.

Maria Paola Costi, S. Salvadori, G. Ponterini, 2014, Journal of medicinal chemistry.

Intracellular quantitative detection of human thymidylate synthase engagement with an unconventional inhibitor using tetracysteine-diarsenical-probe technology

Maria Paola Costi, G. Ponterini, R. Guerrini, 2016, Scientific Reports.

Structure-Based Virtual Screening for the Discovery of Novel Inhibitors of New Delhi Metallo-β-lactamase-1.

F. Spyrakis, S. Cross, L. Cendron, 2018, ACS medicinal chemistry letters.

Repurposing the Trypanosomatidic GSK Kinetobox for the Inhibition of Parasitic Pteridine and Dihydrofolate Reductases

Maria Paola Costi, F. Spyrakis, S. Mangani, 2021, Pharmaceuticals.

Folic Acid–Peptide Conjugates Combine Selective Cancer Cell Internalization with Thymidylate Synthase Dimer Interface Targeting

Maria Paola Costi, F. Spyrakis, G. Ponterini, 2021, Journal of medicinal chemistry.

Destabilizers of the thymidylate synthase homodimer accelerate its proteasomal degradation and inhibit cancer growth

E. Giovannetti, G. Peters, R. Wade, 2022, eLife.

Optimization of peptides that target human thymidylate synthase to inhibit ovarian cancer cell growth.

Maria Paola Costi, S. Salvadori, G. Ponterini, 2014, Journal of medicinal chemistry.

The discovery of aryl-2-nitroethyl triamino pyrimidines as anti-Trypanosoma brucei agents.

S. Mangani, M. Costi, P. Linciano, 2023, European journal of medicinal chemistry.

High-Throughput Phenotypic Screening and Machine Learning Methods Enabled the Selection of Broad-Spectrum Low-Toxicity Antitrypanosomatidic Agents

Kimberley M. Zorn, Daniel H. Foil, S. Ekins, 2023, Journal of medicinal chemistry.

Intrinsic Fluorescence of the Active and the Inactive Functional Forms of Human Thymidylate Synthase

Maria Paola Costi, M. Caselli, G. Ponterini, 2021, Chembiochem : a European journal of chemical biology.

Long period fiber grating biosensor for the detection of drug resistant bacteria: The “OPTObacteria” project

Maria Paola Costi, M. Consales, A. Borriello, 2014, 2014 Third Mediterranean Photonics Conference.