T. Ishihara

发表

Discovery of N-[2-hydroxy-6-(4-methoxybenzamido)phenyl]-4- (4-methyl-1,4-diazepan-1-yl)benzamide (darexaban, YM150) as a potent and orally available factor Xa inhibitor.

K. Mori, T. Kadokura, Yuji Koga, 2011, Journal of medicinal chemistry.

Syntheses of 3-ethylidenequinuclidine derivatives as squalene synthase inhibitors. Part 2: enzyme inhibition and effects on plasma lipid levels.

H. Moritani, T. Ugawa, S. Tsukamoto, 2003, Bioorganic & medicinal chemistry.

Synthesis and biological evaluation of quinuclidine derivatives incorporating phenothiazine moieties as squalene synthase inhibitors.

H. Moritani, T. Ugawa, T. Ishihara, 2004, Chemical & pharmaceutical bulletin.

Comparison of microtubules stabilized with the anticancer drugs cevipabulin and paclitaxel

A. Konagaya, A. Kakugo, K. Sada, 2020, Polymer Journal.

Potent and selective TF/FVIIa inhibitors containing a neutral P1 ligand.

M. Okada, T. Niimi, M. Ohta, 2006, Bioorganic & medicinal chemistry.

Synthesis and biological activity of novel 1,4-diazepane derivatives as factor Xa inhibitor with potent anticoagulant and antithrombotic activity.

Y. Matsumoto, T. Kawasaki, S. Tsukamoto, 2004, Bioorganic & medicinal chemistry.

Design, synthesis and biological activity of selective and orally available TF/FVIIa complex inhibitors containing non-amidine P1 ligands.

M. Okada, T. Niimi, M. Ohta, 2007, Bioorganic & medicinal chemistry.

A Novel Fragment Recommendation Workflow using Direct and Indirect Transfer of SAR According to Integrated Similarities of Scaffold Motifs and SAR Trends: Application to Identifying Factor Xa Inhibitors

Ayako Moritomo, Kenichi Mori, Tsukasa Ishihara, 2017 .

Identification of potent orally active factor Xa inhibitors based on conjugation strategy and application of predictable fragment recommender system.

Yuji Koga, Y. Iwatsuki, F. Hirayama, 2015, Bioorganic & medicinal chemistry.

Novel strategy to boost oral anticoagulant activity of blood coagulation enzyme inhibitors based on biotransformation into hydrophilic conjugates.

K. Mori, Yuji Koga, Y. Iwatsuki, 2014, Bioorganic & medicinal chemistry.

Synthesis and biological activity of novel 1,2-disubstituted benzene derivatives as factor Xa inhibitors.

N. Katayama, Y. Matsumoto, Y. Iwatsuki, 2005, Bioorganic & medicinal chemistry.

Prodrug-based design, synthesis, and biological evaluation of N-benzenesulfonylpiperidine derivatives as novel, orally active factor Xa inhibitors.

M. Orita, Y. Matsumoto, Y. Iwatsuki, 2007, Bioorganic & medicinal chemistry.

Design, synthesis and biological activity of YM-60828 derivatives: potent and orally-bioavailable factor Xa inhibitors based on naphthoanilide and naphthalensulfonanilide templates.

H. Kurihara, N. Katayama, Y. Matsumoto, 2002, Bioorganic & medicinal chemistry.

An easy access to 7-methyl-2-naphthalenecarbonitrile.

Hiroyoshi Yamada, Y. Matsumoto, F. Hirayama, 2005, Chemical & pharmaceutical bulletin.

Syntheses and biological evaluation of novel quinuclidine derivatives as squalene synthase inhibitors.

H. Moritani, T. Ugawa, S. Tsukamoto, 2003, Bioorganic & medicinal chemistry.

Orally active factor Xa inhibitor: synthesis and biological activity of masked amidines as prodrugs of novel 1,4-diazepane derivatives.

Y. Matsumoto, Y. Iwatsuki, T. Kawasaki, 2004, Bioorganic & medicinal chemistry.

One‐Pot Preparation of Unsymmetrical Biaryls via Suzuki Cross‐Coupling Reaction of Aryl Halide using Phase‐Transfer Catalyst in a Biphasic Solvent System

M. Okada, M. Ohta, S. Tsukamoto, 2007 .

Biochemical and Pharmacological Profiles of YM150, an Oral Direct Factor Xa Inhibitor.

Y. Iwatsuki, T. Kawasaki, Yumiko Moritani, 2006 .

Design, synthesis and biological activity of YM-60828 derivatives. Part 2: potent and orally-bioavailable factor Xa inhibitors based on benzothiadiazine-4-one template.

H. Kurihara, N. Katayama, Y. Matsumoto, 2003, Bioorganic & medicinal chemistry.

Synthesis and biological evaluation of novel propylamine derivatives as orally active squalene synthase inhibitors.

H. Moritani, T. Ugawa, T. Ishihara, 2004, Bioorganic & medicinal chemistry.

Stabilization of microtubules by cevipabulin.

A. Konagaya, A. Kakugo, K. Sada, 2019, Biochemical and biophysical research communications.