N. Seki

发表

Discovery of N-[2-hydroxy-6-(4-methoxybenzamido)phenyl]-4- (4-methyl-1,4-diazepan-1-yl)benzamide (darexaban, YM150) as a potent and orally available factor Xa inhibitor.

K. Mori, T. Kadokura, Yuji Koga, 2011, Journal of medicinal chemistry.

Discovery of novel thiourea derivatives as potent and selective beta3-adrenergic receptor agonists.

K. Onda, Takayuki Suzuki, T. Matsui, 2009, Bioorganic & medicinal chemistry.

Orally available pyridinylpyrimidine derivatives as novel RANKL-induced osteoclastogenesis inhibitors.

M. Takeuchi, Toshihiro Watanabe, M. Ohkubo, 2012, Bioorganic & medicinal chemistry letters.

Potent and selective TF/FVIIa inhibitors containing a neutral P1 ligand.

M. Okada, T. Niimi, M. Ohta, 2006, Bioorganic & medicinal chemistry.

A highly bioactive lignophenol derivative from bamboo lignin exhibits a potent activity to suppress apoptosis induced by oxidative stress in human neuroblastoma SH-SY5Y cells.

Y. Akao, Y. Nakagawa, M. Naoi, 2004, Bioorganic & medicinal chemistry.

Design, synthesis and biological activity of selective and orally available TF/FVIIa complex inhibitors containing non-amidine P1 ligands.

M. Okada, T. Niimi, M. Ohta, 2007, Bioorganic & medicinal chemistry.

Prodrug-based design, synthesis, and biological evaluation of N-benzenesulfonylpiperidine derivatives as novel, orally active factor Xa inhibitors.

M. Orita, Y. Matsumoto, Y. Iwatsuki, 2007, Bioorganic & medicinal chemistry.

Synthesis of Na-methoxyindole and Na-methoxy-oxindole alkaloids having yohimbine skeleton

H. Takayama, M. Kitajima, H. Seki, 1992 .

Lig-8, a highly bioactive lignophenol derivative from bamboo lignin, exhibits multifaceted neuroprotective activity.

Y. Akao, H. Hara, Y. Nozawa, 2007, CNS drug reviews.

Application of Tungstate-Catalyzed Oxidation to the Conversion of Oxindoles into the Corresponding N a-methoxyoxindoles in the Gelsemium Alkaloid Synthesis

H. Takayama, M. Kitajima, N. Aimi, 1993 .

Lig-8, a bioactive lignophenol derivative from bamboo lignin, protects against neuronal damage in vitro and in vivo.

Y. Akao, H. Hara, Y. Nozawa, 2006, Journal of pharmacological sciences.