T. Yoshino

发表

Design, synthesis and SAR of novel ethylenediamine and phenylenediamine derivatives as factor Xa inhibitors.

K. Uoto, Makoto Suzuki, A. Mochizuki, 2011, Bioorganic & medicinal chemistry letters.

Evaluation of the therapeutic index of a novel phosphodiesterase 4B-selective inhibitor over phosphodiesterase 4D in mice.

Satoshi Nakamura, T. Mikkaichi, H. Maeda, 2013, Journal of pharmacological sciences.

Identification of the 5,5-dioxo-7,8-dihydro-6H-thiopyrano[3,2-d]pyrimidine derivatives as highly selective PDE4B inhibitors.

Mizuki Takahashi, S. Sasaki, T. Mikkaichi, 2014, Bioorganic & medicinal chemistry letters.

Identification of the fused bicyclic 4-amino-2-phenylpyrimidine derivatives as novel and potent PDE4 inhibitors.

Mizuki Takahashi, S. Sasaki, Tomoko Takahashi, 2013, Bioorganic & medicinal chemistry letters.

A total synthesis of xestodecalactone a and proof of its absolute stereochemistry: interesting observations on dienophilic control with 1,3-disubstituted nonequivalent allenes.

S. Danishefsky, Fay W Ng, T. Yoshino, 2006, Journal of the American Chemical Society.

Total synthesis of an enantiomeric pair of FR900482. 2. Syntheses of the aromatic and the optically active aliphatic segments

T. Katoh, S. Terashima, M. Hashimoto, 1997 .

A novel biogenetic type synthesis of (+)-hydantocidin

T. Katoh, S. Terashima, T. Yoshino, 1993 .

Cycloalkanediamine derivatives as novel blood coagulation factor Xa inhibitors.

N. Haginoya, Tsutomu Nagata, H. Kanno, 2007, Bioorganic & medicinal chemistry letters.

Stereoselective synthesis and biological evaluation of 3,4-diaminocyclohexanecarboxylic acid derivatives as factor Xa inhibitors.

Tsutomu Nagata, H. Kanno, T. Yoshino, 2008, Bioorganic & Medicinal Chemistry Letters.

Discovery of N-[(1R,2S,5S)-2-{[(5-chloroindol-2-yl)carbonyl]amino}-5-(dimethylcarbamoyl)cyclohexyl]-5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxamide hydrochloride: a novel, potent and orally active direct inhibitor of factor Xa.

N. Haginoya, Makoto Suzuki, Tsutomu Nagata, 2009, Bioorganic & medicinal chemistry.

Design, synthesis, and biological activity of novel factor Xa inhibitors: improving metabolic stability by S1 and S4 ligand modification.

Kengo Watanabe, N. Haginoya, Makoto Suzuki, 2006, Bioorganic & medicinal chemistry.

Design, synthesis, and biological activity of non-basic compounds as factor Xa inhibitors: SAR study of S1 and aryl binding sites.

Tsutomu Nagata, N. Haginoya, Makoto Suzuki, 2005, Bioorganic & medicinal chemistry.

Synthesis and evaluation of water-soluble non-prodrug analogs of docetaxel bearing sec-aminoethyl group at the C-10 position.

K. Uoto, T. Soga, T. Yoshino, 1998, Chemical & pharmaceutical bulletin.

A novel enantioselective synthesis of the key intermediate of (−)-huperzine a employing asymmetric palladium-catalyzed bicycloannulation

T. Katoh, S. Terashima, T. Yoshino, 1997 .

Synthetic studies of huperzine A and its fluorinated analogues. 1. Novel asymmetric syntheses of an enantiomeric pair of huperzine A

T. Katoh, S. Terashima, T. Yoshino, 1998 .

Design, synthesis, and SAR of cis-1,2-diaminocyclohexane derivatives as potent factor Xa inhibitors. Part I: exploration of 5-6 fused rings as alternative S1 moieties.

Hiroyuki Naito, Tsutomu Nagata, Kengo Watanabe, 2009, Bioorganic & medicinal chemistry.

Total synthesis of natural (+)-FR900482. 2. Efficient syntheses of the aromatic and the optically active aliphatic fragments

T. Katoh, S. Terashima, M. Hashimoto, 1996 .

New highly active taxoids from 9β-dihydrobaccatin-9,10-acetals. Part 2

K. Uoto, J. Chiba, T. Soga, 2002 .

Total synthesis of natural (+)-FR900482. 1. Synthetic and end-game strategies

T. Katoh, S. Terashima, T. Yoshino, 1996 .

TOTAL SYNTHESIS OF AN ENANTIOMERIC PAIR OF FR900482. 1. SYNTHETIC AND END-GAME STRATEGIES

T. Katoh, S. Terashima, T. Yoshino, 1997 .

Design, synthesis, and biological activity of non-amidine factor Xa inhibitors containing pyridine N-oxide and 2-carbamoylthiazole units.

N. Haginoya, Y. Hirokawa, Tsutomu Nagata, 2004, Bioorganic & medicinal chemistry.

Total synthesis of an enantiomeric pair of FR900482. 3. Completion of the synthesis by assembling the two segments

T. Katoh, S. Terashima, T. Yoshino, 1997 .

Orally active docetaxel analogue: synthesis of 10-deoxy-10-C-morpholinoethyl docetaxel analogues.

K. Uoto, J. Chiba, T. Soga, 2001, Bioorganic & medicinal chemistry letters.

Synthetic studies on quinocarcin and its related compounds. 5.

K. Nakatani, T. Ashizawa, F. Matsuda, 1994 .

An Enantioselective Synthesis of Natural (-)-Huperzine A via Cinchona Alkaloid Promoted Asymmetric Michael Reaction.

T. Katoh, S. Terashima, T. Yoshino, 1998 .

AN ENANTIOSELECTIVE SYNTHESIS OF NATURAL (-)-HUPERZINE A VIA CINCHONA ALKALOIDS-PROMOTED ASYMMETRIC MICHAEL REACTIONS

T. Katoh, S. Terashima, T. Yoshino, 1997 .

Facile Methods for Preparation of Thiazolopyridine and Tetrahydro-thiazolopyridine Derivatives

N. Haginoya, Tsutomu Nagata, H. Kanno, 2004 .

Synthesis and conformational analysis of a non-amidine factor Xa inhibitor that incorporates 5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine as S4 binding element.

Kengo Watanabe, N. Haginoya, Makoto Suzuki, 2004, Journal of medicinal chemistry.

Facile Methods for Preparation of Thiazolopyridine and Tetrahydrothiazolopyridine Derivatives.

N. Haginoya, Tsutomu Nagata, H. Kanno, 2004 .

Synthesis and biological evaluation of 5-carbamoyl-2-phenylpyrimidine derivatives as novel and potent PDE4 inhibitors.

Mizuki Takahashi, S. Sasaki, Tomoko Takahashi, 2013, Bioorganic & medicinal chemistry.

The role of phosphodiesterase 4B in IL-8/LTB4-induced human neutrophil chemotaxis evaluated with a phosphodiesterase 4B inhibitor

Satoshi Nakamura, T. Yoshino, Taiji Goto, 2015, Acta pharmaceutica.

A new method for synthesis of 7-deoxytaxane analogues by hydrogenation of delta(6,7)-taxane derivatives.

Y. Takeda, K. Uoto, T. Soga, 2002, Chemical & pharmaceutical bulletin.

The role of phosphodiesterase 4 B in IL-8 / LTB 4-induced human neutrophil chemotaxis evaluated with a phosphodiesterase 4 B inhibitor

Satoshi Nakamura, T. Yoshino, Taiji Goto, 2015 .