M. Toews

发表

Radioligand binding methods for membrane preparations and intact cells.

D. Bylund, M. Toews, 2011, Methods in molecular biology.

Adenosine Receptors Find a New Partner and Move Out

M. Toews, 2006, Molecular Pharmacology.

A kinetic study of glucose-6-phosphate dehydrogenase.

W. R. Carper, M. Toews, M. Kanji, 1976, The Journal of biological chemistry.

Airway epithelial epidermal growth factor receptor mediates hogbarn dust-induced cytokine release but not Ca2+ response.

D. Romberger, H. Band, A. Heires, 2011, American journal of respiratory cell and molecular biology.

Dual effects of lysophosphatidic acid on human airway smooth muscle cell proliferation and survival.

M. Toews, T. Ediger, 2001, Biochimica et biophysica acta.

Synergistic stimulation of airway smooth muscle cell mitogenesis.

M. Toews, T. Ediger, 2000, The Journal of pharmacology and experimental therapeutics.

Lysophosphatidic acid enhances contractility of isolated airway smooth muscle.

E. Ustinova, M. Toews, H. Schultz, 1997, Journal of applied physiology.

Biphasic changes in airway epithelial cell EGF receptor binding and phosphorylation induced by components of hogbarn dust

D. Romberger, H. Band, A. Heires, 2018, Experimental lung research.

Proteases in agricultural dust induce lung inflammation through PAR-1 and PAR-2 activation.

D. Romberger, J. Poole, T. Wyatt, 2015, American journal of physiology. Lung cellular and molecular physiology.

Upregulation of RGS2: a new mechanism for pirfenidone amelioration of pulmonary fibrosis

T. Casale, S. Rennard, P. Abel, 2016, Respiratory Research.

Quantitative versus qualitative data: the numerical dimensions of drug action.

D. Bylund, M. Toews, 2014, Biochemical pharmacology.

Pharmacological inhibition of soluble epoxide hydrolase prevents renal interstitial fibrogenesis in obstructive nephropathy.

S. Hwang, Jinu Kim, B. Hammock, 2015, American journal of physiology. Renal physiology.

High-affinity binding of agonists to beta-adrenergic receptors on intact cells.

T. K. Harden, J. Perkins, M. Toews, 1983, Proceedings of the National Academy of Sciences of the United States of America.

Phosphodiesterase-4 inhibition augments human lung fibroblast vascular endothelial growth factor production induced by prostaglandin E2.

S. Rennard, C. Feghali-Bostwick, S. Iwasawa, 2013, American journal of respiratory cell and molecular biology.

Leu8 and Pro8 oxytocin agonism differs across human, macaque, and marmoset vasopressin 1a receptors

J. French, Aaryn C. Mustoe, Jack H. Taylor, 2019, Scientific Reports.

Neuropeptide Y Receptor-Mediated Sensitization of ATP-Stimulated Inositol Phosphate Formation

T. Hexum, M. Toews, A. Walls, 2003, Journal of Pharmacology and Experimental Therapeutics.

Modulation of α1B-adrenoceptor expression by agonist and protein kinase inhibitors

M. Toews, K. S. Bird, Jodi L. Anderson, 1997 .

Binding Characteristics of Two Oxytocin Variants and Vasopressin at Oxytocin Receptors from Four Primate Species with Different Social Behavior Patterns

J. French, Jack H. Taylor, M. Toews, 2018, The Journal of Pharmacology and Experimental Therapeutics.

Quantitative determination of lysophosphatidic acids (LPAs) in human saliva and gingival crevicular fluid (GCF) by LC-MS/MS.

M. Nunn, Y. Alnouti, D. R. Cerutis, 2011, Journal of pharmaceutical and biomedical analysis.

Effect of budesonide on fibroblast-mediated collagen gel contraction and degradation

S. Rennard, A. Miller-Larsson, Tetsu Kobayashi, 2011, Journal of inflammation research.

Inhibition of invasion of murine mammary carcinoma cells by the tyrosine kinase inhibitor genistein.

E. Scholar, M. Toews, Eric Scholar, 1994, Cancer letters.

Identification of upregulated phosphoinositide 3-kinase γ as a target to suppress breast cancer cell migration and invasion.

P. Abel, Yan Xie, Y. Tu, 2013, Biochemical pharmacology.

Prostaglandin E₂ inhibits human lung fibroblast chemotaxis through disparate actions on different E-prostanoid receptors.

S. Rennard, M. Nakanishi, Ying-Ji Li, 2011, American journal of respiratory cell and molecular biology.

Sphingosine 1-phosphate potentiates human lung fibroblast chemotaxis through the S1P2 receptor.

S. Rennard, M. Hashimoto, D. R. Cerutis, 2008, American journal of respiratory cell and molecular biology.

Sphingosine 1-Phosphate Potentiates Human Lung Fibroblast Chemotaxis through the S 1 P 2 Receptor

S. Rennard, M. Hashimoto, D. R. Cerutis, 2008 .

Impaired norepinephrine regulation of monocyte inflammatory cytokine balance in heart failure

T. Ng, M. Toews, 2016, World journal of cardiology.

Lysophosphatidic Acid Induces Rapid and Sustained Decreases in Epidermal Growth Factor Receptor Binding via Different Signaling Pathways in BEAS-2B Airway Epithelial Cells

Karen M. Kassel, M. Toews, Puttappa R. Dodmane, 2008, Journal of Pharmacology and Experimental Therapeutics.

Attenuation of inhibitory prostaglandin E2 signaling in human lung fibroblasts is mediated by phosphodiesterase 4.

H. Magnussen, K. Rabe, S. Rennard, 2012, American journal of respiratory cell and molecular biology.

Lysophosphatidic acid mimics serum‐induced sensitization of cyclic AMP accumulation

J. Hoffman, D. Kreps, M. Toews, 1993, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

TGF-β1-induced miR-424 promotes pulmonary myofibroblast differentiation by targeting Slit2 protein expression.

K. Bailey, P. Abel, Yan Xie, 2020, Biochemical pharmacology.

Agonist-induced changes in beta-adrenergic receptors on intact cells.

J. Perkins, M. Toews, 1984, The Journal of biological chemistry.

Lysophosphatidic acid in airway function and disease

D. Romberger, S. Rennard, M. Toews, 2002 .

in airway smooth muscle Invited Review: The circle of life: cell cycle regulation

R. Panettieri, Karen M. Kassel, M. Severgnini, 2015 .

Evidence for alpha 1-adrenergic receptor internalization in DDT1 MF-2 cells following exposure to agonists plus protein kinase C activators.

M. Toews, M. Cowlen, 1988, Molecular pharmacology.

Lysophosphatidic Acid Decreases Epidermal Growth Factor Receptor Binding in Airway Epithelial Cells

Karen M. Kassel, M. Toews, N. Schulte, 2007, Journal of Pharmacology and Experimental Therapeutics.

TGF-beta 1 modulates beta-adrenergic receptor number and function in cultured human tracheal smooth muscle cells.

D. Romberger, S. Rennard, M. Toews, 1994, The American journal of physiology.

Lysophosphatidic acid and EGF stimulate mitogenesis in human airway smooth muscle cells.

D. Romberger, S. Rennard, J. Anderson, 1997, The American journal of physiology.

Relationship between an altered membrane form and a low affinity form of the beta-adrenergic receptor occurring during catecholamine-induced desensitization. Evidence for receptor internalization.

T. K. Harden, J. Perkins, M. Toews, 1984, The Journal of biological chemistry.

β2-Adrenergic agonists attenuate organic dust-induced lung inflammation.

D. Romberger, J. Poole, T. Wyatt, 2016, American journal of physiology. Lung cellular and molecular physiology.

Targeting Phosphoinositide 3-Kinase γ in Airway Smooth Muscle Cells to Suppress Interleukin-13-Induced Mouse Airway Hyperresponsiveness

T. Casale, R. Townley, P. Abel, 2012, Journal of Pharmacology and Experimental Therapeutics.

Chloroform extract of hog barn dust modulates skeletal muscle ryanodine receptor calcium-release channel (RyR1).

D. Romberger, K. Bidasee, C. Shao, 2010, Journal of applied physiology.

Bradykinin augments fibroblast-mediated contraction of released collagen gels.

D. Romberger, S. Rennard, T. Mio, 2001, American journal of physiology. Lung cellular and molecular physiology.

Inhibition of human airway smooth muscle cell proliferation by beta 2-adrenergic receptors and cAMP is PKA independent: evidence for EPAC involvement.

R. Panettieri, Karen M. Kassel, T. Wyatt, 2008, American journal of physiology. Lung cellular and molecular physiology.

Transcription factor activation and mitogenic synergism in airway smooth muscle cells

T. Murphy, M. Toews, N. Schulte, 2003, European Respiratory Journal.

TGF- β 1-induced miR-424 promotes pulmonary myofibroblast differentiation by targeting Slit2 protein expression inhibitor into HLFs reduced TGF- β 1-induced expression of classic myofibroblast differentiation markers including

K. Bailey, P. Abel, Yan Xie, 2022 .

RGS2 Repression Exacerbates Airway Hyperresponsiveness and Remodeling in Asthma

T. Casale, P. Abel, R. Panettieri, 2015 .

Radioligand-binding methods for membrane preparations and intact cells.

D. Bylund, M. Toews, J. Deupree, 2004, Methods in molecular biology.

Agonist-induced desensitization of beta-adrenoceptors of bovine bronchial epithelial cells.

D. Romberger, S. Rennard, M. Toews, 1993, Clinical science.

Proteases In Environmental Dust Induce Airway Epithelial Inflammatory Mediators

D. Romberger, A. Heires, M. Toews, 2010, ATS 2010.

CALCIUM MOBILIZATION IN HUMAN AIRWAY EPITHELIAL CELLS BY AN AIRWAY DISEASE-RELEVANT EXTRACT OF HOG-BARN DUST

D. Romberger, M. Toews, Puttappa R. Dodmane, 2010, ATS 2010.

Hog manure extract and porcine pancreatic elastase modulate airway epithelial cell EGF receptors, calcium signaling, and cytokine release.

A. Heires, M. Toews, Puttappa R. Dodmane, 2010 .

The N Terminus of the Human α1D-Adrenergic Receptor Prevents Cell Surface Expression

C. Hague, K. Minneman, A. Pupo, 2004, Journal of Pharmacology and Experimental Therapeutics.

Comparison of agonist-induced changes in beta- and alpha 1-adrenergic receptors of DDT1 MF-2 cells.

M. Toews, 1987, Molecular pharmacology.

Modulation of epidermal growth factor receptor binding to human airway smooth muscle cells by glucocorticoids and beta2-adrenergic receptor agonists.

Karen M. Kassel, M. Toews, N. Schulte, 2009, American journal of physiology. Lung cellular and molecular physiology.

Characterization of the alpha1-adrenoceptor subtype activating extracellular signal-regulated kinase in submandibular gland acinar cells.

M. Bruchas, P. Abel, M. Toews, 2008, European journal of pharmacology.

Characterization of the α 1 -Adrenoceptor Subtype Activating Extracellular Signal-Regulated Kinase in Submandibular Gland Acinar Cells

M. Bruchas, P. Abel, M. Toews, 2008 .

Regulatory properties of alpha(1B)-adrenergic receptors defective in coupling to phosphoinositide hydrolysis.

M. Toews, N. Schulte, Jodi L. Anderson, 2002, The Journal of pharmacology and experimental therapeutics.

Identification of distinct carboxyl-terminal domains mediating internalization and down-regulation of the hamster alpha(1B)- adrenergic receptor.

J. Anderson, M. Toews, J. Wang, 2000, Molecular pharmacology.

Radioligand binding methods: practical guide and tips

D. Bylund, M. Toews, 1993 .

Development of a phosphatase-resistant, L-tyrosine derived LPA1/LPA3 dual antagonist.

K. Carter, T. Macdonald, K. Lynch, 2011, MedChemComm.

Lysophosphatidic acid augments fibroblast-mediated contraction of released collagen gels.

S. Rennard, T. Mio, Xiangde Liu, 2002, The Journal of laboratory and clinical medicine.

Neuropeptide Y inhibits forskolin-stimulated adenylate cyclase in bovine adrenal chromaffin cells via a pertussis toxin-sensitive process.

T. Hexum, M. Toews, W. Li, 1992, The Journal of pharmacology and experimental therapeutics.

Radioligand binding methods: practical guide and tips.

D. Bylund, M. Toews, 1994, The American journal of physiology.

Lysophosphatidic acid regulation of cyclic AMP accumulation in cultured human airway smooth muscle cells.

D. Romberger, S. Rennard, M. Toews, 1995, Molecular pharmacology.

Isolation of glutamic acid methyl ester from an Escherichia coli membrane protein involved in chemotaxis.

J. Adler, S. J. Kleene, M. Toews, 1977, The Journal of biological chemistry.

Regulation of hamster α1B-adrenoceptors expressed in Chinese hamster ovary cells

D. R. Cerutis, M. Toews, Si-Jia Zhu, 1996 .

Neuropeptide Y promotes GTP photo-incorporation into a 55 kDa protein.

R. Macdonald, T. Hexum, M. Toews, 1994, European journal of pharmacology.

Regulation of histamine H1 receptor-mediated phosphoinositide hydrolysis by histamine and phorbol esters in DDT1 MF-2 cells.

M. Barnes, M. Toews, M. Cowlen, 1990, European journal of pharmacology.

Effects of agonist and phorbol ester on adrenergic receptors of DDT1 MF-2 cells.

M. Toews, M. Cowlen, 1987, The Journal of pharmacology and experimental therapeutics.

A mutation in the hamster alpha1B-adrenergic receptor that differentiates two steps in the pathway of receptor internalization.

J. Anderson, M. Toews, J. Zheng, 1997, Molecular pharmacology.

Agonist-specific desensitization of PGE2-stimulated cAMP signaling due to upregulated phosphodiesterase expression in human lung fibroblasts

S. Rennard, R. Ostrom, R. Penn, 2019, Naunyn-Schmiedeberg's Archives of Pharmacology.

Pharmacologic principles for combination therapy.

David B Bylund, Myron L Toews, D. Bylund, 2005, Proceedings of the American Thoracic Society.

Neuropeptide Y enhances ATP-induced formation of inositol phosphates in chromaffin cells.

J. Zheng, T. Hexum, M. Toews, 1997, Biochemical and Biophysical Research Communications - BBRC.

Lysophosphatidic acid receptor signaling in mammalian retinal pigment epithelial cells.

W. Thoreson, M. Kelly, E. J. Bryson, 2002, Investigative ophthalmology & visual science.

Glucose-6-phosphate dehydrogenase. Purification and partial characterization.

W. R. Carper, M. Toews, M. Kanji, 1976, The Journal of biological chemistry.

Attractants and repellents control demethylation of methylated chemotaxis proteins in Escherichia coli.

J. Adler, M. F. Goy, M S Springer, 1979, Proceedings of the National Academy of Sciences of the United States of America.

TGF‐β1‐induced miR‐424 Mediates Pulmonary Myofibroblast Differentiation via Targeting Slit2

K. Bailey, P. Abel, Yan Xie, 2019, The FASEB Journal.

Agonists and phorbol esters desensitize beta-adrenergic receptors by different mechanisms.

J. Perkins, M. Liang, M. Toews, 1987, Molecular pharmacology.

Lysophosphatidic acid upregulates the epidermal growth factor receptor in human airway smooth muscle cells.

B. Danforth, M. Toews, T. Ediger, 2002, American journal of physiology. Lung cellular and molecular physiology.

Phosphoinositide 3-Kinase γ Regulates Airway Smooth Muscle Contraction by Modulating Calcium Oscillations

T. Casale, P. Abel, Yan Xie, 2010, Journal of Pharmacology and Experimental Therapeutics.

Prostaglandin E2 switches from a stimulator to an inhibitor of cell migration after epithelial-to-mesenchymal transition.

S. Rennard, M. Nakanishi, Xiangde Liu, 2015, Prostaglandins & other lipid mediators.

Methanol formation in vivo from methylated chemotaxis proteins in Escherichia coli.

J. Adler, M. Toews, 1979, Journal of Biological Chemistry.

Modulation of cyclic AMP accumulation in glial cells by exogenous phospholipase C.

J. Hoffman, M. Toews, S. Whittle, 1996, Journal of lipid mediators and cell signalling.

Replicated, replicable and relevant-target engagement and pharmacological experimentation in the 21st century.

Michael Williams, Kevin Mullane, Terry Kenakin, 2014, Biochemical pharmacology.

inhibiting ryanodine receptors mobilization from sarco(endo)plasmic reticulum by 2+ Dust from hog confinement facilities impairs Ca

M. Toews, C. Tian, Puttappa R. Dodmane, 2015 .

Dust from hog confinement facilities impairs Ca2+ mobilization from sarco(endo)plasmic reticulum by inhibiting ryanodine receptors.

D. Romberger, K. Bidasee, C. Shao, 2013, Journal of applied physiology.

Prostacyclin analogs inhibit fibroblast contraction of collagen gels through the cAMP-PKA pathway.

S. Rennard, C. Hogaboam, K. Kamio, 2007, American journal of respiratory cell and molecular biology.

Cbl-family ubiquitin ligases and their recruitment of CIN85 are largely dispensable for epidermal growth factor receptor endocytosis.

S. Ogawa, M. Sanada, V. Band, 2014, The international journal of biochemistry & cell biology.

Protein kinase C activators sensitize cyclic AMP accumulation by intact 1321N1 human astrocytoma cells.

R. A. Johnson, M. Toews, 1990, Molecular pharmacology.

Synopsis of discussions in session 2: Targeting G-protein-coupled receptors in COPD

M. Toews, 2005 .

Alpha 2-adrenergic receptor-mediated sensitization of forskolin-stimulated cyclic AMP production.

J. T. Turner, D. Bylund, M. Toews, 1987, Proceedings of the National Academy of Sciences of the United States of America.

Rapid and Reversible Enhancement of Blood–Brain Barrier Permeability Using Lysophosphatidic Acid

Donald W. Miller, Ngoc H. On, M. Toews, 2013, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

Regulation of alpha-1B adrenergic receptor localization, trafficking, function, and stability.

Steven C. Prinster, M. Toews, N. Schulte, 2003, Life sciences.

Serum-induced sensitization of cyclic AMP accumulation in C62B rat glioma cells.

J. Hoffman, M. Toews, L. Arneson-Rotert, 1992, The Journal of pharmacology and experimental therapeutics.

Serum-induced sensitization of cyclic AMP accumulation in 1321N1 human astrocytoma cells.

J. Hoffman, M. Toews, L. Arneson-Rotert, 1991, Molecular pharmacology.

Regulator of G-protein signaling 2 repression exacerbates airway hyper-responsiveness and remodeling in asthma.

T. Casale, P. Abel, R. Panettieri, 2014, American journal of respiratory cell and molecular biology.

Docosahexaenoic acid enhances amphiregulin-mediated bronchial epithelial cell repair processes following organic dust exposure.

K. Bailey, D. Romberger, A. Heires, 2018, American journal of physiology. Lung cellular and molecular physiology.

Up-regulation of alpha1B-adrenergic receptors with defects in G protein coupling: ligand-induced protection from receptor instability.

Steven C. Prinster, M. Toews, N. Schulte, 2003, Molecular pharmacology.

Intact cell binding properties of cells expressing altered beta-adrenergic receptors.

M. Toews, S. Zhu, 1994, Molecular Pharmacology.

Vasoactive intestinal peptide receptor/adenylate cyclase system: differences between agonist- and protein kinase C-mediated desensitization and further evidence for receptor internalization.

J. T. Turner, D. Bollinger, M. Toews, 1988, The Journal of pharmacology and experimental therapeutics.

α2A- and α2C-Adrenoceptor subtypes are differentially down-regulated by norepinephrine

D. Bylund, M. Toews, P. Shreve, 1991 .

Identification of upregulated phosphoinositide 3-kinase γ as a target to suppress breast cancer cell migration and invasion.

P. Abel, Yan Xie, Y. Tu, 2013, Biochemical pharmacology.

Lysophosphatidic acid in airway function and disease.

D. Romberger, S. Rennard, M. Toews, 2002, Biochimica et biophysica acta.

A kinetic study of pig liver glucose dehydrogenase.

W. R. Carper, R. Thompson, C. M. Buess, 1976, Archives of biochemistry and biophysics.

6-Phosphogluconate dehydrogenase. Purification and kinetics.

W. R. Carper, M. Toews, M. Kanji, 1976, The Journal of biological chemistry.

Phosphodiesterase-4 inhibition augments human lung fibroblast vascular endothelial growth factor production induced by prostaglandin E2.

S. Rennard, C. Feghali-Bostwick, S. Iwasawa, 2013, American journal of respiratory cell and molecular biology.

Comparison of binding of 125I-iodopindolol to control and desensitized cells at 37 degrees and on ice.

J. Perkins, M. Toews, G. L. Waldo, 1986, Journal of cyclic nucleotide and protein phosphorylation research.

Down-regulation of α2-adrenoceptor subtypes

D. Bylund, R. Pleus, M. Toews, 1993 .