J. Cash

发表

High-resolution cryo-EM using beam-image shift at 200 keV

M. Cianfrocco, Yilai Li, S. Kearns, 2020, bioRxiv.

Structural/functional studies of Trio provide insights into its configuration and show that conserved linker elements enhance its activity for Rac1

J. Gutkind, M. Zhalnina, L. Avramova, 2022, The Journal of biological chemistry.

Discovery of Small Molecules That Target the Phosphatidylinositol (3,4,5) Trisphosphate (PIP3)-Dependent Rac Exchanger 1 (P-Rex1) PIP3-Binding Site and Inhibit P-Rex1–Dependent Functions in Neutrophils

J. Tesmer, A. Smrcka, J. Cash, 2020, Molecular Pharmacology.

Structure of Myostatin·Follistatin-like 3

Chandramohan Kattamuri, T. B. Thompson, Huaying Zhao, 2011, The Journal of Biological Chemistry.

Structural Snapshots of a Dynamic Process in the Regulation of P-Rex, a Metastatic Factor

M. Cianfrocco, J. Tesmer, J. Cash, 2018, Microscopy and Microanalysis.

Development of a Small-Molecule Screening Method for Inhibitors of Cellular Response to Myostatin and Activin A

Lisa H. Merck, T. B. Thompson, R. Papoian, 2013, Journal of biomolecular screening.

The structure of myostatin:follistatin 288: insights into receptor utilization and heparin binding

T. B. Thompson, D. Bernard, Carlis A Rejon, 2009, The EMBO journal.

Discovery of Small Molecules That Target the Phosphatidylinositol (3,4,5) Trisphosphate (PIP3)-Dependent Rac Exchanger 1 (P-Rex1) PIP3-Binding Site and Inhibit P-Rex1–Dependent Functions in Neutrophils

J. Tesmer, A. Smrcka, J. Cash, 2020, Molecular Pharmacology.

Structural and Biochemical Characterization of the Catalytic Core of the Metastatic Factor P-Rex1 and Its Regulation by PtdIns(3,4,5)P3.

J. Tesmer, J. Cash, E. M. Davis, 2016, Structure.

Characterization of follistatin-type domains and their contribution to myostatin and activin A antagonism.

H. Keutmann, J. Cash, Elizabeth B. Angerman, 2012, Molecular endocrinology.

High-resolution cryo-EM using beam-image shift at 200 keV

M. Cianfrocco, Yilai Li, S. Kearns, 2020, IUCrJ.

High-throughput cryo-EM enabled by user-free preprocessing routines

Yilai Li, Jennifer N. Cash, John J. G. Tesmer, 2019, bioRxiv.

Cryo–electron microscopy structure and analysis of the P-Rex1–Gβγ signaling scaffold

Michael A. Cianfrocco, Sheng Li, Jennifer N. Cash, 2019, Science Advances.

Structural and biochemical characterization of the pleckstrin homology domain of the RhoGEF P-Rex2 and its regulation by PIP3

J. Tesmer, J. Cash, Prateek Sharma, 2018, Journal of structural biology: X.

The first DEP domain of the RhoGEF P-Rex1 autoinhibits activity and contributes to membrane binding

R. Stahelin, J. Tesmer, Sandeep K. Ravala, 2020, The Journal of Biological Chemistry.

Structural and Biochemical Insights into Myostatin Regulation

J. Cash, 2011 .

Structural analyses of the PKA RIIβ holoenzyme containing the oncogenic DnaJB1-PKAc fusion protein reveal protomer asymmetry and fusion-induced allosteric perturbations in fibrolamellar hepatocellular carcinoma

Susan S. Taylor, S. Simon, M. Cianfrocco, 2020, PLoS biology.

The structure of myostatin:follistatin 288: insights into receptor utilization and heparin binding

D. Bernard, Carlis A Rejon, A. Mcpherron, 2009, The EMBO journal.

Discovery of small molecules that target the P-Rex1 PIP3-binding site and inhibit P-Rex1-dependent functions in neutrophils

J. Tesmer, A. Smrcka, J. Cash, 2019 .

Structural and dynamic changes in P-Rex1 upon activation by PIP3 and inhibition by IP4

M. Cianfrocco, J. Tesmer, Sandeep K. Ravala, 2023, bioRxiv.