D. McCoull

Pranlukast is a novel small molecule activator of the two-pore domain potassium channel TREK2.

A. Mathie, J. Large, E. Veale, 2019, Biochemical and biophysical research communications.

Localization of agonist-sensitive PtdIns(3,4,5)P3 reveals a nuclear pool that is insensitive to PTEN expression

C. Downes, N. Leslie, A. Gray, 2006, Journal of Cell Science.

A “Target Class” Screen to Identify Activators of Two-Pore Domain Potassium (K2P) Channels

A. Mathie, E. Ococks, J. Large, 2020, SLAS discovery : advancing life sciences R & D.

Terbinafine is a novel and selective activator of the two-pore domain potassium channel TASK3.

A. Mathie, E. Ococks, C. Kettleborough, 2017, Biochemical and biophysical research communications.

Aprepitant is a novel, selective activator of the K2P channel TRAAK.

A. Mathie, J. Large, E. Veale, 2021, Biochemical and biophysical research communications.