N. Huebert

发表

Cerebrospinal Fluid Parameters in Healthy Volunteers During Serial Lumbar Punctures

P. Schechter, K. Haegele, L. Persson, 1989, Journal of neurochemistry.

Biochemical and clinical effects of γ‐vinyl GABA in patients with epilepsy

A. Sjoerdsma, P. Schechter, J. Grove, 1984, Neurology.

BIOACTIVATION OF 4-METHYLPHENOL (p-CRESOL) VIA CYTOCHROME P450-MEDIATED AROMATIC OXIDATION IN HUMAN LIVER MICROSOMES

Zhengyin Yan, G. Leo, G. Caldwell, 2005, Drug Metabolism and Disposition.

Isobaric metabolite interferences and the requirement for close examination of raw data in addition to stringent chromatographic separations in liquid chromatography/tandem mass spectrometric analysis of drugs in biological matrix.

Zhengyin Yan, G. Caldwell, N. Huebert, 2008, Rapid communications in mass spectrometry : RCM.

Pharmacokinetic properties of TDP4815 after single intravenous and oral administrations to rat, rabbit, monkey, dog and in vitro drug metabolism

B. Tomczuk, R. Bone, Yanmin Chen, 2008, Biopharmaceutics & drug disposition.

Isocratic high-performance liquid chromatographic method for the separation of testosterone metabolites.

J. Dow, B. Dulery, N. Huebert, 1995, Journal of chromatography. B, Biomedical applications.

A comparison of the effects of reversible and irreversible inhibitors of aromatic L-amino acid decarboxylase on the half-life and other pharmacokinetic parameters of oral L-3,4-dihydroxyphenylalanine.

M. Palfreyman, K. Haegele, N. Huebert, 1983, Drug metabolism and disposition: the biological fate of chemicals.

Use of a trapping agent for simultaneous capturing and high-throughput screening of both "soft" and "hard" reactive metabolites.

Zhengyin Yan, N. Huebert, N. Maher, 2007, Analytical chemistry.

Discovery of N-arylpyrroles as agonists of GPR120 for the treatment of type II diabetes.

Z. Sui, T. Koudriakova, W. Murray, 2018, Bioorganic & medicinal chemistry letters.

FcRn binding is not sufficient for achieving systemic therapeutic levels of immunoglobulin G after oral delivery of enteric‐coated capsules in cynomolgus macaques

P. Cooper, S. Muzammil, P. Hornby, 2016, Pharmacology research & perspectives.

Design, synthesis and structure activity relationships of indazole and indole derivatives as potent glucagon receptor antagonists.

R. DesJarlais, Tianbao Lu, B. Shook, 2019, Bioorganic & medicinal chemistry letters.

Biochemical and clinical effects of gamma-vinyl GABA in patients with epilepsy.

A. Sjoerdsma, P. Schechter, J. Grove, 1984, Neurology.

Structure-based design, synthesis, and biological evaluation of novel 1,4-diazepines as HDM2 antagonists.

Maxwell D Cummings, Mark R Player, D. Parks, 2005, Bioorganic & medicinal chemistry letters.

Orally efficacious thrombin inhibitors with cyanofluorophenylacetamide as the P2 motif.

B. Tomczuk, J. Spurlino, Hui-Sheng Huang, 2008, Bioorganic & medicinal chemistry letters.

Determination of the R(−)- and S(+)-enantiomers of γ-vinyl-γ-aminobutyric acid in human body fluids by gas chromatography—mass spectrometry

K. Haegele, N. Huebert, R. Alken, 1983 .

A method using a liquid chromatographic-electrospray-mass spectrometric assay for the determination of antimigraine compounds: preliminary pharmacokinetics of MDL 74,721, sumatriptan and naratriptan, in rabbit.

B. Dulery, M. Petty, N. Huebert, 1997, Journal of pharmaceutical and biomedical analysis.

Selectivity of MDL 72,974A for MAO-B inhibition based on substrate and metabolite concentrations in plasma.

K. Haegele, V. Schwach, N. Huebert, 1995, Progress in brain research.

Discovery, SAR, and X-ray structure of novel biaryl-based dipeptidyl peptidase IV inhibitors.

B. Tomczuk, R. DesJarlais, J. Spurlino, 2006, Bioorganic & medicinal chemistry letters.

Effects of single doses of vigabatrin on CSF concentrations of GABA, homocarnosine, homovanillic acid and 5-hydroxyindoleacetic acid in patients with complex partial epilepsy

P. Schechter, K. Haegele, L. Persson, 1988, Epilepsy Research.

Design, synthesis and biological evaluation of (2S,3R,4R,5S,6R)-5-fluoro-6-(hydroxymethyl)-2-aryltetrahydro-2H-pyran-3,4-diols as potent and orally active SGLT dual inhibitors.

T. Kirchner, F. Du, S. Lee, 2018, Bioorganic & medicinal chemistry letters.

Rapid detection and characterization of minor reactive metabolites using stable-isotope trapping in combination with tandem mass spectrometry.

Gary W Caldwell, Zhengyin Yan, G. Caldwell, 2005, Rapid communications in mass spectrometry : RCM.

Metabolism and bioactivation of 3-methylindole by human liver microsomes.

Zhengyin Yan, G. Yost, L. Easterwood, 2007, Chemical research in toxicology.

Longitudinal urinary trace amine excretion in a human male.

A. Boulton, N. Huebert, 1979, Journal of chromatography.

The effect of different vigabatrin treatment regimens on CSF biochemistry and seizure control in epileptic patients.

E. Ben-Menachem, P. Schechter, K. Haegele, 1989, British journal of clinical pharmacology.

Pharmacokinetics of vigabatrin: Implications of creatinine clearance

P. Schechter, K. Haegele, N. Huebert, 1988, Clinical pharmacology and therapeutics.

Effect of Long-Term Vigabatrin Therapy on Selected Neurotransmitter Concentrations in Cerebrospinal Fluid

E. Ben-Menachem, K. Haegele, N. Huebert, 1991, Journal of child neurology.

Determination of the R(-)- and S(+)-enantiomers of gamma-vinyl-gamma-aminobutyric acid in human body fluids by gas chromatography--mass spectrometry.

K. Haegele, N. Huebert, R. Alken, 1983, Journal of chromatography.

Improved pharmacokinetic and bioavailability support of drug discovery using serial blood sampling in mice.

Sean X Peng, W. Hageman, William Hageman, 2009, Journal of pharmaceutical sciences.

Characterization of the ZDSD Rat: A Translational Model for the Study of Metabolic Syndrome and Type 2 Diabetes

Michael K. Hansen, R. Peterson, W. de Winter, 2015, Journal of diabetes research.

The Measurement of β-Phenylethylamine in Human Plasma and Rat Brain

K. Haegele, V. Schwach, N. Huebert, 1994 .

DETECTION OF A NOVEL REACTIVE METABOLITE OF DICLOFENAC: EVIDENCE FOR CYP2C9-MEDIATED BIOACTIVATION VIA ARENE OXIDES

Zhengyin Yan, G. Caldwell, H. Zhong, 2005, Drug Metabolism and Disposition.

Studies with an Orally Bioavailable αV Integrin Antagonist in Animal Models of Ocular Vasculopathy: Retinal Neovascularization in Mice and Retinal Vascular Permeability in Diabetic Rats

S. Mousa, S. Bursell, A. Clermont, 2008, Journal of Pharmacology and Experimental Therapeutics.

Pharmacokinetics of TDP223206 following intravenous and oral administration to intact rats and intravenous administration to bile duct‐cannulated rats

B. Tomczuk, J. Marugan, C. Manthey, 2008, Biopharmaceutics & drug disposition.

Human oral drugs absorption is correlated to their in vitro uptake by brush border membrane vesicles.

Yanmin Chen, N. Huebert, N. Oulianova, 2007, International journal of pharmaceutics.

Design and synthesis of polyethylene glycol-modified biphenylsulfonyl-thiophene-carboxamidine inhibitors of the complement component C1s.

B. Tomczuk, C. Molloy, R. Bone, 2012, Bioorganic & medicinal chemistry letters.

Biphenylsulfonyl-thiophene-carboxamidine inhibitors of the complement component C1s.

B. Tomczuk, R. DesJarlais, Hui-Sheng Huang, 2008, Bioorganic & medicinal chemistry letters.

Quantitative analysis of the dihydropyridines, 3-(2-furoyl)-5-methoxycarbonyl-2,6-dimethyl-4-(2-nitrophenyl)- 1,4-dihydropyridine and nifedipine, by high-performance liquid chromatography with electrochemical detection.

M. Spedding, K. Haegele, N. Huebert, 1986, Journal of chromatography.

Simultaneous measurement of dolasetron and its major metabolite, MDL 74,156, in human plasma and urine.

K. Haegele, V. Schwach, N. Huebert, 1996, Journal of chromatography. B, Biomedical applications.

Simultaneous measurement of the major metabolites of dolasetron mesilate in human urine using solid-phase extraction and high-performance liquid chromatography.

K. Haegele, N. Huebert, P. Sanwald, 1994, Journal of chromatography. B, Biomedical applications.

Bioactivation of 4-Methylphenol (p-cresol) via CYP-mediated Aromatic Oxidation in Human Liver Microsomes

Zhengyin Yan, G. Leo, G. Caldwell, 2005 .

Analysis of 2-difluoromethyl-DL-ornithine in human plasma, cerebrospinal fluid and urine by cation-exchange high-performance liquid chromatography.

K. Haegele, N. Huebert, J. Schwartz, 1997, Journal of chromatography. A.