Clement Opoku-Temeng

发表

Agents that inhibit bacterial biofilm formation.

Yue Zheng, H. Sintim, Nira Rabin, 2015, Future medicinal chemistry.

Cyclic dinucleotide (c-di-GMP, c-di-AMP, and cGAMP) signalings have come of age to be inhibited by small molecules.

Jie Zhou, Yue Zheng, H. Sintim, 2016, Chemical communications.

Structure–activity relationship studies of c-di-AMP synthase inhibitor, bromophenol-thiohydantoin

Jie Zhou, Yue Zheng, H. Sintim, 2016 .

Antibacterial Small Molecules That Potently Inhibit Staphylococcus aureus Lipoteichoic Acid Biosynthesis

George A. Naclerio, H. Sintim, Clement Opoku-Temeng, 2019, ChemMedChem.

Hydroxybenzylidene-indolinones, c-di-AMP synthase inhibitors, have antibacterial and anti-biofilm activities and also re-sensitize resistant bacteria to methicillin and vancomycin

Neetu Dayal, H. Sintim, Jacob Miller, 2017 .

Klebsiella pneumoniae capsule polysaccharide as a target for therapeutics and vaccines

F. DeLeo, Scott D. Kobayashi, Clement Opoku-Temeng, 2019, Computational and structural biotechnology journal.

Inhibitors of Intracellular Gram-positive Bacteria Growth Synthesized via Povarov-Doebner Reactions.

M. Zeller, Modi Wang, M. Seleem, 2019, ACS infectious diseases.

N-(1,3,4-oxadiazol-2-yl)benzamide analogs, bacteriostatic agents against methicillin- and vancomycin-resistant bacteria.

M. Seleem, George A. Naclerio, Nader S. Abutaleb, 2018, European journal of medicinal chemistry.

Fluorescent analogs of cyclic and linear dinucleotides as phosphodiesterase and oligoribonuclease activity probes

Jie Zhou, Yue Zheng, Benjamin T. Roembke, 2017 .

3 H -pyrazolo[4,3- f ]quinoline haspin kinase inhibitors and anticancer properties

Neetu Dayal, Clement Opoku-Temeng, M. A. Sooreshjani, 2018 .

Inhibition of cyclic diadenylate cyclase, DisA, by polyphenols

H. Sintim, Clement Opoku-Temeng, 2016, Scientific Reports.

Potent inhibition of cyclic diadenylate monophosphate cyclase by the antiparasitic drug, suramin.

H. Sintim, Clement Opoku-Temeng, 2016, Chemical communications.

Innate Host Defense against Klebsiella pneumoniae and the Outlook for Development of Immunotherapies

F. DeLeo, Scott D. Kobayashi, Natalia Małachowa, 2021, Journal of Innate Immunity.

Subinhibitory Concentrations of Antibiotics Alter the Response of Klebsiella pneumoniae to Components of Innate Host Defense

B. Freedman, F. DeLeo, Liang Chen, 2022, Microbiology spectrum.

Targeting Cyclic Dinucleotide Signaling with Small Molecules

H. Sintim, Clement Opoku-Temeng, 2020 .

Inhibition of P. aeruginosa c-di-GMP phosphodiesterase RocR and swarming motility by a benzoisothiazolinone derivative† †Electronic supplementary information (ESI) available: All experimental, spectroscopic details and supplemental figures. See DOI: 10.1039/c6sc02103d

Yue Zheng, H. Sintim, Genichiro Tsuji, 2016, Chemical science.

Biofilm formation mechanisms and targets for developing antibiofilm agents.

Yue Zheng, H. Sintim, Nira Rabin, 2015, Future medicinal chemistry.

Proteomic analysis of bacterial response to a 4-hydroxybenzylidene indolinone compound, which re-sensitizes bacteria to traditional antibiotics.

U. Aryal, H. Sintim, Clement Opoku-Temeng, 2019, Journal of proteomics.

Targeting c-di-GMP Signaling, Biofilm Formation, and Bacterial Motility with Small Molecules.

H. Sintim, Clement Opoku-Temeng, 2017, Methods in molecular biology.

Dual FLT3/TOPK inhibitor with activity against FLT3-ITD secondary mutations potently inhibits acute myeloid leukemia cell lines

Neetu Dayal, H. Sintim, R. Lapidus, 2018, Future medicinal chemistry.

Aminoisoquinoline benzamides, FLT3 and Src-family kinase inhibitors, potently inhibit proliferation of acute myeloid leukemia cell lines.

G. Chopra, Xiaochu Ma, H. Sintim, 2017, Future medicinal chemistry.

Suramin potently inhibits cGAMP synthase, cGAS, in THP1 cells to modulate IFN-β levels.

Modi Wang, H. Sintim, Clement Opoku-Temeng, 2018, Future medicinal chemistry.

Amino alkynylisoquinoline and alkynylnaphthyridine compounds potently inhibit acute myeloid leukemia proliferation in mice

Modi Wang, B. Elzey, H. Sintim, 2019, EBioMedicine.

Tetrahydro-3H-pyrazolo[4,3-a]phenanthridine-based CDK inhibitor.

Neetu Dayal, H. Sintim, Clement Opoku-Temeng, 2018, Chemical communications.

Cyclic Dinucleotide (c‐di‐GMP, c‐di‐AMP, and cGAMP) Signalings Have Come of Age to Be Inhibited by Small Molecules

Yue Zheng, H. Sintim, Jie-Xing Zhou, 2016 .

Alkynylnicotinamide‐Based Compounds as ABL1 Inhibitors with Potent Activities against Drug‐Resistant CML Harboring ABL1(T315I) Mutant Kinase

H. Sintim, Clement Opoku-Temeng, Elizabeth Larocque, 2018, ChemMedChem.

3-Aminooxazolidinone AHL analogs as hydrolytically-stable quorum sensingagonists in Gram-negative bacteria

Xiaochu Ma, Yue Zheng, H. Sintim, 2015 .

3H-pyrazolo[4,3-f]quinoline haspin kinase inhibitors and anticancer properties.

Neetu Dayal, H. Sintim, Clement Opoku-Temeng, 2018, Bioorganic chemistry.

Geminal dihalogen isosteric replacement in hydrated AI-2 affords potent quorum sensing modulators.

W. Bentley, Yue Zheng, H. Sintim, 2015, Chemical communications.