Jui‐Ling Hsu

发表

Non-immunosuppressive triazole-based small molecule induces anticancer activity against human hormone-refractory prostate cancers: the role in inhibition of PI3K/AKT/mTOR and c-Myc signaling pathways

J. Guh, Shih-Ping Liu, Chia-Chun Yu, 2016, Oncotarget.

Repurposing of phentolamine as a potential anticancer agent against human castration‐resistant prostate cancer: A central role on microtubule stabilization and mitochondrial apoptosis pathway

J. Guh, C. Chao, Shih-Ping Liu, 2015, The Prostate.

Ardisianone, a natural benzoquinone, efficiently induces apoptosis in human hormone‐refractory prostate cancers through mitochondrial damage stress and survivin downregulation

J. Guh, Y. Ho, Chia-Chun Yu, 2013, The Prostate.

Mechanistic Study of Triazole Based Aminodiol Derivatives in Leukemic Cells—Crosstalk between Mitochondrial Stress-Involved Apoptosis and Autophagy

J. Guh, S. P. Swain, Wohn-Jenn Leu, 2020, International journal of molecular sciences.

Pim-1 knockdown potentiates paclitaxel-induced apoptosis in human hormone-refractory prostate cancers through inhibition of NHEJ DNA repair.

C. Chen, J. Guh, Y. Ho, 2012, Cancer letters.

Elucidation of susceptible factors to endoplasmic reticulum stress-mediated anticancer activity in human hepatocellular carcinoma

S. Pan, Po-Cheng Chiang, J. Guh, 2008, Naunyn-Schmiedeberg's Archives of Pharmacology.

Epi-reevesioside F inhibits Na+/K+-ATPase, causing cytosolic acidification, Bak activation and apoptosis in glioblastoma

J. Guh, Chia-Chun Yu, Wei‐Ling Chang, 2015, Oncotarget.

Increased sensitivity of Hep G2 cells toward the cytotoxicity of cisplatin by the treatment of piper betel leaf extract

F. Chou, S. Young, Jui‐Ling Hsu, 2006, Archives of Toxicology.

Protection effect of piper betel leaf extract against carbon tetrachloride-induced liver fibrosis in rats

F. Chou, S. Young, Jing-jing Lin, 2006, Archives of Toxicology.

Para-Toluenesulfonamide Induces Anti-tumor Activity Through Akt-Dependent and -Independent mTOR/p70S6K Pathway: Roles of Lipid Raft and Cholesterol Contents

N. Zhong, J. Guh, Shih-Ping Liu, 2018, Front. Pharmacol..

Inhibitory effect of berberine on the invasion of human lung cancer cells via decreased productions of urokinase-plasminogen activator and matrix metalloproteinase-2.

Y. Hsieh, F. Chou, Jui‐Ling Hsu, 2006, Toxicology and applied pharmacology.

The Combination of a Novel GLUT1 Inhibitor and Cisplatin Synergistically Inhibits Breast Cancer Cell Growth By Enhancing the DNA Damaging Effect and Modulating the Akt/mTOR and MAPK Signaling Pathways

J. Guh, L. Hsu, F. Kung, 2022, Frontiers in Pharmacology.

The (+)-Brevipolide H Displays Anticancer Activity against Human Castration-Resistant Prostate Cancer: The Role of Oxidative Stress and Akt/mTOR/p70S6K-Dependent Pathways in G1 Checkpoint Arrest and Apoptosis

J. Guh, L. Hsu, Wohn-Jenn Leu, 2020, Molecules.

ICAM-1 and AMPK regulate cell detachment and apoptosis by N-methyl-N'-nitro-N-nitrosoguanidine, a widely spread environmental chemical, in human hormone-refractory prostate cancers.

J. Guh, Chia-Chun Yu, Jui‐Ling Hsu, 2011, Toxicology and applied pharmacology.

A novel small molecule hybrid of vorinostat and DACA displays anticancer activity against human hormone-refractory metastatic prostate cancer through dual inhibition of histone deacetylase and topoisomerase I.

S. Pan, J. Guh, Shih-Ping Liu, 2014, Biochemical pharmacology.

Costunolide induces apoptosis through nuclear calcium2+ overload and DNA damage response in human prostate cancer.

S. Pan, J. Guh, Y. Ho, 2011, The Journal of urology.

Tunicamycin induces resistance to camptothecin and etoposide in human hepatocellular carcinoma cells: role of cell-cycle arrest and GRP78

Po-Cheng Chiang, J. Guh, Jui‐Ling Hsu, 2009, Naunyn-Schmiedeberg's Archives of Pharmacology.

Inhibitor development of MTH1 via high-throughput screening with fragment based library and MTH1 substrate binding cavity.

H. Juan, J. Chern, Yi-Sheng Cheng, 2021, Bioorganic chemistry.

Evaluation of the Anticancer Activity of a Bile Acid-Dihydroartemisinin Hybrid Ursodeoxycholic-Dihydroartemisinin in Hepatocellular Carcinoma Cells

J. Guh, D. Perrone, E. Marchesi, 2020, Frontiers in Pharmacology.

Chalcones Display Anti-NLRP3 Inflammasome Activity in Macrophages through Inhibition of Both Priming and Activation Steps—Structure-Activity-Relationship and Mechanism Studies

J. Guh, Wei-Jan Huang, L. Hsu, 2020, Molecules.

The Combination of MK-2206 and WZB117 Exerts a Synergistic Cytotoxic Effect Against Breast Cancer Cells

Shu-Wha Lin, J. Guh, L. Hsu, 2019, Front. Pharmacol..

Enantiomerically pure β-dipeptide derivative induces anticancer activity against human hormone-refractory prostate cancer through both PI3K/Akt-dependent and -independent pathways.

J. Guh, S. Bräse, Shih-Ping Liu, 2017, Oncotarget.

NPRL-Z-1, as a New Topoisomerase II Poison, Induces Cell Apoptosis and ROS Generation in Human Renal Carcinoma Cells

Szu-Ying Wu, C. Teng, S. Pan, 2014, PloS one.

Reevesioside A, a Cardenolide Glycoside, Induces Anticancer Activity against Human Hormone-Refractory Prostate Cancers through Suppression of c-myc Expression and Induction of G1 Arrest of the Cell Cycle

J. Guh, Chia-Chun Yu, I. Chen, 2014, PloS one.

KUD773, a phenylthiazole derivative, displays anticancer activity in human hormone-refractory prostate cancers through inhibition of tubulin polymerization and anti-Aurora A activity

J. Guh, Chia-Chun Yu, K. Kudryavtsev, 2015, Journal of Biomedical Science.

Phosphodiesterase Type 5 Inhibitors Synergize Vincristine in Killing Castration-Resistant Prostate Cancer Through Amplifying Mitotic Arrest Signaling

J. Guh, Shih-Ping Liu, L. Hsu, 2020, Frontiers in Oncology.

Calanquinone A induces anti-glioblastoma activity through glutathione-involved DNA damage and AMPK activation.

J. Guh, F. Kung, Yean-Jang Lee, 2014, European journal of pharmacology.

Genistein induces apoptosis in human hepatocellular carcinomas via interaction of endoplasmic reticulum stress and mitochondrial insult.

Po-Cheng Chiang, J. Guh, Chieh-Yu Peng, 2007, Biochemical pharmacology.

Phosphodiesterase Type 5 (PDE5) Inhibitors Sensitize Topoisomerase II Inhibitors in Killing Prostate Cancer Through PDE5-Independent Impairment of HR and NHEJ DNA Repair Systems

J. Guh, Shih-Ping Liu, Chia-Chun Yu, 2019, Front. Oncol..

Terfenadine induces anti-proliferative and apoptotic activities in human hormone-refractory prostate cancer through histamine receptor-independent Mcl-1 cleavage and Bak up-regulation

J. Guh, Y. Ho, Chia-Chun Yu, 2013, Naunyn-Schmiedeberg's Archives of Pharmacology.

Rottlerin potentiates camptothecin-induced cytotoxicity in human hormone refractory prostate cancers through increased formation and stabilization of topoisomerase I-DNA cleavage complexes in a PKCδ-independent pathway.

J. Guh, Y. Ho, L. Hsu, 2012, Biochemical pharmacology.

Discovery of Novel Agents on Spindle Assembly Checkpoint to Sensitize Vinorelbine-Induced Mitotic Cell Death against Human Non-Small Cell Lung Cancers

J. Guh, L. Hsu, Wohn-Jenn Leu, 2020, International journal of molecular sciences.

A novel hydroxysuberamide derivative potentiates MG132‐mediated anticancer activity against human hormone refractory prostate cancers—the role of histone deacetylase and endoplasmic reticulum stress

J. Guh, Wei-Jan Huang, Chia-Chun Yu, 2013, The Prostate.

A unique amidoanthraquinone derivative displays antiproliferative activity against human hormone-refractory metastatic prostate cancers through activation of LKB1-AMPK-mTOR signaling pathway

J. Guh, Y. Ho, Hsu-Shan Huang, 2014, Naunyn-Schmiedeberg's Archives of Pharmacology.

Moniliformediquinone induces in vitro and in vivo antitumor activity through glutathione involved DNA damage response and mitochondrial stress in human hormone refractory prostate cancer.

S. Pan, J. Guh, Wohn-Jenn Leu, 2014, The Journal of urology.

Autophagic Activation and Decrease of Plasma Membrane Cholesterol Contribute to Anticancer Activities in Non-Small Cell Lung Cancer

N. Zhong, J. Guh, Wohn-Jenn Leu, 2021, Molecules.

A unique amidoanthraquinone derivative displays antiproliferative activity against human hormone-refractory metastatic prostate cancers through activation of LKB1-AMPK-mTOR signaling pathway

J. Guh, Y. Ho, Shih-Ping Liu, 2014, Naunyn-Schmiedeberg's Archives of Pharmacology.

The Prostate

J. Guh, I. Chen, Hsun-Shuo Chang, 2020 .

KUD773, a phenylthiazole derivative, displays anticancer activity in human hormone-refractory prostate cancers through inhibition of tubulin polymerization and anti-Aurora A activity

J. Guh, Shih-Ping Liu, Chia-Chun Yu, 2015, Journal of Biomedical Science.

Terfenadine induces anti-proliferative and apoptotic activities in human hormone-refractory prostate cancer through histamine receptor-independent Mcl-1 cleavage and Bak up-regulation

J. Guh, Y. Ho, Chia-Chun Yu, 2013, Naunyn-Schmiedeberg's Archives of Pharmacology.

A novel HDAC6 inhibitor interferes microtubule dynamics and spindle assembly checkpoint and sensitizes cisplatin‐induced apoptosis in castration‐resistant prostate cancer

J. Guh, L. Hsu, Wohn-Jenn Leu, 2024, The Prostate.

Cardenolide glycosides sensitize gefitinib-induced apoptosis in non-small cell lung cancer: inhibition of Na+/K+-ATPase serving as a switch-on mechanism.

J. Guh, L. Hsu, Wohn-Jenn Leu, 2024, Naunyn-Schmiedeberg's archives of pharmacology.

Mechanistic study of dual‐function inhibitors targeting topoisomerase II and Rad51‐mediated DNA repair pathway against castration‐resistant prostate cancer

J. Guh, Hsu-Shan Huang, L. Hsu, 2023, The Prostate.