D. Lauffer

发表

A practical synthesis of (S) 3-tert-butoxycarbonylamino-2-oxo-2,3,4,5-tetrahydro-1,5-benzodiazepine-1-acetic acid methyl ester as a conformationally restricted dipeptido-mimetic for caspase-1 (ICE) inhibitors.

M. D. Mullican, D. Lauffer, 2002, Bioorganic & medicinal chemistry letters.

The synthesis and evaluation of peptidyl aspartyl aldehydes as inhibitors of ice.

M. Murcko, M. D. Mullican, R. Gillespie, 1994 .

CI-1017, a functionally M1-selective muscarinic agonist: design, synthesis, and preclinical pharmacology.

M. Emmerling, S. Barrett, H. Tecle, 2000, Pharmaceutica acta Helvetiae.

3-Aryl-4-(arylhydrazono)-1H-pyrazol-5-ones: Highly ligand efficient and potent inhibitors of GSK3beta.

E. ter Haar, A. Pierce, Michael Arnost, 2010, Bioorganic & medicinal chemistry letters.

In vitro and in vivo evaluation of the subtype-selective muscarinic agonist PD 151832.

M. Brann, S. Barrett, J. Jaén, 1995, Life sciences.

Discovery of Novel Allosteric HCV NS5B Inhibitors. 2. Lactam-Containing Thiophene Carboxylates.

B. G. Rao, S. Das, D. Bilimoria, 2017, ACS medicinal chemistry letters.

Discovery of Novel Thiophene-Based, Thumb Pocket 2 Allosteric Inhibitors of the Hepatitis C NS5B Polymerase with Improved Potency and Physicochemical Profiles.

B. G. Rao, G. Iyer, L. Chan, 2016, Journal of medicinal chemistry.

Chapter 54: Subtype selective muscarinic agonists: potential therapeutic agents for Alzheimer's disease

D. T. Dudley, H. Tecle, J. Jaén, 1993 .

Synthesis and SAR of bulky 1-azabicyclo[2.2.1]-3-one oximes as muscarinic receptor subtype selective agonists.

H. Tecle, T. Mirzadegan, W. Moos, 1993, Life sciences.

Second-generation antibacterial benzimidazole ureas: discovery of a preclinical candidate with reduced metabolic liability.

P. Charifson, T. Grossman, Tiansheng Wang, 2014, Journal of medicinal chemistry.

Design and synthesis of m1-selective muscarinic agonists: (R)-(-)-(Z)-1-Azabicyclo[2.2.1]heptan-3-one, O-(3-(3'-methoxyphenyl)-2-propynyl)oxime maleate (CI-1017), a functionally m1-selective muscarinic agonist.

M. Brann, S. Barrett, H. Tecle, 1998, Journal of medicinal chemistry.

Pyrazoles inhibiteurs de phosphatidylinositol 3-kinase

D. Lauffer, Alexander Aronov, David Messersmith, 2010 .

Derives d'amide cyclises

M. D. Mullican, D. Lauffer, B. Ledford, 2000 .

Discovery of Potent, Selective Triazolothiadiazole-Containing c-Met Inhibitors.

D. Boucher, A. Aronov, C. Moody, 2021, ACS medicinal chemistry letters.

Discovery of Novel Thiophene-Based, Thumb Pocket 2 Allosteric Inhibitors of the Hepatitis C NS5B Polymerase with Improved Potency and Physicochemical Profiles.

G. Iyer, L. Chan, C. Yannopoulos, 2016, Journal of medicinal chemistry.

Subtype selective muscarinic agonists: potential therapeutic agents for Alzheimer's disease.

D. T. Dudley, H. Tecle, J. Jaén, 1993, Progress in brain research.