John P. Caldwell

发表

Benzimidazole analogs as WTA biosynthesis inhibitors targeting methicillin resistant Staphylococcus aureus.

T. Roemer, S. Koseoglu, Jianping Pan, 2016, Bioorganic & medicinal chemistry letters.

Discovery of potent wall teichoic acid early stage inhibitors.

T. Roemer, S. Koseoglu, C. Garlisi, 2016, Bioorganic & medicinal chemistry letters.

MK-8325: A silyl proline-containing NS5A inhibitor with pan-genotype activity for treatment of HCV.

E. Asante-Appiah, M. Dwyer, A. Nomeir, 2018, Bioorganic & medicinal chemistry letters.

Unprecedented Reversal of Regioselectivity during Methanolysis and an Interception of Curtius Rearrangement

A. Stamford, J. Cumming, P. Orth, 2021, European Journal of Organic Chemistry.

From Screening to Targeted Degradation: Strategies for the Discovery and Optimization of Small Molecule Ligands for PCSK9.

Sujata Sharma, J. Lisnock, P. Orth, 2019, Cell chemical biology.

Structure and activity relationships of tartrate-based TACE inhibitors.

P. Orth, Zhuyan Guo, C. Strickland, 2010, Bioorganic & medicinal chemistry letters.

The discovery and synthesis of novel adenosine receptor (A(2A)) antagonists.

B. Neustadt, Jinsong Hao, D. Tulshian, 2005, Bioorganic & medicinal chemistry letters.

The discovery of tropane derivatives as nociceptin receptor ligands for the management of cough and anxiety.

Walter A. Korfmacher, W. Greenlee, D. Tulshian, 2009, Bioorganic & medicinal chemistry letters.

Iminoheterocycles as gamma-secretase modulators.

Lynn A. Hyde, J. Voigt, Zhaoning Zhu, 2010, Bioorganic & medicinal chemistry letters.

Discovery of silyl proline containing HCV NS5A inhibitors with pan-genotype activity: SAR development.

M. Dwyer, A. Nomeir, R. Mazzola, 2016, Bioorganic & medicinal chemistry letters.

3H-[1,2,4]-Triazolo[5,1-i]purin-5-amine derivatives as adenosine A2A antagonists.

W. Greenlee, D. Tulshian, E. Ongini, 2007, Bioorganic & medicinal chemistry letters.

Discovery of potent iminoheterocycle BACE1 inhibitors.

Brian McKittrick, Andrew Stamford, Xia Chen, 2014, Bioorganic & medicinal chemistry letters.

Design and validation of bicyclic iminopyrimidinones as beta amyloid cleaving enzyme-1 (BACE1) inhibitors: conformational constraint to favor a bioactive conformation.

William Greenlee, Lynn Hyde, Xia Chen, 2012, Journal of medicinal chemistry.

Can We Make Small Molecules Lean? Optimization of a Highly Lipophilic TarO Inhibitor.

T. Roemer, S. Koseoglu, P. Tawa, 2017, Journal of medicinal chemistry.

Cyp1 Inhibition Prevents Doxorubicin‐Induced Cardiomyopathy in a Zebrafish Heart‐Failure Model

Peter S. Kutchukian, D. Johns, R. Peterson, 2020, Chembiochem : a European journal of chemical biology.

Iminopyrimidinones: a novel pharmacophore for the development of orally active renin inhibitors.

Walter A. Korfmacher, W. Greenlee, J. Clader, 2015, Bioorganic & medicinal chemistry letters.

Generation of Leads for γ-Secretase Modulation.

Lynn A. Hyde, A. Palani, Zhaoning Zhu, 2020, Journal of medicinal chemistry.

2D‐LC as an on‐line desalting tool allowing peptide identification directly from MS unfriendly HPLC methods

C. Welch, Fanyu Meng, Jiong Yang, 2017, Journal of pharmaceutical and biomedical analysis.

Structure-Based Design of an Iminoheterocyclic β-Site Amyloid Precursor Protein Cleaving Enzyme (BACE) Inhibitor that Lowers Central Aβ in Nonhuman Primates.

Lynn A. Hyde, W. Greenlee, A. Stamford, 2016, Journal of medicinal chemistry.

Protecting group free radical C–H trifluoromethylation of peptides† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c8sc00368h

Shane W. Krska, Xiaohong Zhu, S. Krska, 2018, Chemical science.

2-(2-Furanyl)-7-phenyl[1,2,4]triazolo[1,5-c]pyrimidin-5-amine analogs: highly potent, orally active, adenosine A2A antagonists. Part 1.

D. Tulshian, G. Varty, A. Fawzi, 2005, Bioorganic & medicinal chemistry letters.

The Discovery and Synthesis of Novel Adenosine Receptor (A2A) Antagonists.

B. Neustadt, Jinsong Hao, D. Tulshian, 2005 .

Overcoming Time-Dependent Inhibition (TDI) of Cytochrome P450 3A4 (CYP3A4) Resulting from Bioactivation of a Fluoropyrimidine Moiety.

Lynn A. Hyde, A. Stamford, J. Cumming, 2018, Journal of medicinal chemistry.

Synthesis and structure-activity relationships of N-substituted spiropiperidines as nociceptin receptor ligands.

D. Tulshian, A. Fawzi, Hongtao Zhang, 2007, Bioorganic & medicinal chemistry letters.

Synthesis and structure-activity relationships of N-substituted spiropiperidines as nociceptin receptor ligands: part 2.

D. Tulshian, R. Mcleod, A. Fawzi, 2009, Bioorganic & medicinal chemistry letters.

From Screening to Targeted Degradation: Strategies for the Discovery and Optimization of Small Molecule Ligands for PCSK9.

Sujata Sharma, P. Orth, J. Shipman, 2021, Cell chemical biology.

Protecting group free radical C–H trifluoromethylation of peptides

Xiaohong Zhu, S. Krska, C. Parish, 2018, Chemical science.