Jun Wang

发表

Antidiabetic and antisteatotic effects of the selective fatty acid synthase (FAS) inhibitor platensimycin in mouse models of diabetes

Margaret S. Wu, Michael E. Lassman, M. Tota, 2011, Proceedings of the National Academy of Sciences.

Process Development for A Novel Pleuromutilin-Derived Antibiotic

E. Webb, P. Liu, D. Patience, 2009 .

Discovery of FabH/FabF Inhibitors from Natural Products

Jun Wang, John F. Barrett, Lynn L. Silver, 2006, Antimicrobial Agents and Chemotherapy.

Isolation, structure and biological activities of platencin A(2)-A(4) from Streptomyces platensis.

M. Motyl, Sheo B. Singh, J. Ondeyka, 2010, Bioorganic & medicinal chemistry.

Isolation, enzyme-bound structure, and activity of platensimycin A1 from Streptomyces platensis

J. W. Becker, S. Soisson, Sheo B. Singh, 2009 .

Synthesis and biological evaluation of platensimycin analogs.

M. Maccoss, Hong C Shen, S. Soisson, 2009, Bioorganic & medicinal chemistry letters.

Isolation, structure and biological activities of platensimycin B4 from Streptomyces platensis

Z. Guan, Sheo B. Singh, J. Ondeyka, 2009, The Journal of Antibiotics.

Isolation, enzyme-bound structure and antibacterial activity of platencin A1 from Streptomyces platensis.

J. W. Becker, S. Soisson, Sheo B. Singh, 2009, Bioorganic & medicinal chemistry letters.

Structure of homoplatensimide A : a potential key biosynthetic intermediate of platensimycin isolated from Streptomyces platensis

Sheo B. Singh, D. Zink, J. Ondeyka, 2008 .

Isolation and structure of platencin: a FabH and FabF dual inhibitor with potent broad-spectrum antibiotic activity.

F. Vicente, R. Cummings, Ó. Salazar, 2007, Angewandte Chemie.

Chemistry of platensimycin

R. Ball, Sheo B. Singh, N. Tsou, 2007 .

Anthrabenzoxocinones from Streptomyces sp. as liver X receptor ligands and antibacterial agents.

Z. Guan, J. Menke, Neelam Sharma, 2005, Journal of natural products.

Structure and semisynthesis of platensimide A, produced by Streptomyces platensis.

Sheo B. Singh, D. Zink, J. Ondeyka, 2008, Organic letters.

Platensimycin is a selective FabF inhibitor with potent antibiotic properties

Jun Wang, Olga Genilloud, Sang Ho Lee, 2006, Nature.

Isolation, structure, and absolute stereochemistry of platensimycin, a broad spectrum antibiotic discovered using an antisense differential sensitivity strategy.

Olga Genilloud, Jun Wang, Francisca Vicente, 2006, Journal of the American Chemical Society.

Discovery of a Small Molecule That Inhibits Cell Division by Blocking FtsZ, a Novel Therapeutic Target of Antibiotics*

D. Cully, F. Vicente, Andrew M. Galgoci, 2003, Journal of Biological Chemistry.

Discovery of platencin, a dual FabF and FabH inhibitor with in vivo antibiotic properties

Jun Wang, Olga Genilloud, Oscar Salazar, 2007, Proceedings of the National Academy of Sciences.

Determination of Selectivity and Efficacy of Fatty Acid Synthesis Inhibitors*

D. Schmatz, D. Cully, R. Painter, 2005, Journal of Biological Chemistry.

Platensimycin and platencin congeners from Streptomyces platensis.

Z. Guan, Sheo B. Singh, D. Zink, 2011, Journal of natural products.

Discovery of bacterial fatty acid synthase inhibitors from a Phoma species as antimicrobial agents using a new antisense-based strategy.

Jun Wang, Francisca Vicente, Katherine Young, 2006, Journal of natural products.

Highly sensitive target-based whole-cell antibacterial discovery strategy by antisense RNA silencing.

J. Phillips, Sheo B Singh, Sheo B. Singh, 2007, Current opinion in drug discovery & development.