S. Jenkins

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Diagnosing Biopharmaceutical Limitations

S. Jenkins, D. Parker, Susan M Jenkins, 2015 .

Discovery of BMS-955176, a Second Generation HIV-1 Maturation Inhibitor with Broad Spectrum Antiviral Activity.

B. Beno, N. Meanwell, Zeyu Lin, 2016, ACS medicinal chemistry letters.

Discovery of BMS-986144, a Third-Generation, Pan-Genotype NS3/4A Protease Inhibitor for the Treatment of Hepatitis C Virus Infection.

A. Mathur, N. Meanwell, Chaoqun Chen, 2020, Journal of medicinal chemistry.

(Carbonyl)oxyalkyl linker-based amino acid prodrugs of the HIV-1 protease inhibitor atazanavir that enhance oral bioavailability and plasma trough concentration.

Murugaiah A. M. Subbaiah, S. Mandlekar, N. Meanwell, 2020, European journal of medicinal chemistry.

Scaffold modifications to the 4-(4,4-dimethylpiperidinyl) 2,6-dimethylpyridinyl class of HIV-1 allosteric integrase inhibitors.

K. Kish, N. Meanwell, M. Krystal, 2022, Bioorganic & medicinal chemistry.

Discovery and Preclinical Profiling of GSK3839919, a Potent HIV-1 Allosteric Integrase Inhibitor.

K. Kish, N. Meanwell, C. Cianci, 2022, ACS medicinal chemistry letters.

Leukotriene receptors are overexpressed in aspirin sensitive asthmatics

S. Jenkins, 2003 .

Improving Drug Delivery While Tailoring Prodrug Activation to Modulate Cmax and Cmin by Optimization of (Carbonyl)oxyalkyl Linker-Based Prodrugs of Atazanavir.

S. Mandlekar, N. Meanwell, M. Krystal, 2022, Journal of medicinal chemistry.

Functionalized triazines as potent HCV entry inhibitors.

N. Meanwell, R. Rajamani, M. Kramer, 2017, Bioorganic & medicinal chemistry letters.

Constrained analogs of CB-1 antagonists: 1,5,6,7-Tetrahydro-4H-pyrrolo[3,2-c]pyridine-4-one derivatives.

Jennifer A. Natoli, Astrid A. Ortiz, B. Podlogar, 2007, Bioorganic & medicinal chemistry letters.

5,6,7,8-Tetrahydro-1,6-naphthyridine Derivatives as Potent HIV-1-Integrase-Allosteric-Site Inhibitors.

Barry L. Johnson, K. Kish, N. Meanwell, 2019, Journal of medicinal chemistry.

Discovery and early clinical evaluation of BMS-605339, a potent and orally efficacious tripeptidic acylsulfonamide NS3 protease inhibitor for the treatment of hepatitis C virus infection.

A. Good, H. Klei, A. Cocuzza, 2014, Journal of medicinal chemistry.

Discovery and Optimization of Novel Pyrazolopyrimidines as Potent and Orally Bioavailable Allosteric HIV-1 Integrase Inhibitors.

K. Kish, G. Trainor, N. Meanwell, 2020, Journal of medicinal chemistry.

Design, Synthesis and SAR Study of Novel C2-Pyrazolopyrimidine Amides and Amide Isosteres as Allosteric Integrase Inhibitors.

N. Meanwell, C. Cianci, M. Krystal, 2020, Bioorganic & medicinal chemistry letters.

Design, Synthesis, and Pharmacokinetic Evaluation of Phosphate and Amino Acid Ester Prodrugs for Improving the Oral Bioavailability of the HIV-1 Protease Inhibitor Atazanavir.

S. Mandlekar, N. Meanwell, M. Krystal, 2019, Journal of medicinal chemistry.

Coupling of an Acyl Migration Prodrug Strategy with Bio-activation To Improve Oral Delivery of the HIV-1 Protease Inhibitor Atazanavir.

S. Mandlekar, N. Meanwell, M. Krystal, 2018, Journal of medicinal chemistry.

Heterocycle amide isosteres: An approach to overcoming resistance for HIV-1 integrase strand transfer inhibitors.

N. Meanwell, D. Langley, Zeyu Lin, 2019, Bioorganic & medicinal chemistry letters.

Optimization of imidazole amide derivatives as cannabinoid-1 receptor antagonists for the treatment of obesity.

Jennifer A. Natoli, Astrid A. Ortiz, S. O'connor, 2007, Bioorganic & medicinal chemistry letters.

Design, Synthesis, and SAR of C-3 Benzoic Acid, C-17 Triterpenoid Derivatives. Identification of the HIV-1 Maturation Inhibitor 4-((1 R,3a S,5a R,5b R,7a R,11a S,11b R,13a R,13b R)-3a-((2-(1,1-Dioxidothiomorpholino)ethyl)amino)-5a,5b,8,8,11a-pentamethyl-1-(prop-1-en-2-yl)-2,3,3a,4,5,5a,5b,6,7,7a,8,1

B. Beno, N. Meanwell, V. Arora, 2018, Journal of medicinal chemistry.

Inhibitors of human immunodeficiency virus type 1 (HIV-1) attachment 13. Synthesis and profiling of a novel amminium prodrug of the HIV-1 attachment inhibitor BMS-585248.

Michael Sinz, Dawn Parker, Kim A Johnson, 2013, Journal of medicinal chemistry.

The design, synthesis and structure-activity relationships associated with C28 amine-based betulinic acid derivatives as inhibitors of HIV-1 maturation.

N. Meanwell, Zeyu Lin, M. Krystal, 2018, Bioorganic & medicinal chemistry letters.

Estrogen Receptor Beta is a Novel Therapeutic Target for Photoaging

J. Chung, L. Freedman, S. Nagpal, 2010 .

Preclinical pharmacokinetics and in vitro metabolism of BMS-605339: a novel HCV NS3 protease inhibitor.

V. Arora, J. Knipe, F. Mcphee, 2014, Journal of pharmaceutical sciences.

Structure-based amelioration of PXR transactivation in a novel series of macrocyclic allosteric inhibitors of HIV-1 integrase.

Stephen R. Johnson, N. Meanwell, D. Langley, 2020, Bioorganic & medicinal chemistry letters.

Design, Synthesis, and Preclinical Profiling of GSK3739936 (BMS-986180), an Allosteric Inhibitor of HIV-1 Integrase with Broad-Spectrum Activity toward 124/125 Polymorphs.

K. Kish, N. Meanwell, H. Lewis, 2022, Journal of medicinal chemistry.

Design, synthesis and SAR study of bridged tricyclic pyrimidinone carboxamides as HIV-1 integrase inhibitors.

A. Mathur, N. Meanwell, Zeyu Lin, 2020, Bioorganic & medicinal chemistry.

Evidence for Classical Cholinergic Toxicity Associated with Selective Activation of M1 Muscarinic Receptors

M. Banks, J. Macor, J. Chen, 2016, The Journal of Pharmacology and Experimental Therapeutics.

Design and exploration of C-3 benzoic acid bioisosteres and alkyl replacements in the context of GSK3532795 (BMS-955176) that exhibit broad spectrum HIV-1 maturation inhibition.

B. Beno, N. Meanwell, M. Krystal, 2021, Bioorganic & medicinal chemistry letters.

Inhibitors of HIV-1 maturation: Development of structure-activity relationship for C-28 amides based on C-3 benzoic acid-modified triterpenoids.

N. Meanwell, M. Krystal, Tricia L. Protack, 2016, Bioorganic & medicinal chemistry letters.

The Discovery of GSK3640254, a Next-Generation Inhibitor of HIV-1 Maturation.

A. Mathur, N. Meanwell, Zeyu Lin, 2022, Journal of medicinal chemistry.

Synthesis, Structure-Activity Relationships, and In Vivo Evaluation of Novel C-17 Amine Derivatives Based on GSK3640254 as HIV-1 Maturation Inhibitors with Broad Spectrum Activity.

N. Meanwell, Zeyu Lin, M. Krystal, 2022, Journal of Medicinal Chemistry.

C-3 benzoic acid derivatives of C-3 deoxybetulinic acid and deoxybetulin as HIV-1 maturation inhibitors.

B. Beno, N. Meanwell, Zeyu Lin, 2016, Bioorganic & medicinal chemistry.

Studies to Further Investigate the Inhibition of Human Liver Microsomal CYP2C8 by the Acyl-β-Glucuronide of Gemfibrozil

A. D. Rodrigues, Stephen R. Johnson, J. Leet, 2011, Drug Metabolism and Disposition.