Benjamin M Johnson

发表

Role of Biotransformation Studies in Minimizing Metabolism-Related Liabilities in Drug Discovery

Y. Shu, Benjamin M. Johnson, Benjamin M Johnson, 2008, The AAPS Journal.

Biotransformation of Daclatasvir In Vitro and in Nonclinical Species: Formation of the Main Metabolite by Pyrrolidine δ-Oxidation and Rearrangement

W. Humphreys, L. Hamann, Y. Shu, 2016, Drug Metabolism and Disposition.

Metabolism of 5-Isopropyl-6-(5-methyl-1,3,4-oxadiazol-2-yl)-N-(2-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)pyrrolo[2,1-f][1,2,4]triazin-4-amine (BMS-645737): Identification of an Unusual N-Acetylglucosamine Conjugate in the Cynomolgus Monkey

Y. Shu, Donna D Wei, L. Qian, 2008, Drug Metabolism and Disposition.

Enhanced antitumor immunity by a novel small molecule HPK1 inhibitor

E. Lees, R. Bhadra, J. Hunt, 2021, Journal for ImmunoTherapy of Cancer.

Hepatitis C virus NS5A replication complex inhibitors: the discovery of daclatasvir.

L. Hamann, A. Fura, N. Meanwell, 2014, Journal of medicinal chemistry.

Identification of novel electrophilic metabolites of piper methysticum Forst (Kava).

J. Bolton, L. Yu, R. V. van Breemen, 2003, Chemical research in toxicology.

Bioactivation of cyclopropyl rings by P450: an observation encountered during the optimisation of a series of hepatitis C virus NS5B inhibitors

Y. Shu, N. Meanwell, K. Yeung, 2018, Xenobiotica; the fate of foreign compounds in biological systems.

Phosphocholine Conjugation: An Unexpected In Vivo Conjugation Pathway Associated with Hepatitis C NS5B Inhibitors Featuring A Bicyclo[1.1.1]Pentane

Joseph L. Cantone, D. Drexler, J. Leet, 2016, Drug Metabolism and Disposition.

Discovery of Pyridazinone and Pyrazolo[1,5-a]pyridine Inhibitors of C-Terminal Src Kinase.

Vijay T. Ahuja, J. Tokarski, D. Xie, 2019, ACS medicinal chemistry letters.

Development, optimization and implementation of a centralized metabolic soft spot assay.

I. Zamora, Y. Shu, T. Zvyaga, 2017, Bioanalysis.

Metabolic and Pharmaceutical Aspects of Fluorinated Compounds.

Y. Shu, N. Meanwell, Benjamin M. Johnson, 2020, Journal of medicinal chemistry.

Identification of novel glutathione conjugates of terbinafine in liver microsomes and hepatocytes across species

D. Singh, Saranjit Singh, M. Ladumor, 2019, Xenobiotica; the fate of foreign compounds in biological systems.

Identification of Glutathione Conjugates of Acetylene-Containing Positive Allosteric Modulators of Metabotropic Glutamate Receptor Subtype 5

Yue-Zhong Shu, Y. Shu, L. Snyder, 2015, Drug Metabolism and Disposition.

Electrophilicity of pyridazine-3-carbonitrile, pyrimidine-2-carbonitrile, and pyridine-carbonitrile derivatives: a chemical model to describe the formation of thiazoline derivatives in human liver microsomes.

S. Mandlekar, S. Sinha, K. Selvakumar, 2014, Chemical research in toxicology.

Discovery and Optimization of Biaryl Alkyl Ethers as a Novel Class of Highly Selective, CNS-Penetrable, and Orally Active Adaptor Protein-2-Associated Kinase 1 (AAK1) Inhibitors for the Potential Treatment of Neuropathic Pain.

G. Shankar, J. Macor, C. Albright, 2022, Journal of medicinal chemistry.

Discovery of (S)-1-((2',6-Bis(difluoromethyl)-[2,4'-bipyridin]-5-yl)oxy)-2,4-dimethylpentan-2-amine (BMS-986176/LX-9211): A Highly Selective, CNS Penetrable, and Orally Active Adaptor Protein-2 Associated Kinase 1 Inhibitor in Clinical Trials for the Treatment of Neuropathic Pain.

Alan G. E. Wilson, G. Shankar, J. Macor, 2022, Journal of medicinal chemistry.

In vitro formation of quinoid metabolites of the dietary supplement Cimicifuga racemosa (black cohosh).

R. V. van Breemen, Benjamin M. Johnson, Benjamin M Johnson, 2003, Chemical research in toxicology.