K. Lown

发表

Interpatient heterogeneity in expression of CYP3A4 and CYP3A5 in small bowel. Lack of prediction by the erythromycin breath test.

J. Kolars, P. Watkins, S. Wrighton, 1994, Drug metabolism and disposition: the biological fate of chemicals.

Hepatic but not intestinal CYP3A4 displays dose‐dependent induction by efavirenz in humans

P. Watkins, S. Mouly, D. Kornhauser, 2002, Clinical pharmacology and therapeutics.

Effect of endotoxin on bile acid transport in rat liver: a potential model for sepsis-associated cholestasis.

F. Suchy, M. Ananthanarayanan, H. Takeda, 1996, The American journal of physiology.

OF ENHANCED ORAL AVAILABILITY OF CYP 3 A 4 SUBSTRATES BY GRAPEFRUIT CONSTITUENTS Decreased enterocyte CYP 3 A 4 concentration and mechanism-based inactivation by furanocoumarins

P. Watkins, P. Woster, K. Thummel, 1997 .

Selective suppression of the cranial bone resonance from 31P NMR experiments with rat brain in vivo

J. Ackerman, J. Evelhoch, R. Deuel, 1984 .

Effects of a chargrilled meat diet on expression of CYP3A, CYP1A, and P-glycoprotein levels in healthy volunteers.

R. Fontana, P. Watkins, A. Greenberg, 1999, Gastroenterology.

P450 3A activity and cyclosporine dosing in kidney and heart transplant recipients

P. Watkins, G. Deeb, R. Merion, 1994, Clinical pharmacology and therapeutics.

CYP3A gene expression in human gut epithelium.

J. Kolars, P. Watkins, S. Wrighton, 1994, Pharmacogenetics.

Growth hormone secretion pattern is an independent regulator of growth hormone actions in humans.

P. Watkins, C. Jaffe, D. Turgeon, 2002, American journal of physiology. Endocrinology and metabolism.

PREDICTION OF INTERPATIENT AND INTRAPATIENT VARIATION IN OG 37–325 DOSING REQUIREMENTS BY THE ERYTHROMYCIN BREATH TEST

T. Annesley, P. Watkins, R. Schmouder, 1994, Transplantation.

The erythromycin breath test predicts the clearance of midazolam

P. Watkins, S. Berent, D. Shen, 1995, Clinical pharmacology and therapeutics.

Mechanisms of enhanced oral availability of CYP3A4 substrates by grapefruit constituents. Decreased enterocyte CYP3A4 concentration and mechanism-based inactivation by furanocoumarins.

P. Watkins, P. Woster, K. He, 1997, Drug metabolism and disposition: the biological fate of chemicals.

Grapefruit juice increases felodipine oral availability in humans by decreasing intestinal CYP3A protein expression.

Morton B. Brown, R. Fontana, P. Watkins, 1997, The Journal of clinical investigation.

Expression of enzymatically active CYP3A4 by Caco-2 cells grown on extracellular matrix-coated permeable supports in the presence of 1alpha,25-dihydroxyvitamin D3.

P. Watkins, K. Thummel, P. Schmiedlin-Ren, 1997, Molecular pharmacology.

Role of intestinal P‐glycoprotein (mdr1) in interpatient variation in the oral bioavailability of cyclosporine

Morton B. Brown, P. Watkins, L. Benet, 1997, Clinical pharmacology and therapeutics.

Molecular and physical mechanisms of first-pass extraction.

R. Fontana, P. Watkins, L. Benet, 1999, Drug metabolism and disposition: the biological fate of chemicals.

Comparison of urinary 6‐β‐cortisol and the erythromycin breath test as measures of hepatic P450IIIA (CYP3A) activity

Kenneth J. Fishman, J. Kolars, P. Watkins, 1992, Clinical pharmacology and therapeutics.

Sequences of intestinal and hepatic cytochrome P450 3A4 cDNAs are identical.

P. Watkins, K. Lown, M. Ghosh, 1998, Drug metabolism and disposition: the biological fate of chemicals.

Low bioavailability of cyclosporine microemulsion and tacrolimus in a small bowel transplant recipient: possible relationship to intestinal P-glycoprotein activity.

M. Abecassis, D. Kaufman, H. Meier‐Kriesche, 1999, Transplantation.

Selective expression of CYP3A5 and not CYP3A4 in human blood.

P. Watkins, K. Thummel, P. Schmiedlin-Ren, 1996, Pharmacogenetics.

The erythromycin breath test selectively measures P450IIIA in patients with severe liver disease

P. Watkins, S. Wrighton, R. Merion, 1992, Clinical pharmacology and therapeutics.

Predicting drug interactions using cultured human hepatocytes

P. Watkins, K. Lown, 1991, Hepatology.

Erratum: Interpatient heterogeneity in expression of CYP3A4 and CYP3A5 in small bowel: Lack of prediction by the erythromycin breath test (Drug Metabolism and Disposition (1994) 22 (947-955))

J. Kolars, P. Watkins, S. Wrighton, 1995 .

The Self‐sustained sequence replication amplification system–move over, PCR

K. Lown, Kenneth S. Lown, 1993 .