Jill Davies

发表

Generation of quinolone antimalarials targeting the Plasmodium falciparum mitochondrial respiratory chain for the treatment and prophylaxis of malaria

J. Hemingway, R. Sinden, M. Delves, 2012, Proceedings of the National Academy of Sciences.

Short-Course, High-Dose Rifampicin Achieves Wolbachia Depletion Predictive of Curative Outcomes in Preclinical Models of Lymphatic Filariasis and Onchocerciasis

Laura J. Myhill, A. Steven, G. Aljayyoussi, 2017, Scientific Reports.

Albendazole and antibiotics synergize to deliver short-course anti-Wolbachia curative treatments in preclinical models of filariasis

J. Hemingway, A. Steven, Raman Sharma, 2017, Proceedings of the National Academy of Sciences.

Course , High Dose Rifampicin Achieves Wolbachia Depletion Predictive of Curative Outcomes in Preclinical Models of Lymphatic Filariasis and

Laura J. Myhill, A. Steven, G. Aljayyoussi, 2017 .

Synthesis and profiling of benzylmorpholine 1,2,4,5-tetraoxane analogue N205: Towards tetraoxane scaffolds with potential for single dose cure of malaria.

David M. Shackleford, Brice Campo, M. Belén, 2018, Bioorganic & medicinal chemistry.

Semi-synthetic and synthetic 1,2,4-trioxaquines and 1,2,4-trioxolaquines: synthesis, preliminary SAR and comparison with acridine endoperoxide conjugates.

Nuna C. P. Araújo, V. Barton, P. Stocks, 2009, Bioorganic & medicinal chemistry letters.

Two-step synthesis of achiral dispiro-1,2,4,5-tetraoxanes with outstanding antimalarial activity, low toxicity, and high-stability profiles.

Peter D Gibbons, R. Amewu, P. Stocks, 2008, Journal of medicinal chemistry.

Design and synthesis of orally active dispiro 1,2,4,5-tetraoxanes; synthetic antimalarials with superior activity to artemisinin.

R. Amewu, N. Berry, S. Ward, 2006, Organic & biomolecular chemistry.

Identification of a 1,2,4,5-tetraoxane antimalarial drug-development candidate (RKA 182) with superior properties to the semisynthetic artemisinins.

B. K. Park, V. Barton, G. Nixon, 2010, Angewandte Chemie.

Enantiomeric 1,2,4‐Trioxanes Display Equivalent in vitro Antimalarial Activity Versus Plasmodium falciparum Malaria Parasites: Implications for the Molecular Mechanism of Action of the Artemisinins

S. Ward, P. O’Neill, G. Posner, 2005, Chembiochem : a European journal of chemical biology.

Mechanism-based design of parasite-targeted artemisinin derivatives: synthesis and antimalarial activity of new diamine containing analogues.

B. K. Park, S. Ward, P. O’Neill, 2002, Journal of medicinal chemistry.

Application of thiol-olefin co-oxygenation methodology to a new synthesis of the 1,2,4-trioxane pharmacophore.

P. Stocks, S. Ward, P. O’Neill, 2004, Organic letters.

Distribution of acridine orange fluorescence in Plasmodium falciparum-infected erythrocytes and its implications for the evaluation of digestive vacuole pH.

K. Kirk, K. Saliba, D. Spiller, 2002, Molecular and biochemical parasitology (Print).

Modular synthesis and in vitro and in vivo antimalarial assessment of C-10 pyrrole mannich base derivatives of artemisinin.

S. Ward, P. O’Neill, R. Brun, 2010, Journal of medicinal chemistry.

Antitumour and antimalarial activity of artemisinin-acridine hybrids.

J. Baird, I. Piantanida, B. K. Park, 2009, Bioorganic & medicinal chemistry letters.

Synthesis and biological activities of 4-N-(anilinyl-n-[oxazolyl])-7-chloroquinolines (n=3' or 4') against Plasmodium falciparum in in vitro models.

Todd G. Smith, S. Ward, Robert A. Gossage, 2011, Bioorganic & medicinal chemistry letters.

Optimisation of the allylsilane approach to C-10 deoxo carba analogues of dihydroartemisinin: synthesis and in vitro antimalarial activity of new, metabolically stable C-10 analogues

B. K. Park, S. Ward, P. O’Neill, 2001 .

Regioselective Mukaiyama hydroperoxysilylation of 2-alkyl- or 2-aryl-prop-2-en-1-ols: application to a new synthesis of 1,2,4-trioxanes

B. K. Park, S. Ward, P. O’Neill, 2001 .

Co(thd)2: a superior catalyst for aerobic epoxidation and hydroperoxysilylation of unactivated alkenes: application to the synthesis of spiro-1,2,4-trioxanes

B. K. Park, P. Stocks, S. Ward, 2003 .

Design and synthesis of endoperoxide antimalarial prodrug models.

Erica Pasini, E. Pasini, E. Verissimo, 2004, Angewandte Chemie.

Synthesis, in vitro and in vivo antimalarial assessment of sulfide, sulfone and vinyl amide-substituted 1,2,4-trioxanes prepared via thiol-olefin co-oxygenation (TOCO) of allylic alcohols.

J. Bacsa, Peter D Gibbons, G. Nixon, 2010, Organic & biomolecular chemistry.

Antimalarial and antitumor evaluation of novel C-10 non-acetal dimers of 10beta-(2-hydroxyethyl)deoxoartemisinin.

Dominic P. Williams, B. K. Park, James Chadwick, 2004, Journal of medicinal chemistry.

Corrigendum: Minocycline as a re-purposed anti-Wolbachia macrofilaricide: superiority compared with doxycycline regimens in a murine infection model of human lymphatic filariasis

Laura J. Myhill, A. Steven, G. Aljayyoussi, 2018, Scientific reports.

Minocycline as a re-purposed anti-Wolbachia macrofilaricide: superiority compared with doxycycline regimens in a murine infection model of human lymphatic filariasis

Laura J. Myhill, A. Steven, Raman Sharma, 2016, Scientific Reports.

A tetraoxane-based antimalarial drug candidate that overcomes PfK13-C580Y dependent artemisinin resistance

David M. Shackleford, R. Price, D. Fidock, 2017, Nature Communications.

Potent Antimalarial 2-Pyrazolyl Quinolone bc 1 (Qi) Inhibitors with Improved Drug-like Properties.

S. Antonyuk, G. Nixon, G. Biagini, 2018, ACS medicinal chemistry letters.

Testing the effect of PAR1 inhibitors on Plasmodium falciparum-induced loss of endothelial cell barrier function

A. Craig, J. Storm, C. Moxon, 2020, Wellcome open research.

Testing the effect of PAR1 inhibitors on Plasmodium falciparum-induced loss of endothelial cell barrier function.

A. Craig, J. Storm, C. Moxon, 2020, Wellcome open research.

Testing the effect of PAR1 inhibitors on Plasmodium falciparum-induced loss of endothelial cell barrier function.

A. Craig, J. Storm, C. Moxon, 2020, Wellcome open research.

Synthesis, antimalarial activity, and preclinical pharmacology of a novel series of 4'-fluoro and 4'-chloro analogues of amodiaquine. Identification of a suitable "back-up" compound for N-tert-butyl isoquine.

S. Parapini, D. Taramelli, C. Davis, 2009, Journal of medicinal chemistry.

Corrigendum: Minocycline as a re-purposed anti-Wolbachia macrofilaricide: superiority compared with doxycycline regimens in a murine infection model of human lymphatic filariasis

Laura J. Myhill, A. Steven, G. Aljayyoussi, 2018, Scientific Reports.

Optimisation of the synthesis of second generation 1,2,4,5 tetraoxane antimalarials

G. Nixon, R. Amewu, S. Ward, 2016 .

Evidence for a common non-heme chelatable-iron-dependent activation mechanism for semisynthetic and synthetic endoperoxide antimalarial drugs.

Ruth H. Hughes, Peter D Gibbons, V. Barton, 2007, Angewandte Chemie.

Piperidine dispiro-1,2,4-trioxane analogues.

P. Stocks, S. Ward, P. O’Neill, 2008, Bioorganic & medicinal chemistry letters.

Synthesis of 1,2,4-trioxepanes via application of thiol-olefin co-oxygenation methodology.

R. Amewu, N. Berry, S. Ward, 2006, Bioorganic & medicinal chemistry letters.

Diels-Alder/thiol-olefin co-oxygenation approach to antimalarials incorporating the 2,3-dioxabicyclo[3.3.1]nonane pharmacophore.

E. Verissimo, P. Stocks, M. L. Cristiano, 2006, Bioorganic & medicinal chemistry letters.

Potent Antimalarial 2-Pyrazolyl Quinolone bc1 (Qi) Inhibitors with Improved Drug-like Properties.

S. Antonyuk, S. Hasnain, G. Nixon, 2018 .

Evidence for a common non-heme chelatable-iron-dependent activation mechanism for semisynthetic and synthetic endoperoxide antimalarial drugs.

Ruth H. Hughes, R. Amewu, G. Biagini, 2007, Angewandte Chemie.

Further comments on the distribution of acridine orange fluorescence in P-falciparum-infected erythrocytes

K. Kirk, K. Saliba, D. Spiller, 2002 .