L. Tu

发表

A Free Energy Barrier Caused by the Refolding of an Oligomeric Intermediate Controls the Lag Time of Amyloid Formation by hIAPP.

D. Raleigh, M. Zanni, J. Lomont, 2017, Journal of the American Chemical Society.

CYP2J2 overexpression increases EETs and protects against angiotensin II-induced abdominal aortic aneurysm in mice[S]

Wanjun Liu, Zhejun Cai, Lei Yang, 2013, Journal of Lipid Research.

Understanding co-polymerization in amyloid formation by direct observation of mixed oligomers

S. Radford, D. Raleigh, A. Ashcroft, 2017, Chemical science.

Insights into the consequences of co-polymerisation in the early stages of IAPP and Aβ peptide assembly from mass spectrometry.

S. Radford, D. Raleigh, A. Ashcroft, 2015, The Analyst.

Role of lysine residue of islet amyloid polypeptide in fibril formation, membrane binding, and inhibitor binding.

L. Tu, Meng-Hsin Wu, Ai-Ci Chan, 2020, Biochimie.

Matrix Metalloproteinase-9 Protects Islets from Amyloid-induced Toxicity*

D. Raleigh, S. Kahn, R. Hull, 2015, The Journal of Biological Chemistry.

Mutational Analysis of the Ability of Resveratrol To Inhibit Amyloid Formation by Islet Amyloid Polypeptide: Critical Evaluation of the Importance of Aromatic–Inhibitor and Histidine–Inhibitor Interactions

S. Radford, D. Raleigh, A. Ashcroft, 2014, Biochemistry.

Mutational analysis of preamyloid intermediates: the role of his-tyr interactions in islet amyloid formation.

D. Raleigh, M. Zanni, Arnaldo L. Serrano, 2014, Biophysical journal.

Effects and mechanism of irbesartan on tubulointerstitial fibrosis in 5/6 nephrectomized rats

Daowen Wang, Pei-hua Wang, Hongyang Zhao, 2010, Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban.

Delivery of recombinant adeno-associated virus-mediated human tissue kallikrein for therapy of chronic renal failure in rats.

D. Zeldin, M. Edin, Xiao Xiao, 2008, Human gene therapy.

Inhibition of soluble epoxide hydrolase alleviates insulin resistance and hypertension via downregulation of SGLT2 in the mouse kidney

Yan Yang, Shuiqing Hu, Ruolan Dong, 2021, The Journal of biological chemistry.

Telmisartan protects against insulin resistance by attenuating inflammatory response in rats

Daowen Wang, G. Li, L. Tu, 2011, Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban.

The immune-metabolic regulatory roles of epoxyeicosatrienoic acids on macrophages phenotypic plasticity in obesity-related insulin resistance.

Meiyan Dai, Daowen Wang, Lujin Wu, 2018, Prostaglandins & other lipid mediators.

Dopamine-Conjugated Carbon Dots Inhibit Human Calcitonin Fibrillation

L. Tu, Jhe-An Wu, Yu-Chieh Chen, 2021, Nanomaterials.

Effect of simvastatin on IL-6 and adiponectin secretion and mRNA expression in 3T3-L1 adipocytes

Huiqing Yang, L. Tu, Xiaoming Yin, 2007, Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban.

Endothelium‐specific CYP2J2 overexpression attenuates age‐related insulin resistance

Daowen Wang, Yan Yang, Zhi-hui Chen, 2018, Aging cell.

CYP2J3 Gene Delivery Reduces Insulin Resistance via Upregulation of eNOS in Fructose-treated Rats

Daowen Wang, Luyun Wang, L. Tu, 2011, Cardiovascular diabetology.

Increased CYP2J3 Expression Reduces Insulin Resistance in Fructose-Treated Rats and db/db Mice

D. Zeldin, M. Edin, Daowen Wang, 2010, Diabetes.

Inulin-Type Fructans Change the Gut Microbiota and Prevent the Development of Diabetic Nephropathy.

Yan Yang, Ruolan Dong, L. Tu, 2022, Pharmacological research.

Epoxyeicosatrienoic acids improve glucose homeostasis by preventing NF-κB-mediated transcription of SGLT2 in renal tubular epithelial cells

Yan Yang, Shuiqing Hu, Zhi-hui Chen, 2020, Molecular and Cellular Endocrinology.

Aspirin, Diabetes, and Amyloid: Re-examination of the Inhibition of Amyloid Formation by Aspirin and Ketoprofen

D. Raleigh, P. Cao, L. Tu, 2014, ACS chemical biology.

CYP2J3 gene delivery up-regulated adiponectin expression via reduced endoplasmic reticulum stress in adipocytes.

Rui Li, G. Li, Daowen Wang, 2013, Endocrinology.

EETs and CYP2J2 inhibit TNF-α-induced apoptosis in pulmonary artery endothelial cells and TGF-β1-induced migration in pulmonary artery smooth muscle cells.

G. Li, Daowen Wang, Gang Zhao, 2013, International journal of molecular medicine.

Gene delivery of cytochrome p450 epoxygenase ameliorates monocrotaline-induced pulmonary artery hypertension in rats.

Rui Li, D. Zeldin, Daowen Wang, 2010, American journal of respiratory cell and molecular biology.

Continuous Positive Airway Pressure Effectively Alleviates Arrhythmias in Patients with Obstructive Sleep Apnea: Possible Relationship with Counteracting Oxidative Stress

Gang Zhao, Xuanchen Zhou, Zhenhua Liu, 2019, Current Medical Science.

Expression of phosphatidylinositol-3 kinase and effects of inhibitor Wortmannin on expression of tumor necrosis factor-α in severe acute pancreatitis associated with acute lung injury.

L. Tu, Jia Li, Ming Wei, 2015, World journal of emergency medicine.

Rationally designed divalent caffeic amides inhibit amyloid-β fibrillization, induce fibril dissociation, and ameliorate cytotoxicity.

Yun-Ru Chen, Yu‐Sheng Chen, Jim-Min Fang, 2018, European journal of medicinal chemistry.

A Fluorogenic Molecule to Probe Islet Amyloid Using Flavonoid as a Scaffold Design.

Wei-Min Liu, Y. Chen, S. Ma, 2020, Biochemistry.

Yan Yang, Zhi-hui Chen, Ruolan Dong, 2020, Molecular medicine reports.

Exogenous Bradykinin Inhibits Tissue Factor Induction and Deep Vein Thrombosis via Activating the eNOS/Phosphoinositide 3-Kinase/Akt Signaling Pathway

Wenshu Chen, Daowen Wang, Yan Yang, 2015, Cellular Physiology and Biochemistry.

Epoxyeicosatrienoic acids protect rat hearts against tumor necrosis factor-α-induced injury[S]

C. Chen, K. Cianflone, Pei-hua Wang, 2012, Journal of Lipid Research.

Delivery of AAV2-CYP2J2 protects remnant kidney in the 5/6-nephrectomized rat via inhibition of apoptosis and fibrosis.

C. Chen, Pei-hua Wang, Xuguang Li, 2012, Human gene therapy.

Dipeptidyl peptidase-4 Inhibition Improves Endothelial Senescence by Activating AMPK/SIRT1/Nrf2 Signaling Pathway.

Yan Yang, Shuiqing Hu, Zhi-hui Chen, 2020, Biochemical pharmacology.

Efficacy and safety of potent P2Y12 inhibitors vs. clopidogrel in elderly patients with acute coronary syndrome

Zhan-qi Pang, L. Tu, Yuanyuan Li, 2020, Chinese medical journal.

EETs reduces LPS-induced hyperpermeability by targeting GRP78 mediated Src activation and subsequent Rho/ROCK signaling pathway.

Daowen Wang, Yan Yang, Zhi-hui Chen, 2017, Oncotarget.

Increased Age-Related Cardiac Dysfunction in Bradykinin B2 Receptor-Deficient Mice.

Daowen Wang, Gang Zhao, Guangwen Long, 2016, The journals of gerontology. Series A, Biological sciences and medical sciences.

Effects of PPAR-γ in the Myocardium on the Development of Ventricular Septation

L. Tu, Lun Zhou, Zhao Wang, 2020, Current Medical Science.

Bradykinin Inhibits Oxidative Stress-Induced Cardiomyocytes Senescence via Regulating Redox State

G. Li, Daowen Wang, Gang Zhao, 2013, PloS one.

CoO engineered Co9S8 catalyst for CO2 photoreduction with accelerated electron transfer endowed by the built-in electric field

Xubiao Luo, S. Luo, Weili Dai, 2021 .

Associations between Dietary Factors and Self-Reported Physical Health in Chinese Scientific Workers

Hong Chen, L. Tu, Liang Zhou, 2015, International journal of environmental research and public health.

Palladium-catalyzed reaction of aryl bromides with 7-hydroxy-1,3-dienes

M. P. Yeh, L. Tu, Ling Hsien Tu, 2005 .

Screening and classifying small molecule inhibitors of amyloid formation using ion mobility spectrometry-mass spectrometry

S. Radford, D. Raleigh, A. Ashcroft, 2014, Nature Chemistry.

Association between Helicobacter pylori infection and overweight or obesity in a Chinese population.

Xi Chen, Xuefeng Yu, Cuntai Zhang, 2015, Journal of infection in developing countries.

TDP-43 interacts with amyloid-β, inhibits fibrillization, and worsens pathology in a model of Alzheimer’s disease

Yun-Ru Chen, Wei-Wei Chang, Ting-Yu Chang, 2020, Nature Communications.

Islet Amyloid Polypeptide: Structure, Function, and Pathophysiology

D. Raleigh, P. Cao, A. Schmidt, 2015, Journal of diabetes research.

sEH Inhibitor Tppu Ameliorates Cecal Ligation and Puncture-Induced Sepsis by Regulating Macrophage Functions

Daowen Wang, Yan Yang, Shuiqing Hu, 2020, Shock.

EETs reduces LPS-induced hyperpermeability by targeting GRP78 mediated Src activation and subsequent Rho/ROCK signaling pathway

Daowen Wang, Yan Yang, Zhi-hui Chen, 2017, Oncotarget.

Islet amyloid: From fundamental biophysics to mechanisms of cytotoxicity

Peter Marek, D. Raleigh, P. Marek, 2012, FEBS letters.

Hepatic lipase deficiency. Clinical, biochemical, and molecular genetic characteristics.

R. Hegele, J. Little, T. Wolever, 1993, Arteriosclerosis and thrombosis : a journal of vascular biology.

Exploring the Impact of Glyoxal Glycation on β-Amyloid Peptide (Aβ) Aggregation in Alzheimer's Disease.

Han-Chen Lin, Hsiu-Fang Fan, Jian-wei Huang, 2021, The journal of physical chemistry. B.

Protein Glycation by Glyoxal Promotes Amyloid Formation by Islet Amyloid Polypeptide.

Y. Chen, Yi-Hsuan Hsu, Yun-Wen Chen, 2019, Biophysical journal.

Inhibiting Human Calcitonin Fibril Formation with its Most Relevant Aggregation-Resistant Analog.

Chian-Hui Lai, L. Tu, Yi-Ting Chen, 2019, The journal of physical chemistry. B.

Liver Kinase B1/AMP-Activated Protein Kinase Pathway Activation Attenuated the Progression of Endotoxemia in the Diabetic Mice

Daowen Wang, Yan Yang, Zhi-hui Chen, 2017, Cellular Physiology and Biochemistry.

The efficacy and safety of P2Y12 inhibitor monotherapy in patients after percutaneous coronary intervention

Shuiqing Hu, Zhi-hui Chen, L. Tu, 2019, Clinical cardiology.

Celastrol-Induced Suppression of the MiR-21/ERK Signalling Pathway Attenuates Cardiac Fibrosis and Dysfunction

Gang Wu, Cuntai Zhang, Mian Cheng, 2016, Cellular Physiology and Biochemistry.

Oxymatrine inhibits aldosterone-induced rat cardiac fibroblast proliferation and differentiation by attenuating smad-2,-3 and-4 expression: an in vitro study

Xiang-chun Shen, L. Tu, Yan Chen, 2016, BMC Complementary and Alternative Medicine.

The potential association between common comorbidities and severity and mortality of coronavirus disease 2019: A pooled analysis

Yan Yang, Shuiqing Hu, Zhi-hui Chen, 2020, Clinical cardiology.

Time-resolved studies define the nature of toxic IAPP intermediates, providing insight for anti-amyloidosis therapeutics

D. Raleigh, P. Cao, M. Zanni, 2016, eLife.

Human kallikrein overexpression alleviates cardiac aging by alternatively regulating macrophage polarization in aged rats

Daowen Wang, Yan Yang, Zhi-hui Chen, 2019, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Exogenous nerve growth factor protects the hypoglossal nerve against crush injury

Zhongchao Wang, L. Tu, Pin Wang, 2015, Neural regeneration research.

11,12-EET suppressed LPS induced TF expression and thrombus formation by accelerating mRNA degradation rate via strengthening PI3K-Akt signaling pathway and inhibiting p38-TTP pathway.

Ruolan Dong, L. Tu, Jinlan Luo, 2023, Prostaglandins & other lipid mediators.

Differential effects of clozapine on ethanol-induced ascorbic acid release in mouse and rat striatum

Chunfu Wu, Yue Hou, Jing Y Yang, 2005, Neuroscience Letters.

Role of aromatic interactions in amyloid formation by islet amyloid polypeptide.

D. Raleigh, L. Tu, 2013, Biochemistry.

The role of the microbiota-gut-brain axis and intestinal microbiome dysregulation in Parkinson’s disease

Qi Zhou, Xia-hua Shi, L. Tu, 2023, Frontiers in Neurology.

Bradykinin prevents the apoptosis of NIT-1 cells induced by TNF-α via the PI3K/Akt and MAPK signaling pathways.

Daowen Wang, L. Tu, Xizhen Xu, 2012, International journal of molecular medicine.

Sensitivity of amyloid formation by human islet amyloid polypeptide to mutations at residue 20.

Ann Marie Schmidt, Olesya Levsh, D. Raleigh, 2012, Journal of molecular biology.

[Effects of ozone exposure on percentage of CD4(+)CD25(high)Foxp(3+) regulatory T cells and mRNA expression of Foxp3 in asthmatic rats].

Jia Liu, Jun-Hua Zhang, L. Tu, 2013, Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases.