P. Ragunathan

发表

Disrupting coupling within mycobacterial F-ATP synthases subunit ε causes dysregulated energy production and cell wall biosynthesis

W. Saw, G. Grüber, Joon Shin, 2019, Scientific Reports.

The NMR solution structure of Mycobacterium tuberculosis F‐ATP synthase subunit ε provides new insight into energy coupling inside the rotary engine

G. Grüber, T. Dick, Subhashri Kundu, 2018, The FEBS journal.

Pyrazinamide triggers degradation of its target aspartate decarboxylase

T. Akopian, E. Rubin, G. Grüber, 2019, Nature Communications.

Pyrazinamide triggers degradation of its target aspartate decarboxylase

T. Akopian, E. Rubin, Joon Shin, 2019, Nature Communications.

Anti-Mycobacterium abscessus Activity of Tuberculosis F-ATP Synthase Inhibitor GaMF1

G. Grüber, T. Dick, P. Ragunathan, 2022, Antimicrobial agents and chemotherapy.

Discovery of a novel Mycobacterial F-ATP synthase inhibitor and its potency in combination with diarylquinolines.

W. Saw, G. Grüber, Joon Shin, 2020, Angewandte Chemie.

Discovery of a Novel Mycobacterial F‐ATP Synthase Inhibitor and its Potency in Combination with Diarylquinolines

W. Saw, G. Grüber, Joon Shin, 2020, Angewandte Chemie.

TBAJ-876 Displays Bedaquiline-Like Mycobactericidal Potency without Retaining the Parental Drug’s Uncoupler Activity

G. Grüber, T. Dick, C. Cooper, 2019, Antimicrobial Agents and Chemotherapy.

Unique structural and mechanistic properties of mycobacterial F-ATP synthases: Implications for drug design.

W. Saw, G. Grüber, Joon Shin, 2019, Progress in biophysics and molecular biology.

Atomic solution structure of Mycobacterium abscessus F‐ATP synthase subunit ε and identification of Ep1MabF1 as a targeted inhibitor

G. Grüber, A. Harikishore, T. Dick, 2022, The FEBS journal.

Pyrazinoic Acid Inhibits Mycobacterial Coenzyme A Biosynthesis by Binding to Aspartate Decarboxylase PanD.

G. Grüber, T. Dick, V. Dartois, 2017, ACS infectious diseases.

Mutational Analysis of Mycobacterial F-ATP Synthase Subunit δ Leads to a Potent δ Enzyme Inhibitor.

V. Müller, Dennis Litty, W. Saw, 2022, ACS chemical biology.

Structural and Mechanistic Insights into Mycobacterium abscessus Aspartate Decarboxylase PanD and a Pyrazinoic Acid-Derived Inhibitor.

W. Saw, G. Grüber, Joon Shin, 2022, ACS infectious diseases.

Structural Elements Involved in ATP Hydrolysis Inhibition and ATP Synthesis of Tuberculosis and Nontuberculous Mycobacterial F-ATP Synthase Decipher New Targets for Inhibitors

H. Noji, Dennis Litty, W. Saw, 2022, Antimicrobial agents and chemotherapy.

Mycobacterium tuberculosis PanD Structure-Function Analysis and Identification of a Potent Pyrazinoic Acid-Derived Enzyme Inhibitor.

G. Grüber, Joon Shin, S. Rishikesan, 2021, ACS chemical biology.

Targeting the menaquinol binding loop of mycobacterial cytochrome bd oxidase

G. Grüber, A. Harikishore, R. Bates, 2020, Molecular Diversity.

Targeting the menaquinol binding loop of mycobacterial cytochrome bd oxidase

G. Grüber, A. Harikishore, R. Bates, 2020, Molecular Diversity.

TBAJ-876 Retains Bedaquiline’s Activity against Subunits c and ε of Mycobacterium tuberculosis F-ATP Synthase

Christopher B. Cooper, G. Grüber, Joon Shin, 2019, Antimicrobial Agents and Chemotherapy.

Title The uniqueness of subunit of mycobacterial F-ATPsynthases : An evolutionary variant for niche adaptation

G. Grüber, T. Dick, T. Wohland, 2019 .

Structure activity relationship of pyrazinoic acid analogs as potential antimycobacterial agents.

G. Grüber, A. Harikishore, T. Dick, 2022, Bioorganic & medicinal chemistry.

AhpC of the mycobacterial antioxidant defense system and its interaction with its reducing partner Thioredoxin-C

W. Saw, G. Grüber, Joon Shin, 2017, Scientific Reports.

A systematic assessment of mycobacterial F1‐ATPase subunit ε’s role in latent ATPase hydrolysis

S. Sze, W. Saw, G. Grüber, 2020, The FEBS journal.

The uniqueness of subunit α of mycobacterial F-ATP synthases: An evolutionary variant for niche adaptation

G. Grüber, T. Dick, T. Wohland, 2017, The Journal of Biological Chemistry.

Atomic structure of the regulatory TGS domain of Rel protein from Mycobacterium tuberculosis and its interaction with deacylated tRNA

G. Grüber, Ardina Grüber, Shin Joon, 2021, FEBS letters.

Atomic structure of, and valine binding to the regulatory ACT domain of the Mycobacterium tuberculosis Rel protein

G. Grüber, Joon Shin, M. Chen, 2020, The FEBS journal.

Structure and function of Mycobacterium-specific components of F-ATP synthase subunits α and ε.

G. Grüber, Joon Shin, S. Bhushan, 2018, Journal of structural biology.

Atomic insights of an up and down conformation of the Acinetobacter baumannii F1‐ATPase subunit ε and deciphering the residues critical for ATP hydrolysis inhibition and ATP synthesis

W. Saw, G. Grüber, Joon Shin, 2023, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Targeting Mycobacterial F-ATP Synthase C-Terminal α Subunit Interaction Motif on Rotary Subunit γ

V. Müller, Dennis Litty, G. Grüber, 2021, Antibiotics.

Deletion of a unique loop in the mycobacterial F‐ATP synthase γ subunit sheds light on its inhibitory role in ATP hydrolysis‐driven H+ pumping

G. Grüber, T. Dick, Subhashri Kundu, 2016, The FEBS journal.

The FGFR inhibitor PD173074 binds to the C‐terminus of oncofetal HMGA2 and modulates its DNA‐binding and transcriptional activation functions

R. Schäfer, G. Grüber, Joon Shin, 2023, FEBS letters.

GaMF1.39’s antibiotic efficacy and its enhanced antitubercular activity in combination with clofazimine, Telacebec, ND-011992, or TBAJ-876

Dennis Litty, A. Harikishore, T. Dick, 2023, Microbiology spectrum.