Meir Glick

发表

Extending crystallographic information with semiempirical quantum mechanics and molecular mechanics: A case of aspartic proteinases

Amiram Goldblum, Anwar Rayan, Amit Fliess, 1993, J. Chem. Inf. Comput. Sci..

SPREAD—exploiting chemical features that cause differential activity behavior

Andreas Bender, Meir Glick, Ben Cornett, 2009 .

SPREAD - exploiting chemical features that cause differential activity behavior

Meir Glick, Ben Cornett, Josef Scheiber, 2009, Stat. Anal. Data Min..

CHEMGENIE: integration of chemogenomics data for applications in chemical biology.

Anne Mai Wassermann, Meir Glick, Dante A. Pertusi, 2018, Drug discovery today.

The role of computational methods in the identification of bioactive compounds.

Meir Glick, Edgar Jacoby, M. Glick, 2011, Current opinion in chemical biology.

Prospective Assessment of Virtual Screening Heuristics Derived Using a Novel Fusion Score

Anne Mai Wassermann, Meir Glick, Daniel Riley, 2017, SLAS discovery : advancing life sciences R & D.

Experimental Design Strategy: Weak Reinforcement Leads to Increased Hit Rates and Enhanced Chemical Diversity

Anne Mai Wassermann, Eugen Lounkine, Meir Glick, 2015, J. Chem. Inf. Model..

Prediction of Biological Targets for Compounds Using Multiple-Category Bayesian Models Trained on Chemogenomics Databases

Meir Glick, Jeremy L. Jenkins, John W. Davies, 2006, J. Chem. Inf. Model..

Streamlining lead discovery by aligning in silico and high-throughput screening.

Meir Glick, Jeremy L Jenkins, John W Davies, 2006, Current opinion in chemical biology.

Enrichment of High-Throughput Screening Data with Increasing Levels of Noise Using Support Vector Machines, Recursive Partitioning, and Laplacian-Modified Naive Bayesian Classifiers

Meir Glick, Jeremy L. Jenkins, John W. Davies, 2006, J. Chem. Inf. Model..

“Plate Cherry Picking”: A Novel Semi-Sequential Screening Paradigm for Cheaper, Faster, Information-Rich Compound Selection

Andreas Bender, Meir Glick, Christian N Parker, 2007, Journal of biomolecular screening.

Construction of Drug‐Like Compounds by Markov Chains

Eugen Lounkine, Meir Glick, Eugene I. Shakhnovich, 2013 .

"Bayes Affinity Fingerprints" Improve Retrieval Rates in Virtual Screening and Define Orthogonal Bioactivity Space: When Are Multitarget Drugs a Feasible Concept?

Andreas Bender, Meir Glick, Jeremy L. Jenkins, 2006, J. Chem. Inf. Model..

Anne Mai Wassermann, Eugen Lounkine, Meir Glick, 2013, J. Chem. Inf. Model..

Enrichment of Extremely Noisy High-Throughput Screening Data Using a Naïve Bayes Classifier

Meir Glick, Pierre Acklin, Anthony E. Klon, 2004, Journal of biomolecular screening.

Andreas Bender, Meir Glick, Jeremy L. Jenkins, 2009, J. Chem. Inf. Model..

Understanding False Positives in Reporter Gene Assays: in Silico Chemogenomics Approaches To Prioritize Cell-Based HTS Data

Andreas Bender, Meir Glick, Jeremy L. Jenkins, 2007, J. Chem. Inf. Model..

CHEMOMETRIC APPLICATIONS OF NAÏVE BAYESIAN MODELS IN DRUG DISCOVERY

Eugen Lounkine, Meir Glick, Peter S. Kutchukian, 2013 .

Extending 'predict first' to the design-make-test cycle in small-molecule drug discovery.

Meir Glick, Charlie Chang, Zhengwei Peng, 2017, Future medicinal chemistry.

The opportunities of mining historical and collective data in drug discovery.

Anne Mai Wassermann, Meir Glick, John W Davies, 2015, Drug discovery today.

Flexible 3D pharmacophores as descriptors of dynamic biological space.

Andreas Bender, Meir Glick, Alex M Clark, 2007, Journal of molecular graphics & modelling.

Data to Decisions: Creating a Culture of Model-Driven Drug Discovery

Chris L. Waller, Meir Glick, Charlie Chang, 2017, The AAPS Journal.

Computational methods for early predictive safety assessment from biological and chemical data

Meir Glick, Florian Nigsch, Ben Cornett, 2011, Expert opinion on drug metabolism & toxicology.

From in silico target prediction to multi-target drug design: current databases, methods and applications.

Andreas Bender, Meir Glick, Alexios Koutsoukas, 2011, Journal of proteomics.

Large Scale Meta-Analysis of Fragment-Based Screening Campaigns

Anne Mai Wassermann, Meir Glick, S Kirk Wright, 2015, Journal of biomolecular screening.

Experimental error, kurtosis, activity cliffs, and methodology: What limits the predictivity of QSAR models?

Meir Glick, Robert P Sheridan, Yuting Xu, 2020, Journal of chemical information and modeling.

Application of Machine Learning To Improve the Results of High-Throughput Docking Against the HIV-1 Protease

Meir Glick, John W. Davies, Anthony E. Klon, 2004, J. Chem. Inf. Model..

Prediction of Drug‐Likeness and its Integration into the Drug Discovery Process

Meir Glick, Ansgar Schuffenhauer, M. Glick, 2009 .

Activity-Aware Clustering of High Throughput Screening Data and Elucidation of Orthogonal Structure-Activity Relationships

Eugen Lounkine, Meir Glick, Florian Nigsch, 2011, J. Chem. Inf. Model..

Public Domain HTS Fingerprints: Design and Evaluation of Compound Bioactivity Profiles from PubChem's Bioassay Repository

Anne Mai Wassermann, Meir Glick, Mateusz Maciejewski, 2016, J. Chem. Inf. Model..

Pattern recognition and massively distributed computing

Meir Glick, W. Graham Richards, E. Keith Davies, 2002, J. Comput. Chem..

Gaining Insight into Off-Target Mediated Effects of Drug Candidates with a Comprehensive Systems Chemical Biology Analysis

Bin Chen, Andreas Bender, Meir Glick, 2009, J. Chem. Inf. Model..

Efficient search of chemical space: navigating from fragments to structurally diverse chemotypes.

Anne Mai Wassermann, Eugen Lounkine, Meir Glick, 2013, Journal of medicinal chemistry.

Stable, soluble T-cell receptor molecules for crystallization and therapeutics.

Meir Glick, Bent K Jakobsen, M. Glick, 2003, Protein engineering.

Interaction between the CD8 Coreceptor and Major Histocompatibility Complex Class I Stabilizes T Cell Receptor-Antigen Complexes at the Cell Surface*

Andrew K. Sewell, Meir Glick, Daniel C. Douek, 2005, Journal of Biological Chemistry.

A stochastic algorithm for global optimization and for best populations: A test case of side chains in proteins

Amiram Goldblum, Meir Glick, M. Glick, 2002, Proceedings of the National Academy of Sciences of the United States of America.

Extending Crystallographic Information with Semiempirical Quantum Mechanics and Molecular Mechanics: A Case of Aspartic Proteinases.

Amiram Goldblum, Meir Glick, Anwar Rayan, 1993 .

A screening pattern recognition method finds new and divergent targets for drugs and natural products.

Anne Mai Wassermann, Eugen Lounkine, Meir Glick, 2014, ACS chemical biology.

Determining proton positions in an enzyme-inhibitor complex is a first step for theoretical mechanistic studies of aspartic proteinases

Amiram Goldblum, Meir Glick, Anwar Rayan, 1993 .

Docking of flexible molecules using multiscale ligand representations.

Meir Glick, W Graham Richards, Guy H Grant, 2002, Journal of medicinal chemistry.

A lead discovery strategy driven by a comprehensive analysis of proteases in the peptide substrate space

Rajiv Chopra, Meir Glick, Florian Nigsch, 2010, Protein science : a publication of the Protein Society.

Dark chemical matter as a promising starting point for drug lead discovery.

Anne Mai Wassermann, Eugen Lounkine, Meir Glick, 2015, Nature chemical biology.

"Virtual fragment linking": an approach to identify potent binders from low affinity fragment hits.

Andreas Bender, Meir Glick, Mariusz Milik, 2008, Journal of medicinal chemistry.

The CD8 T Cell Coreceptor Exhibits Disproportionate Biological Activity at Extremely Low Binding Affinities*

Andrew K. Sewell, Meir Glick, David A. Price, 2003, Journal of Biological Chemistry.

Biodiversity of small molecules--a new perspective in screening set selection.

Anne Mai Wassermann, Eugen Lounkine, Meir Glick, 2013, Drug discovery today.

Pinpointing anthrax-toxin inhibitors

Meir Glick, Guy H. Grant, W. Graham Richards, 2002, Nature Biotechnology.

Construction of a 3D-shaped, natural product like fragment library by fragmentation and diversification of natural products.

Meir Glick, Peter Ertl, Guido Koch, 2017, Bioorganic & medicinal chemistry.

Chemotography for multi-target SAR analysis in the context of biological pathways.

Eugen Lounkine, Meir Glick, Paula Petrone, 2012, Bioorganic & medicinal chemistry.

Novel CD8+ T Cell Antagonists Based on β2-Microglobulin*

Andrew K. Sewell, Meir Glick, Bent K. Jakobsen, 2002, The Journal of Biological Chemistry.

Plate-Based Diversity Selection Based on Empirical HTS Data to Enhance the Number of Hits and Their Chemical Diversity

Andreas Bender, Meir Glick, Dmitri Mikhailov, 2009, Journal of biomolecular screening.

Inside the Mind of a Medicinal Chemist: The Role of Human Bias in Compound Prioritization during Drug Discovery

Meir Glick, John D. Coley, Peter S. Kutchukian, 2012, PloS one.

Deorphanization strategies for dark chemical matter.

Anne Mai Wassermann, Meir Glick, Matthew Tudor, 2017, Drug discovery today. Technologies.