M. Bio

发表

Process Development and Multikilogram-Scale Synthesis of a TRPV1 Antagonist

Jeremy P. Scott, D. J. Wallace, Faye J. Sheen, 2013 .

Rh(III)-catalyzed C-H activation and double directing group strategy for the regioselective synthesis of naphthyridinones.

T. Hwang, O. Thiel, M. Bio, 2013, Journal of the American Chemical Society.

Crystallization-Induced Dynamic Resolution of a Diarylmethylamine toward the Synthesis of a Potent TRPM8 Inhibitor

Matthew G. Beaver, Yuan-Qing Fang, H. Tan, 2016 .

Flow Asymmetric Propargylation: Development of Continuous Processes for a Chiral beta-Amino Alcohol

Yuan-Qing Fang, Andrew M. Clausen, M. Bio, 2017 .

Flow Asymmetric Propargylation: Development of Continuous Processes for the Preparation of a Chiral β-Amino Alcohol.

Yuan-Qing Fang, Andrew M. Clausen, M. Bio, 2017, Angewandte Chemie.

Enantioselective hydrogenation of an α-alkoxy substituted ketone with chiral ruthenium (phosphinoferrocenyl)oxazoline complexes

D. Tellers, Yong-kui Sun, J. McWilliams, 2006 .

Synthesis of 4-Substituted Phthalazin-1(2H)-ones from 2-Acylbenzoic Acids: Controlling Hydrazine in a Pharmaceutical Intermediate through PAT-Guided Process Development

Kelly A. Nadeau, Steven M. Mennen, M. Mak-Jurkauskas, 2015 .

Telescoped Process to Manufacture 6,6,6-Trifluorofucose via Diastereoselective Transfer Hydrogenation: Scalable Access to an Inhibitor of Fucosylation Utilized in Monoclonal Antibody Production.

S. W. Roberts, Michal M. Achmatowicz, Christopher J. Borths, 2016, The Journal of organic chemistry.

Regioselective coupling reactions of 2,4-diaminopyridine derivatives with aryl halides: the synthesis of elaborated pyridines

Simon E. Hamilton, Faye J. Sheen, Ed Cleator, 2009 .

Ni-Catalyzed Electrochemical Decarboxylative C–C Couplings in Batch and Continuous Flow

Christopher P. Breen, T. Jamison, Yuan-Qing Fang, 2018, Organic Letters.

Stereoconvergent palladium-catalyzed carbonylation of both E and Z isomers of a 2-trifloxy-1,3-butadiene.

J. L. Leighton, M. Bio, 2000, Organic letters.

AN APPROACH TO THE SYNTHESIS OF CP-263,114 : A REMARKABLY FACILE SILYLOXY-COPE REARRANGEMENT

J. L. Leighton, M. Bio, 1999 .

An approach to the synthesis of the phomoidrides.

J. L. Leighton, M. Bio, 2003, The Journal of organic chemistry.

Continuous Process for Preparing the Difluoromethylating Reagent [(DMPU)2Zn(CF2H)2] and Improved Synthesis of the ICHF2 Precursor

Adam R. C. Brown, Yuan-Qing Fang, J. Hawkins, 2020 .

A highly regioselective Friedländer reaction mediated by lanthanum chloride

T. Hwang, Jinkun Huang, M. Bio, 2012 .

Highly Regioselective Halogenation of Pyridine N-Oxide: Practical Access to 2-Halo-Substituted Pyridines.

J. Tedrow, T. Hwang, R. P. Farrell, 2015, Organic letters.

Some Practical Methods for the Application of 5-Metallo-1-benzyl-1H-tetrazoles in Synthesis

K. Hansen, M. Bio, N. F. Langille, 2012 .

Magnesium Coordination-Directed N-Selective Stereospecific Alkylation of 2-Pyridones, Carbamates, and Amides Using α-Halocarboxylic Acids.

Yuan-Qing Fang, Andrew M. Clausen, K. Hansen, 2011 .

Magnesium coordination-directed n-selective stereospecific alkylation of 2-pyridones, carbamates, and amides using α-halocarboxylic acids.

Yuan-Qing Fang, Andrew M. Clausen, K. Hansen, 2010, Journal of the American Chemical Society.

Practical syntheses of a CXCR3 antagonist.

Kyle D. Baucom, M. Faul, B. Burke, 2011, The Journal of organic chemistry.

An Efficient Synthesis of an NMDA Receptor Antagonist via Stereoselective Fluorination

M. Waters, Z. Song, M. Bio, 2008 .

Development of a Robust and Highly Selective Ru(II)-Catalyzed Dynamic Kinetic Resolution Used to Manufacture AMG 232

J. Tedrow, K. Diker, J. Colyer, 2020 .

Selective protodeboronation: synthesis of 4-methyl-2-thiopheneboronic anhydride and demonstration of its utility in Suzuki–Miyaura reactions

Liane M. Klingensmith, M. Bio, G. Moniz, 2007 .

A Scalable Membrane Pervaporation Approach for Continuous Flow Olefin Metathesis

Christopher P. Breen, T. Jamison, C. Parrish, 2020, Organic Process Research & Development.

Practical synthesis of a potent hepatitis C virus RNA replication inhibitor.

R. Volante, E. Grabowski, Feng Xu, 2004, The Journal of organic chemistry.

Scalable On-Demand Production of Purified Diazomethane Suitable for Sensitive Catalytic Reactions

Christopher P. Breen, Yuan-Qing Fang, S. Hecker, 2021 .

SLC46A3 Is Required to Transport Catabolites of Noncleavable Antibody Maytansine Conjugates from the Lysosome to the Cytoplasm.

D. Rock, Brooke M. Rock, W. Fanslow, 2015, Cancer research.

Access to site-specific Fc-cRGD peptide conjugates through streamlined expressed protein ligation.

J. B. Jordan, T. Muir, O. Thiel, 2016, Organic & biomolecular chemistry.

Regioselective synthesis of N-substituted-4-substituted isothiazolidine-1,1-dioxides

Faye J. Sheen, Ed Cleator, M. Bio, 2006 .

Regioselective Synthesis of N-Substituted-4-substituted Isothiazolidine-1,1-dioxides.

Faye J. Sheen, Ed Cleator, M. Bio, 2006 .

An improved synthesis of N-isocyanoiminotriphenylphosphorane and its use in the preparation of diazoketones

Z. Song, M. Bio, Gary J Javadi, 2004 .

A Continuous Flow Process for LSN647712 via Double Organometallic Additions to Dimethylcarbamyl Chloride.

Martin D. Johnson, Yuan-Qing Fang, S. Frank, 2021, The Journal of organic chemistry.

A Practical and Scaleable Synthesis of 1R,5S-Bicyclo[3.1.0]hexan-2-one: The Development of a Catalytic Lithium 2,2,6,6-Tetramethylpiperidide (LTMP) Mediated Intramolecular Cyclopropanation of (R)-1,2-Epoxyhex-5-ene

Ed Cleator, M. Bio, A. Davies, 2007 .

Practical Access to Metallo Thiophenes: Regioselective Synthesis of 2,4-Disubstituted Thiophenes

M. Bio, S. Asselin, N. Langille, 2010 .

An efficient asymmetric synthesis of an estrogen receptor modulator by sulfoxide-directed borane reduction.

D. Zewge, D. Mathre, R. Volante, 2004, Proceedings of the National Academy of Sciences of the United States of America.