C. A. Blum

发表

Pyrido[2,3-b]pyrazines, discovery of TRPV1 antagonists with reduced potential for the formation of reactive metabolites.

S. Boyce, J. Krause, Xiaozhang Zheng, 2010, Bioorganic & medicinal chemistry letters.

Crystallographic structure of a small molecule SIRT1 activator-enzyme complex

F. Jiang, Beth L. Pietrak, T. Riera, 2014, Nature Communications.

Design, synthesis, and biological evaluation of substituted 2-cyclohexyl-4-phenyl-1H-imidazoles: potent and selective neuropeptide Y Y5-receptor antagonists.

S. De Lombaert, Xiaozhang Zheng, Xiaozhang Zheng, 2004, Journal of medicinal chemistry.

The conversion of car☐ylic acids to keto phosphorane precursors of 1,2,3-vicinal tricarbonyl compounds

V. Rotello, H. Wasserman, C. A. Blum, 1992 .

From arylureas to biarylamides to aminoquinazolines: discovery of a novel, potent TRPV1 antagonist.

J. Chandrasekhar, S. De Lombaert, Xiaozhang Zheng, 2006, Bioorganic & medicinal chemistry letters.

Aminoquinazolines as TRPV1 antagonists: modulation of drug-like properties through the exploration of 2-position substitution.

Mark T. Kershaw, J. Chandrasekhar, J. Krause, 2008, Bioorganic & medicinal chemistry letters.

The chemistry of vicinal tricarbonyls. Use of vinyl and acetylenic derivatives in the synthesis of substituted indoles

H. Wasserman, C. A. Blum, 1994 .

Discovery of novel 6,6-heterocycles as transient receptor potential vanilloid (TRPV1) antagonists.

Mark T. Kershaw, S. Boyce, J. Krause, 2010, Journal of medicinal chemistry.

The vanilloid receptor TRPV1: 10 years from channel cloning to antagonist proof-of-concept

A. Szallasi, Arpad Szallasi, S. R. Eid, 2007, Nature Reviews Drug Discovery.

Total synthesis of (+)- and (−)-norsecurinine

R. Desimone, P. Jacobi, C. A. Blum, 1989 .

Evidence for a Common Mechanism of SIRT1 Regulation by Allosteric Activators

Dudley Lamming, D. Sinclair, K. Howitz, 2013, Science.

Discovery and evaluation of pyrazolo[1,5-a]pyrimidines as neuropeptide Y1 receptor antagonists.

T. Maurer, D. Hargrove, C. Mack, 2011, Bioorganic & medicinal chemistry letters.

Substituted 3-(2-benzoxazyl)-benzimidazol-2-(1H)-ones: a new class of GABA(A) brain receptor ligands.

R. Desimone, C. A. Blum, 2000, Bioorganic & medicinal chemistry letters.

Substituted 3-(2-Benzoxazyl)-benzimidazol-2-(1H)-ones: A New Class of GABAA Brain Receptor Ligands

R. Desimone, C. A. Blum, 2001 .

Discovery of thieno[3,2-d]pyrimidine-6-carboxamides as potent inhibitors of SIRT1, SIRT2, and SIRT3.

Siva Lavu, Lei Jin, T. Graybill, 2013, Journal of medicinal chemistry.

SIRT1 modulation as a novel approach to the treatment of diseases of aging.

J. Ellis, R. Stein, R. Perni, 2011, Journal of medicinal chemistry.

Killing by Bactericidal Antibiotics Does Not Depend on Reactive Oxygen Species

D. Sinclair, K. Howitz, J. Moss, 2022 .

The Conversion of Carboxylic Acids to Keto Phosphorane Precursors of 1, 2,3-Vicinal Tricarbonyl Compounds.

V. Rotello, H. Wasserman, C. A. Blum, 1993 .

Bis-heteroannulation. 15. Enantiospecific syntheses of (+)- and (-)-norsecurinine

P. Jacobi, C. A. Blum, U. Udodong, 1991 .

Pyrido[2,3-b]pyrazines, discovery of TRPV1 antagonists with reduced potential for the formation of reactive metabolites.

S. Boyce, J. Krause, Xiaozhang Zheng, 2010, Bioorganic & medicinal chemistry letters.