B. Murphy

发表

Pyrido[2,3-b]pyrazines, discovery of TRPV1 antagonists with reduced potential for the formation of reactive metabolites.

S. Boyce, J. Krause, Xiaozhang Zheng, 2010, Bioorganic & medicinal chemistry letters.

Structure–activity relationship of linear tetrapeptides Tic-DPhe-Arg-Trp-NH2 at the human melanocortin-4 receptor and effects on feeding behaviors in rat

D. Macintyre, A. Patchett, R. Nargund, 2005, Peptides.

Contribution of the tetrodotoxin-resistant voltage-gated sodium channel NaV1.9 to sensory transmission and nociceptive behavior.

S. Kash, D. Macintyre, P. Liberator, 2005, Proceedings of the National Academy of Sciences of the United States of America.

Discovery and Pharmacology of a Novel Somatostatin Subtype 5 (SSTR5) Antagonist: Synergy with DPP-4 Inhibition.

Margaret S. Wu, Yun-ping Zhou, A. Howard, 2018, ACS medicinal chemistry letters.

Cholesteryl ester transfer protein (CETP) inhibitors based on cyclic urea, bicyclic urea and bicyclic sulfamide cores.

D. Johns, P. Váchal, Q. Deng, 2020, Bioorganic & medicinal chemistry letters.

siRNA-mediated inhibition of SREBP cleavage-activating protein reduces dyslipidemia in spontaneously dysmetabolic rhesus monkeys.

Shirly Pinto, R. Mogg, D. McLaren, 2017, Metabolism: clinical and experimental.

Effects of small interfering RNA-mediated hepatic glucagon receptor inhibition on lipid metabolism in db/db mice[S]

Shirly Pinto, T. Roddy, Kristian K. Jensen, 2013, Journal of Lipid Research.

DGAT2 Inhibition Alters Aspects of Triglyceride Metabolism in Rodents but Not in Non-human Primates.

Dermot F. Reilly, S. Bartz, D. Reilly, 2018, Cell metabolism.

Potential mechanism of enhanced postprandial glucagon‐like peptide‐1 release following treatment with a diacylglycerol acyltransferase 1 inhibitor

Shirly Pinto, T. Roddy, D. McLaren, 2015, Pharmacology research & perspectives.

Discovery and Pharmacology of a Novel Class of Diacylglycerol Acyltransferase 2 Inhibitors.

Shirly Pinto, D. McLaren, Sheng-ping Wang, 2015, Journal of medicinal chemistry.

Series of Novel and Highly Potent Cyclic Peptide PCSK9 Inhibitors Derived from an mRNA Display Screen and Optimized via Structure-Based Design.

K. Seyb, D. Johns, P. Orth, 2020, Journal of medicinal chemistry.

Effects of siRNA-mediated hepatic glucagon receptor inhibition on lipid metabolism in db/db mice

Shirly Pinto, T. Roddy, Kristian K. Jensen, 2013 .

Optimization of Preclinical Metabolism for Somatostatin Receptor Subtype 5-Selective Antagonists.

F. A. Romero, F. Ujjainwalla, A. Howard, 2018, ACS medicinal chemistry letters.

Use of [13C18] oleic acid and mass isotopomer distribution analysis to study synthesis of plasma triglycerides in vivo: analytical and experimental considerations.

M. Cleary, D. Johns, J. Castro-Pérez, 2013, Analytical chemistry.

Potent DGAT1 Inhibitors in the Benzimidazole Class with a Pyridyl-oxy-cyclohexanecarboxylic Acid Moiety.

Shirly Pinto, J. Lisnock, R. DeVita, 2013, ACS medicinal chemistry letters.

Discovery of novel 6,6-heterocycles as transient receptor potential vanilloid (TRPV1) antagonists.

Mark T. Kershaw, S. Boyce, J. Krause, 2010, Journal of medicinal chemistry.

Benzimidazole-based DGAT1 inhibitors with a [3.1.0] bicyclohexane carboxylic acid moiety.

Shirly Pinto, M. Reibarkh, R. DeVita, 2019, Bioorganic & medicinal chemistry letters.

Invention of MK-8262, a Cholesteryl Ester Transfer Protein (CETP) Inhibitor Backup to Anacetrapib with Best-in-Class Properties.

Joseph James Duffy, D. Johns, Rupesh P. Amin, 2021, Journal of medicinal chemistry.

Accelerating the discovery of DGAT1 inhibitors through the application of parallel medicinal chemistry (PMC).

Shirly Pinto, R. Nargund, P. Váchal, 2019, Bioorganic & medicinal chemistry letters.

Discovery of Novel Indoline Cholesterol Ester Transfer Protein Inhibitors (CETP) through a Structure-Guided Approach.

D. Johns, A. Crespo, P. Váchal, 2016, ACS medicinal chemistry letters.

A rapid method for cross-species quantitation of apolipoproteins A1, B48 and B100 in plasma by ultra-performance liquid chromatography/tandem mass spectrometry.

Michael E. Lassman, Kenny K. Wong, J. Castro-Pérez, 2012, Rapid communications in mass spectrometry : RCM.

AMP-activated protein kinase and nitric oxide regulate the glucose sensitivity of ventromedial hypothalamic glucose-inhibited neurons.

Annie Beuve, Zhentao Song, V. Routh, 2009, American journal of physiology. Cell physiology.

Glucagon like receptor 1/ glucagon dual agonist acutely enhanced hepatic lipid clearance and suppressed de novo lipogenesis in mice

A. Pocai, D. McLaren, S. Previs, 2017, PloS one.

Microscale High-Throughput Experimentation as an Enabling Technology in Drug Discovery: Application in the Discovery of (Piperidinyl)pyridinyl-1H-benzimidazole Diacylglycerol Acyltransferase 1 Inhibitors.

Andreas Verras, Yang Yu, Edward C Sherer, 2017, Journal of medicinal chemistry.

A Series of Novel, Highly Potent, and Orally Bioavailable Next-Generation Tricyclic Peptide PCSK9 Inhibitors.

Jeffrey T. Kuethe, D. Johns, P. Orth, 2021, Journal of medicinal chemistry.

Fasting enhances the response of arcuate neuropeptide Y-glucose-inhibited neurons to decreased extracellular glucose.

V. Routh, L. Pénicaud, A. Lorsignol, 2009, American journal of physiology. Cell physiology.

Title: Fasting enhances the response of arcuate neuropeptide Y (NPY)-glucose-inhibited (GI) neurons to decreased extracellular glucose. Abbreviated Title: Fasting modulates glucose responses in NPY neurons

V. Routh, L. Pénicaud, A. Lorsignol, 2009 .

glucose ted neurons to decreased extracellular Fasting enhances the response of arcuate neuropeptide

V. Routh, L. Pénicaud, A. Lorsignol, 2009 .

Discovery of benzodihydroisofurans as novel, potent, bioavailable and brain-penetrant prolylcarboxypeptidase inhibitors.

Michael E. Lassman, Shirly Pinto, M. Garcia-Calvo, 2012, Bioorganic & medicinal chemistry letters.

Impaired wound contraction in stromelysin-1-deficient mice.

T. K. Hunt, Z. Werb, J. Mudgett, 1999, Annals of surgery.

Effects of small interfering RNA-mediated hepatic glucagon receptor inhibition on lipid metabolism in db/db mice[S]

Shirly Pinto, T. Roddy, Kristian K. Jensen, 2013, Journal of Lipid Research.