D. Trivedi

发表

Design and microwave-assisted synthesis of novel macrocyclic peptides active at melanocortin receptors: discovery of potent and selective hMC5R receptor antagonists.

E. Novellino, P. Grieco, V. Hruby, 2008, Journal of medicinal chemistry.

Cell Signaling and Trafficking of Human Melanocortin Receptors in Real Time Using Two‐photon Fluorescence and Confocal Laser Microscopy: Differentiation of Agonists and Antagonists

M. Staňková, V. Hruby, M. Cai, 2006, Chemical biology & drug design.

Design of novel melanotropin agonists and antagonists with high potency and selectivity for human melanocortin receptors

M. Staňková, Jinfa Ying, V. Hruby, 2005, Peptides.

Effects of [1-N alpha-trinitrophenylhistidine, 12-homoarginine]glucagon on cyclic AMP levels and free fatty acid release in isolated rat adipocytes.

V. Hruby, J. Pelton, D. Trivedi, 1986, Biochimica et biophysica acta.

Structure-activity studies of hydrophobic amino acid replacements at positions 9, 11 and 16 of glucagon.

V. Hruby, D. Trivedi, B. Y. Azizeh, 2009, The journal of peptide research : official journal of the American Peptide Society.

Synthetic glucagon antagonists and partial agonists.

V. Hruby, C. Zechel, D. Trivedi, 2009, International journal of peptide and protein research.

Hyperglycemia of diabetic rats decreased by a glucagon receptor antagonist.

V. Hruby, D. Johnson, D. Trivedi, 1982, Science.

Structure−Activity Relationships of Novel Cyclic α-MSH/β-MSH Hybrid Analogues That Lead to Potent and Selective Ligands for the Human MC3R and Human MC5R

P. Grieco, V. Hruby, M. Cai, 2003 .

Effects of Macrocycle Size and Rigidity on Melanocortin Receptor‐1 and ‐5 Selectivity in Cyclic Lactam α‐Melanocyte‐Stimulating Hormone Analogs

V. Hruby, So-Yeop Han, M. Cai, 2006, Chemical biology & drug design.

Structure–activity studies of new melanocortin peptides containing an aromatic amino acid at the N-terminal position

P. Grieco, V. Hruby, M. Cai, 2006, Peptides.

Biological and conformational study of beta-substituted prolines in MT-II template: steric effects leading to human MC5 receptor selectivity.

C. Xiong, V. Hruby, M. Cai, 2004, The journal of peptide research : official journal of the American Peptide Society.

Exploring the Stereostructural Requirements of Peptide Ligands for the Melanocortin Receptors

P. Grieco, V. Hruby, M. Cai, 2003, Annals of the New York Academy of Sciences.

Design and synthesis of conformationally constrained glucagon analogues.

V. Hruby, D. Trivedi, K. Schram, 2000, Journal of medicinal chemistry.

Structure-function studies on positions 17, 18, and 21 replacement analogues of glucagon: the importance of charged residues and salt bridges in glucagon biological activity.

S. Burley, V. Hruby, J. Krstenansky, 1998, Journal of medicinal chemistry.

Development of potent truncated glucagon antagonists.

V. Hruby, D. Trivedi, M. Medeiros, 2001, Journal of medicinal chemistry.

Low level cyclic adenosine 3',5'-monophosphate accumulation analysis of [des-His1, des- Phe6, Glu9] glucagon-NH2 identifies glucagon antagonists from weak partial agonists/antagonists.

V. Hruby, M. Houslay, B. V. Van Tine, 1996, Endocrinology.

Synthetic linear and cyclic glucagon antagonists.

Andrew J. Bannister, V. Hruby, D. Tourwé, 2009, International journal of peptide and protein research.

Synthesis of two glucagon antagonists: receptor binding, adenylate cyclase, and effects on blood plasma glucose levels.

V. Hruby, D. Johnson, D. Trivedi, 1987, Journal of medicinal chemistry.

Design, synthesis and biological evaluation of ligands selective for the melanocortin-3 receptor.

James P. Cain, V. Hruby, M. Cai, 2007, Current topics in medicinal chemistry.

An Unusual Conformation of MSH Analogues Leads to a Selective Human Melanocortin 1 Receptor Antagonist for Targeting Melanoma Cells

M. Staňková, V. Hruby, M. Cai, 2013 .

Perifused precision-cut liver slice system for the study of hormone-regulated hepatic glucose metabolism.

A. J. Gandolfi, D. Johnson, K. Brendel, 1988, Journal of pharmacological methods.

Receptor binding and adenylate cyclase activities of glucagon analogues modified in the N-terminal region.

V. Hruby, D. Johnson, D. Coy, 1986, Biochemistry.

Metabolic effects and cyclic AMP levels produced by glucagon, (1-N alpha-Trinitrophenylhistidine,12-homoarginine)glucagon and forskolin in isolated rat hepatocytes.

V. Hruby, S. Corvera, J. Pelton, 1984, Biochimica et biophysica acta.

Glucagon amino groups. Evaluation of modifications leading to antagonism and agonism.

V. Hruby, D. Trivedi, M. D. Bregman, 1980, The Journal of biological chemistry.

Activities of glucagon antagonists on normal liver: Evidence for cAMP-independent events

V. Hruby, K. Brendel, C. Zechel, 1988 .

Modulation of glucagon actions by phorbol myristate acetate in isolated hepatocytes. Effect of hypothyroidism.

V. Hruby, M. Macías-Silva, S. Hernández-Sotomayor, 1990, Cellular signalling.

Importance of the C‐terminal α‐helical structure for glucagon's biological activity

V. Hruby, C. Zechel, J. Krstenansky, 2009 .

Positional Cyclization Scanning: A New Method to Evaluate the Bioactive Conformation of Glucagon

V. Hruby, Jung-Mo Ahn, P. Gitu, 2001 .

[des His1, des Phe6, Glu9]glucagon amide: A newly designed “pure” glucagon antagonist

V. Hruby, B. V. Tine, D. Trivedi, 1995 .

Design of novel melanocortin receptor ligands: multiple receptors, complex pharmacology, the challenge.

James P. Cain, V. Hruby, M. Cai, 2011, European journal of pharmacology.

The rapid desensitization of glucagon-stimulated adenylate cyclase is a cyclic AMP-independent process that can be mimicked by hormones which stimulate inositol phospholipid metabolism.

V. Hruby, M. Houslay, M. Wakelam, 1987, The Biochemical journal.

The role of phenylalanine at position 6 in glucagon's mechanism of biological action: multiple replacement analogues of glucagon.

V. Hruby, D. Trivedi, B. Y. Azizeh, 1997, Journal of medicinal chemistry.

Solid-phase peptide head-to-side chain cyclodimerization: Discovery of C2-symmetric cyclic lactam hybrid α-melanocyte-stimulating hormone (MSH)/agouti-signaling protein (ASIP) analogues with potent activities at the human melanocortin receptors

James P. Cain, V. Hruby, M. Cai, 2010, Peptides.

Design and synthesis of novel χ2-constrained phenylalanine, naphthylalanine, and tryptophan analogues and their use in biologically active melanotropin peptides

Wei Wang, C. Xiong, V. Hruby, 2002 .

Design, synthesis, and biological evaluation of new cyclic melanotropin peptide analogues selective for the human melanocortin-4 receptor.

Jinfa Ying, V. Hruby, M. Cai, 2006, Journal of medicinal chemistry.

Design, synthesis, and biological evaluation of a new class of small molecule peptide mimetics targeting the melanocortin receptors.

V. Hruby, M. Cai, H. Wang, 2006, Bioorganic & medicinal chemistry letters.

Opioid and melanocortin receptors: Do they have overlapping pharmacophores?

James P. Cain, V. Hruby, M. Cai, 2008, Biopolymers.

Novel cyclic templates of alpha-MSH give highly selective and potent antagonists/agonists for human melanocortin-3/4 receptors.

Paolo Grieco, Jinfa Ying, Jinfa Ying, 2002, Journal of medicinal chemistry.

Substitution of arginine with proline and proline derivatives in melanocyte-stimulating hormones leads to selectivity for human melanocortin 4 receptor.

P. Grieco, V. Hruby, M. Cai, 2009, Journal of medicinal chemistry.

An unusual conformation of γ-melanocyte-stimulating hormone analogues leads to a selective human melanocortin 1 receptor antagonist for targeting melanoma cells.

M. Staňková, V. Hruby, M. Cai, 2013, Biochemistry.

New glucagon analogues with conformational restrictions and altered amphiphilicity: effects on binding, adenylate cyclase and glycogenolytic activities.

V. Hruby, D. Johnson, D. Trivedi, 1993, Life sciences.

Importance of the 10-13 region of glucagon for its receptor interactions and activation of adenylate cyclase.

V. Hruby, J. Krstenansky, D. Trivedi, 1986, Biochemistry.

Conformational considerations in the design of glucagon agonists and antagonists: examination using synthetic analogs.

V. Hruby, J. Pelton, J. Krstenansky, 1986, Biopolymers.

Further structure–activity studies of lactam derivatives of MT-II and SHU-9119: Their activity and selectivity at human melanocortin receptors 3, 4, and 5

E. Novellino, P. Grieco, V. Hruby, 2007, Peptides.

Structure-activity relationships of cyclic lactam analogues of alpha-melanocyte-stimulating hormone (alpha-MSH) targeting the human melanocortin-3 receptor.

James P. Cain, V. Hruby, M. Cai, 2008, Journal of medicinal chemistry.

Design and synthesis of glucagon partial agonists and antagonists.

V. Hruby, D. Johnson, D. Trivedi, 1986, Biochemistry.

Pure Glucagon Antagonists: Biological Activities and cAMP Accumulation Using Phosphodiesterase Inhibitors

V. Hruby, B. V. Tine, D. Trivedi, 1997, Peptides.

Development of potent glucagon antagonists: structure-activity relationship study of glycine at position 4.

V. Hruby, D. Trivedi, M. Medeiros, 2001, The journal of peptide research : official journal of the American Peptide Society.

Solution structures of cyclic melanocortin agonists and antagonists by NMR.

Jinfa Ying, V. Hruby, K. Kövér, 2003, Biopolymers.

Novel 3D Pharmacophore of α-MSH/γ-MSH Hybrids Leads to Selective Human MC1R and MC3R Analogues†

M. Staňková, V. Hruby, M. Cai, 2005 .

Structure-activity relationships of gamma-MSH analogues at the human melanocortin MC3, MC4, and MC5 receptors. Discovery of highly selective hMC3R, hMC4R, and hMC5R analogues.

Paolo Grieco, P. Grieco, V. Hruby, 2003, Journal of medicinal chemistry.

Structure-activity studies of the melanocortin peptides: discovery of potent and selective affinity antagonists for the hMC3 and hMC4 receptors.

Paolo Grieco, Antonio Lavecchia, P. Grieco, 2002, Journal of medicinal chemistry.

Peptide and non-peptide mimetics utilize different pathways for signal transduction.

V. Hruby, M. Cai, G. Tsaprailis, 2009, Advances in Experimental Medicine and Biology.

Real time differentiation of G-protein coupled receptor (GPCR) agonist and antagonist by two photon fluorescence laser microscopy.

M. Staňková, V. Hruby, M. Cai, 2004, Journal of the American Chemical Society.

Novel 3D pharmacophore of alpha-MSH/gamma-MSH hybrids leads to selective human MC1R and MC3R analogues.

M. Staňková, V. Hruby, M. Cai, 2005, Journal of medicinal chemistry.

A new approach to search for the bioactive conformation of glucagon: positional cyclization scanning.

V. Hruby, P. Gitu, D. Trivedi, 2001, Journal of medicinal chemistry.

Cyclic lactam hybrid α-MSH/Agouti-related protein (AGRP) analogues with nanomolar range binding affinities at the human melanocortin receptors.

James P. Cain, V. Hruby, M. Cai, 2011, Bioorganic & medicinal chemistry letters.

Development of cyclic gamma-MSH analogues with selective hMC3R agonist and hMC3R/hMC5R antagonist activities.

V. Hruby, M. Cai, K. Chandler, 2006, Journal of medicinal chemistry.

Novel MTII/AGRP Hybrid Analogs that Lead to Selective Ligands for the Human Melanocortin Receptors

V. Hruby, M. Cai, K. Chandler, 2006 .

Design and Synthesis of Novel α-MSH Peptide Analogs Highly Selective for the hMC4R

Jinfa Ying, V. Hruby, M. Cai, 2006 .

Novel and Highly Selective Antagonist Scaffold for Human Melanocortin 3 Receptor: Computer-Aided Design and Biological Evaluation

V. Hruby, M. Cai, K. Chandler, 2006 .

Conformational Considerations in the Design of a Glucagon Analogue with Increased Receptor Binding and Adenylate Cyclase Potencies

V. Hruby, J. Krstenansky, D. Trivedi, 1986 .

Re-evaluation of glucagon1-6: the N-terminal hexapeptide of glucagon is not biologically active in the hepatic adenylate cyclase system.

V. Hruby, J. Pelton, D. Trivedi, 1983, Life sciences.

James P. Cain, V. Hruby, J. Vagner, 2010, Peptides.

The Development of a Novel Highly Selective and Potent Agonist for Human Melanocortin 4 Receptor

V. Hruby, M. Kavarana, D. Trivedi, 2001 .

Asymmetric amino acid substitution at the Tyr10 position of glucagon leads to greater binding differences

V. Hruby, B. V. Tine, D. Trivedi, 1995 .

The Design and Biological Activities of Glucagon Agonists and Antagonists,and their Use in Examining the Mechanisms of Glucose Action

V. Hruby, D. Trivedi, J-M Ahn, 2001 .

Stimulation and inhibition of cAMP accumulation by glucagon in canine hepatocytes.

V. Hruby, T. Grady, H. Tager, 1987, The Journal of biological chemistry.