I. Byrjalsen

P. Alexandersen, L. Alvarez, N. Guañabens, 2004, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Bone turnover and bone collagen maturation in osteoporosis: effects of antiresorptive therapies

M. Karsdal, C. Christiansen, P. Qvist, 2008, Osteoporosis International.

The effects of oral calcitonin on bone collagen maturation: implications for bone turnover and quality

M. Karsdal, C. Christiansen, P. Delmas, 2008, Osteoporosis International.

The Collagenolytic Activity of Cathepsin K Is Unique among Mammalian Proteinases*

P. Delmas, J. Delaissé, P. Garnero, 1998, The Journal of Biological Chemistry.

Raloxifene and estrogen reduces progression of advanced atherosclerosis--a study in ovariectomized, cholesterol-fed rabbits.

C. Christiansen, P. Alexandersen, J. Haarbo, 2001, Atherosclerosis.

Raloxifene reduces atherosclerosis: studies of optimized raloxifene doses in ovariectomized, cholesterol‐fed rabbits

C. Christiansen, J. Haarbo, R. Kauffman, 2000, Clinical endocrinology.

Biomarkers of collagen turnover are related to annual change in FEV1 in patients with chronic obstructive pulmonary disease within the ECLIPSE study

L. Edwards, R. Zuwallack, J. Wedzicha, 2017, BMC Pulmonary Medicine.

Natural androgens inhibit male atherosclerosis: a study in castrated, cholesterol-fed rabbits.

C. Christiansen, P. Alexandersen, H. Lawaetz, 1999, Circulation research.

The effect of oral salmon calcitonin delivered with 5-CNAC on bone and cartilage degradation in osteoarthritic patients: a 14-day randomized study.

M. Karsdal, C. Christiansen, B. Riis, 2010, Osteoarthritis and cartilage.

Optimizing bioavailability of oral administration of small peptides through pharmacokinetic and pharmacodynamic parameters: The effect of water and timing of meal intake on oral delivery of Salmon Calcitonin

M. Karsdal, C. Christiansen, B. Riis, 2008, BMC clinical pharmacology.

Investigation of the diurnal variation in bone resorption for optimal drug delivery and efficacy in osteoporosis with oral calcitonin

C. Christiansen, M. Karsdal, I. Byrjalsen, 2008, BMC clinical pharmacology.

Human endometrial proteins with cyclic changes in the expression during the normal menstrual cycle: characterization by protein sequence analysis

C. Christiansen, S. Fey, P. Larsen, 1995 .

Two-dimensional gel analysis of human endometrial proteins: cyclic changes in the expression of specific proteins during the normal menstrual cycle.

C. Christiansen, S. Fey, P. Larsen, 1995, Human reproduction.

A MMP derived versican neo-epitope is elevated in plasma from patients with atherosclerotic heart disease.

M. Karsdal, C. Christiansen, A. Diederichsen, 2013, International journal of clinical and experimental medicine.

Rabbits Natural Androgens Inhibit Male Atherosclerosis : A Study in Castrated , Cholesterol-Fed

C. Christiansen, H. Lawaetz, J. Haarbo, 1999 .

Tibolone inhibits bone resorption without secondary positive effects on cartilage degradation

C. Christiansen, M. Karsdal, I. Byrjalsen, 2008, BMC musculoskeletal disorders.

Oral salmon calcitonin reduces cartilage and bone pathology in an osteoarthritis rat model with increased subchondral bone turnover.

M. Karsdal, A. Bay-Jensen, R. H. Nielsen, 2011, Osteoarthritis and cartilage.

Low doses of estradiol in combination with gestodene to prevent early postmenopausal bone loss.

C. Christiansen, C. Hassager, J. Haarbo, 2000, American journal of obstetrics and gynecology.

Disassociation of bone resorption and formation by GLP-2: a 14-day study in healthy postmenopausal women.

J. Holst, C. Christiansen, P. Alexandersen, 2007, Bone.

Evaluation of the efficacy, safety and pharmacokinetic profile of oral recombinant human parathyroid hormone [rhPTH(1-31)NH(2)] in postmenopausal women with osteoporosis.

M. Karsdal, C. Christiansen, P. Alexandersen, 2013, Bone.

Enzyme-linked immunosorbent assay (ELISAs) for metalloproteinase derived type II collagen neoepitope, CIIM--increased serum CIIM in subjects with severe radiographic osteoarthritis.

M. Karsdal, E. Dam, P. Qvist, 2011, Clinical biochemistry.

Does moderate intensity impact exercise and non-impact exercise induce acute changes in collagen biochemical markers related to osteoarthritis? - An exploratory randomized cross-over trial.

M. Karsdal, H. B. Nielsen, M. Boesen, 2021, Osteoarthritis and cartilage.

The Relative Use of Eight Collagenous and Noncollagenous Markers for Diagnosis of Skeletal Metastases in Breast, Prostate, or Lung Cancer Patients

L. Tankó, P. Qvist, M. Koizumi, 2006, Cancer Epidemiology Biomarkers & Prevention.

Does increased local bone resorption secondary to breast and prostate cancer result in increased cartilage degradation?

M. Karsdal, C. Christiansen, N. Lynnerup, 2008, BMC Cancer.

Human macrophage foam cells degrade atherosclerotic plaques through cathepsin K mediated processes

M. Karsdal, C. Christiansen, N. Barascuk, 2010, BMC cardiovascular disorders.

A comparison of glycemic control, water retention, and musculoskeletal effects of balaglitazone and pioglitazone in diet-induced obese rats.

M. Karsdal, C. Christiansen, H. Beck-Nielsen, 2009, European journal of pharmacology.

At what level of serum total creatine kinase activity can measurement of serum creatine kinase MB isoenzyme activity be omitted in suspected myocardial infarction?

I. Byrjalsen, P. Hildebrandt, J. Knudsen, 1989, Scandinavian journal of clinical and laboratory investigation.

Tissue metabolite of type I collagen, C1M, and CRP predicts structural progression of rheumatoid arthritis

M. Karsdal, M. Genovese, M. Weinblatt, 2019, BMC Rheumatology.

Serological identification of fast progressors of structural damage with rheumatoid arthritis

M. Karsdal, C. Christiansen, D. Leeming, 2013, Arthritis Research & Therapy.

Lessons Learned From the Development of Oral Calcitonin: The First Tablet Formulation of a Protein in Phase III Clinical Trials

C. Christiansen, P. Qvist, K. Henriksen, 2011, Journal of clinical pharmacology.

Investigations of inter- and intraindividual relationships between exposure to oral salmon calcitonin and a surrogate marker of pharmacodynamic efficacy

M. Karsdal, C. Christiansen, B. Riis, 2009, European Journal of Clinical Pharmacology.

An immunoassay for measuring fragments of newly synthesized collagen type I produced during metastatic invasion of bone.

C. Christiansen, P. Qvist, P. Cloos, 2004, Clinical laboratory.

A Pharmacokinetic and Pharmacodynamic Comparison of Synthetic and Recombinant Oral Salmon Calcitonin

M. Karsdal, C. Christiansen, B. Riis, 2009, Journal of clinical pharmacology.

The measurement of secretory endometrial protein PP14 in serum from postmenopausal women receiving unopposed estrogen or continuously combined estrogen/progestogen.

C. Christiansen, B. Riis, I. Byrjalsen, 1989, Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology.

Progestational effects of combinations of gestodene on the postmenopausal endometrium during hormone replacement therapy.

C. Christiansen, N. Bjarnason, I. Byrjalsen, 1999, American journal of obstetrics and gynecology.

Enzyme-linked immunosorbent serum assays (ELISAs) for rat and human N-terminal pro-peptide of collagen type I (PINP)--assessment of corresponding epitopes.

M. Karsdal, P. Qvist, B. Riis, 2010, Clinical biochemistry.

Blood levels of matrix metalloproteinase generated C-reactive protein metabolite (CRPM) are a sensitive measure of chronic inflammation in OA

M. Karsdal, C. Christiansen, C. Ladel, 2020 .

Matrix metalloproteinase-12 (MMP-12) in osteoclasts: new lesson on the involvement of MMPs in bone resorption.

M. C. Ovejero, S. Shapiro, J. Delaissé, 2004, Bone.

Incidence of total hip and total knee replacements from the prospective epidemiologic risk factor study: considerations for event driven clinical trial design

M. Karsdal, C. Bager, A. Bihlet, 2019, BMC Musculoskeletal Disorders.

The influence of smoking on uterine bleeding during continuous and interrupted oral hormone therapy

C. Christiansen, P. Alexandersen, H. L. Jørgensen, 2007, Climacteric : the journal of the International Menopause Society.

The influence of smoking on uterine bleeding during sequential oral hormone therapy

C. Christiansen, H. L. Jørgensen, N. Bjarnason, 2007, Climacteric : the journal of the International Menopause Society.

Protein fingerprinting of the extracellular matrix remodelling in a rat model of liver fibrosis—a serological evaluation

M. Karsdal, C. Christiansen, W. Jiménez, 2013, Liver international : official journal of the International Association for the Study of the Liver.

Reduction of nocturnal rise in bone resorption by subcutaneous GLP-2.

J. Holst, C. Christiansen, P. Alexandersen, 2004, Bone.

Selective monitoring of vitamin D2 and D3 supplementation with a highly specific 25-hydroxyvitamin D3 immunoassay with negligible cross-reactivity to 25-hydroxyvitamin D2.

C. Christiansen, P. Glendenning, S. Vasikaran, 2009, Clinica chimica acta; international journal of clinical chemistry.

A low cartilage formation and repair endotype predicts radiographic progression of symptomatic knee osteoarthritis

M. Karsdal, S. Abramson, M. Attur, 2020, Journal of Orthopaedics and Traumatology.

Combined antiretroviral therapy attenuates hepatic extracellular matrix remodeling in HIV patients assessed by novel protein fingerprint markers

M. Karsdal, C. Strassburg, J. Rockstroh, 2014, AIDS.

Influence of food intake on the bioavailability and efficacy of oral calcitonin.

M. Karsdal, C. Christiansen, B. Riis, 2009, British Journal of Clinical Pharmacology.

Piperazine oestrone sulphate and interrupted norethisterone: effects on the postmenopausal endometrium

P. Alexandersen, I. Byrjalsen, Glaus Christiansen, 2000, BJOG : an international journal of obstetrics and gynaecology.

Long-term structural and symptomatic effects of intra-articular sprifermin in patients with knee osteoarthritis: 5-year results from the FORWARD study

F. Eckstein, M. Hochberg, P. Conaghan, 2021, Annals of the Rheumatic Diseases.

Strontium ranelate effect in postmenopausal women with different clinical levels of osteoarthritis

M. Karsdal, C. Christiansen, P. Alexandersen, 2011, Climacteric : the journal of the International Menopause Society.

Type IV collagen metabolism is associated with disease activity, radiographic progression and response to tocilizumab in rheumatoid arthritis.

M. Karsdal, P. Junker, N. Gudmann, 2018, Clinical and experimental rheumatology.

Early changes in blood-based joint tissue destruction biomarkers are predictive of response to tocilizumab in the LITHE study

M. Karsdal, C. Christiansen, A. Platt, 2016, Arthritis Research & Therapy.

IL-6 receptor inhibition positively modulates bone balance in rheumatoid arthritis patients with an inadequate response to anti-tumor necrosis factor therapy: biochemical marker analysis of bone metabolism in the tocilizumab RADIATE study (NCT00106522).

M. Karsdal, P. Emery, A. Platt, 2012, Seminars in arthritis and rheumatism.

Human inter-alpha-trypsin inhibitor and immunologically related inhibitors investigated by quantitative immunoelectrophoresis. II. Pathological conditions.

I. Byrjalsen, L. Odum, G. Hansen-Nord, 1987, Clinica chimica acta; international journal of clinical chemistry.

Slow migrating proteinase inhibitors in human serum.

L. Ødum, I. Byrjalsen, 1984 .

Increased urinary excretion of C-telopeptides of type II collagen (CTX-II) predicts cartilage loss over 21 months by MRI.

M. Karsdal, C. Christiansen, E. Dam, 2009, Osteoarthritis and cartilage.

Effect of tocilizumab combined with methotrexate on circulating biomarkers of synovium, cartilage, and bone in the LITHE study.

M. Karsdal, C. Christiansen, A. Platt, 2014, Seminars in arthritis and rheumatism.

Circulating Protein Fragments of Cartilage and Connective Tissue Degradation Are Diagnostic and Prognostic Markers of Rheumatoid Arthritis and Ankylosing Spondylitis

M. Karsdal, C. Christiansen, W. Maksymowych, 2013, PloS one.

Identification of progressors in osteoarthritis by combining biochemical and MRI-based markers

Mads Nielsen, Claus Christiansen, Marco Loog, 2009, Arthritis research & therapy.

Relationship between serum levels of tau fragments and clinical progression of Alzheimer's disease.

M. Karsdal, C. Christiansen, K. Henriksen, 2014, Journal of Alzheimer's disease : JAD.

Effect of Intra-Articular Sprifermin vs Placebo on Femorotibial Joint Cartilage Thickness in Patients With Osteoarthritis: The FORWARD Randomized Clinical Trial.

Felix Eckstein, Ali Guermazi, Marc C Hochberg, 2019, JAMA.

Acyl group distributions in tissue lipids of rats fed evening primrose oil (λ-linolenic plus linoleic acid) or soybean oil (α-linolenic plus linoleic acid)

C. Høy, I. Byrjalsen, D. Kirstein, 1983, Lipids.

GWAS of bone size yields twelve loci that also affect height, BMD, osteoarthritis or fractures

A. Uitterlinden, J. V. van Meurs, E. Zeggini, 2019, Nature Communications.

Two-dimensional gel analysis of human endometrial proteins: characterization of proteins with increased expression in hyperplasia and adenocarcinoma.

C. Christiansen, M. Larsen, S. Fey, 1999, Molecular human reproduction.

Serum placental protein 14: a novel marker of selective oestrogen receptor modulator action on the postmenopausal endometrium

C. Christiansen, L. Tankó, Y. Bagger, 2002, Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals.

Contribution of the advanced glycation end product pentosidine and of maturation of type I collagen to compressive biomechanical properties of human lumbar vertebrae.

M. Bouxsein, P. Delmas, S. Viguet-Carrin, 2006, Bone.

Cohort Profile: The Prospective Epidemiological Risk Factor (PERF) study.

M. Karsdal, C. Christiansen, P. Alexandersen, 2016, International journal of epidemiology.

Matrix Metalloproteinase Mediated Type I Collagen Degradation — An Independent Risk Factor for Mortality in Women

M. Karsdal, C. Christiansen, P. Alexandersen, 2015, EBioMedicine.

Serum endotrophin identifies optimal responders to PPARγ agonists in type 2 diabetes

M. Karsdal, C. Christiansen, D. Schuppan, 2016, Diabetologia.

PRO-C3-Levels in Patients with HIV/HCV-Co-Infection Reflect Fibrosis Stage and Degree of Portal Hypertension

Jonel Trebicka, Aleksander Krag, Inger Byrjalsen, 2014, PloS one.

Collagen Type III and VI Turnover in Response to Long-Term Immobilization

M. Karsdal, D. Felsenberg, D. Belavy, 2015, PloS one.

Suppression of active, but not total MMP-3, is associated with treatment response in a phase III clinical study of rheumatoid arthritis.

M. Karsdal, C. Christiansen, A. Siebuhr, 2018, Clinical and experimental rheumatology.

Immunoturbidimetry of Serum C-Reactive Protein in Low Concentration of Polyethylene Glycol

S. Ingwersen, I. Byrjalsen, 1985, Annals of Clinical Biochemistry.

A randomized, double-blind, multicenter, placebo-controlled study to evaluate the efficacy and safety of oral salmon calcitonin in the treatment of osteoporosis in postmenopausal women taking calcium and vitamin D.

M. Karsdal, C. Christiansen, P. Alexandersen, 2016, Bone.

High levels of biomarkers of collagen remodeling are associated with increased mortality in COPD – results from the ECLIPSE study

M. Karsdal, J. Vestbo, B. Miller, 2016, Respiratory Research.

Symptomatic and structural benefit of cathepsin K inhibition by MIV-711 in a subgroup with unilateral pain: post-hoc analysis of a randomised phase 2a clinical trial.

P. Conaghan, F. Öberg, M. Bowes, 2022, Clinical and experimental rheumatology.

Treatment of symptomatic knee osteoarthritis with oral salmon calcitonin: results from two phase 3 trials.

M. Karsdal, C. Christiansen, P. Alexandersen, 2015, Osteoarthritis and cartilage.

Relationships Between Knee Pain and Osteoarthritis Biomarkers Based on Systemic Fluids and Magnetic Resonance Imaging

Lars Arendt-Nielsen, Erik B. Dam, Claus Christiansen, 2011 .

Clinical evaluation of a matrix metalloproteinase-12 cleaved fragment of titin as a cardiovascular serological biomarker

M. Karsdal, K. Duffin, L. Rasmussen, 2012, Journal of Translational Medicine.

Fibrogenesis assessed by serological type III collagen formation identifies patients with progressive liver fibrosis and responders to a potential antifibrotic therapy.

M. Karsdal, C. Christiansen, D. Schuppan, 2016, American journal of physiology. Gastrointestinal and liver physiology.

OA phenotypes, rather than disease stage, drive structural progression--identification of structural progressors from 2 phase III randomized clinical studies with symptomatic knee OA.

M. Karsdal, C. Christiansen, P. Alexandersen, 2015, Osteoarthritis and cartilage.

Clinical and biochemical factors associated with risk of total joint replacement and radiographic progression in osteoarthritis: Data from two phase III clinical trials.

M. Karsdal, A. Bihlet, I. Byrjalsen, 2020, Seminars in arthritis and rheumatism.

Associations between biomarkers of bone and cartilage turnover, gender, pain categories and radiographic severity in knee osteoarthritis

M. Karsdal, C. Christiansen, B. Riis, 2019, Arthritis Research & Therapy.

Impact of source data verification on data quality in clinical trials: an empirical post hoc analysis of three phase 3 randomized clinical trials.

Jeppe Ragnar Andersen, Inger Byrjalsen, Asger Bihlet, 2015, British journal of clinical pharmacology.

Novel serological neo-epitope markers of extracellular matrix proteins for the detection of portal hypertension

M. Karsdal, C. Christiansen, J. Trebicka, 2013, Alimentary pharmacology & therapeutics.

Biochemical markers and the FDA Critical Path: How biomarkers may contribute to the understanding of pathophysiology and provide unique and necessary tools for drug development

M. Karsdal, C. Christiansen, E. Dam, 2009, Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals.

The Efficacy and Safety of Multiple Dose Regimens of Kudzu (Pueraria lobata) Root Extract on Bone and Cartilage Turnover and Menopausal Symptoms

M. Karsdal, C. Christiansen, B. Riis, 2021, Frontiers in Pharmacology.

Four-month treatment with GLP-2 significantly increases hip BMD: a randomized, placebo-controlled, dose-ranging study in postmenopausal women with low BMD.

J. Holst, C. Christiansen, P. Alexandersen, 2009, Bone.

Alpha CTX as a Biomarker of Skeletal Invasion of Breast Cancer: Immunolocalization and the Load Dependency of Urinary Excretion

M. Karsdal, L. Tankó, P. Qvist, 2006, Cancer Epidemiology Biomarkers & Prevention.

Role of Gastrointestinal Hormones in Postprandial Reduction of Bone Resorption

J. Holst, C. Christiansen, P. Alexandersen, 2003, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Biochemical markers identify influences on bone and cartilage degradation in osteoarthritis - the effect of sex, Kellgren-Lawrence (KL) score, Body Mass Index (BMI), oral salmon calcitonin (sCT) treatment and diurnal variation

M. Karsdal, C. Christiansen, B. Riis, 2010, BMC musculoskeletal disorders.

Serum C-reactive protein metabolite (CRPM) is associated with incidence of contralateral knee osteoarthritis

M. Karsdal, C. Christiansen, C. Ladel, 2021, Scientific Reports.

Serological Biomarkers of Joint Tissue Turnover Predict Tocilizumab Response at Baseline

M. Karsdal, C. Christiansen, A. Platt, 2014, Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases.

Secretory endometrial protein PP14 in serum from post-menopausal women receiving continuous combined oestradiol-cyproterone acetate: correlation with serum hormone concentrations and bleeding patterns.

C. Christiansen, B. Riis, I. Byrjalsen, 1992, Maturitas.

Serum placental protein 14 in pre-menopausal and post-menopausal women--dependency on oestrogen/progestogen status.

C. Christiansen, B. Riis, I. Byrjalsen, 1990, Maturitas.

"Mad pursuits"--markers of cell activity?

I. Byrjalsen, L. Thormann, 1991, Fertility and Sterility.