X. Huang

发表

Introduction to NMR and Its Application in Metabolite Structure Determination

R. Powers, V. Roongta, A. Tymiak, 2007 .

Biotransformation of Daclatasvir In Vitro and in Nonclinical Species: Formation of the Main Metabolite by Pyrrolidine δ-Oxidation and Rearrangement

W. Humphreys, L. Hamann, Y. Shu, 2016, Drug Metabolism and Disposition.

Discovery of BMS-955176, a Second Generation HIV-1 Maturation Inhibitor with Broad Spectrum Antiviral Activity.

B. Beno, N. Meanwell, Zeyu Lin, 2016, ACS medicinal chemistry letters.

15N chemical shifts of a series of isatin oxime ethers and their corresponding nitrone isomers

V. Roongta, N. Sin, B. Venables, 2010, Magnetic resonance in chemistry : MRC.

Bioactivation of cyclopropyl rings by P450: an observation encountered during the optimisation of a series of hepatitis C virus NS5B inhibitors

Y. Shu, N. Meanwell, K. Yeung, 2018, Xenobiotica; the fate of foreign compounds in biological systems.

Phosphocholine Conjugation: An Unexpected In Vivo Conjugation Pathway Associated with Hepatitis C NS5B Inhibitors Featuring A Bicyclo[1.1.1]Pentane

Joseph L. Cantone, D. Drexler, J. Leet, 2016, Drug Metabolism and Disposition.

Observation of OH…N scalar coupling across a hydrogen bond in nocathiacin I

K. Constantine, V. Roongta, J. Leet, 2007, Magnetic resonance in chemistry : MRC.

Discovery of 6-chloro-2-trifluoromethyl-7-aryl-7H-imidazo[1,2-a]imidazol-3-ylmethylamines, a novel class of corticotropin-releasing factor receptor type 1 (CRF1R) antagonists.

J. Macor, D. Zuev, G. Dubowchik, 2010, Bioorganic & medicinal chemistry letters.

Microbial transformations of betulinic and betulonic acids

F. Rinaldi, Zhiwei Guo, A. Goswami, 2015 .

Chemical conversion of nocathiacin I to nocathiacin II and a lactone analogue of glycothiohexide alpha.

J. Leet, M. Pucci, T. Connolly, 2005, Journal of natural products.

Inhibitors of HCV NS5A: From Iminothiazolidinones to Symmetrical Stilbenes.

N. Meanwell, M. Deshpande, Scott W. Martin, 2011, ACS medicinal chemistry letters.

Infrared and Nuclear Magnetic Resonance Spectroscopic Study of Secondary Amide Hydrogen Bonding in Benzoyl PABA Derivatives (Retinoids)

R. Dalterio, Kuo-Long Yu, X. Huang, 2007, Applied spectroscopy.

Identification of Glutathione Conjugates of Acetylene-Containing Positive Allosteric Modulators of Metabotropic Glutamate Receptor Subtype 5

Yue-Zhong Shu, Y. Shu, L. Snyder, 2015, Drug Metabolism and Disposition.

Tiered analytics for purity assessment of macrocyclic peptides in drug discovery: Analytical consideration and method development

D. Drexler, A. Tymiak, X. Huang, 2017, Journal of pharmaceutical and biomedical analysis.

Design, Synthesis, and SAR of C-3 Benzoic Acid, C-17 Triterpenoid Derivatives. Identification of the HIV-1 Maturation Inhibitor 4-((1 R,3a S,5a R,5b R,7a R,11a S,11b R,13a R,13b R)-3a-((2-(1,1-Dioxidothiomorpholino)ethyl)amino)-5a,5b,8,8,11a-pentamethyl-1-(prop-1-en-2-yl)-2,3,3a,4,5,5a,5b,6,7,7a,8,1

B. Beno, N. Meanwell, V. Arora, 2018, Journal of medicinal chemistry.

Inhibitors of human immunodeficiency virus type 1 (HIV-1) attachment 13. Synthesis and profiling of a novel amminium prodrug of the HIV-1 attachment inhibitor BMS-585248.

Michael Sinz, Dawn Parker, Kim A Johnson, 2013, Journal of medicinal chemistry.

Potential CRF1R PET imaging agents: N-fluoroalkyl-8-(6-methoxy-2-methylpyridin-3-yl)-2,7-dimethyl-N-alkylpyrazolo[1,5-a][1,3,5]triazin-4-amines.

J. Macor, D. Zuev, R. Mattson, 2011, Bioorganic & medicinal chemistry letters.

Discovery of Potent Hepatitis C Virus NS5A Inhibitors with Dimeric Structures

N. Meanwell, Scott W. Martin, Joseph L. Cantone, 2011, Antimicrobial Agents and Chemotherapy.

Identification of Glutathione Conjugates of Acetylene-Containing Positive Allosteric Modulators of Metabotropic Glutamate Receptor Subtype 5

Y. Shu, L. Snyder, Benjamin M. Johnson, 2015, Drug Metabolism and Disposition.

Bioactivation of cyclopropyl rings by P450: an observation encountered during the optimisation of a series of hepatitis C virus NS5B inhibitors

Y. Shu, N. Meanwell, K. Yeung, 2018, Xenobiotica; the fate of foreign compounds in biological systems.