N. Hutchinson

发表

Differential effects of IL-1 and TNF alpha on the expression of stromelysin, collagenase and their natural inhibitor, TIMP, in rheumatoid human synovial fibroblasts.

M. Lark, M. Tocci, K. Macnaul, 1992, Matrix (Stuttgart, Germany). Supplement.

Differential in vivo expression of collagenase messenger RNA in synovium and cartilage. Quantitative comparison with stromelysin messenger RNA levels in human rheumatoid arthritis and osteoarthritis patients and in two animal models of acute inflammatory arthritis.

M. Lark, K. Macnaul, F. Buechel, 1993, Arthritis and rheumatism.

Expression in Escherichia coli of fully active recombinant human IL 1 beta: comparison with native human IL 1 beta.

P. Cameron, J. Chin, J. Schmidt, 1987, Journal of immunology.

Susceptibility of stromelysin 1-deficient mice to collagen-induced arthritis and cartilage destruction.

J. Mudgett, Howard Y. Chen, H. Chen, 1998, Arthritis and rheumatism.

The immunosuppressant FK506 selectively inhibits expression of early T cell activation genes.

F. Dumont, J. Siekierka, C. S. Lin, 1989, Journal of immunology.

Expression of 92-kD type IV collagenase/gelatinase (gelatinase B) in osteoarthritic cartilage and its induction in normal human articular cartilage by interleukin 1.

W. Stetler-Stevenson, D. Schurman, F. Torti, 1993, The Journal of clinical investigation.

Molecular cloning, structure, and chromosomal localization of the human inducible nitric oxide synthase gene.

E. Hoffman, J. Mudgett, A. Nussler, 1994, The Journal of biological chemistry.

Discoordinate expression of stromelysin, collagenase, and tissue inhibitor of metalloproteinases-1 in rheumatoid human synovial fibroblasts. Synergistic effects of interleukin-1 and tumor necrosis factor-alpha on stromelysin expression.

M. Lark, M. Tocci, K. Macnaul, 1990, The Journal of biological chemistry.

Analysis of IL-1 and TNF-alpha gene expression in human rheumatoid synoviocytes and normal monocytes by in situ hybridization.

M. Tocci, K. Macnaul, N. Hutchinson, 1990, Journal of immunology.

Differential expression of iNOS and cNOS mRNA in human vascular smooth muscle cells and endothelial cells under normal and inflammatory conditions.

K. Macnaul, N. Hutchinson, 1993, Biochemical and biophysical research communications.

In vivo expression of stromelysin in synovium and cartilage of rabbits injected intraarticularly with interleukin-1 beta.

M. Lark, K. Macnaul, N. Hutchinson, 1992, Arthritis and rheumatism.

Induction of increased levels of proteoglycan fragments in synovial fluid (SF) and increased levels of stromelysin in cartilage, synovium and SF by intraarticular injection of canine monocyte conditioned medium into dogs.

M. Lark, N. Hutchinson, E. Bayne, 1994, The Journal of rheumatology.

Characterization of a new simian virus 40 mutant, tsA3900, isolated from deletion mutant tsA1499

N. Bouck, T. Shenk, M. M. Pater, 1985, Journal of virology.

Transformation by purified early genes of simian virus 40.

M. M. Pater, L. Chang, N. Hutchinson, 1984, Virology.

Lipopolysaccharide-induced hypotension and vascular hyporeactivity in the rat: tissue analysis of nitric oxide synthase mRNA and protein expression in the presence and absence of dexamethasone, NG-monomethyl-L-arginine or indomethacin.

D. Macintyre, T. Bach, S. Grant, 1995, The Journal of pharmacology and experimental therapeutics.

Effects of fluid‐induced shear on articular chondrocyte morphology and metabolism in vitro

N. Hutchinson, D. Carter, J. Cooke, 1995, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

The potential role of fibroblasts in periprosthetic osteolysis: Fibroblast response to titanium particles

J. Galante, T. Glant, K. Mikecz, 1995, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Expression and Immunoaffinity Purification of Human Inducible Nitric-oxide Synthase

M. MacCoss, P. Griffin, J. Weidner, 1996, The Journal of Biological Chemistry.

Altered responses to bacterial infection and endotoxic shock in mice lacking inducible nitric oxide synthase

C. Nathan, Howard Y. Chen, G. Hom, 1995, Cell.

Organization and expression of the major genes from the long inverted repeat of the human cytomegalovirus genome.

M. Tocci, N. Hutchinson, R. T. Sondermeyer, 1986, Virology.

Production, purification and characterization of canine prostromelysin.

M. Lark, P. Cameron, K. Macnaul, 1992, Matrix.

Aggrecan degradation in human cartilage. Evidence for both matrix metalloproteinase and aggrecanase activity in normal, osteoarthritic, and rheumatoid joints.

J. Weidner, L. Lohmander, M. Lark, 1997, The Journal of clinical investigation.

Characterization and complementation methylotrophus that have thermolabile C1 metabolism of mutants of Methylophilus forms of proteins involved in

P. Goodwin, N. Hutchinson, 1993 .

Characterization of a major early gene from the human cytomegalovirus long inverted repeat; predicted amino acid sequence of a 30-kDa protein encoded by the 1.2-kb mRNA.

M. Tocci, N. Hutchinson, 1986, Virology.

Inducible Nitric Oxide Synthase Requires Both the Canonical Calmodulin-binding Domain and Additional Sequences in Order to Bind Calmodulin and Produce Nitric Oxide in the Absence of Free Ca2+*

C. Nathan, J. Ruan, Q. Xie, 1996, The Journal of Biological Chemistry.

Human fibroblast stromelysin catalytic domain: expression, purification, and characterization of a C-terminally truncated form.

H K Chan, J. Hermes, W. Hagmann, 1991, Biochemistry.

Inducible Nitric Oxide Synthase Requires Both the Canonical Calmodulin-binding Domain and Additional Sequences in Order to Bind Calmodulin and Produce Nitric Oxide in the Absence of Free Ca 2

C. Nathan, J. Ruan, Q. Xie, 1996 .

Inducible Nitric Oxide Synthase Requires Both the Canonical Calmodulin-binding Domain and Additional Sequences in Order to Bind Calmodulin and Produce Nitric Oxide in the Absence of Free Ca*

C. Nathan, Q. Xie, N. Hutchinson, 1996 .

Active-site structure analysis of recombinant human inducible nitric oxide synthase using imidazole.

J. Kozarich, T. Kelly, R. Chabin, 1996, Biochemistry.

Differential amplification of specific areas of phage T4 genome as revealed by hybridization to cloned genetic segments.

N. Hutchinson, T. Mattson, A. Kozinski, 1980, Proceedings of the National Academy of Sciences of the United States of America.