J. Parker

发表

Site-selective modification strategies in antibody-drug conjugates.

Stephen J. Walsh, J. Carroll, D. Spring, 2020, Chemical Society reviews.

Correction: A general approach for the site-selective modification of native proteins, enabling the generation of stable and functional antibody–drug conjugates

Stephen J. Walsh, J. Carroll, D. Spring, 2018, Chemical science.

Rapid and robust cysteine bioconjugation with vinylheteroarenes†

Stephen J. Walsh, J. Carroll, D. Spring, 2021, Chemical science.

All-in-one disulfide bridging enables the generation of antibody conjugates with modular cargo loading

Stephen J. Walsh, J. Carroll, D. Spring, 2022, Chemical science.

General dual functionalisation of biomacromolecules via a cysteine bridging strategy.

Stephen J. Walsh, J. Carroll, D. Spring, 2020, Organic & biomolecular chemistry.

A general approach for the site-selective modification of native proteins, enabling the generation of stable and functional antibody–drug conjugates† †Dedicated to Professor Jack Baldwin on the occasion of his 80th birthday. ‡ ‡Electronic supplementary information (ESI) available. See DOI: 10.1039/c

Stephen J. Walsh, J. Carroll, D. Spring, 2018, Chemical science.

Synthesis and cycloaddition reactions of strained alkynes derived from 2,2'-dihydroxy-1,1'-biaryls.

M. Wills, J. Parker, Richard C. Knighton, 2018, Organic & biomolecular chemistry.

Discovery and Chemical Development of Tesirine: An Antitumor Pyrrolobenzodiazepine Antibody-Drug Conjugate Drug-Linker

A. Tiberghien, J. Parker, 2020 .

Cleavable linkers in antibody-drug conjugates.

D. Spring, Albert Isidro-Llobet, Jonathan D Bargh, 2019, Chemical Society reviews.

An Isomerization Approach to Tesirine and Pyrrolobenzodiazepines

A. Tiberghien, J. Parker, A. Campbell, 2019, Organic Process Research & Development.

An Alternative Focus for Route Design for the Synthesis of Antibody-Drug Conjugate Payloads.

A. Tiberghien, P. Howard, William R. F. Goundry, 2019, The Journal of organic chemistry.

The Development and Scale-Up of an Antibody Drug Conjugate Tubulysin Payload

David W. Anderson, Beatrice A. Maltman, J. Parker, 2017 .

A strained alkyne-containing bipyridine reagent; synthesis, reactivity and fluorescence properties

M. Wills, N. Chmel, J. Parker, 2019, RSC advances.

Novel thienopyrrole glycogen phosphorylase inhibitors: synthesis, in vitro SAR and crystallographic studies.

Paul M. Murray, L. Otterbein, N. Oikonomakos, 2006, Bioorganic & medicinal chemistry letters.

New modes for the osmium-catalyzed oxidative cyclization.

T. Donohoe, J. Parker, C. Callens, 2010, Organic letters.

Design and optimisation of dendrimer-conjugated Bcl-2/xL inhibitor, AZD0466, with improved therapeutic index for cancer therapy

E. Hennessy, S. Fawell, B. Davies, 2021, Communications biology.

Payloads for Antibody–Drug Conjugates

William R. F. Goundry, J. Parker, 2022, Organic Process Research & Development.

Synthesis and characterization of dendrimer-based polysarcosine star polymers: well-defined, versatile platforms designed for drug delivery applications.

A. Gunnarsson, M. Ashford, Richard M. England, 2020, Biomacromolecules.

Bifurcate, tandem ATRC reactions: Towards 2-oxabicyclo[4.3.0]nonane core of eunicellins

J. Raftery, M. Helliwell, P. Quayle, 2005 .

Peracetic Acid: An Atom-Economical Reagent for Pd-Catalyzed Acetoxylation of C–H Bonds

K. K. Hii, J. Parker, Christopher J. Mulligan, 2018, ACS Sustainable Chemistry & Engineering.

Expedited Kilolab Development of AZD7624 Using Kulinkovich-de Meijere Cyclopropanation

A. Steven, M. Ashok, H. Leuser, 2021, Organic Process Research & Development.

A New Approach to the Rapid Parallel Development of Four Neurokinin Antagonists. Part 3. Assembly of Neurokinin Antagonists

W. O. Moss, M. J. Young, Paul M. Murray, 2003 .

A robust first-pass protocol for the heck-mizoroki reaction

Paul M. Murray, Joseph B. Sweeney, Jeremy S. Parker, 2013 .

Spiro-fused pyrrolidine, piperidine, and oxindole scaffolds from lactams.

Matthew W D Perry, Timothy Gallagher, C. Hirschhäuser, 2012, Organic letters.

Manganese(III) acetate mediated oxidative radical cyclizations. Toward vicinal all-carbon quaternary stereocenters.

J. Burton, J. Parker, Angus W J Logan, 2012, Organic letters.

Atom transfer radical cyclization reactions (ATRC): Synthetic applications

J. Raftery, Chris D. Edlin, M. Helliwell, 2006 .

Total synthesis of (+)-cis-sylvaticin: double oxidative cyclization reactions catalyzed by osmium.

Robert M. Harris, T. Donohoe, J. Burrows, 2006, Journal of the American Chemical Society.

Toward catalyst economy : A programmed approach to the synthesis of bicyclic lactones and lactams

J. Raftery, Chris D. Edlin, D. House, 2006 .

Studies towards a postulated biomimetic Diels-Alder reaction for the synthesis of himgravine

J. Baldwin, A. Russell, R. Chesworth, 1995 .

Total Synthesis of (+)‐cis‐Sylvaticin: Double Oxidative Cyclization Reactions Catalyzed by Osmium.

Robert M. Harris, T. Donohoe, J. Burrows, 2007 .

A new approach to the rapid parallel development of four neurokinin antagonists. Part 5. Preparation of zm374979 cyanoacid and selective crystallisation of ZM374979 atropisomers

W. O. Moss, N. Smith, J. Parker, 2004 .

Concise syntheses of the natural products (+)-sylvaticin and (+)-cis-sylvaticin.

Robert M. Harris, T. Donohoe, J. Burrows, 2009, Journal of the American Chemical Society.

Asymmetric Reduction of Lactam-Based β-Aminoacrylates. Synthesis of Heterocyclic β(2)-Amino Acids.

T. Gallagher, M. Perry, H. Campello, 2016, Organic letters.

Kepner-Tregoe Decision Analysis as a Tool to Aid Route Selection. Part 1

Jonathan D. Moseley, Jeremy S. Parker, J. Moseley, 2008 .

Total synthesis and biological evaluation of simplified aplyronine analogues as synthetically tractable anticancer agents.

Stephen J. Walsh, J. Carroll, D. Spring, 2020, Chemical communications.

Pyridine-N-oxide as a mild reoxidant which transforms osmium-catalyzed oxidative cyclization.

T. Donohoe, P. Glossop, J. Parker, 2008, Angewandte Chemie.

Macrocyclisation and functionalisation of unprotected peptides via divinyltriazine cysteine stapling.

Stephen J. Walsh, D. Spring, N. Robertson, 2019, Chemical communications.

Concise copper-catalyzed synthesis of tricyclic biaryl ether-linked aza-heterocyclic ring systems.

D. Spring, W. R. Galloway, J. Parker, 2013, Organic letters.

New osmium-based reagent for the dihydroxylation of alkenes.

Robert M. Harris, T. Donohoe, S. Butterworth, 2006, The Journal of organic chemistry.

Revisiting the mechanism of the Fujiwara–Moritani reaction

K. K. Hii, J. Parker, Christopher J. Mulligan, 2020, Reaction Chemistry & Engineering.

Scale-up Synthesis of Tesirine

A. Tiberghien, P. Howard, C. Noti, 2018, Organic Process Research & Development.

RETRACTED: Biomimetic approach to Galbulimina type I alkaloids

J. Baldwin, K. Tchabanenko, R. Adlington, 2005 .

Pyridine-N-oxide as a mild reoxidant which transforms osmium-catalyzed oxidative cyclization.

T. Donohoe, P. Glossop, J. Parker, 2008, Angewandte Chemie.

Stephen J. Walsh, J. Carroll, D. Spring, 2018, Chemical science.

Macrocyclisation and functionalisation of unprotected peptides via divinyltriazine cysteine stapling.

Stephen J. Walsh, D. Spring, Yuteng Wu, 2019, Chemical communications.

Tandem catalysis in the polycyclisation of dienes to produce multi-substituted tetrahydrofurans

T. Donohoe, J. Parker, P. Lindsay-Scott, 2009 .

Design and optimisation of dendrimer-conjugated Bcl-2/xL inhibitor, AZD0466, with improved therapeutic index for cancer therapy

E. Hennessy, S. Fawell, B. Davies, 2021, Communications Biology.