L. Chen

发表

N-terminally PEGylated human interferon-beta-1a with improved pharmacokinetic properties and in vivo efficacy in a melanoma angiogenesis model.

A. Whitty, D. Baker, D. Lindner, 2006, Bioconjugate chemistry.

Identification of potent type I MetAP inhibitors by simple bioisosteric replacement. Part 1: Synthesis and preliminary SAR studies of thiazole-4-carboxylic acid thiazol-2-ylamide derivatives.

F. Nan, Q. Ye, Jia Li, 2005, Bioorganic & medicinal chemistry letters.

Specificity for inhibitors of metal-substituted methionine aminopeptidase.

F. Nan, Jia Li, Q. Ye, 2003, Biochemical and biophysical research communications.

Functional Characterization of Integrin α6β4 Adhesion Interactions Using Soluble Integrin Constructs Reveals the Involvement of Different Functional Domains in the β4 Subunit

Samuel Y. Cho, K. Mclachlan, Heather A. Huet, 2008, Cell communication & adhesion.

Impact of Substituents Attached to N‐Heterocyclic Carbenes on the Catalytic Activity of Copper Complexes in the Reduction of Carbonyl Compounds with Triethoxysilane

Jiajian Peng, Zheng Xu, Huayu Qiu, 2009 .

Inhibitors of type I MetAPs containing pyridine-2-carboxylic acid thiazol-2-ylamide. Part 2: SAR studies on the pyridine ring 3-substituent.

F. Nan, Q. Ye, Jia Li, 2005, Bioorganic & medicinal chemistry letters.

Synthetic antibodies and peptides recognizing progressive multifocal leukoencephalopathy-specific point mutations in polyomavirus JC capsid viral protein 1

K. Simon, P. Weinreb, S. Sidhu, 2015, mAbs.

Discovery and structural modification of inhibitors of methionine aminopeptidases from Escherichia coli and Saccharomyces cerevisiae.

F. Nan, G. Lushington, Q. Ye, 2003, Journal of medicinal chemistry.

Rapid Selective Defunctionalization of the Carbonyl Group of α,β-Unsaturated Ketones with Trialkoxylsilane/ZnX2

Jiajian Peng, G. Lai, Jiayun Li, 2011 .

Characterization of full length and truncated type I human methionine aminopeptidases expressed from Escherichia coli.

M. Gu, F. Nan, Q. Ye, 2004, Biochemistry.

Mutations at the S1 Sites of Methionine Aminopeptidases from Escherichia coli and Homo sapiens Reveal the Residues Critical for Substrate Specificity*

M. Gu, F. Nan, Q. Ye, 2004, Journal of Biological Chemistry.

Structure of a NEMO/IKK-associating domain reveals architecture of the interaction site.

Scott Bowes, Alexey Lugovskoy, Ling Ling Chen, 2008, Structure.

The Src Kinase p56 lck Up-regulates VLA-4 Integrin Affinity

R. Alon, D. Yablonski, T. Yednock, 2001, The Journal of Biological Chemistry.

Antibody blockade of the Cripto CFC domain suppresses tumor cell growth in vivo.

Mohammad Zafari, Kevin P Williams, Ling Ling Chen, 2003, The Journal of clinical investigation.

Antibodies directed to α6β4 highlight the adhesive and signaling functions of the integrin in breast cancer cell lines

Samuel Y. Cho, Christilyn P. Graff, K. Mclachlan, 2010, Cancer biology & therapy.

Expression, purification, and characterization of rat interferon-beta, and preparation of an N-terminally PEGylated form with improved pharmacokinetic parameters.

B. Domon, D. Baker, R. Arduini, 2004, Protein expression and purification.

Antibody humanization by redesign of complementarity-determining region residues proximate to the acceptor framework.

Herman W T van Vlijmen, Alexey Lugovskoy, Ling Ling Chen, 2014, Methods.

Evidence That Ligand and Metal Ion Binding to Integrin α4β1 Are Regulated through a Coupled Equilibrium*

A. Whitty, R. Petter, R. Pepinsky, 2001, The Journal of Biological Chemistry.

Multiple Activation States of Integrin α4β1 Detected through Their Different Affinities for a Small Molecule Ligand*

A. Whitty, R. Pepinsky, S. Adams, 1999, The Journal of Biological Chemistry.

Comparative assessment of the ligand and metal ion binding properties of integrins alpha9beta1 and alpha4beta1.

A. Whitty, B. Dolinski, C. Raab, 2002, Biochemistry.

Herbicidal activity and bioactive components of Brucea javanica (L.) Merr. residue

S. Y. Liu, Dongqiang Zeng, W. Tang, 2021, Arabian Journal of Chemistry.

Inhibitors of type I MetAPs containing pyridine-2-carboxylic acid thiazol-2-ylamide. Part 1: SAR studies on the determination of the key scaffold.

F. Nan, Q. Ye, Qun-Li Luo, 2005, Bioorganic & medicinal chemistry letters.

Identification of potent type I MetAPs inhibitors by simple bioisosteric replacement. Part 2: SAR studies of 5-heteroalkyl substituted TCAT derivatives.

F. Nan, Q. Ye, L. Chen, 2005, Bioorganic & medicinal chemistry letters.

The increased potency of cross-linked lymphocyte function-associated antigen-3 (LFA-3) multimers is a direct consequence of changes in valency.

R. Pepinsky, L. L. Chen, W. Meier, 1991, The Journal of biological chemistry.

Design and synthesis of chromogenic thiopeptolide substrates as MetAPs active site probes.

F. Nan, Q. Ye, L. Chen, 2004, Bioorganic & medicinal chemistry.