T. Luker

发表

Substituted indole-1-acetic acids as potent and selective CRTh2 antagonists-discovery of AZD1981.

S. Teague, S. Thom, A. Cook, 2011, Bioorganic & medicinal chemistry letters.

Prediction of Efficacious Inhalation Lung Doses via the Use of In Silico Lung Retention Quantitative Structure-Activity Relationship Models and In Vitro Potency Screens

Anne Cooper, Tim Potter, Tim Luker, 2010, Drug Metabolism and Disposition.

Facile and regioselective synthesis of novel 2,4-disubstituted-5-fluoropyrimidines as potential kinase inhibitors

H. Sanganee, H. Wada, T. Luker, 2012 .

Palladium catalysed amination of electron deficient halothiophenes

H. Beaton, D. Cheshire, M. Whiting, 2000 .

Substituted Indole‐1‐acetic Acids as Potent and Selective CRTh2 Antagonists — Discovery of AZD1981 (I).

T. Luker, 2012 .

Synthesis and reactivity of pyrrolidinone- and piperidinone-derived enol triflates

H. Hiemstra, W. Speckamp, T. Luker, 1996 .

Deferitazole, a new orally active iron chelator.

V. Abbate, Xiaole Kong, R. Hider, 2015, Dalton transactions.

Switching between agonists and antagonists at CRTh2 in a series of highly potent and selective biaryl phenoxyacetic acids.

A. Davis, G. Pairaudeau, S. Thom, 2011, Bioorganic & medicinal chemistry letters.

Organozirconium methods for the efficient construction of the bicyclo[9.3.0]tetradecane dolabellane skeleton

R. Whitby, T. Luker, 1996 .

The tandem insertion of lithium chloroallylide and various electrophiles into zirconacyclopentanes

R. Whitby, T. Luker, 1995 .

The tandem insertion of allyl carbenoids and aldehydes or ketones into zirconacyclopentanes: Variation of the allyl Moiety and functionalisation of the final carbon-zirconium bond

R. Whitby, T. Luker, 1994 .

Enantioselective formal total synthesis of roseophilin.

H. Hiemstra, W. Speckamp, T. Luker, 2000, Organic letters.

Lipophilicity of acidic compounds: impact of ion pair partitioning on drug design.

M. Wenlock, P. Barton, T. Luker, 2011, Bioorganic & medicinal chemistry letters.

Molybdenum-mediated carbonylation of aryl halides with nucleophiles using microwave irradiation.

Bryan E. Roberts, L. Alcaraz, Michael J. Stocks, 2010, Organic letters.

Molybdenum-mediated synthesis of quinazolin-4(3H)-ones via cyclocarbonylation using microwave irradiation

Nicola J. Webb, Bryan E. Roberts, Michael J. Stocks, 2011 .

Zwitterionic CRTh2 antagonists.

S. Thom, A. Cook, S. Paine, 2011, Journal of medicinal chemistry.

Insertion of phenyl azide and diphenyldiazomethane into bis(cyclopentadienyl)zirconacyclopentanes. Crystal structure of an 18-electron alkyl zirconocene triazenido complex

R. Whitby, T. Luker, M. Webster, 1995 .

Permanganate oxidation of 1,5,9-trienes: stereoselective synthesis of tetrahydrofuran-containing fragments.

R. Hughes, C. Bataille, Richard C. D. Brown, 2002, The Journal of organic chemistry.

Formation of medium-size bridged ring systems via ring-closing metathesis of 2,5-disubstituted-2,3-dihydro-1H-pyrroles

H. Schenk, K. Goubitz, H. Hiemstra, 2000 .

trans-2-Tritylcyclohexanol as a chiral auxiliary in permanganate-mediated oxidative cyclization of 2-methylenehept-5-enoates: application to the synthesis of trans-(+)-linalool oxide.

C. Bataille, N. Camp, Richard C. D. Brown, 2014, Organic letters.

Total Synthesis of Desoxoprosophylline: Application of a Lactam-Derived Enol Triflate to Natural Product Synthesis

H. Hiemstra, W. Speckamp, T. Luker, 1997 .

The Regiochemistry of Carbenoid Insertion into Zirconacycles

R. Whitby, T. Luker, M. Tuckett, 2000 .

Elaboration of zirconacyclopentanes by sequential insertion of lithium chloroallylide and ketones or aldehydes

R. Whitby, T. Luker, 1994 .

The discovery of novel, potent and highly selective inhibitors of inducible nitric oxide synthase (iNOS).

Glen Andrews, Paul D Leeson, Anders Åberg, 2011, Bioorganic & medicinal chemistry letters.

Discovery of potent and selective adamantane-based small-molecule P2X(7) receptor antagonists/interleukin-1beta inhibitors.

Martin Braddock, Mark Furber, Keith Bowers, 2007, Journal of medicinal chemistry.

Strategies to improve in vivo toxicology outcomes for basic candidate drug molecules.

Niklas Blomberg, Britt-Marie Swahn, Paul D Leeson, 2011, Bioorganic & medicinal chemistry letters.

Enantioselective formal synthesis of eurylene: synthesis of the cis- and trans-THF fragments using oxidative cyclization.

C. Bataille, Richard C. D. Brown, T. Luker, 2010, Organic letters.

trans-2-Tritylcyclohexanol as a chiral auxiliary in permanganate-mediated oxidative cyclization of 2-methylenehept-5-enoates: application to the synthesis of trans-(+)-linalool oxide.

C. Bataille, N. Camp, Richard C. D. Brown, 2014, Organic letters.