Wenlin Huang

发表

Novel Bumped Kinase Inhibitors Are Safe and Effective Therapeutics in the Calf Clinical Model for Cryptosporidiosis.

Dustin J Maly, W. V. Van Voorhis, K. Ojo, 2016, The Journal of infectious diseases.

One health therapeutics: Target-Based drug development for cryptosporidiosis and other apicomplexa diseases.

Dustin J Maly, W. V. Voorhis, S. Tzipori, 2020, Veterinary parasitology.

5-Fluoroimidazo[4,5-b]pyridine Is a Privileged Fragment That Conveys Bioavailability to Potent Trypanosomal Methionyl-tRNA Synthetase Inhibitors

M. Gelb, F. Buckner, C. Verlinde, 2016, ACS infectious diseases.

5-Aminopyrazole-4-carboxamide analogues are selective inhibitors of Plasmodium falciparum microgametocyte exflagellation and potential malaria transmission blocking agents.

Dustin J Maly, S. Lindner, W. V. Van Voorhis, 2016, Bioorganic & medicinal chemistry letters.

Bumped Kinase Inhibitors as therapy for apicomplexan parasitic diseases: lessons learned.

Dustin J Maly, D. Kempf, R. Hackman, 2020, International journal for parasitology.

Structure-guided design of novel Trypanosoma brucei Methionyl-tRNA synthetase inhibitors.

F. Buckner, C. Verlinde, W. Hol, 2016, European journal of medicinal chemistry.

Development of an Orally Available and Central Nervous System (CNS) Penetrant Toxoplasma gondii Calcium-Dependent Protein Kinase 1 (TgCDPK1) Inhibitor with Minimal Human Ether-a-go-go-Related Gene (hERG) Activity for the Treatment of Toxoplasmosis.

Dustin J Maly, W. Hol, M. Parsons, 2016, Journal of medicinal chemistry.

SAR Studies of 5-Aminopyrazole-4-carboxamide Analogues as Potent and Selective Inhibitors of Toxoplasma gondii CDPK1

Dustin J Maly, W. Hol, M. Parsons, 2015, ACS medicinal chemistry letters.

Pharmacokinetics and In Vivo Efficacy of Pyrazolopyrimidine, Pyrrolopyrimidine, and 5-Aminopyrazole-4-Carboxamide Bumped Kinase Inhibitors against Toxoplasmosis.

Dustin J Maly, M. Parsons, A. DeRocher, 2018, The Journal of infectious diseases.

Development of 5-Aminopyrazole-4-carboxamide-based Bumped-Kinase Inhibitors for Cryptosporidiosis Therapy.

R. Hackman, W. V. Van Voorhis, K. Ojo, 2019, Journal of medicinal chemistry.

5-Aminopyrazole-4-Carboxamide-Based Compounds Prevent the Growth of Cryptosporidium parvum

Dustin J Maly, W. V. Van Voorhis, K. Ojo, 2017, Antimicrobial Agents and Chemotherapy.

7 H-Pyrrolo[2,3- d]pyrimidin-4-amine-Based Inhibitors of Calcium-Dependent Protein Kinase 1 Have Distinct Inhibitory and Oral Pharmacokinetic Characteristics Compared with 1 H-Pyrazolo[3,4- d]pyrimidin-4-amine-Based Inhibitors.

Dustin J Maly, E. Merritt, W. V. Van Voorhis, 2018, ACS infectious diseases.

Necessity of Bumped Kinase Inhibitor Gastrointestinal Exposure in Treating Cryptosporidium Infection

Dustin J Maly, B. Striepen, W. V. Van Voorhis, 2017, The Journal of infectious diseases.

Optimization of a binding fragment targeting the "enlarged methionine pocket" leads to potent Trypanosoma brucei methionyl-tRNA synthetase inhibitors.

F. Buckner, C. Verlinde, W. Hol, 2017, Bioorganic & medicinal chemistry letters.

Design, synthesis and biological evaluation of indolizine derivatives as HIV-1 VIF–ElonginC interaction inhibitors

Xianghui Yu, L. Zhang, Zhenjun Yang, 2013, Molecular Diversity.

Design, synthesis and biological evaluation of indolizine derivatives as HIV-1 VIF–ElonginC interaction inhibitors

Xianghui Yu, Zhenjun Yang, Lihe Zhang, 2013, Molecular Diversity.

Optimization of Methionyl tRNA-Synthetase Inhibitors for Treatment of Cryptosporidium Infection

F. Buckner, C. Verlinde, W. Hol, 2019, Antimicrobial Agents and Chemotherapy.

Development of Methionyl-tRNA Synthetase Inhibitors as Antibiotics for Gram-Positive Bacterial Infections

F. Buckner, C. Verlinde, W. Hol, 2017, Antimicrobial Agents and Chemotherapy.

Chemical Identity of Interaction of Protein with Reactive Metabolite of Diosbulbin B In Vitro and In Vivo

Jiang Zheng, Dongju Lin, Kai Wang, 2017, Toxins.

Chemical Reactivity of Emodin and Its Oxidative Metabolites to Thiols.

Jiang Zheng, Ying Peng, Wenlin Huang, 2016, Chemical Research in Toxicology.

Cysteine-Based Protein Adduction by Epoxide-Derived Metabolite(s) of Benzbromarone.

Jiang Zheng, Xiucai Guo, Ying Peng, 2016, Chemical research in toxicology.

Structure-guided discovery of selective methionyl-tRNA synthetase inhibitors with potent activity against Trypanosoma brucei.

F. Buckner, C. Verlinde, W. Hol, 2020, RSC medicinal chemistry.

Chemical Interaction of Protein Cysteine Residues with Reactive Metabolites of Methyleugenol.

Jiang Zheng, Ying Peng, Wenlin Huang, 2017, Chemical research in toxicology.

Comparative Study of Hepatotoxicity of Pyrrolizidine Alkaloids Retrorsine and Monocrotaline.

Yingqiong Sun, Jiang Zheng, Xiucai Guo, 2017, Chemical research in toxicology.

Design, synthesis and biological evaluation of indolizine derivatives as HIV-1 VIF–ElonginC interaction inhibitors

Xianghui Yu, L. Zhang, Zhenjun Yang, 2013, Molecular Diversity.

A Novel Calcium-Dependent Kinase Inhibitor, Bumped Kinase Inhibitor 1517, Cures Cryptosporidiosis in Immunosuppressed Mice.

W. V. Van Voorhis, K. Ojo, Kasey L. Rivas, 2016, The Journal of infectious diseases.

Potent and selective inhibitors of CDPK1 from T. gondii and C. parvum based on a 5-aminopyrazole-4-carboxamide scaffold.

Dustin J Maly, K. Comess, C. Verlinde, 2014, ACS medicinal chemistry letters.

Comparison of Toxicities among Different Bumped Kinase Inhibitor Analogs for Treatment of Cryptosporidiosis

S. Tzipori, D. Kempf, R. Hackman, 2023, Antimicrobial agents and chemotherapy.

Comparative assessment of the effects of bumped kinase inhibitors on early zebrafish embryo development and pregnancy in mice

Dustin J Maly, Joachim Müller, W. V. Van Voorhis, 2020, bioRxiv.

Indolizine Derivatives as HIV‐1 VIF–ElonginC Interaction Inhibitors

Xianghui Yu, L. Zhang, Zhenjun Yang, 2013, Chemical biology & drug design.