J. N. Johnston

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Rapid synthesis of cyclic oligomeric depsipeptides with positional, stereochemical, and macrocycle size distribution control

Suzanne M. Batiste, J. N. Johnston, J. Johnston, 2016, Proceedings of the National Academy of Sciences.

Oxidative inter-/intermolecular alkene diamination of hydroxy styrenes with electron-rich amines.

J. N. Johnston, Michael W. Danneman, K. Hong, 2015, Organic letters.

Alkene diamination using electron-rich amines: hypervalent iodine-promoted inter-/intramolecular C-N bond formation.

J. N. Johnston, K. Hong, J. Johnston, 2014, Organic letters.

Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space

Jared T. Shaw, Derek S. Tan, D. E. Olson, 2018, ACS central science.

Characterization of Staphylococcus aureus infections in children with Down syndrome.

S. Kaplan, E. Mason, K. Hulten, 2015, Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy.

Synthesis and biological evaluation of flavonoids and related compounds as gastroprotective agents

J. N. Johnston, J. Ares, P. Outt, 1996 .

Enantioselective small molecule synthesis by carbon dioxide fixation using a dual Brønsted acid/base organocatalyst.

Thomas J. Struble, J. N. Johnston, Weiwei Wang, 2015, Journal of the American Chemical Society.

The inverted ketene synthon: a double umpolung approach to enantioselective β2,3-amino amide synthesis† †Electronic supplementary information (ESI) available: Complete experimental details and analytical data for all new compounds. See DOI: 10.1039/c8sc04330b

J. N. Johnston, Mahesh Vishe, J. Johnston, 2018, Chemical science.

Free radical-mediated vinyl amination: a mild, general pyrrolidinyl enamine synthesis

E. Prabhakaran, J. N. Johnston, Benjamin M. Nugent, 2003 .

Free Radical-Mediated Vinyl Amination: Access to N,N-Dialkyl Enamines and Their β-Stannyl and β-Thio Derivatives

E. Prabhakaran, J. N. Johnston, Kristen E. Nailor, 2002 .

Development of an Intermittent-Flow Enantioselective Aza-Henry Reaction Using an Arylnitromethane and Homogeneous Brønsted Acid-Base Catalyst with Recycle.

Martin D. Johnson, Michael A. Watkins, Martin D Johnson, 2016, Organic process research & development.

Exercise Causes Arrhythmogenic Remodeling of Intracellular Calcium Dynamics in Plakophilin-2–Deficient Hearts

B. Knollmann, A. Lundby, M. Delmar, 2022, Circulation.

Adaptation of a Small-Molecule Hydrogen-Bond Donor Catalyst to an Enantioselective Hetero-Diels–Alder Reaction Hypothesized for Brevianamide Biosynthesis

Daniel J Sprague, J. N. Johnston, Brandon A Vara, 2015, Organic letters.

Bifunctional asymmetric catalysis: amplification of Brønsted basicity can orthogonally increase the reactivity of a chiral Brønsted acid.

Tyler A. Davis, J. N. Johnston, J. Wilt, 2010, Journal of the American Chemical Society.

Use of comparative triazolinium triflate fragmentation rates as a tool to assay relative competency of Brønsted bases in N-->N proton transfer.

Matthew G. Donahue, J. N. Johnston, K. Hong, 2009, Bioorganic & medicinal chemistry letters.

A diastereo- and enantioselective synthesis of alpha-substituted anti-alpha,beta-diaminophosphonic acid derivatives.

M. Pink, J. N. Johnston, J. Wilt, 2008, Chemical communications.

A diastereo- and enantioselective synthesis of alpha-substituted syn-alpha,beta-diamino acids.

Anand Singh, J. N. Johnston, J. Johnston, 2008, Journal of the American Chemical Society.

Preparation of a protected phosphoramidon precursor via an H-phosphonate coupling strategy.

Matthew G. Donahue, J. N. Johnston, J. Johnston, 2006, Bioorganic & medicinal chemistry letters.

Synthesis of an advanced intermediate en route to the mitomycin natural products.

J. Srinivasan, J. N. Johnston, Amie L. Williams, 2006, Organic letters.

Chiral proton catalysis: a catalytic enantioselective direct aza-Henry reaction.

J. N. Johnston, Benjamin M. Nugent, Ryan A. Yoder, 2004, Journal of the American Chemical Society.

The Formation of Impossible Rings in Macrocyclooligomerizations for Cyclodepsipeptide Synthesis: The 18-from-12 Paradox.

J. N. Johnston, Abigail N. Smith, J. Johnston, 2021, The Journal of organic chemistry.

Direct Observation and Analysis of the Halo-Amino-Nitro Alkane Functional Group.

Michael S. Crocker, M. Pink, Kazuyuki Tokumaru, 2019, Chem.

Discovery of competing anaerobic and aerobic pathways in umpolung amide synthesis allows for site-selective amide 18O-labeling

Bo Shen, J. N. Johnston, Jessica P. Shackleford, 2011, Proceedings of the National Academy of Sciences.

Origins of selectivity in Brønsted acid-promoted diazoalkane-azomethine reactions (the aza-Darzens aziridine synthesis).

J. N. Johnston, H. Muchalski, K. Hong, 2011, Organic letters.

Enantioselective Synthesis of β-Fluoro Amines via β-Amino α-Fluoro Nitroalkanes and a Traceless Activating Group Strategy.

J. N. Johnston, Brandon A Vara, J. Johnston, 2016, Journal of the American Chemical Society.

A Unified Approach to the Four Azaindoline Families by Inter-/Intramolecular Annulative Diamination of Vinylpyridines.

J. N. Johnston, Michael W. Danneman, K. Hong, 2015, Organic letters.

Nonconventional carbon additions to azomethines. aryl amination/indoline synthesis by direct aryl radical addition to azomethine nitrogen.

E. Prabhakaran, M. Plotkin, J. N. Johnston, 2001, Organic letters.

Total synthesis of the lycopodium alkaloid (+)-serratezomine A.

J. N. Johnston, Julie A Pigza, A. Chandra, 2009, Journal of the American Chemical Society.

The first azacyclopentenyl carbinyl radical isomerizations (ACCRI): independent use of steric and electronic (polarization) effects as gating elements.

J. N. Johnston, R. Viswanathan, Daniel Mutnick, 2003, Journal of the American Chemical Society.

Enantioselective iodolactonization to prepare ε-lactone rings using hypervalent iodine

J. N. Johnston, Jenna L. Payne, Zihang Deng, 2022, Chemical science.

A Unified Approach to the Four Azaindoline Families by Inter‐/Intramolecular Annulative Diamination of Vinylpyridines.

J. N. Johnston, Michael W. Danneman, K. Hong, 2015 .

Free Radical-Mediated Aryl Amination: A Practical Synthesis of (R)- and (S)-7-Azaindoline α-Amino Acid.

J. Srinivasan, J. N. Johnston, Heather E Burks, 2005, Synthesis.

1,3,4-Oxadiazole and Heteroaromatic-Fused 1,2,4-Triazole Synthesis Using Diverted Umpolung Amide Synthesis

Kazuyuki Tokumaru, K. Bera, J. N. Johnston, 2017, Synthesis.

Free radical-mediated aryl amination and its use in a convergent [3 + 2] strategy for enantioselective indoline alpha-amino acid synthesis.

E. Prabhakaran, M. Plotkin, J. N. Johnston, 2003, Journal of the American Chemical Society.

‘Umpolung’ Reactivity in Semiaqueous Amide and Peptide Synthesis

Bo Shen, Bo Shen, Dawn M. Makley, 2010, Nature.

A case study in biomimetic total synthesis: polyolefin carbocyclizations to terpenes and steroids.

J. N. Johnston, Ryan A. Yoder, J. Johnston, 2005, Chemical reviews.

Total synthesis of the chlorine-containing hapalindoles K, A, and G.

J. N. Johnston, A. Chandra, J. Johnston, 2011, Angewandte Chemie.

Synthesis of the ABC- and D-ring systems of the indole alkaloid ambiguine G.

J. N. Johnston, R. Viswanathan, A. Chandra, 2007, Organic letters.

Lithium Aluminum Hydride–Cerium(III) Chloride

J. N. Johnston, 2001 .

Enantioselective and diastereoselective Mukaiyama-Michael reactions catalyzed by bis(oxazoline) copper(II) complexes.

K. Scheidt, M. Willis, D. Evans, 2001, Journal of the American Chemical Society.

Preparation of (-)-Nutlin-3 using enantioselective organocatalysis at decagram scale.

Tyler A. Davis, A. Richmond, A. Vilgelm, 2013, The Journal of organic chemistry.

Catalytic, Enantioselective Synthesis of Stilbene cis-Diamines: A Concise Preparation of (-)-Nutlin-3, a Potent p53/MDM2 Inhibitor.

Tyler A. Davis, J. N. Johnston, J. Johnston, 2011, Chemical science.

Stereoselective synthesis of complex polycyclic aziridines: use of the Brønsted acid-catalyzed aza-Darzens reaction to prepare an orthogonally protected mitomycin C intermediate with maximal convergency.

J. Srinivasan, J. Huffman, J. N. Johnston, 2011, Chemical communications.

A Remarkably Facile Zirconium(IV) → Aluminum(III) β-Diketiminate Transmetalation That Also Results in a More Active Olefin Polymerization Catalyst upon Activation

M. Pink, J. N. Coalter, J. N. Johnston, 2004 .

IAN‐Amines: Direct Entry to a Chiral C2‐Symmetric Zirconium(IV) β‐Diketimine Complex

J. N. Johnston, Sarah B. Cortright, J. Johnston, 2002 .

STUDIES DIRECTED TOWARD THE TOTAL SYNTHESIS OF POLYCAVERNOSIDE A. ENANTIOSELECTIVE SYNTHESIS OF THE DISACCHARIDE COMPONENT

L. Paquette, J. N. Johnston, J. Johnston, 1995 .

Single Stereodifferentiation Associated with Carbon Atom Insertion during the Oxonium Ion-Initiated Pinacol Rearrangement of Dihydrofuranyl and Dihydropyranyl Carbinols

L. Paquette, J. N. Johnston, J. Lanter, 1997 .

Cluster Preface: Alkene Halofunctionalization

T. Rovis, J. N. Johnston, J. Johnston, 2018, Synlett.

Bronsted acid-promoted olefin aziridination and formal anti-aminohydroxylation.

J. M. Mahoney, J. N. Johnston, Colin R. Smith, 2005, Journal of the American Chemical Society.

On the nature of rate acceleration in the synthesis and fragmentation of triazolines by Brønsted acid: secondary catalysis by water (hydronium triflate).

Matthew G. Donahue, J. N. Johnston, K. Hong, 2008, Journal of the American Chemical Society.

The Brønsted acid-catalyzed direct aza-Darzens synthesis of N-alkyl cis-aziridines.

J. N. Johnston, Amie L. Williams, A. L. Williams, 2004, Journal of the American Chemical Society.

Enantioselective Organocatalytic Amine-Isocyanate Capture-Cyclization: Regioselective Alkene Iodoamination for the Synthesis of Chiral Cyclic Ureas.

Thomas J. Struble, M. Pink, J. N. Johnston, 2018, ACS catalysis.

Enantioselective synthesis of α-oxy amides via Umpolung amide synthesis.

Bo Shen, J. N. Johnston, Matthew W. Leighty, 2012, Journal of the American Chemical Society.

Chiral Brønsted base-promoted nitroalkane alkylation: enantioselective synthesis of sec-alkyl-3-substituted indoles.

J. N. Johnston, Mark C. Dobish, J. Johnston, 2010, Organic letters.

To protonate or alkylate? Stereoselective Brønsted acid catalysis of C-C bond formation using diazoalkanes.

J. N. Johnston, H. Muchalski, Timothy L. Troyer, 2010, Angewandte Chemie.

Brønsted acid activation of alpha-diazo imide: a syn-selective glycolate Mannich reaction.

J. N. Johnston, H. Muchalski, Timothy L. Troyer, 2009, Chemical communications.

Fluorine-induced diastereodivergence discovered in an equally rare enantioselective syn-aza-Henry reaction

N. Schley, J. N. Johnston, Jade A Bing, 2022, Chemical science.

DFT-Based Stereochemical Rationales for the Bifunctional Brønsted Acid/Base-Catalyzed Diastereodivergent and Enantioselective aza-Henry Reactions of α-Nitro Esters.

Thomas J. Struble, T. Dudding, J. N. Johnston, 2021, The Journal of organic chemistry.

Catalytic enantioselective Michael additions to unsaturated ester derivatives using chiral copper(II) Lewis acid complexes.

M. Willis, D. Evans, J. N. Johnston, 1999, Organic letters.

Silyl Imine Electrophiles in Enantioselective Catalysis: A Rosetta Stone for Peptide Homologation, Enabling Diverse N-Protected Aryl Glycines from Aldehydes in Three Steps

Dawn M. Makley, J. N. Johnston, J. Johnston, 2014, Organic letters.

2,6‐Bis[(4S)‐4‐isopropyloxazolin‐2‐yl]pyridine

M. Kozlowski, J. N. Johnston, Alison E. Metz, 2014 .

Enantioselective Synthesis of cis- and trans-Cycloheptyl β-Fluoro Amines by Sequential aza-Henry Addition/Ring-Closing Metathesis.

J. N. Johnston, Jade A Bing, J. Johnston, 2023, Organic letters.

Chiral proton catalysis: enantioselective Brønsted acid catalyzed additions of nitroacetic acid derivatives as glycine equivalents.

Anand Singh, Bo Shen, J. N. Johnston, 2007, Journal of the American Chemical Society.

P-Chiral Phosphoramidates from a Catalytic Asymmetric Halocyclization

M. Pink, B. List, M. Monaco, 2015, Synfacts.

Enantioselective and Diastereoselective Mukaiyama—Michael Reactions Catalyzed by Bis(oxazoline) Copper(II) Complexes.

K. Scheidt, Davidr . Evans, M. Willis, 2001 .

Total synthesis of the Lycopodium alkaloid serratezomine A using free radical-mediated vinyl amination to prepare a β-stannyl enamine linchpin.

M. Pink, J. N. Johnston, Julie A Pigza, 2013, The Journal of organic chemistry.

Brønsted acid-promoted azide–olefin [3 + 2] cycloadditions for the preparation of contiguous aminopolyols: The importance of disiloxane ring size to a diastereoselective, bidirectional approach to zwittermicin A

J. N. Johnston, H. Muchalski, K. Hong, 2010, Beilstein journal of organic chemistry.

N‐Propenoyl Camphor‐10,2‐sultam

J. N. Johnston, 2003 .

Preparation of N-Aryl Amides by Epimerization-Free Umpolung Amide Synthesis.

Michael S. Crocker, J. N. Johnston, Michael S Crocker, 2022, Journal of the American Chemical Society.

Chromium(VI) Oxide–3,5‐Dimethylpyrazole

J. N. Johnston, J. Johnston, 2001 .

Free radical-mediated aryl amination: convergent two- and three-component couplings to chiral 2,3-disubstituted indolines.

E. Prabhakaran, J. N. Johnston, R. Viswanathan, 2008, The Journal of organic chemistry.

IAN Amines: Chiral C2-Symmetric Zirconium(IV) Complexes from Readily Modified Axially Chiral C1-Symmetric β-Diketimines

J. Huffman, J. N. Coalter, J. N. Johnston, 2004 .

Umpolung Amide Synthesis Using Substoichiometric N-Iodosuccinimide (NIS) and Oxygen as a Terminal Oxidant

Bo Shen, Kenneth E. Schwieter, J. N. Johnston, 2014, Organic letters.

Achiral counterion control of enantioselectivity in a Brønsted acid-catalyzed iodolactonization.

J. N. Johnston, Mark C. Dobish, 2012, Journal of the American Chemical Society.

PREPARATION OF ISOPROPYL 2-DIAZOACETYL(PHENYL)CARBAMATE.

J. N. Johnston, H. Muchalski, Timothy L. Troyer, 2012, Organic syntheses; an annual publication of satisfactory methods for the preparation of organic chemicals.

Continuous Platform to Generate Nitroalkanes On-Demand (in situ) using Peracetic Acid-Mediated Oxidation in a PFA Pipes-in-Series Reactor.

Martin D. Johnson, M. Yates, S. May, 2018, Organic process research & development.

Substituted Imidazoline Synthesis: A Diastereo- and Enantioselective aza-Henry Route to a Human Proteasome Modulator.

Daniel J Sprague, J. N. Johnston, J. Johnston, 2020, Organic letters.

A one-pot amidation of primary nitroalkanes.

Kenneth E. Schwieter, J. N. Johnston, J. Johnston, 2016, Chemical communications.

Stereoselective Synthesis of Complex Polycyclic Aziridines (XI): Use of the Broensted Acid-Catalyzed Aza-Darzens Reaction to Prepare an Orthogonally Protected Mitomycin C Intermediate with Maximal Convergency.

J. Srinivasan, J. Huffman, J. N. Johnston, 2011 .

Use of the vicinal element effect for regiochemical control of quinone substitutions and its implication for convergent mitomycin construction.

J. N. Johnston, A. L. Cox, 2001, Organic letters.

Organocatalytic, Diastereo- and Enantioselective Synthesis of Nonsymmetric cis-Stilbene Diamines: A Platform for the Preparation of Single-Enantiomer cis-Imidazolines for Protein–Protein Inhibition

Tyler A. Davis, Jaeki Min, Kristin E. Finch, 2014, The Journal of organic chemistry.

MDM2 Antagonists Counteract Drug-Induced DNA Damage

G. Ayers, D. Flaherty, Douglas B. Johnson, 2017, EBioMedicine.

Enantioselective Addition of Bromonitromethane to Aliphatic N-Boc Aldimines Using a Homogeneous Bifunctional Chiral Organocatalyst.

Kenneth E. Schwieter, J. N. Johnston, J. Johnston, 2015, ACS catalysis.

Preparation of (‐)‐Nutlin‐3 Using Enantioselective Organocatalysis at Decagram Scale.

Tyler A. Davis, A. Richmond, A. Vilgelm, 2014 .

VNI cures acute and chronic experimental Chagas disease.

M. Waterman, P. Nde, Candice A. Johnson, 2013, The Journal of infectious diseases.

Preparation of H,(4) PyrrolidineQuin-BAM (PBAM).

Tyler A. Davis, Aspen C Chun, Kenneth E. Schwieter, 2014, Organic syntheses; an annual publication of satisfactory methods for the preparation of organic chemicals.

Organocatalytic, enantioselective synthesis of VNI: a robust therapeutic development platform for Chagas, a neglected tropical disease.

M. Waterman, F. Villalta, G. Lepesheva, 2012, Organic letters.

Chiral proton catalysis of secondary nitroalkane additions to azomethine: synthesis of a potent GlyT1 inhibitor.

Tyler A. Davis, J. N. Johnston, Michael W. Danneman, 2012, Chemical communications.

A formal enantioselective acetate Mannich reaction: the nitro functional group as a traceless agent for activation and enantiocontrol in the synthesis of beta-amino acids.

Bo Shen, J. N. Johnston, 2008, Organic letters.

IAN-Amines: Direct Entry to a Chiral C2-Symmetric Zirconium(IV) β-Diketimine Complex Financial support has been provided by a GAANN Fellowship to S.B.C. (2001) and by Indiana University. IAN-amines are amines that are derived from Isoquinoline and 2-Amino Naphthalene.

J. N. Johnston, Sarah B. Cortright, 2002 .

A chiral N-phosphinyl phosphoramide: another offspring for the sage phosphoric acid progenitor.

J. N. Johnston, 2011, Angewandte Chemie.

Enantioselective synthesis of d-α-amino amides from aliphatic aldehydes

Kenneth E. Schwieter, J. N. Johnston, 2015, Chemical science.

Evidence for Ion-Templation During Macrocyclooligomerization of Depsipeptides.

Suzanne M. Batiste, J. N. Johnston, 2018, Journal of the American Chemical Society.

Structure-Activity Relationships for the N-Me- Versus N-H-Amide Modification to Macrocyclic ent-Verticilide Antiarrhythmics.

C. Hopkins, B. Knollmann, N. Schley, 2022, ACS medicinal chemistry letters.

Ring Size as an Independent Variable in Cyclooligomeric Depsipeptide Antiarrhythmic Activity.

B. Knollmann, Daniel J. Blackwell, J. N. Johnston, 2021, ACS medicinal chemistry letters.

Unnatural verticilide enantiomer inhibits type 2 ryanodine receptor-mediated calcium leak and is antiarrhythmic

R. Cornea, B. Knollmann, Daniel J. Blackwell, 2019, Proceedings of the National Academy of Sciences.

Chiral Proton Catalysis: pK a Determination for a BAM-HX Brnsted Acid

J. N. Johnston, Ryan A. Yoder, A. Hess, 2006 .

A convergent synthesis of 1,3,4-oxadiazoles from acyl hydrazides under semiaqueous conditions† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c7sc00195a Click here for additional data file.

Kazuyuki Tokumaru, J. N. Johnston, J. Johnston, 2017, Chemical science.

Stereochemical Models for the Enantiocontrolled Construction of Fully Functionalized C Rings via Intramolecular Aldolization in Advanced Precursors to Paclitaxel

L. Paquette, J. N. Johnston, Qingbei Zeng, 1998 .

Biomimetic Desymmetrization of a Carboxylic Acid.

M. Pink, J. N. Johnston, Michael W. Danneman, 2018, Journal of the American Chemical Society.

Methanesulfonic acid, 1,1,1-trifluoro-, comd. with (1R,2R)-N1,N2-di-2-quinolinyl-1,2-cyclohexanediamine (1:1)

J. N. Johnston, Roozbeh Yousefi, 2016 .