D. Wieczorek

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The rat alpha-tropomyosin gene generates a minimum of six different mRNAs coding for striated, smooth, and nonmuscle isoforms by alternative splicing

C. W. Smith, B. Nadal-Ginard, D. Wieczorek, 1988, Molecular and cellular biology.

A mouse model of familial hypertrophic cardiomyopathy caused by a α-tropomyosin mutation

B. Aronow, G. Boivin, J. Molkentin, 2003, Molecular and Cellular Biochemistry.

Sphingosine-1-Phosphate Receptor Modulator, FTY720, Improves Diastolic Dysfunction and Partially Reverses Atrial Remodeling in a Tm-E180G Mouse Model Linked to Hypertrophic Cardiomyopathy.

Shamim A. K. Chowdhury, C. Liew, B. Wolska, 2019, Circulation. Heart failure.

Functional effects of a tropomyosin mutation linked to FHC contribute to maladaptation during acidosis.

Katherine A. Sheehan, K. Sheehan, B. Wolska, 2011, Journal of molecular and cellular cardiology.

Investigations into tropomyosin function using mouse models.

G. Jagatheesan, S. Rajan, D. Wieczorek, 2010, Journal of molecular and cellular cardiology.

Cardiac myosin light chain phosphorylation and inotropic effects of a biased ligand, TRV120023, in a dilated cardiomyopathy model.

J. Violin, B. Wolska, C. Cowan, 2015, Cardiovascular research.

Tropomyosin pseudo-phosphorylation results in dilated cardiomyopathy

S. Liggett, B. Wolska, R. Solaro, 2018, The Journal of Biological Chemistry.

Analysis of fibrosis in control or pressure overloaded rat hearts after mechanical unloading by heterotopic heart transplantation

Tessa R Werner, H. Reichenspurner, K. Lorenz, 2019, Scientific Reports.

Characterization of a developmentally regulated perinatal myosin heavy-chain gene expressed in skeletal muscle.

B. Nadal-Ginard, M. Periasamy, D. Wieczorek, 1984, The Journal of biological chemistry.

Loss of the AE3 anion exchanger in a hypertrophic cardiomyopathy model causes rapid decompensation and heart failure.

S. Alper, J. Lorenz, V. Prasad, 2011, Journal of molecular and cellular cardiology.

Myocardial Infarction-induced N-terminal Fragment of Cardiac Myosin-binding Protein C (cMyBP-C) Impairs Myofilament Function in Human Myocardium*

T. Irving, P. D. de Tombe, Ying Ge, 2014, The Journal of Biological Chemistry.

Developmental analysis of tropomyosin gene expression in embryonic stem cells and mouse embryos

P. Howles, T. Doetschman, L. Pajak, 1993, Molecular and cellular biology.

Use of 2‐D DIGE analysis reveals altered phosphorylation in a tropomyosin mutant (Glu54Lys) linked to dilated cardiomyopathy

R. Solaro, C. Warren, S. Rajan, 2008, Proteomics.

Compensatory changes in Ca2+ and myocardial O2 consumption in β-tropomyosin transgenic hearts

A. Koretsky, G. MacGowan, C. Du, 2001 .

Compensatory changes in Ca(2+) and myocardial O(2) consumption in beta-tropomyosin transgenic hearts.

A. Koretsky, G. MacGowan, C. Du, 2001, American journal of physiology. Heart and circulatory physiology.

Desensitization of Myofilaments to Ca2+ as a Therapeutic Target for Hypertrophic Cardiomyopathy With Mutations in Thin Filament Proteins

S. Sadayappan, B. Wolska, J. Robbins, 2014, Circulation. Cardiovascular genetics.

p90 ribosomal S6 kinase 3 contributes to cardiac insufficiency in α-tropomyosin Glu180Gly transgenic mice.

M. Kapiloff, M. Kritzer, Zoharit Cozacov, 2013, American journal of physiology. Heart and circulatory physiology.

p 90 ribosomal S 6 kinase 3 contributes to cardiac insufficiency in-tropomyosin Glu 180 Gly transgenic mice

M. Kapiloff, M. Kritzer, Zoharit Cozacov, 2013 .

Ectopic expression of tropomyosin promotes myofibrillogenesis in mutant axolotl hearts

D. Dube, M. Muthuchamy, L. Lemanski, 1998, Developmental dynamics : an official publication of the American Association of Anatomists.

Molecular and Physiological Effects of α-Tropomyosin Ablation in the Mouse

T. Hewett, G. Boivin, B. Wolska, 1998 .

Molecular and Physiological Effects of (cid:97) -Tropomyosin Ablation in the Mouse

G. Boivin, B. Wolska, R. Solaro, 1998 .

Molecular and physiological effects of alpha-tropomyosin ablation in the mouse.

T. Hewett, G. Boivin, B. Wolska, 1998, Circulation research.

Striated muscle tropomyosin isoforms differentially regulate cardiac performance and myofilament calcium sensitivity

G. Boivin, S. Liggett, H. Tae, 2010, Journal of Muscle Research and Cell Motility.

β-Tropomyosin Overexpression Induces Severe Cardiac Abnormalities

G. Boivin, I. Grupp, M. Muthuchamy, 1998 .

Beta-tropomyosin overexpression induces severe cardiac abnormalities.

G. Boivin, I. Grupp, M. Muthuchamy, 1998, Journal of molecular and cellular cardiology.

Exchange of - for -Tropomyosin in Hearts of Transgenic Mice Induces Changes in Thin Filament Response to Ca, Strong Cross-bridge Binding, and Protein Phosphorylation (*)

R. Solaro, K. A. Palmiter, R. Solaro, 1996, The Journal of Biological Chemistry.

Regulation of alternatively spliced alpha-tropomyosin gene expression by nerve extract.

D. Wieczorek, 1988, The Journal of biological chemistry.

An internal domain of beta-tropomyosin increases myofilament Ca(2+) sensitivity.

G. Boivin, S. Liggett, M. Ashraf, 2009, American journal of physiology. Heart and circulatory physiology.

Altered hemodynamics in transgenic mice harboring mutant tropomyosin linked to hypertrophic cardiomyopathy.

B. Wolska, R. Solaro, M. Muthuchamy, 2000, American journal of physiology. Heart and circulatory physiology.

Cardiomyopathy: Getting Bigger All the Time - Lessons Learned about Heart Disease from Tropomyosin

D. Wieczorek, 2021 .

Mouse model of a familial hypertrophic cardiomyopathy mutation in alpha-tropomyosin manifests cardiac dysfunction.

G. Boivin, I. Grupp, B. Hoit, 1999, Circulation research.

The Role of Tropomyosin in Cardiac Function and Disease

D. Wieczorek, 2018, Cardiac Diseases and Interventions in 21st Century.

Early sensitization of myofilaments to Ca2+ prevents genetically linked dilated cardiomyopathy in mice

B. Wolska, R. Solaro, C. Warren, 2017, Cardiovascular research.

Tropomyosin Dephosphorylation Results in Compensated Cardiac Hypertrophy*

J. Molkentin, B. Wolska, R. Solaro, 2012, The Journal of Biological Chemistry.

Tropomyosin 3 expression leads to hypercontractility and attenuates myofilament length-dependent Ca(2+) activation.

G. Boivin, T. Irving, I. Grupp, 2002, American journal of physiology. Heart and circulatory physiology.

Tropomyosin 3 increases striated muscle isoform diversity.

D. Wieczorek, K. Pieples, Kathy Pieples, 2000, Biochemistry.

Identification of two new regions in the N‐terminus of cardiac troponin T that have divergent effects on cardiac contractile function

R. Mamidi, M. Chandra, D. Wieczorek, 2013, The Journal of physiology.

PKA accelerates rate of force development in murine skinned myocardium expressing alpha- or beta-tropomyosin.

R. Moss, S. Buck, M. Muthuchamy, 2001, American journal of physiology. Heart and circulatory physiology.

Tropomyosin structure and function new insights.

M. Muthuchamy, D. Wieczorek, P. Rethinasamy, 1997, Trends in cardiovascular medicine.

Ablation of plasma membrane Ca(2+)-ATPase isoform 4 prevents development of hypertrophy in a model of hypertrophic cardiomyopathy.

Jack Rubinstein, J. Lorenz, V. Prasad, 2014, Journal of molecular and cellular cardiology.

Tropomyosin de-phosphorylation in the heart: What are the consequences?

D. Wieczorek, E. M. Schulz, 2013, Journal of Muscle Research and Cell Motility.

Expression of tropomyosin-κ induces dilated cardiomyopathy and depresses cardiac myofilament tension by mechanisms involving cross-bridge dependent activation and altered tropomyosin phosphorylation

R. Solaro, C. Warren, S. Rajan, 2011, Journal of Muscle Research and Cell Motility.

Diminished myofibril organization in mutant axolotl hearts transfected with site-directed mutants of sarcomeric tropomyosins

D. Dube, B. Poiesz, M. Muthuchamy, 2007, Cardiovascular Toxicology.

Alteration of cardiac myofibrillogenesis by liposome-mediated delivery of exogenous proteins and nucleic acids into whole embryonic hearts

G. Işıtmangil, D. Dube, L. Lemanski, 2000, Anatomy and Embryology.

hypoxiaresponses of newborn rats to intermittent Threshold levels of maternal nicotine impairing

Shamim A. K. Chowdhury, A. Fuglevand, R. Levine, 2015 .

An internal domain of -tropomyosin increases myofilament Ca sensitivity

G. Boivin, S. Liggett, M. Ashraf, 2009 .

The Function of Normal and Familial Hypertrophic Cardiomyopathy-Associated Tropomyosin

R. Prabhakar, G. Jagatheesan, D. Wieczorek, 2002 .

Rescue of High Expression β-Tropomyosin Transgenic Mice by 5-Propyl-2-thiouracil

G. Boivin, B. Hoit, R. Prabhakar, 1999, The Journal of Biological Chemistry.

Sarcomeric myosin heavy chain gene family: organization and pattern of expression.

B. Nadal-Ginard, S. Izumo, E. Strehler, 1986, Medicine and science in sports and exercise.

Prevention of cardiac hypertrophy in mice by calcineurin inhibition.

Mark A Sussman, E. Olson, N. Gude, 1998, Science.

Molecular and Physiological Effects of Overexpressing Striated Muscle β-Tropomyosin in the Adult Murine Heart (*)

G. Boivin, I. Grupp, G. Grupp, 1995, The Journal of Biological Chemistry.

Mutually exclusive exon splicing of the cardiac calcium channel alpha 1 subunit gene generates developmentally regulated isoforms in the rat heart.

P. Ellinor, W. Koch, A. Schwartz, 1992, Proceedings of the National Academy of Sciences of the United States of America.

Developmentally regulated cDNA expressed exclusively in neural tissue.

D. Wieczorek, S. Hughes, 1991, Brain research. Molecular brain research.

The role of tropomyosin in the regulation of myocardial contraction and relaxation

B. Wolska, David F. Wieczorek, Beata M. Wolska, 2003, Pflügers Archiv.

Molecular and Functional Characterization of a Novel Cardiac-Specific Human Tropomyosin Isoform

Christian F. Bulcao, G. Boivin, S. Liggett, 2009, Circulation.

Expression of a novel tropomyosin isoform in axolotl heart and skeletal muscle

Anish Thomas, D. Dube, B. Poiesz, 2010, Journal of cellular biochemistry.

The role of tropomyosin in heart disease.

G. Jagatheesan, S. Rajan, D. Wieczorek, 2008, Advances in experimental medicine and biology.

Rescue of tropomyosin-induced familial hypertrophic cardiomyopathy mice by transgenesis.

G. Boivin, S. Liggett, R. Solaro, 2007, American journal of physiology. Heart and circulatory physiology.

Altered signaling surrounding the C-lobe of cardiac troponin C in myofilaments containing an α-tropomyosin mutation linked to familial hypertrophic cardiomyopathy

R. Prabhakar, R. Solaro, M. Sumandea, 2003 .

A familial hypertrophic cardiomyopathy alpha-tropomyosin mutation causes severe cardiac hypertrophy and death in mice.

G. Boivin, I. Grupp, B. Hoit, 2001, Journal of molecular and cellular cardiology.

PKA accelerates rate of force development in murine skinned myocardium expressing α- or β-tropomyosin

R. Moss, Daniel P. Fitzsimons, Jitandrakumar R. Patel, 2001 .

Conserved Asp-137 Is Important for both Structure and Regulatory Functions of Cardiac α-Tropomyosin (α-TM) in a Novel Transgenic Mouse Model Expressing α-TM-D137L*

Shamim A. K. Chowdhury, V. Gaponenko, B. Wolska, 2013, The Journal of Biological Chemistry.

Decreased Tropomyosin Flexibility in Ejecting Hearts

V. Gaponenko, M. Monasky, S. Rajan, 2013 .

Ceramide-mediated depression in cardiomyocyte contractility through PKC activation and modulation of myofilament protein phosphorylation

Shamim A. K. Chowdhury, S. Sadayappan, B. Wolska, 2014, Basic Research in Cardiology.

Co-expression of multiple myosin heavy chain genes, in addition to a tissue-specific one, in extraocular musculature

G. Butler-Browne, B. Nadal-Ginard, M. Periasamy, 1985, The Journal of cell biology.

Divergent Regulation of the Sarcomere and the Cytoskeleton*

G. O'Neill, E. Hardeman, T. Fath, 2008, Journal of Biological Chemistry.

Rescue of Familial Hypertrophic Cardiomyopathy by Altering Sarcomeric Exposure and Response to Calcium

B. Wolska, D. Wieczorek, 2011 .

Reprogramming of myosin light chain 1/3 expression in muscle heterokaryons.

M. Mariappan, L. Pajak, D. Wieczorek, 1991, Developmental biology.

Co-expression of Multiple Myosin Heavy In Addition to a Tissue-Specific One , in Extraocular Musculature Chain Genes ,

G. Butler-Browne, B. Nadal-Ginard, M. Periasamy, 2003 .

Physiological significance of troponin T binding domains in striated muscle tropomyosin.

G. Boivin, P. D. de Tombe, R. Solaro, 2004, American journal of physiology. Heart and circulatory physiology.

proteins during development of heart failure Exercise training normalizes altered calcium-handling

J. Seidman, C. Seidman, M. Eldar, 2015 .

Dilated Cardiomyopathy Mutant Tropomyosin Mice Develop Cardiac Dysfunction With Significantly Decreased Fractional Shortening and Myofilament Calcium Sensitivity

G. Boivin, S. Liggett, B. Wolska, 2007, Circulation research.

Microarray analysis of gene expression during early stages of mild and severe cardiac hypertrophy.

B. Aronow, G. Jagatheesan, A. Schwartz, 2006, Physiological genomics.

Reduced levels of mRNA for myofibrillar proteins in skeletal muscle from septic rats.

J. Fischer, P. Hasselgren, U. Angerås, 1991, Life Science.

N-acetylcysteine reverses diastolic dysfunction and hypertrophy in familial hypertrophic cardiomyopathy.

B. Wolska, R. Solaro, D. Ryba, 2015, American journal of physiology. Heart and circulatory physiology.

Early effects in vitro of the muscular dysgenesis mutation on nervous tissue in the mouse

D. Wieczorek, 1984, Muscle & nerve.

Long-term rescue of a familial hypertrophic cardiomyopathy caused by a mutation in the thin filament protein, tropomyosin, via modulation of a calcium cycling protein.

Shamim A. K. Chowdhury, E. Kranias, B. Wolska, 2011, Journal of molecular and cellular cardiology.

A mouse model of familial hypertrophic cardiomyopathy caused by a alpha-tropomyosin mutation.

B. Aronow, G. Boivin, J. Molkentin, 2003, Molecular and cellular biochemistry.

Neonatal gene transfer of Serca2a delays onset of hypertrophic remodeling and improves function in familial hypertrophic cardiomyopathy.

R. Hajjar, B. Wolska, R. Solaro, 2010, Journal of molecular and cellular cardiology.

Microarray analysis of active cardiac remodeling genes in a familial hypertrophic cardiomyopathy mouse model rescued by a phospholamban knockout.

B. Aronow, A. Jegga, B. Wolska, 2013, Physiological genomics.

Tropomyosin de-phosphorylation in the heart: What are the consequences?

D. Wieczorek, E. M. Schulz, E. Schulz, 2013, Journal of Muscle Research and Cell Motility.

Correlation between myofilament response to Ca2+ and altered dynamics of contraction and relaxation in transgenic cardiac cells that express beta-tropomyosin.

P. D. de Tombe, B. Wolska, R. Solaro, 1999, Circulation research.

Effects of nicotine administration in a mouse model of familial hypertrophic cardiomyopathy, α-tropomyosin D175N.

Shamim A. K. Chowdhury, B. Wolska, Cibele T D Ribeiro, 2011, American journal of physiology. Heart and circulatory physiology.

Decreasing Tropomyosin Phosphorylation Rescues Tropomyosin-induced Familial Hypertrophic Cardiomyopathy*

Shamim A. K. Chowdhury, B. Wolska, R. Solaro, 2013, The Journal of Biological Chemistry.

Analysis of fibrosis in control or pressure overloaded rat hearts after mechanical unloading by heterotopic heart transplantation

Tessa R Werner, K. Lorenz, H. Ehmke, 2019, Scientific Reports.

Functional Importance of the Carboxyl-terminal Region of Striated Muscle Tropomyosin*

George M. Hilliard, G. Boivin, R. Solaro, 2003, Journal of Biological Chemistry.

Molecular and Physiological Effects of (cid:97) -Tropomyosin Ablation in the Mouse

G. Boivin, B. Wolska, R. Solaro, 1998 .

Molecular and physiological effects of alpha-tropomyosin ablation in the mouse.

R. Solaro, M. Muthuchamy, D. Wieczorek, 1998, Circulation research.

Molecular and Physiological Effects of (cid:97) -Tropomyosin Ablation in the Mouse

R. Solaro, M. Muthuchamy, D. Wieczorek, 1998 .