John F. Mehlmann

发表

Discovery of Pyrazolocarboxamides as Potent and Selective Receptor Interacting Protein 2 (RIP2) Kinase Inhibitors.

Joseph P. Romano, N. C. Goodwin, J. Bertin, 2019, ACS medicinal chemistry letters.

Synthesis and biological evaluation of piperazinyl heterocyclic antagonists of the gonadotropin releasing hormone (GnRH) receptor.

J. Cottom, D. Hauze, J. Pelletier, 2010, Bioorganic & medicinal chemistry letters.

Regioselective synthesis of substituted pyrroles: efficient palladium-catalyzed cyclization of internal alkynes and 2-amino-3-iodoacrylate derivatives.

P. Mahaney, M. L. Crawley, I. Goljer, 2006, Organic letters.

Discovery of a First-in-Class Receptor Interacting Protein 2 (RIP2) Kinase Specific Clinical Candidate, 2-((4-(Benzo[ d]thiazol-5-ylamino)-6-( tert-butylsulfonyl)quinazolin-7-yl)oxy)ethyl Dihydrogen Phosphate, for the Treatment of Inflammatory Diseases.

J. Bertin, K. Erhard, M. Convery, 2019, Journal of medicinal chemistry.

Design of amidobenzimidazole STING receptor agonists with systemic activity

Joseph P. Romano, J. Bertin, J. Adams, 2018, Nature.

(1-(4-(Naphthalen-2-yl)pyrimidin-2-yl)piperidin-4-yl)methanamine: a wingless beta-catenin agonist that increases bone formation rate.

Raymond J. Unwalla, P. Bodine, R. Magolda, 2009, Journal of medicinal chemistry.

Efficient, regioselective palladium-catalyzed tandem Heck-isomerization reaction of aryl bromides and non-allylic benzyl alcohols.

P. Mahaney, Kristin M Phipps, M. L. Crawley, 2009, Organic letters.

Design and Synthesis of Foldamers Based on an Anthracene Diels–Alder Adduct

P. Axelsen, J. Winkler, John F. Mehlmann, 2001 .

The Identification and Pharmacological Characterization of 6-(tert-Butylsulfonyl)-N-(5-fluoro-1H-indazol-3-yl)quinolin-4-amine (GSK583), a Highly Potent and Selective Inhibitor of RIP2 Kinase.

Carol A. Capriotti, J. Bertin, M. Convery, 2016, Journal of medicinal chemistry.

Identification of Quinoline-Based RIP2 Kinase Inhibitors with an Improved Therapeutic Index to the hERG Ion Channel.

J. Bertin, M. Convery, D. Lipshutz, 2018, ACS medicinal chemistry letters.

Design of amidobenzimidazole STING receptor agonists with systemic activity

J. Bertin, J. Adams, M. Bantscheff, 2018, Nature.

Author Correction: Design of amidobenzimidazole STING receptor agonists with systemic activity

Joseph P. Romano, J. Bertin, M. Bantscheff, 2019, Nature.

pH sensors based on luminescent ruthenium(II) alpha-diimine complexes with diethylaminomethyl sensing groups

James N. Demas, Benjamin A. DeGraff, James E. Collins, 1999, Other Conferences.

Improvement of physiochemical properties of the tetrahydroazepinoindole series of farnesoid X receptor (FXR) agonists: beneficial modulation of lipids in primates.

M. Evans, P. Mahaney, W. Hum, 2010, Journal of medicinal chemistry.

Pyrrole[2,3-d]azepino compounds as agonists of the farnesoid X receptor (FXR).

M. Evans, P. Mahaney, Callain Y Kim, 2009, Bioorganic & medicinal chemistry letters.

Identification of Quinoline-Based RIP2 Kinase Inhibitors with an Improved Therapeutic Index to the hERG Ion Channel.

Carol A. Capriotti, J. Bertin, M. Convery, 2018, ACS medicinal chemistry letters.